scholarly journals Vigorous convection in porous media

2020 ◽  
Vol 476 (2239) ◽  
pp. 20200111 ◽  
Author(s):  
D. R. Hewitt
Keyword(s):  
Porous Media ◽  
Saturated Porous Medium ◽  
Experimental Studies ◽  
Detailed Examination ◽  
Future Research ◽  
Mathematical Framework ◽  
Black Smoker ◽  
Ocean Ridges ◽  
Set Up ◽  
Convection In Porous Media

The problem of convection in a fluid-saturated porous medium is reviewed with a focus on ‘vigorous’ convective flow, when the driving buoyancy forces are large relative to any dissipative forces in the system. This limit of strong convection is applicable in numerous settings in geophysics and beyond, including geothermal circulation, thermohaline mixing in the subsurface and heat transport through the lithosphere. Its manifestations range from ‘black smoker’ chimneys at mid-ocean ridges to salt-desert patterns to astrological plumes, and it has received a great deal of recent attention because of its important role in the long-term stability of geologically sequestered CO 2 . In this review, the basic mathematical framework for convection in porous media governed by Darcy’s Law is outlined, and its validity and limitations discussed. The main focus of the review is split between ‘two-sided’ and ‘one-sided’ systems: the former mimics the classical Rayleigh–Bénard set-up of a cell heated from below and cooled from above, allowing for detailed examination of convective dynamics and fluxes; the latter involves convection from one boundary only, which evolves in time through a series of regimes. Both set-ups are reviewed, accounting for theoretical, numerical and experimental studies in each case, and studies that incorporate additional physical effects are discussed. Future research in this area and various associated modelling challenges are also discussed.

A Review of Theoretical and Experimental Research on Various Autofrettage Processes

2018 ◽  
Vol 140 (5) ◽  
Author(s):  
Rajkumar Shufen ◽  
Uday S. Dixit
Keyword(s):  
Experimental Studies ◽  
Theoretical Models ◽  
Pressure Vessels ◽  
Future Research ◽  
Spherical Vessel ◽  
Considerable Research ◽  
Wide Range ◽  
Set Up ◽  
Compressive Residual Stresses ◽  
Spherical Pressure

Autofrettage is a metal forming technique widely incorporated for strengthening the thick-walled cylindrical and spherical pressure vessels. The technique is based on the principle of initially subjecting the cylindrical or spherical vessel to partial plastic deformation and then unloading it; as a result of which compressive residual stresses are set up. On the basis of the type of the forming load, autofrettage can be classified into hydraulic, swage, explosive, thermal, and rotational. Considerable research studies have been carried out on autofrettage with a variety of theoretical models and experimental methods. This paper presents an extensive review of various types of autofrettage processes. A wide range of theoretical models and experimental studies are described. Optimization of an autofrettage process is also discussed. Based on the review, some challenging issues and key areas for future research are identified.

Non-Darcy Mixed Convection With Thermal Dispersion in a Saturated Porous Medium

2009 ◽  
Vol 132 (1) ◽  
Author(s):  
V. V. Sobha ◽  
R. Y. Vasudeva ◽  
K. Ramakrishna ◽  
K. Hema Latha
Keyword(s):  
Heat Transfer ◽  
Porous Medium ◽  
Porous Media ◽  
Nusselt Number ◽  
Mixed Convection ◽  
Vertical Plate ◽  
Saturated Porous Medium ◽  
Thermal Dispersion ◽  
Convection In Porous Media ◽  
Infinite Vertical Plate

Thermal dispersion due to local flows is significant in heat transfer with forced convection in porous media. The effects of parametrized melting (M), thermal dispersion (D), inertia (F), and mixed convection (Ra/Pe) on the velocity distribution, temperature, and Nusselt number on non-Darcy, mixed convective heat transfer from an infinite vertical plate embedded in a saturated porous medium are examined. It is observed that the Nusselt number decreases with increase in melting parameter and increases with increase in thermal dispersion.

