Habitual physical exercise has beneficial effects on telomere length in postmenopausal women

Irisin, a skeletal muscle-secreted myokine, produced in response to physical exercise, has protective functions in both the central and the peripheral nervous systems, including the regulation of brain-derived neurotrophic factors and modification of telomere length. Such beneficial effects may inhibit or delay the emergence of neurodegenerative diseases, including Alzheimer’s disease (AD). This review is based on the hypothesis that irisin produced by physical exercise helps control AD progression. Herein, we describe the physiology of irisin and its potential role in delaying or preventing AD. Although current and ongoing studies on irisin show promising results, further research is required to clarify its potential as a meaningful therapeutic target for treating human diseases.

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Effect of physical exercise on cardiometabolic parameters in post-menopause: an integrative review

Revista Brasileira de Geriatria e Gerontologia ◽

10.1590/1981-22562019022.190133 ◽

2019 ◽

Vol 22 (5) ◽

Author(s):

Rafaela Dias Rodrigues ◽

Brenda Lemos Carvalho ◽

Gleisy Kelly Neves Gonçalves

Keyword(s):

Oxidative Stress ◽

Physical Exercise ◽

Postmenopausal Women ◽

Abdominal Circumference ◽

Inclusion Criteria ◽

Inflammatory Reactions ◽

Beneficial Effects ◽

The Third ◽

Post Menopause ◽

Second Category

Abstract Objective: To identify the evidence available in literature which relates the practice of physical exercise to improvements in the cardiovascular and metabolic parameters of postmenopausal women. Method: A search was performed of works published between 2008 and 2018 included in the MEDLINE, BDENF, IBCS and LILACS databases. Of the 792 studies identified, 23 met the inclusion criteria. Results: Following analysis, the studies were separated into three categories. In the first category it was observed that physical exercise improved lipid metabolism, reduced abdominal circumference and promoted weight loss. The second category revealed that physical exercise reduced systolic blood pressure, prevented the development of arterial hypertension and reduced the release of sympathomimetic hormones. In the third category the studies indicated that physical exercise elevated the antioxidant mediators and reversed the oxidative stress involved in the inflammatory reactions present in cardiovascular diseases. Conclusion: The studies confirm the beneficial effects of physical exercise on the metabolic and cardiovascular parameters of postmenopausal women.

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Physical Exercise and Cardiac Repair: The Potential Role of Nitric Oxide in Boosting Stem Cell Regenerative Biology

Antioxidants ◽

10.3390/antiox10071002 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1002

Author(s):

Fabiola Marino ◽

Mariangela Scalise ◽

Eleonora Cianflone ◽

Luca Salerno ◽

Donato Cappetta ◽

...

Keyword(s):

Nitric Oxide ◽

Stem Cell ◽

Physical Exercise ◽

Cell Biology ◽

Molecular Mechanisms ◽

Heart Function ◽

Stem Cell Biology ◽

Myocardial Repair ◽

Beneficial Effects

Over the years strong evidence has been accumulated showing that aerobic physical exercise exerts beneficial effects on the prevention and reduction of cardiovascular risk. Exercise in healthy subjects fosters physiological remodeling of the adult heart. Concurrently, physical training can significantly slow-down or even reverse the maladaptive pathologic cardiac remodeling in cardiac diseases, improving heart function. The underlying cellular and molecular mechanisms of the beneficial effects of physical exercise on the heart are still a subject of intensive study. Aerobic activity increases cardiovascular nitric oxide (NO) released mainly through nitric oxidase synthase 3 activity, promoting endothelium-dependent vasodilation, reducing vascular resistance, and lowering blood pressure. On the reverse, an imbalance between increasing free radical production and decreased NO generation characterizes pathologic remodeling, which has been termed the “nitroso-redox imbalance”. Besides these classical evidence on the role of NO in cardiac physiology and pathology, accumulating data show that NO regulate different aspects of stem cell biology, including survival, proliferation, migration, differentiation, and secretion of pro-regenerative factors. Concurrently, it has been shown that physical exercise generates physiological remodeling while antagonizes pathologic remodeling also by fostering cardiac regeneration, including new cardiomyocyte formation. This review is therefore focused on the possible link between physical exercise, NO, and stem cell biology in the cardiac regenerative/reparative response to physiological or pathological load. Cellular and molecular mechanisms that generate an exercise-induced cardioprotective phenotype are discussed in regards with myocardial repair and regeneration. Aerobic training can benefit cells implicated in cardiovascular homeostasis and response to damage by NO-mediated pathways that protect stem cells in the hostile environment, enhance their activation and differentiation and, in turn, translate to more efficient myocardial tissue regeneration. Moreover, stem cell preconditioning by and/or local potentiation of NO signaling can be envisioned as promising approaches to improve the post-transplantation stem cell survival and the efficacy of cardiac stem cell therapy.

