Some requirements for the study of the organization of cellular processes

1954 ◽  
Vol 142 (907) ◽  
pp. 137-140 ◽  
Keyword(s):  
Spatial Resolution ◽  
Biological Activities ◽  
Living Systems ◽  
Cellular Processes ◽  
The Subject ◽  
High Degree ◽  
Electrical Activities ◽  
Difficult Word ◽  
The Way

The subject of this discussion is the organization of enzymic processes within cells. Organization is a difficult word; perhaps a distasteful one to many biochemists, who often wonder whether people who ask them to study organization mean anything precise. Yet if biological activities are to be treated in chemical terms it is necessary to study not only individual enzymic processes but also the way that these are related to each other (Peters 1930; Hopkins 1935). One of the chief difficulties in doing this is that in living systems diverse processes go on very close to each other and yet in separate compartments. This may indeed be a large part of the secret of the synthetic feats performed by enzymic action. To study the relation of these various nearby processes in the cell we require above all methods providing a high degree of resolution in space. Any discussion of the subject is bound to be concerned largely with how to obtain this resolution. It can probably only be achieved by microscopy, including its recent refinements. The microscope provides a power of spatial resolution much greater than can be obtained, in most cases, by such methods as extraction or isolation or the study of electrical activities, valuable though these are in their proper places.

The Relative Emphasis Upon Mechanical Skill and Applications of Elementary Mathematics

1921 ◽  
Vol 14 (8) ◽  
pp. 435-443
Author(s):  
Fiske Allen
Keyword(s):  
Elementary Mathematics ◽  
Daily Life ◽  
The Other ◽  
The Third ◽  
Division Of Fractions ◽  
Life Problems ◽  
The Subject ◽  
High Degree ◽  
The Way

The teaching of elementary mathematics has two distinct purposes, quite closely connected with each other and yet easily distinguished. The pupil must develop a skill in the manipulation of the symbols of elementary mathematics and he must develop a power to apply them to the solution of life problems. By special emphasis upon either phase of the subject an ability can be developed in it without a corresponding ability in the other phase, and sometimes at the expense of ability in the other phase. It is easy to develop in pupils a high degree of skill in the mechanical processes of computation with almost no ability to decide in a particular problem what process is to be used. And in pioneer days many men were quite able to solve the problems met in daily life though knowing nothing of the use of figures for purposes of computation. It has been very interesting to me to note that pupils in the third and fourth grades, utterly innocent of the use of the symbols in division of fractions, will frequently solve problems involving division of fractious more readily than will those same pupils after they have been taught to “invert the divisor and multiply.” This does not mean that skill in computation with figures stands in the way of solving concrete problems, but that during the time devoted to acquiring the skill they have lost power in thinking number relations, possibly through a transfer of interest.

Offer of methods for minimizing key investment risks of “R-Pharm” JSC

2020 ◽  
Vol 17 (1) ◽  
pp. 58-67
Author(s):  
N. A. Kabanova ◽  
I. K. Alekseeva
Keyword(s):  
Strategic Planning ◽  
Pharmaceutical Company ◽  
Simulation Modeling ◽  
Return On Investment ◽  
System Analysis ◽  
Social Orientation ◽  
Pharmaceutical Companies ◽  
The Subject ◽  
High Degree

The article is devoted to the assessment of potential investment risks of the pharmaceutical company “R-Pharm” JSC with the aim of identifying the highest priority risks and developing methods for minimizing them. The relevance of the study is determined by the fact that the pharmaceutical business is characterized by a high degree of social orientation and annually invests $ 140 billion in the development of production and research, which determines the need for a risk-based approach to ensure the return on investment. The subject of this article is the investment risks of pharmaceutical companies, and the subject of research is the domestic pharmaceutical company “R-Pharm”. In order to assess the potential investment risks of “R-Pharm” JSC, the authors used elements of simulation modeling and system analysis. The proposed methods to minimize key investment risks are aimed at improving the efficiency of investment activities and is recommended as an element of the strategic planning of the company.

