scholarly journals Ian Read Gibbons. 30 October 1931—30 January 2018

2019 ◽  
Vol 66 ◽  
pp. 201-223
Author(s):  
Wendy E. Gibbons ◽  
Ronald D. Vale ◽  
Winfield S. Sale
Keyword(s):  
Molecular Biology ◽  
Mitotic Spindle ◽  
Molecular Motor ◽  
Experimental Methods ◽  
Vital Role ◽  
Biological Processes ◽  
Scientific Career ◽  
Innovative Solutions ◽  
Cilia And Flagella ◽  
The Right

Ian Read Gibbons is best known for discovering dynein, a molecular motor that powers the motion of cilia and flagella, is involved in assembling the mitotic spindle and moves chromosomes as well as other cargoes inside cells. Gibbons devoted his career in the lab of more than 50 years to understanding the mechanism of how dynein works in driving motility. In doing so, he built a life-long reputation as a creative, collaborative and tenacious researcher with an unusual gift for crafting innovative solutions to tricky experimental problems. His experimental methods spanned electron as well as light microscopy, biochemistry, molecular biology, crystallography and molecular modelling. He perceived the right set of experimental moves that would allow him to dissect and observe the physical underpinnings of minute biological processes such as the delicate movements of dynein. Gibbons traced his success to the ability to envision how pieces of a scientific puzzle might fit together to make a coherent story: ‘My own approach to research has always emphasized intuition over logic. Perhaps for that reason, I get attracted to questions with aesthetic appeal.’ Even though dynein holds much promise for helping to engineer ways to fight disease, Gibbons' focus was always on the intrinsic grace of understanding nature's workings. Gibbons’ marriage to his biochemist wife Barbara played a particularly vital role in his life. Barbara and Ian worked frequently together as she built her own scientific career through their partnership in the study of dynein. Ian's many scientific accomplishments as well as his dedication to his friends and family represent enduring gifts to us all.

Challenge-Based Acquisition: Stimulating Innovative Solutions Faster and Cheaper by Asking the Right Questions

2013 ◽  
Author(s):  
Richard Weatherly ◽  
Virginia Wydler ◽  
Matthew D. Way ◽  
Scott Anderson ◽  
Michael Arendt
Keyword(s):  
Innovative Solutions ◽  
The Right

LncRNAs a New Target for Post-Stroke Recovery

2020 ◽  
Vol 26 (26) ◽  
pp. 3115-3121
Author(s):  
Jun Yang ◽  
Jingjing Zhao ◽  
Xu Liu ◽  
Ruixia Zhu
Keyword(s):  
Ischemic Stroke ◽  
Microglial Activation ◽  
Vital Role ◽  
Stroke Recovery ◽  
Biological Processes ◽  
Current Development ◽  
Post Stroke ◽  
Cascade Processes ◽  
Non Coding Rnas ◽  
Neuron Injury

LncRNAs (long non-coding RNAs) are endogenous molecules, involved in complicated biological processes. Increasing evidence has shown that lncRNAs play a vital role in the post-stroke pathophysiology. Furthermore, several lncRNAs were reported to mediate ischemia cascade processes include apoptosis, bloodbrain barier breakdown, angiogenesis, microglial activation induced neuroinflammation which can cause neuron injury and influence neuron recovery after ischemic stroke. In our study, we first summarize current development about lncRNAs and post-stroke, focus on the regulatory roles of lncRNAs on pathophysiology after stroke. We also reviewed genetic variation in lncRNA associated with functional outcome after ischemic stroke. Additionally, lncRNA-based therapeutics offer promising strategies to decrease brain damage and promote neurological recovery following ischemic stroke. We believe that lncRNAs will become promising for the frontier strategies for IS and can open up a new path for the treatment of IS in the future.

Comparison and Analysis of Computational Methods for Identifying N6 - methyladenosine Sites in Saccharomyces Cerevisiae

2020 ◽  
Vol 26 ◽  
Author(s):  
Pengmian Feng ◽  
Lijing Feng ◽  
Chaohui Tang
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Computational Methods ◽  
Computational Analysis ◽  
Computational Prediction ◽  
Experimental Methods ◽  
Biological Processes ◽  
Biological Functions ◽  
Precise Location ◽  
Future Directions ◽  
The Past

Background and Purpose: N 6 -methyladenosine (m6A) plays critical roles in a broad set of biological processes. Knowledge about the precise location of m6A site in the transcriptome is vital for deciphering its biological functions. Although experimental techniques have made substantial contributions to identify m6A, they are still labor intensive and time consuming. As good complements to experimental methods, in the past few years, a series of computational approaches have been proposed to identify m6A sites. Methods: In order to facilitate researchers to select appropriate methods for identifying m6A sites, it is necessary to give a comprehensive review and comparison on existing methods. Results: Since researches on m6A in Saccharomyces cerevisiae are relatively clear, in this review, we summarized recent progresses on computational prediction of m6A sites in S. cerevisiae and assessed the performance of existing computational methods. Finally, future directions of computationally identifying m6A sites were presented. Conclusion: Taken together, we anticipate that this review will provide important guides for computational analysis of m 6A modifications.

