scholarly journals The relationship between modularity and robustness in signalling networks

2013 ◽  
Vol 10 (88) ◽  
pp. 20130771 ◽  
Author(s):  
Tien-Dzung Tran ◽  
Yung-Keun Kwon

Many biological networks tend to have a high modularity structural property and the dynamic characteristic of high robustness against perturbations. However, the relationship between modularity and robustness is not well understood. To investigate this relationship, we examined real signalling networks and conducted simulations using a random Boolean network model. As a result, we first observed that the network robustness is negatively correlated with the network modularity. In particular, this negative correlation becomes more apparent as the network density becomes sparser. Even more interesting is that, the negative relationship between the network robustness and the network modularity occurs mainly because nodes in the same module with the perturbed node tend to be more sensitive to the perturbation than those in other modules. This result implies that dynamically similar nodes tend to be located in the same module of a network. To support this, we show that a pair of genes associated with the same disease or a pair of functionally similar genes is likely to belong to the same module in a human signalling network.

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
K Popov ◽  
A Novitskiy ◽  
Y Shvarts

Abstract Funding Acknowledgements Type of funding sources: None. Background. Many patients with COVID-19 suffer from arterial hypertension and have marked variations in blood pressure (BP) during the acute period of infection. The reasons for such changes are poorly understood. Purpose. To assess the relationship between the level of BP and the severity of changes in the main clinical and laboratory parameters in patients with arterial hypertension and with a moderate course of COVID-19 at the stage of the height of the disease. Materials and methods. The study included 86 hospitalized patients with verified coronavirus disease of moderate severity: 46 of them were male, the median age was 65 years. Patients received adequate hypertension therapy for a long time. After hospitalization, treatment was adjusted if necessary. The level of laboratory parameters in the acute period of the disease was determined, including the electrolytes, C-reactive protein (CRP), albumin, ferritin, general blood test, etc. BP measured daily. The relationship between laboratory parameters and BP level was evaluated by nonparametric correlation using the Spearman coefficient and multivariate analysis based on the "generalized nonlinear model". Results. In 67.44% of patients with hypertension, an elevated BP level (>140/90) was observed against the background of moderate COVID-19. There was a significant negative correlation between the levels of CRP and BP throughout the stay in the hospital, the most significant is the 5th day of hospitalization. At the same time, a slightly stronger relationship is observed with diastolic BP (r = -0.4425) than with systolic BP (r = -0.3525). A similar trend is observed in all BP measurements. Besides, a negative correlation was found between potassium levels and BP values. The strongest association of potassium levels is with systolic BP on the day of hospitalization (r = -0.4850) and diastolic pressure on the 1st day of hospitalization (r = -0.3561). Multivariate analysis confirmed independent and reliable "influence" of CRP (p = 0.00018) and potassium (p = 0.03921) as independent predictors of diastolic pressure. Conclusions. Most patients with hypertension and moderate COVID-19 have elevated BP levels. There is a statistically significant negative relationship between the values of BP and levels of CRP and potassium. The obtained data may correspond to the existing hypothesis about the significant role of the kinin–kallikrein system in the pathogenesis of COVID-19.


1969 ◽  
Vol 29 (2) ◽  
pp. 395-400 ◽  
Author(s):  
D. D. Sawatzky ◽  
H. W. Zingle

The primary intent of this study was to investigate the relationship between “open-mindedness” and accuracy of interpersonal perception. Specifically, a negative correlation was hypothesized between scores on the Rokeach (1960) Dogmatism Scale and total test scores on the Cline Interpersonal Perception Test. The sample included 70 graduate and 61 undergraduate students. The hypothesis was not confirmed. However, a significant ( p < .05) negative relationship was evident between dogmatism and the subtest of the Cline subtest, “Perception and Memory of Verbal Stimuli.” When the total sample was divided into five subgroups according to level of dogmatism, no significant differences were noted on the film test performances. However, the group with the highest dogmatism scores obtained the highest scores on 3 of the 4 subtests. Suggested improvements of the film test questionnaires are discussed.


2017 ◽  
Vol 12 (3) ◽  
pp. 142-148 ◽  
Author(s):  
Tariq Alzoubi

This research analyzes the determinants of liquidity risk in Islamic banks by using a comprehensive model that incorporates several variables that impact the liquidity of Islamic banks. A panel data analysis is conducted on a sample of 42 Islamic banks from 15 countries between 2007 and 2014. The results show a negative correlation between liquidity risk and cash ratio, as the cash balance can be used to meet any demands for liquidity from the bank’s customers. There is negative correlation between liquidity risk and securities held by the bank, since banks which need liquidity can sell these assets to meet any liquidity shortages they face. Bank size also has a negative relationship with liquidity risk, as larger banks tend to have more stability and customers feel safer dealing with large banks. Bank’s equity also has a negative correlation with liquidity risk, as equity is a more stable source of funding for banks, a higher ratio of equity lowers liquidity risk. On the other hand, there is a positive relationship with high profit assets, as banks shift their portfolio towards more profitable assets in order to increase their earnings, they face greater liquidity risk, a positive relationship also exists with bad finance provision. Additionally, the findings demonstrate that the relationship between bank size and liquidity risk is not linear.