RECLAMATION AND CULVERT CROSSINGS MADE OF CORRUGATED PIPES ON SPAWNING STREAMS

2020 ◽  
pp. 68-77
Author(s):  
O.N. CHERNYKH ◽  
◽  
A.V. RBURLACHENKO
Keyword(s):  
Single Point ◽  
Experimental Studies ◽  
Fish Passage ◽  
Future Research ◽  
Fish Stocks ◽  
Metal Structures ◽  
Natural Reproduction ◽  
Spiral Shape ◽  
Corrugated Metal ◽  
Spawning Streams

Recommendations are presented for solving issues that arise in the design and operation of tubular transport crossings of corrugated metal structures through spawning streams while ensuring the safety and natural reproduction of fish stocks. There are discussed the results of experimental studies of culverts made of metal corrugated pipes with a normal and spiral shape of corrugation the bottom of which is buried and filled with suitable granular material to the level of the natural channel of a small watercourse. It is established that when 10% of the area of the corrugated pipe is occupied by stone filling, its throughput is reduced by about 10-12%. Based on the review of the existing literature and the results of laboratory experiments, data is provided to estimate the values of the roughness coefficients of the composite cross-section of a single-point junction and directions for future research on culvert reclamation are outlined. Studying of the structure of the velocity distribution in culverts can lead to the improved conditions for fish passage without installing special structural elements in the transit path of the fish passage structure.

The use of ICT by SMMEs in a Digital Economy: A case study in Buffalo City Metropolitan in South Africa [Abstract]

10.28945/4314 ◽  
2019 ◽  
Keyword(s):  
South Africa ◽  
Technology Acceptance ◽  
21St Century ◽  
Common Knowledge ◽  
Digital Economy ◽  
Future Research ◽  
Wealth Creation ◽  
Underdeveloped Areas ◽  
And Gender ◽  
Set Up

Aim/Purpose: The goal of this study is to advance understanding of ICT utilization by SMMEs by checking access, ability (in terms of technological skills) and usage of ICT among some SMMEs entrepreneurs operating their businesses in an underdeveloped areas to enhance their business activities in order to utilizes the digital opportunities 21st century digital economies present. Background: In today’s world no nation or region is untouched by the forces of globalization and digital economy. One of the key pioneering forces of globalization is the advances of ICT like internet, social networks, etc. In the sphere of business, this pioneering force has also altered the way businesses and organizations communicate and interact with customers and society at large. Such alternation presents obvious opportunities for wealth creation and growth for businesses and organizations that are well-equipped to take advantages of them. But for those that are less-equipped, particularly SMMEs, globalization can easily lead to fore-closures and marginalization. It is a common knowledge that SMMEs entrepreneurs mostly rely on ICT gadgets like mobile phone, Laptops, Tablets to conduct their business activities as many of them don’t have enough capital to set up offices with necessary equipment. Therefore, using various ICT functions/programs on these ICT devices to enhance their business activities are critical to their businesses in the 21st century digital economies. Methodology: Purposeful sampling was used to approach fifty-four SMMEs entrepreneurs operating their businesses in underdeveloped areas locally called Townships in Buffalo City Metropolitan. Microsoft excel was used in the descriptive statistics. Contribution: This research will add to the growing knowledge ICT usage in SMMEs in the 21st century digital economies. Findings: The results indicate that the participating SMMEs entrepreneurs need to be educated, trained and supported in the use of the ICT applicable to enhance their business activities in order for them to take advantages of 21st century digital economies present. Recommendations for Practitioners: The agencies tasked with looking after SMMEs in South Africa needs to consider the lacked of utilisation of ICTs by SMMEs entrepreneurs operating their businesses in underdeveloped areas as one of the barrier to growing of their businesses and take necessary steps to address it. Recommendation for Researchers: Since age and gender have been proven to be key-moderating variables in many technology acceptance models. There is a need to explore in depth whether the factors of gender and age also act as barriers. Impact on Society: The research will assist stakeholders, policy makers and agencies tasked with looking after SMMEs to identify the barriers hindering SMMEs to grow and address them accordingly. Future Research: More work needs to be done to check whether gender, age of the SMMEs entrepreneurs have some effects on their attitude towards the integration of ICT into their business activities.

