Infected Scalp Hematoma Presenting With Low-Grade Fever and Significant Weight Loss

Gallbladder tuberculosis (TB) as an isolated infection and is an extremely rare entity even in parts of the world with endemicity. Though it has myriad ways of presentation, it can be cured successfully. We present a case of a 53-year-old man who presented with epigastric fullness and bloating with on and off low-grade fever for 2 months and significant weight loss. He underwent a CT scan, which showed a soft tissue gallbladder mass causing mural thickening of the antrum and lesser curvature. This was followed by a CT-guided core biopsy and gastric antrum biopsy via gastroscopy. Histopathology revealed chronic granulomatous inflammation in both samples. Various clinical presentations of gallbladder TB have been reported in literature, but to the best of our knowledge, the present case has a unique presentation and has never been reported before.

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Visceral leishmaniasis presenting as haemophagocytic lymphohistiocytosis

BMJ Case Reports ◽

10.1136/bcr-2019-232576 ◽

2019 ◽

Vol 12 (12) ◽

pp. e232576

Author(s):

Lewis Vanhinsbergh ◽

Aaron Mason ◽

Andrew Godfrey

Keyword(s):

Weight Loss ◽

Fever Of Unknown Origin ◽

Hospital Admissions ◽

Unknown Origin ◽

Low Grade ◽

Extensive Investigation ◽

Significant Weight Loss ◽

Haemophagocytic Lymphohistiocytosis ◽

Clinical Criteria ◽

Medical Specialists

A 53-year-old man presented with a number of hospital admissions for investigation of fever of unknown origin. He became gradually weaker with significant weight loss, pancytopenia and progressive splenomegaly over a 6-month period of extensive investigation. This was undertaken at different NHS hospitals with involvement of multiple medical specialists. Clinical criteria for haemophagocytic lymphohistiocytosis were met. Following investigation, this was felt likely secondary to a low-grade lymphoma of the spleen, necessitating splenectomy for diagnostic and therapeutic purposes. Ultimately, this risky surgical procedure was avoided when positive Leishmania serology led to successful treatment with amphotericin B.

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Abstract #615: Hispanic People Achieve Clinically Significant Weight loss with Liraglutide 3.0 Mg for Weight Management

Endocrine Practice ◽

10.1016/s1530-891x(20)42679-5 ◽

2015 ◽

Vol 21 ◽

pp. 121

Author(s):

Patrick O’Neil ◽

W. Timothy Garvey ◽

J. Michael Gonzalez-Campoy ◽

Pablo Mora ◽

Rafael Violante Ortiz ◽

...

Keyword(s):

Weight Loss ◽

Weight Management ◽

Significant Weight Loss ◽

Hispanic People ◽

Clinically Significant

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Primary hyperparathyroidism in pregnancy: Uncommon manifestation of significant weight loss

Endocrine Abstracts ◽

10.1530/endoabs.69.p39 ◽

2020 ◽

Author(s):

Timea Varga ◽

Isuri Kurera ◽

James Clark ◽

Benjamin Field ◽

Vidhu Nayyar ◽

...

Keyword(s):

Weight Loss ◽

Primary Hyperparathyroidism ◽

Significant Weight Loss ◽

In Pregnancy

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Significant weight loss as an unusual presentation of empty sella – case report

Endocrine Abstracts ◽

10.1530/endoabs.70.ep324 ◽

2020 ◽

Author(s):

Cristina Ene

Keyword(s):

Weight Loss ◽

Case Report ◽

Empty Sella ◽

Unusual Presentation ◽

Significant Weight Loss

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Combining ecological momentary assessment, wrist-based eating detection, and dietary assessment to characterize dietary lapse: A multi-method study protocol

Digital Health ◽

10.1177/2055207620988212 ◽

2021 ◽

Vol 7 ◽

pp. 205520762098821

Author(s):

Stephanie P Goldstein ◽

Adam Hoover ◽

E Whitney Evans ◽

J Graham Thomas

Keyword(s):

