scholarly journals Preparation and application of pH-responsive composite hydrogel beads as potential delivery carrier candidates for controlled release of berberine hydrochloride

2020 ◽  
Vol 7 (11) ◽  
pp. 200676
Author(s):  
Jiande Gao ◽  
Dongying Fan ◽  
Ping Song ◽  
Shudan Zhang ◽  
Xiong Liu
Keyword(s):  
Composite Hydrogel ◽  
Swelling Ratio ◽  
Ph Responsive ◽  
X Ray Diffraction ◽  
Swelling Properties ◽  
Pharmaceutical Dosage Forms ◽  
Berberine Hydrochloride ◽  
X Ray ◽  
Hydrogel Beads ◽  
Cumulative Release

For improving the effective concentration of berberine hydrochloride (BH) in the gastrointestinal tract, a series of pH-responsive hydrogel beads were prepared based on carboxymethylstarch-g-poly (acrylic acid)/palygorskite/starch/sodium alginate (CMS-g-PAA/PGS/ST/SA) in the present work. The developed hydrogel beads were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TG). Effect of palygorskite (PGS) content on the swelling properties of hydrogel beads and BH cumulative release were discussed. The pH responsiveness of hydrogel beads was also investigated in different media. Results illustrated that swelling of hydrogel beads and BH cumulative release from hydrogel beads were obviously affected by PGS content. The swelling ratio and BH cumulative release of composite hydrogel beads remarkably slowed down with PGS content increasing in the range from 10 to 40 wt%. The composite hydrogel beads were pH-responsive. At pH 7.4, the swelling ratio and BH cumulative release from composite hydrogel beads were the fastest among the dissolution media of pH 1.2, pH 6.8 and pH 7.4. The BH cumulative release from hydrogel beads was related to the swelling and relaxation of composite hydrogel beads and could be fitted better by the Higuchi model. The obtained composite hydrogel beads could be potentially used for the development of BH pharmaceutical dosage forms.

scholarly journals Fabrication, Structure and Functional Characterizations of pH-Responsive Hydrogels Derived from Phytoglycogen

Foods ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2653
Author(s):  
Xiuting Hu ◽  
Yao Liu ◽  
Yimei Chen ◽  
Tao Zhang ◽  
Ming Miao
Keyword(s):  
Electrostatic Repulsion ◽  
Swelling Ratio ◽  
Ph Responsive ◽  
X Ray Diffraction ◽  
Carrier System ◽  
Bioactive Substances ◽  
X Ray ◽  
Gelation Rate ◽  
Responsive Hydrogels ◽  
Scanning Electron

The pH-responsive hydrogels were obtained through successive carboxymethylation and phosphorylase elongatation of phytoglycogen and their structure and functional characterizations were investigated. Phytoglycogen (PG) was first carboxymethylated to obtain carboxymethyl phytoglycogen (CM-PG) with degree of substitution (DS) at 0.15, 0.25, 0.30, and 0.40, respectively. Iodine staining and X-ray diffraction analysis suggested that the linear glucan chains were successfully phosphorylase-elongated from the non-reducing ends at the CM-PG surface and assembled into the double helical segments, leading to formation of the hydrogel. The DS of CM-PG significantly influenced elongation of glucan chains. Specifically, fewer glucan chains were elongated for CM-PG with higher DS and the final glucan chains were shorter, resulting in lower gelation rate of chain-elongated CM-PG and lower firmness of the corresponding hydrogels. Scanning electron microscope observed that the hydrogels exhibited a porous and interconnected morphology. The swelling ratio and volume of hydrogels was low at pH 3–5 and then became larger at pH 6–8 due to electrostatic repulsion resulting from deprotonated carboxymethyl groups. Particularly, the hydrogel prepared from chain-elongated CM-PG (DS = 0.25) showed the highest sensitivity to pH. These results suggested that phosphorylase-treated CM-PG formed the pH-responsive hydrogel and that the elongation degree and the properties of hydrogels depended on the carboxymethylation degree. Thus, it was inferred that these hydrogels was a potential carrier system of bioactive substances for their targeted releasing in small intestine.

scholarly journals Nanoporous Sodium Carboxymethyl Cellulose-g-poly (Sodium Acrylate)/FeCl3 Hydrogel Beads: Synthesis and Characterization