Amruthapala (Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter): A Comprehensive Review on Diversity, Therapeutic Uses, and Valorization of Bioactive Constituents

2019 ◽  
Vol 20 (5) ◽  
pp. 376-389 ◽  
Author(s):  
Sonali Mishra ◽  
Nupur Srivastava ◽  
Velusamy Sundaresan ◽  
Karuna Shanker
Keyword(s):  
Secondary Metabolite ◽  
Current Knowledge ◽  
Experimental Studies ◽  
Critical Discussion ◽  
Future Research ◽  
Bioactive Constituents ◽  
Medicinal Uses ◽  
Comprehensive Review ◽  
Therapeutic Uses ◽  
Decalepis Arayalpathra

Background: Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter is used primarily for nutrition besides its therapeutic values. Traditional preparations/formulations from its tuber are used as a vitalizer and blood purifier drink. The folklore medicinal uses cover inflammation, cough, wound healing, antipyretic, and digestive system management. A comprehensive review of the current understanding of the plant is required due to emerging concerns over its safety and efficacy. Objective: The systematic collection of the authentic information from different sources with the critical discussion is summarised in order to address various issues related to botanical identity, therapeutic medicine, nutritional usage, phytochemical, and pharmacological potentials of the D. arayalpathra. Current use of traditional systems of medicine can be used to expand future research opportunities. Materials and Methods: Available scripted information was collected manually, from peered review research papers and international databases viz. Science Direct, Google Scholar, SciFinder, Scopus, etc. The unpublished resources which were not available in database were collected through the classical books of ‘Ayurveda’ and ‘Siddha’ published in regional languages. The information from books, Ph.D. and MSc dissertations, conference papers and government reports were also collected. We thoroughly screened the scripted information of classical books, titles, abstracts, reports, and full-texts of the journals to establish the reliability of the content. Results: Tuber bearing vanilla like signature flavor is due to the presence of 2-hydroxy-4-methoxybenzaldehyde (HMB). Among five other species, Decalepis arayalpathra (DA) has come under the ‘critically endangered’ category, due to over-exploitation for traditional, therapeutic and cool drink use. The experimental studies proved that it possesses gastro-protective, anti-tumor, and antiinflammatory activities. Some efforts were also made to develop better therapeutics by logical modifications in 2-Hydroxy-4-methoxy-benzaldehyde, which is a major secondary metabolite of D. arayalpathra. ‘Amruthapala’ offers the enormous opportunity to develop herbal drink with health benefits like gastro-protective, anti-oxidant and anti-inflammatory actions. Results: The plant has the potential to generate the investigational new lead (IND) based on its major secondary metabolite i.e. 2-Hydroxy-4-methoxy-benzaldehyde. The present mini-review summarizes the current knowledge on Decalepis arayalpathra, covering its phytochemical diversity, biological potentials, strategies for its conservation, and intellectual property rights (IPR) status. Chemical Compounds: 2-hydroxy-4-methoxybenzaldehyde (Pubchem CID: 69600), α-amyrin acetate (Pubchem CID: 293754), Magnificol (Pubchem CID: 44575983), β-sitosterol (Pubchem CID: 222284), 3-hydroxy-p-anisaldehyde (Pubchem CID: 12127), Naringenin (Pubchem CID: 932), Kaempferol (Pubchem CID: 5280863), Aromadendrin (Pubchem CID: 122850), 3-methoxy-1,2-cyclopentanedione (Pubchem CID: 61209), p-anisaldehyde (Pubchem CID: 31244), Menthyl acetate (Pubchem CID: 27867), Benzaldehyde (Pubchem CID: 240), p-cymene (Pubchem CID: 7463), Salicylaldehyde (Pubchem CID: 6998), 10-epi-γ-eudesmol (Pubchem CID: 6430754), α -amyrin (Pubchem CID: 225688), 3-hydroxy-4-methoxy benzaldehyde (Pubchem CID: 12127).