Weight Loss ◽

Eating Behavior ◽

Ecological Momentary Assessment ◽

Structured Interview ◽

Self Report ◽

Significant Weight Loss ◽

Clinically Significant ◽

Ecological Momentary ◽

Momentary Assessment ◽

Lapse Behavior

Objectives Behavioral obesity treatment (BOT) produces clinically significant weight loss and health benefits for many individuals with overweight/obesity. Yet, many individuals in BOT do not achieve clinically significant weight loss and/or experience weight regain. Lapses (i.e., eating that deviates from the BOT prescribed diet) could explain poor outcomes, but the behavior is understudied because it can be difficult to assess. We propose to study lapses using a multi-method approach, which allows us to identify objectively-measured characteristics of lapse behavior (e.g., eating rate, duration), examine the association between lapse and weight change, and estimate nutrition composition of lapse. Method We are recruiting participants (n = 40) with overweight/obesity to enroll in a 24-week BOT. Participants complete biweekly 7-day ecological momentary assessment (EMA) to self-report on eating behavior, including dietary lapses. Participants continuously wear the wrist-worn ActiGraph Link to characterize eating behavior. Participants complete 24-hour dietary recalls via structured interview at 6-week intervals to measure the composition of all food and beverages consumed. Results While data collection for this trial is still ongoing, we present data from three pilot participants who completed EMA and wore the ActiGraph to illustrate the feasibility, benefits, and challenges of this work. Conclusion This protocol will be the first multi-method study of dietary lapses in BOT. Upon completion, this will be one of the largest published studies of passive eating detection and EMA-reported lapse. The integration of EMA and passive sensing to characterize eating provides contextually rich data that will ultimately inform a nuanced understanding of lapse behavior and enable novel interventions. Trial registration: Registered clinical trial NCT03739151; URL: https://clinicaltrials.gov/ct2/show/NCT03739151

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Synthesis and properties of a benzoxazine monomer containing maleimide and biphenyl groups

High Performance Polymers ◽

10.1177/0954008321996745 ◽

2021 ◽

pp. 095400832199674

Author(s):

Tao Guo ◽

Yang Fan ◽

Chang Bo ◽

Zhang Qi ◽

Han Tao ◽

...

Keyword(s):

Weight Loss ◽

Loss Rate ◽

Proton Nuclear Magnetic Resonance ◽

Significant Weight Loss ◽

Scanning Calorimetry ◽

Weight Loss Rate ◽

Reaction Heat ◽

H Nmr ◽

Curing Reaction ◽

Dsc Curves

Benzoxazine resin exhibits excellent properties and is widely used in many fields. Herein, the synthesis of a novel compound, the bis(2,4-dihydro-2 H-3-(4- N-maleimido)phenyl-1,3-benzoxazinyl)biphenyl (BMIPBB), has been reported, which was synthesized by reacting N-(4-aminophenyl)maleimide (APMI), formaldehyde, and 4,4’-dihydroxybiphenyl. 1,3,5-three(4-(maleimido)phenyl)-1,3,5-triazine (TMIPT) was formed as an intermediate during the reaction. The proton nuclear magnetic resonance (1H-NMR) and Fourier transform-infrared (FTIR) spectroscopy experiments were conducted to determine the structure of BMIPBB. BMIPBB was obtained as a reddish-brown solid in 40.1% yield. The thermal properties of BMIPBB were investigated using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) techniques. Analysis of the DSC curves revealed that the broad peak representing the release of curing reaction heat appeared in the temperature range of 140–330°C. The peak temperature was 242.59°C and the heat of the reaction was 393.82 J/g, indicating that the rate of the curing reaction was low and the heat of the reaction was high. Analysis of the TGA results revealed that the weight loss rate was 5% at 110°C. The monomer exhibited a significant weight loss in the range of 320–500°C. The compound lost 50% of its weight at a temperature of 427°C.

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Fecal Metaproteomics Reveals Reduced Gut Inflammation and Changed Microbial Metabolism Following Lifestyle-Induced Weight Loss

Biomolecules ◽

10.3390/biom11050726 ◽

2021 ◽

Vol 11 (5) ◽

pp. 726

Author(s):

Ronald Biemann ◽

Enrico Buß ◽

Dirk Benndorf ◽

Theresa Lehmann ◽

Kay Schallert ◽

...