Gels ◽  
2020 ◽  
Vol 6 (4) ◽  
pp. 49
Author(s):  
Bijender Kumar ◽  
Ruchir Priyadarshi ◽  
Sauraj ◽  
Farha Deeba ◽  
Anurag Kulshreshtha ◽  
...  
Keyword(s):  
Carboxymethyl Cellulose ◽  
Sodium Carboxymethyl Cellulose ◽  
Sodium Acrylate ◽  
X Ray Diffraction ◽  
Hybrid Hydrogel ◽  
X Ray ◽  
Hydrogel Beads ◽  
Force Microscopy ◽  
Atomic Force ◽  
Potential Applications

Novel sodium carboxymethyl cellulose-g-poly (sodium acrylate)/Ferric chloride (CMC-g-PNaA/FeCl3) nanoporous hydrogel beads were prepared based on the ionic cross-linking between CMC-g-PNaA and FeCl3. The structure of CMC and CMC-g-PNaA were elucidated by Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) spectroscopy, and the elemental composition was analyzed by energy dispersive X-ray analysis (EDX). The physicochemical properties of the CMC-g-PNaA/FeCl3 hydrogel beads were analyzed by X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM) and thermogravimetric analysis (TGA). The swelling percentage of hydrogel beads was studied at different time periods. The obtained CMC-g-PNaA/FeCl3 hydrogel beads exhibited a higher nanoporous morphology than those of CMC-g-PNaA and CMC beads. Furthermore, an AFM image of the CMC-g-PNaA/FeCl3 beads shows granule type topology. Compared to the CMC-g-PNaA (189 °C), CMC-g-PNaA/FeCl3 hydrogel beads exhibited improvement in thermal stability (199 °C). Furthermore, CMC-g-PNaA/FeCl3 hydrogel beads depicted a higher swelling percentage capacity of around 1452%, as compared to CMC-g-PNaA (1096%). Moreover, this strategy with preliminary results could be useful for the development of polysaccharide-based hybrid hydrogel beads for various potential applications.

Effect of Polymerization on the Swelling Properties of a Sodium Bentonite and its Mechanism

2020 ◽  
Vol 1003 ◽  
pp. 228-232
Author(s):  
Ji Xiang Nie ◽  
Ryoga Tanaka ◽  
Jin Chun Chai
Keyword(s):  
Free Radical ◽  
Deionized Water ◽  
Polymer Chains ◽  
Nacl Solution ◽  
X Ray Diffraction ◽  
Swelling Properties ◽  
Sodium Bentonite ◽  
X Ray ◽  
Free Swelling ◽  
Polymerization Method

The effect of polymerization on the swelling properties of a sodium bentonite has been investigated experimentally using free swelling index (FSI). Using free radical polymerization method in cationic solution with acrylate acid as the monomer (M) and potassium persulfate as initiator (I), the optimum conditons for higher FSI value in 0.6 M NaCl solution were pH of 5.5 and I/M ratio of 0.005. The polymerized bentonite (PB) had much higher FSI values than that of untreated bentonite (UB) in deionized water and 0.6 M NaCl solution. However, in the 0.6 M CaCl2 solution, the FSI value of PB was slightly lower than that of UB and the reason is not clear yet. The X-ray diffraction (XRD) test shows that polymer chains did not enter the interlayer of sodium bentonite crystals and it is postulated that the polymers only wrapped around the particles of the bentonite.

Thermally stable coordination compounds intercalated in montmorillonite clay mineral

1992 ◽  
Vol 70 (7) ◽  
pp. 1927-1931 ◽  
Author(s):  
N. K. Labhsetwar ◽  
O. P. Shrivastava
Keyword(s):  
Clay Mineral ◽  
Coordination Compounds ◽  
Structure And Properties ◽  
X Ray Diffraction ◽  
Magnetic Studies ◽  
Swelling Properties ◽  
X Ray ◽  
Good Thermal Stability ◽  
Intercalated Compounds ◽  
Layered Clay

Montmorillonite is a natural layered clay mineral having myriad applications due mainly to its remarkable ion exchange, intercalation, and swelling properties. It can act as a good host for several compounds. Two intercalated coordination compounds of Cu(II) and Ni(II) with 2,2′-bipyridyl have been prepared in the interlayer spaces of montmorillonite structure. They are characterized on the basis of elemental analysis, infrared spectroscopy, magnetic studies, and X-ray diffraction. Both compounds show similarity in their structure and properties with the respective normal complexes of similar composition. These compounds show good thermal stability. The present intercalated compounds might be useful for their nitrogen-immobilizing properties and high-temperature applications.