scholarly journals Application of intelligent orienteering based on Internet of things

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Donghui Zhang ◽  
Ruijie Liu
Keyword(s):  
Internet Of Things ◽  
Network Architecture ◽  
Emergency Services ◽  
Simulation Experiment ◽  
Experimental Studies ◽  
Signal Stability ◽  
Anchor Nodes ◽  
Set Up ◽  
The Relationship ◽  
The Internet Of Things

Abstract Orienteering has gradually changed from a professional sport to a civilian sport. Especially in recent years, orienteering has been widely popularized. Many colleges and universities in China have also set up this course. With the improvement of people’s living conditions, orienteering has really become a leisure sport in modern people’s life. The reduced difficulty of sports enables more people to participate, but it also exposes a series of problems. As the existing positioning technology is relatively backward, the progress in personnel tracking, emergency services, and other aspects is slow. To solve these problems, a new intelligent orienteering application system is developed based on the Internet of things. ZigBee network architecture is adopted in the system. ZigBee is the mainstream scheme in the current wireless sensor network technology, which has many advantages such as convenient carrying, low power consumption, and signal stability. Due to the complex communication environment in mobile signal, the collected information is processed by signal amplification and signal anti-interference technology. By adding anti-interference devices, video isolators and other devices, the signal is guaranteed to the maximum extent. In order to verify the actual effect of this system, through a number of experimental studies including the relationship between error and traffic radius and the relationship between coverage and the number of anchor nodes, the data shows that the scheme studied in this paper has a greater improvement in comprehensive performance than the traditional scheme, significantly improving the accuracy and coverage. Especially the coverage is close to 100% in the simulation experiment. This research has achieved good results and can be widely used in orienteering training and competition.

Monosaccharide Biosynthesis Pathways Database

Glycobiology ◽  
2021 ◽  
Author(s):  
Jaya Srivastava ◽  
P Sunthar ◽  
Petety V Balaji
Keyword(s):  
Expression Profiling ◽  
Experimental Studies ◽  
Structural Complexity ◽  
Evolutionary Relationships ◽  
Enzyme Assays ◽  
Biosynthesis Pathway ◽  
Knock Out ◽  
Set Up ◽  
Function Relationship ◽  
Natural Glycans

Abstract A distinctive feature of glycans vis-à-vis proteins and nucleic acids is its structural complexity which arises from the huge repertoire of monosaccharides, isomeric linkages and branching. A very large number of monosaccharides have so far been discovered in natural glycans. Experimentally, pathways for the biosynthesis have been characterized completely for 55 monosaccharides and partially for a few more. However, there is no single platform which provides information about monosaccharide biosynthesis pathways and associated enzymes We have gathered 572 experimentally characterized enzymes of 66 biosynthesis pathways from literature and set up a first of its kind database called the Monosaccharide Biosynthesis Pathways Database http://www.bio.iitb.ac.in/mbpd/). Annotations such as the reaction catalysed, substrate specificity, biosynthesis pathway and PubMed IDs are provided for all the enzymes in the database. Sequence homologs of the experimentally characterized enzymes found in nearly 13,000 completely sequenced genomes from Bacteria and Archaea have also been included in the database. This platform will help in the deduction of evolutionary relationships among enzymes such as aminotransferases, nucleotidyltransferases, acetyltransferases and SDR family enzymes. It can also facilitate experimental studies such as direct enzyme assays to validate putative annotations, establish structure–function relationship, expression profiling to determine the function, determine the phenotypic consequences of gene knock-out/knock-in and complementation studies.

scholarly journals Affinity Selection in Germinal Centers: Cautionary Tales and New Opportunities