2019 ◽  
Vol 3 (1) ◽  
pp. 37
Author(s):  
Faris Zaky Rinanda ◽  
Haryanta

One of the factors that contribute to the athlete’s perfomance is his emotional state. Athletes who are emotionally unstable tend to be more easily expressed aggression in front of opponents. This research aims to investigate the relationship between emotional intellegence and aggressiveness among futsal athlete. It was hypothesized that there a negative relationship between emotional intelligence and aggressiveness. There were 111 futsal athletes of University X from many faculties in this research. Data analysis using Product Moment correlation technique from Pearson showed rxy=-0.488 with p<0,01 pointing out that there is significant negative correlation between emotional intelligence and aggressiveness among futsal athlete. That result proved that hypothesis was accepted.


2019 ◽  
Vol 2 (1) ◽  
pp. 47-54
Author(s):  
Ferry Ferry ◽  
Rianda Elvinawanty ◽  
Yulinda S. Manurung

This study aims to determine the relationship between emotional intelligence and internet addiction. The hypothesis proposed in research is there any negative correlation between emotional intelligence with internet addiction on teenagers in internet café of Kelurahan Sekip Medan, assuming that the higher emotional intelligence, the lower the internet addiction, and vice versa. The subjects of this study were 114 teenagers in internet café of Kelurahan Sekip Medan. This research used emotional intelligence and internet addiction scale. Product Moment (Pearson Correlation) was used to analyze the correlation between two variable using SPSS 20 for windows. The results of the data analysis showed that the correlation coefficient was -0,737 with a significance value of 0.000 (p <0.05). It shows there is a negative correlation between emotional intelligence with internet addiction. The results of this study indicate that the contributions made by the variable of internet addiction on personal adjustment was 54,3 percent, while the remaining 45,7 percent was influenced by other factors that were not examined. Baged on these results, it is concluded that the hypothesis, is acceptale, and there is a negative relationship between the emotional intelligence and internet addiction.


2021 ◽  
Vol 9 ◽  
Author(s):  
Teerachai Amnuaylojaroen ◽  
Nichapa Parasin

This mini-review aims to highlight both the positive and negative relationship between COVID-19 and air pollution and climate change based on current studies. Since, COVID-19 opened a bibliographic door to scientific production, so there was a limit to research at the moment. There were two sides to the relationship between COVID-19 and both air pollution and climate change. The associated with climate change, in particular, defines the relationship very loosely. Many studies have revealed a positive correlation between COVID-19 and each air pollutants, while some studies shown a negative correlation. There were a few studies that focused on the relationship between COVID-19 in terms of climate. Meanwhile, there were many studies explained the relationship with meteorological factors instead.


1979 ◽  
Vol 23 (3) ◽  
pp. 250-261 ◽  
Author(s):  
Russell A. Docking ◽  
Jennifer A. Thornton

Two studies were conducted to determine whether an antecedent of ineffective communication, cognitive incongruence, is related to raised states of anxiety and to lower achievement. A response paradigm derived from Rogers' self theory was considered as a possible explanation of the frequently observed negative correlation between anxiety and achievement. It was hypothesized that there was a significant positive relationship between student/lecturer congruence and student performance with that lecturer, and that there was a significant negative relationship between student/lecturer congruence and student anxiety. The findings of both studies supported these hypotheses. The results lend support to the Rogers/Hogan paradigm as a potential explanation of the relationship between anxiety and achievement.


Author(s):  
Dauksha L.M. ◽  
Adamovich E.V.