Adsorptive Removal of Ni(II) Ions from Aqueous Solution by Polyacrylic Acid/Attapulgite Composite Hydrogels

2017 ◽  
Vol 727 ◽  
pp. 859-865 ◽  
Author(s):  
Yi Wei Zheng ◽  
Wen Wen Tao ◽  
Gui Fang Zhang ◽  
Chao Lv ◽  
Yi Ping Zhao ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Adsorption Capacity ◽  
Polyacrylic Acid ◽  
Swelling Ratio ◽  
X Ray Diffraction ◽  
X Ray ◽  
Adsorptive Removal ◽  
Composite Hydrogels ◽  
Ph Values ◽  
Ft Ir

Polyacrylic acid/attapulgite (PAA/ATP) composite hydrogels used for removal of heavy metal ions from aqueous solution was synthesized via radical polymerization with acrylic acid (AA) and attapulgite (ATP) modified by hydrochloric acid as adsorbent. Chemical composition of the modified ATP was characterized by Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) and the morphology of the PAA/ATP hydrogels was characterized by scanning electron microscope (SEM), respectively. The swelling ratio, pH-sensitivity and adsorption performance of Ni (II) ions of the composite hydrogels were studied. The results showed the swelling ratio of the PAA/ATP composite hydrogels was higher than that of PAA hydrogels and the composite hydrogels displayed sensitivity to pH values with a sharp increase of swelling ratio when the pH values increased from 4 to 6. Comparing with PAA hydrogels, the composite hydrogels obtained a larger adsorption capacity of Ni (II) ions, the average adsorption capacity could reach 72.8 mg/g and adsorption ratio could reach 84%.

X-Ray Diffraction and Fluorescence in the Analysis of Pharmaceutical Excipients

1981 ◽  
Vol 25 ◽  
pp. 383-388
Author(s):  
A. J. Durbetaki ◽  
T. F. Quail
Keyword(s):  
Fluorescence Spectroscopy ◽  
Dosage Forms ◽  
X Ray Diffraction ◽  
Pharmaceutical Dosage Forms ◽  
X Ray ◽  
Pharmaceutical Excipients ◽  
Pharmaceutical Tablets

The majority of pharmaceutical dosage forms are marketed as tablets which are formulated to satisfy various basic requirements. The analysis of the resultant multicomponent pharmaceutical and product is usually a lengthy task.This paper describes the complementary use of X-ray diffraction (XRD) and X-ray fluorescence spectroscopy (XRS) to characterize and quantify excipients in pharmaceutical tablets.

Hierarchical Core–Shell Fe3O4@mSiO2@Chitosan Nanoparticles for pH-Responsive Drug Delivery

2021 ◽  
Vol 21 (5) ◽  
pp. 3020-3027
Author(s):  
Ning Zhang ◽  
Chengzheng Jia ◽  
Xingyue Ma ◽  
Jinfeng Li ◽  
Shige Wang ◽  
...  
Keyword(s):  
Silica Surface ◽  
Solvothermal Method ◽  
Chitosan Nanoparticles ◽  
Release Behavior ◽  
Ph Responsive ◽  
X Ray Diffraction ◽  
Drug Release Rate ◽  
X Ray ◽  
Transmission Electron ◽  
Micelle System

Hierarchical nanoparticles are of great interest because they possess unique physicochemical properties and multiple functionalities, providing a wealth of possibilities for various applications. In this work, we have developed a well-designed method to prepare hierarchical magnetic nanoparticles Fe3O4@mSiO2@CS by integrating a solvothermal method for synthesizing the Fe3O4 core, a dualtemplating micelle system for preparing a layer of mesoporous silica (mSiO2) shell, and a silane coupling method via γ-glycidoxypropyltrimethoxysilane for binding a chitosan (CS) layer on the silica surface. The porous hierarchical nanoparticles were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), dynamic light scattering nanoparticle size analyzer, and specific surface area and pore size analyzer. The loading capacity and the release behavior of the as-prepared nanoparticles for doxorubicin hydrochloride were studied, and it was found that the drug release rate was faster at pH 6.0 than at pH 7.4, revealing the pH-responsive property of the nanoparticles.

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