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1040
Author(s):  
Jose Faro ◽  
Mario Castro
Keyword(s):  
T Cell ◽  
B Cell ◽  
Cell Receptor ◽  
Future Research ◽  
Mathematical Framework ◽  
Immune Synapse ◽  
Cell Receptors ◽  
3 Dimensional ◽  
Fine Grained ◽  
Ligand Interactions

Our current quantitative knowledge of the kinetics of antibody-mediated immunity is partly based on idealized experiments throughout the last decades. However, new experimental techniques often render contradictory quantitative outcomes that shake previously uncontroversial assumptions. This has been the case in the field of T-cell receptors, where recent techniques for measuring the 2-dimensional rate constants of T-cell receptor–ligand interactions exposed results contradictory to those obtained with techniques measuring 3-dimensional interactions. Recently, we have developed a mathematical framework to rationalize those discrepancies, focusing on the proper fine-grained description of the underlying kinetic steps involved in the immune synapse. In this perspective article, we apply this approach to unveil potential blind spots in the case of B-cell receptors (BCR) and to rethink the interactions between B cells and follicular dendritic cells (FDC) during the germinal center (GC) reaction. Also, we elaborate on the concept of “catch bonds” and on the recent observations that B-cell synapses retract and pull antigen generating a “retracting force”, and propose some testable predictions that can lead to future research.

Intelligent diagnosis and analysis of brain lymphoma based on imaging features

2021 ◽  
pp. 1-11
Author(s):  
Yipu Mao ◽  
Muliang Jiang ◽  
Fanyu Zhao ◽  
Liling Long
Keyword(s):  
Imaging Techniques ◽  
Experimental Studies ◽  
Diagnostic Value ◽  
Imaging Features ◽  
Flow Properties ◽  
Brain Lymphoma ◽  
Diagnosis And Prognosis ◽  
Primary Brain Lymphoma ◽  
Set Up ◽  
Prognosis Evaluation

Currently, DSC has been extensively studied in the diagnosis, differential diagnosis and prognosis evaluation of brain lymphoma, but it has not obtained a uniform standard. By combining DSC imaging features, this study investigated the imaging features and diagnostic value of several types of tumors such as primary brain lymphoma. At the same time, this study obtained data from brain lymphoma patients by data collection and set up different groups to conduct experimental studies to explore the correlation between IVIM-MRI perfusion parameters and DSC perfusion parameters in brain lymphoma. Through experimental research, it can be seen that the combination of two perfusion imaging techniques can more fully reflect the blood flow properties of the lesion, which is beneficial to determine the nature of the lesion.

scholarly journals Local Anesthetics and Recurrence after Cancer Surgery-What’s New? A Narrative Review

2021 ◽  
Vol 10 (4) ◽  
pp. 719
Author(s):  
Sarah D. Müller ◽  
Jonathan S. H. Ziegler ◽  
Tobias Piegeler
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Local Anesthetics ◽  
Experimental Studies ◽  
Perioperative Period ◽  
Cancer Surgery ◽  
Narrative Review ◽  
Future Research ◽  
Inflammatory Stress ◽  
Research Activities

The perioperative use of regional anesthesia and local anesthetics is part of almost every anesthesiologist’s daily clinical practice. Retrospective analyses and results from experimental studies pointed towards a potential beneficial effect of the local anesthetics regarding outcome—i.e., overall and/or recurrence-free survival—in patients undergoing cancer surgery. The perioperative period, where the anesthesiologist is responsible for the patients, might be crucial for the further course of the disease, as circulating tumor cells (shed from the primary tumor into the patient’s bloodstream) might form new micro-metastases independent of complete tumor removal. Due to their strong anti-inflammatory properties, local anesthetics might have a certain impact on these circulating tumor cells, either via direct or indirect measures, for example via blunting the inflammatory stress response as induced by the surgical stimulus. This narrative review highlights the foundation of these principles, features recent experimental and clinical data and provides an outlook regarding current and potential future research activities.

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