IMPROVING STUDENTS’ ACHIEVEMENT IN SPEAKING THROUGH TWO STAY TWO STRAY STRATEGY

2013 ◽  
Vol 2 (2) ◽  
Author(s):  
Dita Masyitah Sianipar And Sumarsih
Keyword(s):  
Action Research ◽  
Learning Process ◽  
Quantitative Data ◽  
Test Score ◽  
Qualitative Data ◽  
Speaking Test ◽  
The Subject ◽  
The Mean ◽  
Teaching Learning ◽  
The Way

This study deals with the way to improve students’ achievement in speaking particularly through Two Stay Two Stray Strategy. This study was conducted by using classroom action research. The subject of of the research was class X-AP SMK Swasta Harapan Danau Sijabut in Asahan Regency that consisted of 34 students. The research was conducted in two cycles consisted of three meetings in each cycle. The instruments of collecting data for quantitative data used Speaking Test and instrument for analysis of qualitative data used observation, interview and questionnaire sheet. Based on the speaking test score, students’ score kept improving in every test. In the test I the mean was 61,47, in the test II the mean was 67,41 and the test III the mean was 78,52. Based on observation sheet and questionnaire sheet, it was found that teaching learning process run well and lively. Students were active and interest in speaking. The using of Two Stay Two Stray Strategy is significantly improved students’ achievement in speaking.

Tanks in the Spa Town. The New Book about the Events of the Year 1968 in Czechoslovakia

2019 ◽  
Vol 14 (1-2) ◽  
pp. 278-282
Author(s):  
Kirill A. Popov
Keyword(s):  
Fiftieth Anniversary ◽  
Warsaw Pact ◽  
Scientific Event ◽  
The Social ◽  
Prague Spring ◽  
The Subject ◽  
Scientific Terms ◽  
Selection Of ◽  
Regional Perspective ◽  
The Way

This review is devoted to the monograph by Jan Nedvěd “We do not decline our heads. The events of the year 1968 in Karlovy Vary”. The Karlovy Vary municipal museum coincided its publishing with the fiftieth anniversary of the Prague spring which, considering the way of the presentation, turned the book not only to scientific event but also to the social one. The book describes sociopolitical trends in the region before the year 1968, the development of the reformist movement, the invasion and advance of the armies of the Warsaw Pact countries, and finally the decline of the reformist mood and the beginning of the normalization. Working on his writing, the author deeply studied the materials of the local archive and gathered the unique selection of the photographs depicting the passage of the soviet army through the spa town and the protest actions of its inhabitants. In the meantime, Nedvěd takes undue freedom with scientific terms, and his selection of historiography raises questions. The author bases his research on the Czech papers and scarcely uses the books of Russian origin. He also did not study the subject of the participating of the GDR’s army in the operation Danube, although these troops were concentrated on the borders of Karlovy Vary region as well. Because of this decision, there are no materials from German archives or historiography in the monograph. In general, the work lacks the width of studying its subject, but it definitively accomplishes the task of depicting the Prague spring from the regional perspective.

AUX FONDEMENTS DE L’INSTITUTION ECCLÉSIALE: LA POSITION DE SAINT PIERRE PARMI LES APÔTRES (MT 16, 13–20) ET SON RETENTISSEMENT Á L’ÉPOQUE APOSTOLIQUE ET PATRISTIQUE

2016 ◽  
Vol 9 (1) ◽  
pp. 91-105
Author(s):  
Jacek Wojda
Keyword(s):  
Special Role ◽  
Church Community ◽  
Special Place ◽  
The Subject ◽  
The Church ◽  
The Way

Big activity passed Popes, with the least Francis Bergoglio, is a question about receptiontheir lives and action, especially in times of modern medium broadcasting. Sometimes presentedcontent could be treated as sensation, and their receptiveness deprived of profound historical andtheological meaning. This article depends of beginnings of the Church, when it started to organizeitself, with well known historically-theological arguments. Peter confessed Jesus as the Christ andgot special place among Apostles. His role matures in young Church community, which is escapingfrom Jewish religion.Peter tramps the way from Jerusalem thru Antioch to Rome, confirming his appointing to thefirst among Apostles and to being Rock in the Church. Nascent Rome Church keeps this specialPeter’s succession. Clement, bishop of Rome, shows his prerogatives as a successor of Peter. Later,bishop of Cartagena, Cyprian, confirms special role both Peter and each bishop of Rome amongother bishops. He also was finding appropriate role for each of them. Church institution, basedon Peter and Apostles persists and shows truth of the beginnings and faithfulness to them innowadays papacy.Methodological elements Presented in the introduction let for the lecture of Gospel and patristictexts without positivistic prejudices presented in old literature of the subject.

Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity

2020 ◽  
Vol 20 (19) ◽  
pp. 2019-2035
Author(s):  
Esmaeil Sheikh Ahmadi ◽  
Amir Tajbakhsh ◽  
Milad Iranshahy ◽  
Javad Asili ◽  
Nadine Kretschmer ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Biological Activity ◽  
Small Molecules ◽  
Anticancer Activity ◽  
Clinical Significance ◽  
Phase Ii ◽  
Biological Activities ◽  
Phase Ii Clinical Trials ◽  
Naturally Occurring ◽  
The Subject

Naturally occurring naphthoquinones (NQs) comprising highly reactive small molecules are the subject of increasing attention due to their promising biological activities such as antioxidant, antimicrobial, apoptosis-inducing activities, and especially anticancer activity. Lapachol, lapachone, and napabucasin belong to the NQs and are in phase II clinical trials for the treatment of many cancers. This review aims to provide a comprehensive and updated overview on the biological activities of several new NQs isolated from different species of plants reported from January 2013 to January 2020, their potential therapeutic applications and their clinical significance.

A view on Practical Utility of Paradi Gunas

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Sachin Bagali ◽  
Umapati Baragi ◽  
M. R. Sajjanshetti
Keyword(s):  
Clinical Practice ◽  
Professional Practice ◽  
Continuous Process ◽  
Clinical Activity ◽  
Successful Management ◽  
Knowledge Domain ◽  
Practical Utility ◽  
The Subject ◽  
The Way

In the present day scenario prime need of Ayurveda is practical applicability of Ayurvedic fundamental principles and research should be more focused on all aspects where scientific inputs should confirm Ayurveda’s principles and philosophy. In Ayurveda, Gunas are described as the way of presentation of action without which no Karma (action) can be possible. Ayurveda has provided significance to every Guna so that they become useful in clinical practice. Clinical practice or research is a continuous process including a series of events which need to be performed in a sequential manner. Though there are many factors on which accomplishment of treatment depends, among these Charaka has given prime importance to Paradi Gunas. In clinical practice, Guna which are to be with Bhishak are mainly the Paradi Gunas which can also be called as miscellaneous Gunas. As rightly quoted by Acarya Charaka, for getting success in the treatment Paradi Gunas are the best. The Sutra quotes "Sidhyupaya Chikitsayam" which means that Chikitsa i.e. Dhatusamya will be done mainly with the help of Paradi Gunas. Knowledge of Paradi Gunas are required to be present in pharmacists, physicians and Researchers. Acharya Charaka says that Chikitsa Siddhi i.e. successful management of disease is not possible without the knowledge of Paradi Gunas. Paradi Gunas play an important role in selection, adaption and manifestation of drug as per condition of the disease and the patient in particular Desha and Kala. The ultimate goal of any clinical activity is to contribute in the knowledge domain and to improve professional practice. Thus this literary review of Paradi Gunas serves to explore the subject of the clinical practice.

scholarly journals Evolution of university governance in Morocco: Which impacts?

2020 ◽  
Vol 9 (5) ◽  
pp. 94
Author(s):  
Khalid Ayad ◽  
Khaoula Dobli Bennani ◽  
Mostafa Elhachloufi
Keyword(s):  
Higher Education ◽  
Economic Development ◽  
Empirical Studies ◽  
University Governance ◽  
General Review ◽  
Theoretical Literature ◽  
Quality Of Higher Education ◽  
The Subject ◽  
The Way

The concept of governance has become ubiquitous since it is recognized as an important tool for improving quality in all aspects of higher education.In Morocco, few scientific articles have dealt with the subject of university governance. Therefore, we will present a general review of the evolution of governance through laws and reforms established by Moroccan Governments from 1975 to 2019. The purpose of the study is to detect the extent of the presence of university governance principles in these reforms.This study enriches the theoretical literature on the crisis of Moroccan university and opens the way to new empirical studies to better understand the perception of university governance concept in the Moroccan context and to improve the quality of higher education and subsequently the economic development of the country.The findings of this study show an increasing evolution of the presence of university governance principles in reforms and higher education laws.