Abiotic Stress Tolerance in Soybean : Regulated by ncRNA

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
YASIN JESHIMA KHAN ◽  
HUSNARA Tyagi ◽  
Anil kumar Singh ◽  
Santosh kumar. Magadum
Keyword(s):  
Abiotic Stresses ◽  
Target Genes ◽  
Abiotic Stress Tolerance ◽  
Crop Improvement ◽  
Vital Role ◽  
Grain Legume ◽  
Biological Processes ◽  
Small Interfering Rnas ◽  
Cellular Environment ◽  
Non Coding Rnas

Plants respond through a cascade of reactions resulting in varied cellular environment leading to alterations in the patterns of protein expression resulting in phonotypic changes. Single cell genomics and global proteomics came out to be powerful tools and efficient techniques in studying stress tolerant plants. Non-coding RNAs are a distinct class of regulatory RNAs in plants and animals that control a variety of biological processes. Small ncRNAs play a vital role in post transcriptional gene regulation by either translational repression or by inducing mRNA cleavage. The major classes of small RNAs include microRNAs (miRNAs) and small interfering RNAs (siRNAs), which differ in their biogenesis. miRNAs control the expression of cognate target genes by binding to complementary sequences, resulting in cleavage or translational inhibition of the target RNAs. siRNAs too have a similar structure, function, and biogenesis like miRNAs but are derived from long double-stranded RNAs and can often direct DNA methylation at target sequences.In this review, we focus on the involvement of ncRNAs in comabting abiotic stresses of soybean. This review emphasis on previously known miRNAs as they play important role in several abiotic stresses like drought, salinity, chilling and heat stress by their diverse roles in mediating biological processes like gene expression, chromatin formation, defense of genome against invading viruses. This review attempts to elucidate the various kinds of non-coding RNAs explored, their discovery, biogenesis, functions, and response for different type of abiotic stresses and future aspects for crop improvement in the context of soybean, a representative grain legume.

scholarly journals bCNN-Methylpred: Feature-Based Prediction of RNA Sequence Modification Using Branch Convolutional Neural Network

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1155
Author(s):  
Naeem Islam ◽  
Jaebyung Park
Keyword(s):  
Neural Network ◽  
Convolutional Neural Network ◽  
Domain Knowledge ◽  
Feature Space ◽  
Experimental Methods ◽  
Machine Learning Techniques ◽  
Rna Modification ◽  
Biological Processes ◽  
Rna Sequence ◽  
Functional Mechanisms

RNA modification is vital to various cellular and biological processes. Among the existing RNA modifications, N6-methyladenosine (m6A) is considered the most important modification owing to its involvement in many biological processes. The prediction of m6A sites is crucial because it can provide a better understanding of their functional mechanisms. In this regard, although experimental methods are useful, they are time consuming. Previously, researchers have attempted to predict m6A sites using computational methods to overcome the limitations of experimental methods. Some of these approaches are based on classical machine-learning techniques that rely on handcrafted features and require domain knowledge, whereas other methods are based on deep learning. However, both methods lack robustness and yield low accuracy. Hence, we develop a branch-based convolutional neural network and a novel RNA sequence representation. The proposed network automatically extracts features from each branch of the designated inputs. Subsequently, these features are concatenated in the feature space to predict the m6A sites. Finally, we conduct experiments using four different species. The proposed approach outperforms existing state-of-the-art methods, achieving accuracies of 94.91%, 94.28%, 88.46%, and 94.8% for the H. sapiens, M. musculus, S. cerevisiae, and A. thaliana datasets, respectively.

Computational insights into the calcium ions role in protein-glycosaminoglycan systems

2021 ◽  
Author(s):  
Małgorzata M Kogut ◽  
Martyna Maszota-Zieleniak ◽  
Mateusz Marcisz ◽  
Sergey Samsonov
Keyword(s):  
Extracellular Matrix ◽  
Calcium Ions ◽  
Vital Role ◽  
Biological Processes ◽  
Periodic Linear

Glycosaminoglycans (GAGs) are anionic periodic, linear polysaccharides which are composed of periodic disaccharide units. They play a vital role in many biological processes ongoing in the extracellular matrix. In terms...