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Effect of Adherence to Physical Exercise on Cardiometabolic Profile in Postmenopausal Women

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18020656 ◽

2021 ◽

Vol 18 (2) ◽

pp. 656

Author(s):

Valentina Bucciarelli ◽

Francesco Bianco ◽

Francesco Mucedola ◽

Andrea Di Blasio ◽

Pascal Izzicupo ◽

...

Keyword(s):

Physical Exercise ◽

Diastolic Function ◽

Postmenopausal Women ◽

Serum Glucose ◽

Moderate Intensity ◽

Adherence Rate ◽

Before And After ◽

Estrogen Depletion ◽

The Impact ◽

Cardiometabolic Profile

Background: Menopause is associated with negative cardiovascular adaptations related to estrogen depletion, which could be counteracted by physical exercise (PhE). However, the impact of total adherence-rate (TA) to PhE and sedentary time (SedT) on cardiometabolic profile in this population has not been elucidated. Methods: For 13-weeks, 43 women (57.1 ± 4.7 years) participated in a 4-days-a-week moderate-intensity walking training. They underwent laboratory, anthropometric and echocardiographic assessment, before and after training (T0–T1). Spontaneous physical activity (PhA) was assessed with a portable multisensory device. The sample was divided according to TA to PhE program: <70% (n = 17) and ≥70% (n = 26). Results: TA ≥ 70% group experienced a significant T1 improvement of relative wall thickness (RWT), diastolic function, VO2max, cortisol, cortisol/dehydroandrostenedione-sulphate ratio and serum glucose. After adjusting for SedT and 10-min bouts of spontaneous moderate-to-vigorous PhA, TA ≥ 70% showed the most significant absolute change of RWT and diastolic function, body mass index, weight and cortisol. TA ≥ 70% was major predictor of RWT and cortisol improvement. Conclusions: In a group of untrained, postmenopausal women, a high TA to a 13-weeks aerobic PhE program confers a better improvement in cardiometabolic profile, regardless of SedT and PhA levels.

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Nutrition in Menopausal Women: A Narrative Review

Nutrients ◽

10.3390/nu13072149 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2149

Author(s):

Thais R. Silva ◽

Karen Oppermann ◽

Fernando M. Reis ◽

Poli Mara Spritzer

Keyword(s):

Body Composition ◽

Postmenopausal Women ◽

Bone Fractures ◽

Blood Pressure Reduction ◽

Antioxidant Properties ◽

Narrative Review ◽

Current Evidence ◽

Beneficial Effects ◽

Clinical Endpoints ◽

Postmenopausal Period

Among the various aspects of health promotion and lifestyle adaptation to the postmenopausal period, nutritional habits are essential because they concern all women, can be modified, and impact both longevity and quality of life. In this narrative review, we discuss the current evidence on the association between dietary patterns and clinical endpoints in postmenopausal women, such as body composition, bone mass, and risk markers for cardiovascular disease. Current evidence suggests that low-fat, plant-based diets are associated with beneficial effects on body composition, but further studies are needed to confirm these results in postmenopausal women. The Mediterranean diet pattern along with other healthy habits may help the primary prevention of bone, metabolic, and cardiovascular diseases in the postmenopausal period. It consists on the use of healthy foods that have anti-inflammatory and antioxidant properties, and is associated with a small but significant decrease in blood pressure, reduction of fat mass, and improvement in cholesterol levels. These effects remain to be evaluated over a longer period of time, with the assessment of hard outcomes such as bone fractures, diabetes, and coronary ischemia.