scholarly journals Naphthalimide-Containing BP100 Leads to Higher Model Membranes Interactions and Antimicrobial Activity

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 542
Author(s):  
Gustavo Penteado Battesini Carretero ◽  
Greice Kelle Viegas Saraiva ◽  
Magali Aparecida Rodrigues ◽  
Sumika Kiyota ◽  
Marcelo Porto Bemquerer ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Activities ◽  
Biological Effects ◽  
Membrane Surface ◽  
Helical Structure ◽  
Helical Conformation ◽  
Property A ◽  
Cellular Processes ◽  
Double Stranded Dna ◽  
Low Toxicity

In a large variety of organisms, antimicrobial peptides (AMPs) are primary defenses against pathogens. BP100 (KKLFKKILKYL-NH2), a short, synthetic, cationic AMP, is active against bacteria and displays low toxicity towards eukaryotic cells. BP100 acquires a α-helical conformation upon interaction with membranes and increases membrane permeability. Despite the volume of information available, the action mechanism of BP100, the selectivity of its biological effects, and possible applications are far from consensual. Our group synthesized a fluorescent BP100 analogue containing naphthalimide linked to its N-terminal end, NAPHT-BP100 (Naphthalimide-AAKKLFKKILKYL-NH2). The fluorescence properties of naphthalimides, especially their spectral sensitivity to microenvironment changes, are well established, and their biological activities against transformed cells and bacteria are known. Naphthalimide derived compounds are known to interact with DNA disturbing related processes as replication and transcription, and used as anticancer agents due to this property. A wide variety of techniques were used to demonstrate that NAPHT-BP100 bound to and permeabilized zwitterionic POPC and negatively charged POPC:POPG liposomes and, upon interaction, acquired a α-helical structure. Membrane surface high peptide/lipid ratios triggered complete permeabilization of the liposomes in a detergent-like manner. Membrane disruption was driven by charge neutralization, lipid aggregation, and bilayer destabilization. NAPHT-BP100 also interacted with double-stranded DNA, indicating that this peptide could also affect other cellular processes besides causing membrane destabilization. NAPHT-BP100 showed increased antibacterial and hemolytic activities, compared to BP100, and may constitute an efficient antimicrobial agent for dermatological use. By conjugating BP100 and naphthalimide DNA binding properties, NAPHT-BP100 bound to a large extent to the bacterial membrane and could more efficiently destabilize it. We also speculate that peptide could enter the bacteria cell and interact with its DNA in the cytoplasm.

scholarly journals Chromatography-Independent Fractionation and Newly Identified Molecular Features of the Adzuki Bean (Vigna angularis Willd.) β-vignin Protein

2021 ◽  
Vol 22 (6) ◽  
pp. 3018
Author(s):  
Biane Philadelpho ◽  
Victória Souza ◽  
Fabiani Souza ◽  
Johnnie Santos ◽  
Fabiana Batista ◽  
...  
Keyword(s):  
Metal Binding ◽  
Cardiovascular Health ◽  
Binding Capacity ◽  
Biological Activities ◽  
Electrophoretic Analysis ◽  
Adzuki Bean ◽  
Molecular Features ◽  
Health Promoting ◽  
High Degree

Adzuki seed β-vignin, a vicilin-like globulin, has proven to exert various health-promoting biological activities, notably in cardiovascular health. A simple scalable enrichment procedure of this protein for further nutritional and functional studies is crucial. In this study, a simplified chromatography-independent protein fractionation procedure has been optimized and described. The electrophoretic analysis showed a high degree of homogeneity of β-vignin isolate. Furthermore, the molecular features of the purified protein were investigated. The adzuki bean β-vignin was found to have a native size of 146 kDa, and the molecular weight determined was consistent with a trimeric structure. These were identified in two main polypeptide chains (masses of 56–54 kDa) that are glycosylated polypeptides with metal binding capacity, and one minor polypeptide chain with a mass 37 kDa, wherein these features are absent. The in vitro analysis showed a high degree of digestibility of the protein (92%) and potential anti-inflammatory capacity. The results lay the basis not only for further investigation of the health-promoting properties of the adzuki bean β-vignin protein, but also for a possible application as nutraceutical molecule.

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