scholarly journals Conserved developmental processes and the formation of evolutionary novelties: examples from butterfly wings

2008 ◽  
Vol 363 (1496) ◽  
pp. 1549-1556 ◽  
Author(s):  
Suzanne V Saenko ◽  
Vernon French ◽  
Paul M Brakefield ◽  
Patrícia Beldade
Keyword(s):  
Gene Networks ◽  
Evolutionary Developmental Biology ◽  
Model Organisms ◽  
Bicyclus Anynana ◽  
Developmental Processes ◽  
Key Issues ◽  
Or Gene ◽  
Morphological Novelties ◽  
Shed Light ◽  
Evolutionary Novelties

The origin and diversification of evolutionary novelties—lineage-specific traits of new adaptive value—is one of the key issues in evolutionary developmental biology. However, comparative analysis of the genetic and developmental bases of such traits can be difficult when they have no obvious homologue in model organisms. The finding that the evolution of morphological novelties often involves the recruitment of pre-existing genes and/or gene networks offers the potential to overcome this challenge. Knowledge about shared developmental processes obtained from extensive studies in model organisms can then be used to understand the origin and diversification of lineage-specific structures. Here, we illustrate this approach in relation to eyespots on the wings of Bicyclus anynana butterflies. A number of spontaneous mutations isolated in the laboratory affect eyespots, lepidopteran-specific features, and also processes that are shared by most insects. We discuss how eyespot mutants with disturbed embryonic development may help elucidate the genetic pathways involved in eyespot formation, and how venation mutants with altered eyespot patterns might shed light on mechanisms of eyespot development.

scholarly journals Homology of process: developmental dynamics in comparative biology

2021 ◽  
Vol 11 (3) ◽  
Author(s):  
James DiFrisco ◽  
Johannes Jaeger
Keyword(s):  
Gene Networks ◽  
Morphological Characters ◽  
Model Organisms ◽  
Comparative Biology ◽  
Levels Of Organization ◽  
Research Programmes ◽  
Systems Modelling ◽  
Or Gene ◽  
Diversity Of Life ◽  
Developmental Dynamics

Comparative biology builds up systematic knowledge of the diversity of life, across evolutionary lineages and levels of organization, starting with evidence from a sparse sample of model organisms. In developmental biology, a key obstacle to the growth of comparative approaches is that the concept of homology is not very well defined for levels of organization that are intermediate between individual genes and morphological characters. In this paper, we investigate what it means for ontogenetic processes to be homologous, focusing specifically on the examples of insect segmentation and vertebrate somitogenesis. These processes can be homologous without homology of the underlying genes or gene networks, since the latter can diverge over evolutionary time, while the dynamics of the process remain the same. Ontogenetic processes like these therefore constitute a dissociable level and distinctive unit of comparison requiring their own specific criteria of homology. In addition, such processes are typically complex and nonlinear, such that their rigorous description and comparison requires not only observation and experimentation, but also dynamical modelling. We propose six criteria of process homology, combining recognized indicators (sameness of parts, morphological outcome and topological position) with novel ones derived from dynamical systems modelling (sameness of dynamical properties, dynamical complexity and evidence for transitional forms). We show how these criteria apply to animal segmentation and other ontogenetic processes. We conclude by situating our proposed dynamical framework for homology of process in relation to similar research programmes, such as process structuralism and developmental approaches to morphological homology.

“The unity based on memories of former intimacy is an attempt to warm up at a went out fire…” The letters from V.M. Chernov to O.S. Minor and M.I. Klyaver

2021 ◽  
Vol 2021 (04-1) ◽  
pp. 4-39
Author(s):  
Olga Konovalova ◽  
Vera Fedorova ◽  
Anna Dvoretskaya
Keyword(s):  
Civil War ◽  
Social History ◽  
Russian Revolution ◽  
International Institute ◽  
Warm Up ◽  
History Of ◽  
Key Issues ◽  
Shed Light ◽  
Foreign Delegation

In the publication, O.V. Konovalova, V.I. Fedorova, A.P. Dvoretskaya presented letters 1931-1932 of the leader and theoretician of the party of socialists-revolutionaries V.M. Chernov to a prominent figure of the party O.S. Minor and a representative of Harbin socialists-revolutionaries organization M. I. Klyaver regarding the split of the Foreign delegation of the socialists-revolutionaries. They are preserved in the collection of VM. Chernov of the International Archives and Collections at the International Institute of Social History in Amsterdam. The presented letters help to clarify VM. Chernov’s position on the key issues of the history of the SR party during the Russian revolution, Civil War, and emigration of the 1920s, and also shed light on the deep reasons for the split of the ZD AKP.