Keyword(s):

Metabolic Syndrome ◽

Weight Loss ◽

Gut Microbiome ◽

Taxonomic Composition ◽

Low Grade ◽

Gut Inflammation ◽

Functional Changes ◽

Microbiome Composition ◽

Before And After ◽

Human Proteins

Gut microbiota-mediated inflammation promotes obesity-associated low-grade inflammation, which represents a hallmark of metabolic syndrome. To investigate if lifestyle-induced weight loss (WL) may modulate the gut microbiome composition and its interaction with the host on a functional level, we analyzed the fecal metaproteome of 33 individuals with metabolic syndrome in a longitudinal study before and after lifestyle-induced WL in a well-defined cohort. The 6-month WL intervention resulted in reduced BMI (−13.7%), improved insulin sensitivity (HOMA-IR, −46.1%), and reduced levels of circulating hsCRP (−39.9%), indicating metabolic syndrome reversal. The metaprotein spectra revealed a decrease of human proteins associated with gut inflammation. Taxonomic analysis revealed only minor changes in the bacterial composition with an increase of the families Desulfovibrionaceae, Leptospiraceae, Syntrophomonadaceae, Thermotogaceae and Verrucomicrobiaceae. Yet we detected an increased abundance of microbial metaprotein spectra that suggest an enhanced hydrolysis of complex carbohydrates. Hence, lifestyle-induced WL was associated with reduced gut inflammation and functional changes of human and microbial enzymes for carbohydrate hydrolysis while the taxonomic composition of the gut microbiome remained almost stable. The metaproteomics workflow has proven to be a suitable method for monitoring inflammatory changes in the fecal metaproteome.

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Extrusion of both Superficial and Deep Cuffs of a Functional Double-Cuff Peritoneal Dialysis Catheter after Significant Weight Loss

Case Reports in Nephrology and Dialysis ◽

10.1159/000515049 ◽

2021 ◽

pp. 190-194

Author(s):

Aravindh S. Ganapathy ◽

Myron S. Powell ◽

James L. Pirkle

Keyword(s):

Weight Loss ◽

Peritoneal Dialysis ◽

Subcutaneous Tissue ◽

Peritoneal Dialysis Catheter ◽

Dialysis Catheter ◽

Review Of The Literature ◽

Significant Weight Loss ◽

Exit Site ◽

Special Circumstances ◽

Uncommon Complication

Extrusion of the superficial cuff of a peritoneal dialysis (PD) catheter is an uncommon complication that may be associated with infection or malfunction. However, extrusion of both the superficial and deep cuffs of a double-cuff catheter is rare and uniformly associated with failure and peritonitis. We report a case of a presternal-type PD double-cuff catheter with extrusion of both cuffs through an abdominal exit site after 6 years of use that has remained functional, which has not been previously reported. In this case, the patient had achieved a 60-kg weight loss resulting in retraction of the subcutaneous tissue around both cuffs, while the catheter was held in place by the titanium connector between the presternal extension tubing and the inner, coiled catheter. In such special circumstances, extrusion of both cuffs may not necessitate urgent catheter removal. A review of the literature revealed previous cases of superficial cuff extrusions with catheters remaining functional but not with deep cuff extrusion.

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Preferred versus Nonpreferred Treatment, and Self-Control Training versus Determination Raising as Treatments of Obesity: A Pilot Study

Psychological Reports ◽

10.2466/pr0.1976.38.1.191 ◽

1976 ◽

Vol 38 (1) ◽

pp. 191-198 ◽

Cited By ~ 15

Author(s):

D. C. Murray

Keyword(s):

Weight Loss ◽

Pilot Study ◽

Treatment Group ◽

Self Control ◽

The Other ◽

Significant Weight Loss ◽

Overweight Women

Of 12 overweight women half received 10 wk. of self-control training and the rest received an equal period aimed at increasing determination to lose weight. Half of each treatment group had expressed a preference for the type of treatment they received and half for the other type of treatment. Both groups lost a statistically significant amount of weight, and at a 3-mo. follow-up there was still a significant weight loss. Follow-up at 6 mo. on 9 of the 12 original subjects indicated both groups regained much of their lost weight. There was no evidence that either type of treatment or receiving one's preferred type of treatment was related to weight loss.

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