scholarly journals Freedom and Engineering for All

2012 ◽  
Vol 134 (09) ◽  
pp. 32-37
Author(s):  
Jessica M. Wyndham
Keyword(s):  
Human Rights ◽  
Educational Program ◽  
American Association ◽  
Scientific Progress ◽  
Vital Role ◽  
Professional Societies ◽  
Academic Instruction ◽  
Scientists And Engineers ◽  
The Right ◽  
Engineering Enterprise

This article discusses benefits and challenges in engaging engineers in connecting engineering and human rights. Engineers have a vital role to play in giving visibility to human rights, particularly in matters relevant to their field or discipline. Academic instruction in ethics is increasingly viewed as integral to a rigorous educational program in science or engineering. The Science and Human Rights Coalition of the American Association for the Advancement of Science is one network of professional societies that recognize a role for scientists and engineers in human rights. An important way in which engineers can protect and promote human rights is by ensuring that the products they develop benefit people in need. Engineers have human rights that need to be respected in order for the engineering enterprise to flourish and the benefits of engineering to be broadly enjoyed. Engineers have opportunities to contribute to human rights compliance when designing and implementing projects, and to contribute to the realization of the right to benefit from scientific progress and its applications.

scholarly journals The authority of the ecumenical patriarch in the Orthodox Church: A historico-canonical analysis

2010 ◽  
pp. 301-322
Author(s):  
Vasilije Vranic
Keyword(s):  
20Th Century ◽  
Canon Law ◽  
Historical Analysis ◽  
Vital Role ◽  
Eastern Orthodox ◽  
Orthodox Church ◽  
Christian Church ◽  
Exact Role ◽  
History Of ◽  
The Right

During the 20th century, the exact role and the scope of jurisdictional authority of the Ecumenical Patriarch was an object of attention of both theologians and historians. The problem of defining the Patriarch was reactualized through the intensification of conciliar negotiations of Orthodox Churches. The purpose of this article is to demonstrate that the pretensions of the Ecumenical Patriarch for universal jurisdiction over the entire Orthodox Diaspora, and the pretensions for the right of final arbitration in the ecclesial matters of the entire Orthodox communion, do not have a support in the Orthodox Ecclesiology. This will be argued in a historical analysis of the relevant prescriptions of the Eastern Orthodox Canon Law, which will be placed into the context of the history of the Christian Church, primarily of the Patristic period, since there disciplines play a vital role in the Orthodox understanding of Ecclesiological Tradition.

scholarly journals A Mini-review of the Computational Methods Used in Identifying RNA 5- Methylcytosine Sites

2020 ◽  
Vol 21 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Jianwei Li ◽  
Yan Huang ◽  
Yuan Zhou
Keyword(s):  
Computational Model ◽  
Computational Methods ◽  
Experimental Methods ◽  
Rna Metabolism ◽  
Vital Role ◽  
Accurate Localization ◽  
Growing Body ◽  
Tissue Cells

RNA 5-methylcytosine (m5C) is one of the pillars of post-transcriptional modification (PTCM). A growing body of evidence suggests that m5C plays a vital role in RNA metabolism. Accurate localization of RNA m5C sites in tissue cells is the premise and basis for the in-depth understanding of the functions of m5C. However, the main experimental methods of detecting m5C sites are limited to varying degrees. Establishing a computational model to predict modification sites is an excellent complement to wet experiments for identifying m5C sites. In this review, we summarized some available m5C predictors and discussed the characteristics of these methods.

scholarly journals ROLE OF A PEDODONTIST IN CLEFT LIP AND CLEFT PALATE REHABILITATION - AN OVERVIEW

2021 ◽  
Vol 9 (07) ◽  
pp. 882-906
Author(s):  
Payel Basu ◽  
◽  
Rani Somani ◽  
Deepti Jawa ◽  
Shipra Jaidka ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Multidisciplinary Care ◽  
Vital Role ◽  
Pediatric Dentist ◽  
Orofacial Region ◽  
The Right ◽  
Potential Area

Cleft lip and palate is one of the most common congenital anomalies requiring multidisciplinary care. Such anomaly is associated with many problems such as impaired feeding, defective speech, hearing difficulties, malocclusion, dental abnormalities, gross facial deformity as well severe psychological problems. Cleft of the lip and palate is one of the complex conditions that occur at a functionally potential area in the orofacial region and also at such a crucial time that strategic interventions at the right age by the concerned specialists becomes the need of the hour. Pediatric dentist is an integral part of the cleft rehabilitative process right from the neonatal period upto the phase of permanent dentition. Being well versed with a childs growth and development, both physical and mental, a Pedodontist helps in restoring function and esthetics in a cleft child, in a most empathetic way. This article describes the enormous challenges faced by these innocent souls and the vital role played by a Pedodontist, to provide comprehensive cleft care, be it preventive, restorative, or interventional care, in order to achieve the best possible outcome and meaningfully improve their quality of life.

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