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Functional variants in CYP1B1, KRAS and MTHFR genes are associated with shorter telomere length in postmenopausal women

Mechanisms of Ageing and Development ◽

10.1016/j.mad.2015.05.003 ◽

2015 ◽

Vol 149 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Jasmina Z. Cerne ◽

Maja Pohar-Perme ◽

Petra Cerkovnik ◽

Ksenija Gersak ◽

Srdjan Novakovic

Keyword(s):

Postmenopausal Women ◽

Telomere Length ◽

Functional Variants

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Beneficial effects of weight loss on plasma apolipoproteins in postmenopausal women

The Journal of Nutritional Biochemistry ◽

10.1016/j.jnutbio.2004.07.001 ◽

2004 ◽

Vol 15 (12) ◽

pp. 717-721 ◽

Cited By ~ 13

Author(s):

Maria Luz Fernandez ◽

Shiva Metghalchi ◽

Sonia Vega-López ◽

Karin Conde-Knape ◽

Timothy G. Lohman ◽

...

Keyword(s):

Weight Loss ◽

Postmenopausal Women ◽

Beneficial Effects

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Acute hormonal responses of a high impact physical exercise session in early postmenopausal women

European Journal of Applied Physiology ◽

10.1007/s00421-003-0874-7 ◽

2003 ◽

Vol 90 (1-2) ◽

pp. 199-209 ◽

Cited By ~ 26

Author(s):

W. Kemmler ◽

L. Wildt ◽

K. Engelke ◽

R. Pintag ◽

M. Pavel ◽

...

Keyword(s):

Physical Exercise ◽

Postmenopausal Women ◽

High Impact ◽

Exercise Session ◽

Hormonal Responses ◽

Early Postmenopausal Women ◽

Acute Hormonal Responses

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Exercise intensity to maximal aerobic speed, physical activity level and heart rate variability in postmenopausal women

Cuadernos de Psicología del Deporte ◽

10.6018/cpd.379111 ◽

2020 ◽

Vol 20 (2) ◽

pp. 63-70

Author(s):

Felipe de Ornelas ◽

Danilo Rodrigues Batista ◽

Vlademir Meneghel ◽

Wellington Gonçalves Dias ◽

Guilherme Borsetti Businari ◽

...

Keyword(s):

Physical Activity ◽

Heart Rate ◽

Heart Rate Variability ◽

Physical Exercise ◽

Postmenopausal Women ◽

Aerobic Capacity ◽

Exercise Intensity ◽

Physical Activity Level ◽

Activity Level ◽

Maximal Aerobic Speed

Physical inactivity is main cause of disease worldwide. Identify the physical exercise preference, resulting in increases adherence and future intention to perform physical activity. The preference of the intensity of exercise questionnaire (PRETIE-Q) is the main tool used to assess preference in physical exercise. Variables as age, body mass index (BMI), usual physical activity level (PAL), maximal oxygen uptake (VO2máx), can influence in PRETIE-Q answers. The purpose of this study was investigate if there is relation between preference for exercise intensity with maximal aerobic speed (MAS), PAL and heart rate variability (HRV) in postmenopausal women phase. Participated of study 30 subjects who answer PRETIE-Q together with analyses of MAS, PAL and HRV. Preference was large correlated with MAS (r = 0.63), PAL (r = 0.57) and HRVRMSSD (r = 0.52). Together, MAS (40.4%), PAL (10.7%) and HRVRMSSD (6.4%) explained 57.5% of the preference score. This results study allow to health professional, that prescribe physical exercise, understand that subjects with high aerobic capacity, cardiovagal modulation and usual PAL will have preference for high intensity exercise. In consequence, can increase the adherence to systematic practice of physical exercise. Conclude that preference of exercise intensity for women in postmenopausal phase is related with aerobic capacity, high HRV and physical activity level.

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