scholarly journals Cardiac Dysfunction Indices and Their Prognostic Value in Acute Exacerbation COPD Patients

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ahmad B. Elden ◽  
Mohamed F. Abdelghany ◽  
Mostafa K. Ahmed ◽  
Dalia Tarek
Keyword(s):  
Acute Exacerbation ◽  
Cardiac Dysfunction ◽  
Prognostic Value ◽  
Copd Patients

Serum Magnesium Levels in Exacerbation of COPD: A Single Centre Prospective Study from Kashmir, India.

JMS SKIMS ◽  
2010 ◽  
Vol 13 (1) ◽  
pp. 15-19
Author(s):  
Bashir Ahmed Shah ◽  
Muzafar Ahmed Naik ◽  
Sajjad Rajab ◽  
Syed Muddasar ◽  
Ghulam Nabi Dhobi ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Serum Magnesium ◽  
Stage Iii ◽  
Advanced Stage ◽  
Copd Exacerbation ◽  
Post Discharge ◽  
Duration Of Symptoms ◽  
Copd Patients ◽  
Exacerbation Of Copd ◽  
Time Of Admission

Objective: To study the significance of serum magnesium levels during COPD exacerbation and stability.Materials & Methods: The patient population consisted of all patients of COPD admitted as acute exacerbation as defined by the Anthonisens criteria, from June 2006 to may 2008. Same patients one month post discharge presenting to the OPD for routine check up as stable COPD served as controls. Results: A total number of 77 patients of COPD presenting as acute exacerbation were included in the study. The incidence of Hypomagnesaemia was 33.8% at admission; 5% at discharge and 4% at one month of post discharge in COPD patients. The mean serum magnesium levels were significantly lower in cases than controls (1.88±0.67mg/ dl V/S 2.3±0.36mg/dl; p<0.0001). Also, hypomagnesemia was present in higher number of cases (22/77, 33.8%) compared to controls, 3/75, 4.0%; (p<0.0001). Patients of COPD with acute exacerbation and hypomagnesemia, had longer duration of symptoms and had advanced stage III of COPD (p<0.001); and had raised mean corpuscle volume (p<0.045) and longer hospital stay (p<0.008).  Conclusion: We conclude COPD exacerbation is associated with hypomagnesemia. The duration of symptoms of more than 8 days, advanced stage of COPD (stage III) and raised MCV were associated with hypomagnesemia. We recommend to monitor serum magnesium levels in COPD patients with acute exacerbation at the time of admission and during their stay in the hospital.J Med Sci.2010;13(1);15-19

scholarly journals Prediction of severe acute exacerbation using changes in breathing pattern of COPD patients on home noninvasive ventilation

2018 ◽  
Vol Volume 13 ◽  
pp. 2577-2586 ◽  
Author(s):  
Sophie Blouet ◽  
Jasmine Sutter ◽  
Emeline Fresnel ◽  
Adrien Kerfourn ◽  
Antoine Cuvelier ◽  
...  
Keyword(s):  
Acute Exacerbation ◽  
Noninvasive Ventilation ◽  
Breathing Pattern ◽  
Severe Acute Exacerbation ◽  
Copd Patients

scholarly journals Effects of Mangosteen pericarp Extract to Clinical Improvements, The Plasma Level of IL-6 and Malondialdehyde in Acute Exacerbation of COPD Patients

2018 ◽  
Vol 38 (3) ◽  
pp. 164-172
Author(s):  
Khilyatul Baroroh ◽  
Suradi Suradi ◽  
Ade Rima
Keyword(s):  
Treatment Group ◽  
Plasma Level ◽  
Length Of Stay ◽  
Acute Exacerbation ◽  
Clinical Symptoms ◽  
Control Group ◽  
Chronic Obstructive ◽  
Copd Patients ◽  
Significant Difference ◽  
And Control