E-Government Development and Implementation

2011 ◽  
pp. 497-507
Author(s):  
Wayne Huang ◽  
Yinging Chen ◽  
K. L. Wang
Keyword(s):  
Developing Countries ◽  
Future Trends ◽  
Important Research ◽  
Research Issues ◽  
Future Studies ◽  
Key Issues ◽  
Government Research ◽  
Shed Light ◽  
Government Development

This article intends to review important research issues in e-government and aims to shed light on future studies on e-government in a global setting. Specifically, this article: (1) reviews the background and development of e-government in developed and developing countries; and (2) identifies and discusses key issues and future trends/challenges in e-government research, which provides some insights and directions for future studies in e-government.

scholarly journals STRIPAK, a highly conserved signaling complex, controls multiple eukaryotic cellular and developmental processes and is linked with human diseases

2019 ◽  
Vol 400 (8) ◽  
pp. 1005-1022 ◽  
Author(s):  
Ulrich Kück ◽  
Daria Radchenko ◽  
Ines Teichert
Keyword(s):  
Protein Complexes ◽  
Model Systems ◽  
Human Diseases ◽  
Physical Interaction ◽  
Developmental Processes ◽  
Signaling Complex ◽  
Macromolecular Assembly ◽  
Complex Functions ◽  
Key Issues ◽  
Eukaryotic Organisms

Abstract The striatin-interacting phosphatases and kinases (STRIPAK) complex is evolutionary highly conserved and has been structurally and functionally described in diverse lower and higher eukaryotes. In recent years, this complex has been biochemically characterized better and further analyses in different model systems have shown that it is also involved in numerous cellular and developmental processes in eukaryotic organisms. Further recent results have shown that the STRIPAK complex functions as a macromolecular assembly communicating through physical interaction with other conserved signaling protein complexes to constitute larger dynamic protein networks. Here, we will provide a comprehensive and up-to-date overview of the architecture, function and regulation of the STRIPAK complex and discuss key issues and future perspectives, linked with human diseases, which may form the basis of further research endeavors in this area. In particular, the investigation of bi-directional interactions between STRIPAK and other signaling pathways should elucidate upstream regulators and downstream targets as fundamental parts of a complex cellular network.

scholarly journals Transcriptome Analysis in Domesticated Species: Challenges and Strategies

2015 ◽  
Vol 9S4 ◽  
pp. BBI.S29334 ◽  
Author(s):  
Jessica P. Hekman ◽  
Jennifer L Johnson ◽  
Anna V. Kukekova
Keyword(s):  
Complex Traits ◽  
Gene Networks ◽  
Association Studies ◽  
Cultural Value ◽  
Genomic Research ◽  
Model Organisms ◽  
Genome Wide Association Studies ◽  
Rna Seq ◽  
Genome Wide ◽  
Genome Assemblies

Domesticated species occupy a special place in the human world due to their economic and cultural value. In the era of genomic research, domesticated species provide unique advantages for investigation of diseases and complex phenotypes. RNA sequencing, or RNA-seq, has recently emerged as a new approach for studying transcriptional activity of the whole genome, changing the focus from individual genes to gene networks. RNA-seq analysis in domesticated species may complement genome-wide association studies of complex traits with economic importance or direct relevance to biomedical research. However, RNA-seq studies are more challenging in domesticated species than in model organisms. These challenges are at least in part associated with the lack of quality genome assemblies for some domesticated species and the absence of genome assemblies for others. In this review, we discuss strategies for analyzing RNA-seq data, focusing particularly on questions and examples relevant to domesticated species.

scholarly journals Reconstructing the invasion route of DNA transposons using extant population samples

2019 ◽  
Author(s):  
Lukas Weilguny ◽  
Christos Vlachos ◽  
Divya Selvaraju ◽  
Robert Kofler
Keyword(s):  
P Element ◽  
Model Organisms ◽  
Migration Patterns ◽  
Dna Transposons ◽  
Time Points ◽  
Wide Range ◽  
Invasion Routes ◽  
Geographic Regions ◽  
Extant Population ◽  
Shed Light

AbstractReconstructing invasion routes of transposable elements (TEs), so far, required capturing an ongoing invasion with population samples from different geographic regions and time points. Here, we propose a more accessible approach. Abundantly occurring internal deletions of DNA transposons allow to trace the direction as well as the path of an invasion, even hundreds of generations after the spread of a TE. We validated this hypothesis with computer simulations and by accurately reproducing the route of the P-element invasion in Drosophila melanogaster. Finally, we used our method to shed light on the controversial hobo invasion in D. melanogaster. Our approach solely requires sequenced samples from extant populations and sequences of TEs of interest. Hence, DNA transposons in a wide range of model and non-model organisms may be analyzed. Our approach will further our understanding of TE dynamics, migration patterns, and the ecology of species.

scholarly journals Interlinkage between Governance and Economic Development: A Review of Existing Literature

2021 ◽  
Vol 9 (1) ