Overestimation of the adaptive substitution rate in fluctuating populations
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Estimating the proportion of adaptive substitutions ( α ) is of primary importance to uncover the determinants of adaptation in comparative genomic studies. Several methods have been proposed to estimate α from patterns polymorphism and divergence in coding sequences. However, estimators of α can be biased when the underlying assumptions are not met. Here we focus on a potential source of bias, i.e. variation through time in the long-term population size ( N ) of the considered species. We show via simulations that ancient demographic fluctuations can generate severe overestimations of α , and this is irrespective of the recent population history.
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2016 ◽
Vol 5
(2)
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pp. 162-167
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2012 ◽
Vol 2012
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pp. 1-8
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2021 ◽
Vol 288
(1963)
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