Background: Amplification of inflammation in acute exacerbation of chronic obstructive pulmonary disease (COPD) increases inflammatory mediators and oxidative stress in the airways, pulmonary and systemic circulation that are characterized by increased plasma level of IL-6 and MDA, resulting in worsening of clinical symptoms. Xanthones in mangosteen pericarp have anti-inflammatory and antioxidant effects, potentially as an adjuntive therapy in acute exacerbations of COPD. Methods: The aim of this study was to determine the effect of mangosteen pericarp extract to clinical improvements, plasma level of IL-6 and MDA of acute exacerbation COPD patients. A clinical trial of experimental with pretest and posttest was conducted on 34 acute exacerbation of COPD patients in Dr. Moewardi Hospital Surakarta and Dr. Ario Wirawan Lung Hospital Salatiga from April until May 2016. The sample was taken by consecutive sampling. Subjects were divided by randomized double blind technique into the treatment group (n=17) received mangosteen pericarp extract 2x1100mg/day and control group (n = 17) received placebo. Clinical improvements were measured in CAT score and length of stay. CAT score, plasma level of IL-6 and MDA were measured on admission and at discharge. Length of stay based on the number of days of care in hospitals. Results: There was significant difference (p=0,011) towards decreased of IL-6 plasma level between treatment group (-2,17 ± 3,46 pg/ mL) and control group (+1,67 ± 6,81 pg/mL). There were no significant difference towards decreased of length of stay (p=0,34) between treatment group (4,12 ± 1,54 days) and control group (5,24 ± 2,49 days), towards decreased of CAT score (p=0,252) between treatment group (-19,18 ± 3,96) and control group (-18,24 ± 2,75), and towards decreased of MDA plasma level (p=0,986) between treatment group (+0,03 ± 0,36μmol/L) and control group (+0,35 ± 1,58). Conclusions: The addition of mangosteen pericarp extract 2x1100mg/day during hospitalization was significantly lowered plasma levels of IL-6, but were not significant in lowering the CAT score, shortening the length of stay, and reducing the increase in plasma level of MDA.

scholarly journals RELATIONSHIP OF MEAN PLATELET VOLUME WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS SEVERITY- AN OBSERVATIONAL STUDY

2021 ◽  
Vol 9 (10) ◽  
pp. 423-428
Author(s):  
Kishore Kumar Sharma ◽  
Mani Ram Kumhar ◽  
Mayank Shrivastav ◽  
Harsh Tak
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Body Mass Index ◽  
Acute Exacerbation ◽  
Mean Platelet Volume ◽  
Chronic Obstructive ◽  
Platelet Volume ◽  
Obstructive Pulmonary Disease ◽  
Bode Index ◽  
Copd Patients ◽  
Relationship Of

Background & Objectives: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation and inflammation. Mean platelet volume (MPV) may be used as a marker of inflammation. We aimed to study the association between MPV and COPD patients during acute attack and relationship of MPV with severity of COPD by FEV1 (%predicted), BODE Index, PaO2, mMRC grade and 6MWD test. Methods: 100 patients with COPD (50 with acute exacerbation and 50 with stable COPD) and 30 healthy controls were enrolled in the study. Mean platelet volume (MPV), spirometry, arterial blood gases, body mass index, renal function tests and BODE index (body mass index, airflow obstruction,dyspnoea and exercise) were assessed. Level of MPV was compared between cases and controls. Results: Of 100 COPD patients, 87(87%) were male and 13(13%)were female.MPV was significantly higher in COPD patients than control and also higher in acute exacerbation group than stable COPD (p=0.001). Interpretation & Conclusions: In the present study,MPV remain in normal range in all COPD patients, but MPV values were significantly higher in COPD cases compared with control.Increased MPV was associated with acute exacerbation and also increasing with severity of COPD.

scholarly journals Sleep Quality in Chronic Obstructive Pulmonary Disease With High Risk of Acute Exacerbation

2021 ◽  
Author(s):  
Chong Xing ◽  
Hui Shen ◽  
Wenyang Li ◽  
Wei Wang
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
High Risk ◽  
Sleep Quality ◽  
Acute Exacerbation ◽  
Overlap Syndrome ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Sleep Parameters

Abstract This was a prospective case-control study aimed to explore the sleep quality, especially sleep-related disorders, among chronic obstructive pulmonary disease (COPD) patients with high risk of acute exacerbation, and to determine the risk factors. We enrolled COPD patients with acute exacerbation or health control visited the first hospital of China Medical University from October 1st, 2017 to October 28th, 2018. The subjective and objective sleep parameters were compared among them, and then the stepwise multiple regression analysis were performed. We found that COPD patients with high risk of acute exacerbation had decreased subjective and objective sleep quality. Patients with COPD-obstructive sleep apnea overlap syndrome revealed decreased slow wave sleep than patients with COPD alone. The subjective sleep parameters were correlated with the frequency of acute exacerbation, dyspnea index and Epworth sleepiness score. The objective sleep parameters were related to the degree of airflow obstruction, COPD Assessment Test score and the Modified British Medical Research Council dyspena score. So, we believe that the subjective and objective sleep quality of patients with high risk of acute exacerbations of COPD was poor, and the sleep quality of patients with overlap syndrome was worse than that of patients with COPD alone.