Purpose. The aim of the study was to study the relationship between the propensity for auto-destructive behavior and the emotional intelligence of adolescents.Methods. The methodology for diagnosing deviant behavior of minors (SDP test – propensity to deviant behavior) was developed by E. V. Leus. Two scales were used from this technique: addictive (dependent), self-injurious (auto-aggressive) behavior. The questionnaire of suicidal risk (SR) in the modification of T. N. Razuvaeva and the questionnaire for emotional intelligence (D. V. Lyusina).Results. in the main part, based on empirical material, it is shown that there is a negative relationship between demonstrativeness and interpersonal emotional intelligence, intrapersonal emotional intelligence, understanding of emotions, emotion management by adolescents. A negative relationship between affectivity and interpersonal emotional intelligence, intrapersonal emotional intelligence, understanding of emotions, and emotion management by adolescents was revealed. The uniqueness of adolescents negatively correlates with intrapersonal emotional intelligence, understanding of emotions, and emotion management by adolescents. A negative correlation was established between the failure and interpersonal emotional intelligence, intrapersonal emotional intelligence, understanding of emotions and emotion management by adolescents. A negative correlation of social pessimism and interpersonal emotional intelligence, intrapersonal emotional intelligence, understanding of emotions, and emotion management of adolescents was revealed. The time perspective negatively correlates with interpersonal emotional intelligence, understanding of emotions, and emotion management in adolescents. A negative relationship between the impossibility of constructive future planning and intrapersonal emotional intelligence of adolescents has been revealed. The tendency to dependent behavior of adolescents is negatively associated with interpersonal emotional intelligence, intrapersonal emotional intelligence, understanding of emotions and managing emotions. The tendency to auto-aggressive behavior of adolescents negatively correlates with interpersonal emotional intelligence, intrapersonal emotional intelligence, understanding of emotions and emotion management.Conclusions. As a result of an empirical study, the relationship between the propensity for auto-destructive behavior and the emotional intelligence of adolescents was revealed. In conclusion, as a promising line of development of this study, the approbation of the technology for the development of high emotional intelligence as a psychological barrier to the tendency to auto-destructive behavior of adolescents is outlined.Key words: interpersonal emotional intelligence, intrapersonal emotional intelligence, tendency to dependent behavior, tendency to self-injurious behavior, tendency to suicidal behavior. Целью исследования являлось изучение связи склонности к аутодеструктивному поведению и эмоционального интеллекта подростков.Методы. Методика диагностики девиантного поведения несовершеннолетних (тест СДП – склонности к девиантному поведению) разработан Э.В. Леус. Из данной методики использовали две шкалы: аддиктивное (зависимое) и самоповреждающее (аутоагрессивное) поведение. Опросник суицидального риска (ОСР) в модификации Т.Н. Разуваевой и опросник на эмоциональный интеллект (Д.В. Люсина).Результаты. В основной части на эмпирическом материале показано, что существует отрицатель-ная связь между демонстративностью и межличностным эмоциональным интеллектом, внутриличностным эмоциональным интеллектом, пониманием эмоций, управлением эмоциями подростками. Выявлена отрицательная связь между аффективностью и межличностным эмоциональным интеллектом, внутриличностным эмоциональным интеллектом, пониманием эмоций, управление эмоциями подростками. Установлено, что такие показатели, как «уникальность подростков», «несостоятельность», «социальный пессимизм», «временная перспектива, «планирование будущего», «склонность к зависимому поведению», «склонность к аутоагрессивному поведению», отрицательно коррелируют с внутриличностным эмоциональным интеллектом, межличностным эмоциональным интеллектом, пониманием эмоций, управлением эмоциями подростками. Выводы. В результате эмпирического исследования выявлена отрицательная связь склонности к аутоде-структивному поведению и эмоционального интеллекта подростков. В заключении в качестве перспективной линии развития настоящего исследования намечена апробация технологии развития высокого эмоционального интеллекта как психологического барьера склонности к аутодеструктивному поведению подростков.Ключевые слова: межличностный эмоциональный интеллект, внутриличностный эмоциональ-ный интеллект, склонность к зависимому поведению, склонность к самоповреждающему поведению, склонность к суицидальному поведению.


2016 ◽  
pp. 59-70
Author(s):  
Ninh Le Khuong ◽  
Nghiem Le Tan ◽  
Tho Huynh Huu

This paper aims to detect the impact of firm managers’ risk attitude on the relationship between the degree of output market uncertainty and firm investment. The findings show that there is a negative relationship between these two aspects for risk-averse managers while there is a positive relationship for risk-loving ones, since they have different utility functions. Based on the findings, this paper proposes recommendations for firm managers to take into account when making investment decisions and long-term business strategies as well.


2019 ◽  
Vol 34 (2) ◽  
pp. 367-382
Author(s):  
Irsa Fatima Makhdoom ◽  
Mohsin Atta ◽  
Najma Iqbal Malik

The present study was an endeavor to extend the literature of perceived organizational politics by examining its moderating role between the relationship of organizational citizenship behavior and production deviance. Organizational Citizenship Behavior Scale (Mackenzie, Podsakoff, & Paine, 1999), Production Deviance sub-scale of Counterproductive Work Behavior Checklist-32 (Spector et al., 2006), and Perception of Organizational Politics Scale (Kacmar & Carlson, 1997) were used in present study. Hierarchical regression analyses revealed that low levels of perceived organizational politics moderated the relationship between courtesy and production deviance by strengthening the negative relationship of these behaviors while perceived organizational politics did not act as a moderator for the relationship of civic virtue and conscientiousness with production deviance. High level of go-along-to-get-ahead as a moderator strengthened the relationship of civic virtue and conscientiousness with production deviance and its low level was found to be moderating the relationship between courtesy and production deviance. Future implications of the study were also discussed.


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