“RESPIRATORY VIRAL INFECTION: AN UNDERRATED ENTITY THAT NEED TO CONSIDER IN MANAGEMENT OF ACUTE EXACERBATION OF COPD”

2021 ◽  
pp. 6-8
Author(s):  
Gyan Singh Meena ◽  
Ajith Kumar M S ◽  
Shashank Sharma ◽  
SP Agnihotri
Keyword(s):  
Acute Exacerbation ◽  
Viral Infections ◽  
Respiratory Viruses ◽  
Cross Sectional Study ◽  
Viral Etiology ◽  
Cross Sectional ◽  
Acute Exacerbation Of Copd ◽  
Medical College ◽  
Copd Patients ◽  
Exacerbation Of Copd

BACKGROUND: Acute exacerbation of COPD (AECOPD) is one of the most common cause of hospital admission. It causes signicant morbidity, mortality and inexorable decline in ling function. Many exacerbations are believed to be due to upper and/ lower respiratory tract viral infections, but the incidence of these infections in patients with COPD is still undetermined. Objectives of the study are-(a) To nd out the viral etiology in patients having acute exacerbation of COPD. (b) To correlate the severity of COPD patients having exacerbations with viral etiology. METHODS: This cross-sectional study was carried out on 70 AECOPD patients admitted in department of Respiratory Medicine, Institute of Respiratory Diseases, SMS Medical College, Jaipur during July 2019–June 2020. Demographic and clinical parameters were recorded from each patient during admission. Twin nasopharyngeal/oropharyngeal swabs were collected and are tested for Respiratory viruses via RT-PCR. RESULTS: Respiratory viruses were detected in 15 of 70 (21.42%) patients during exacerbations of COPD. The viruses detected were inuenza (10%), rhinovirus (5.71%), adenovirus (4.29%) and RSV (1.42%). Majority of the patients had exacerbations in severe COPD subgroup, had duration of hospital stay of more than or equal to 5 days, had one episode of acute exacerbation per year and 5, 9, 11 respiratory viruses were detected in this group respectively. CONCLUSION: Viral infections seem to contribute to the exacerbations of COPD in our settings and should be strongly considered in the management of such patients. Considering appropriate antiviral therapy can timely reduce morbidity in an event of an inuenza viral exacerbation.

scholarly journals Lymphocytes Apoptosis in Patients with Acute Exacerbation of Asthma

1999 ◽  
Vol 8 (4-5) ◽  
pp. 237-243 ◽  
Author(s):  
Agnès Hamzaoui ◽  
Kamel Hamzaoui ◽  
Habib Salah ◽  
Abdellatif Chabbou
Keyword(s):  
Acute Exacerbation ◽  
Mononuclear Cells ◽  
Allergic Inflammation ◽  
Induced Sputum ◽  
Chronic Obstructive ◽  
Complex Method ◽  
Healthy Controls ◽  
Asthmatic Patients ◽  
Copd Patients ◽  
Tnf Α

Asthma is characterized by airway inflammation, which can be now assessed by the analysis of induced sputum . Ten patients with asthma were investigated during acute exacerbation for the quantification of apoptosis, for Bcl-2 and Fas expression, in induced sputum lymphocytes. They were compared to 12 patients with chronic obstructive pulmonary disease (COPD), and 10 healthy controls. Spontaneous apoptosis was determined by staining nuclei with propidium iodide, and analyzed with a FACScan. Bcl-2 was measured by Western blotting, and results were obtained by densitometric scanning, done by the gel proanalyser. The investigation of Fas was performed using the streptavidin-biotin preroxidase-complex method. Patients with asthma and patients with COPD exhibited a significant increase of cellularity, percentage of neutrophils, eosinophils and lymphocytes when compared to healthy controls. Apoptosis in induced sputum mononuclear cells was found decreased in patients with asthma compared to COPD patients and healthy controls. The quantification of apoptosis was measured after exposure to anticytokine antibodies. Anti-TNF-α antibody blocked the apoptosis in both patients groups and healthy controls, suggesting that TNF-α acted as an inducer of apoptosis. Anti-IL-10 blocked apoptosis completely exclusively in patients with asthma. Bcl-2 expression was found to be increased in induced sputum mononuclear cells from patients with asthma, compared to healthy controls and patients with COPD. Expression of Fas could be detected in patients with asthma, at a lower level than COPD patients and healthy controls. Distinct mechanisms of apoptosis were found in patients with asthma and patients with COPD, characterized by different levels of Bcl-2 and Fas expression. Induction of apoptosis should be a beneficial process in allergic inflammation traduced in induced sputum mononuclear cells. The apoptosis process is assumed by two different mechanisms in asthma and COPD. Our findings indicated that in asthmatic patients, activated lymphocytes accumulate in the bronchi; because of their prolonged survival that maintains inflammation.

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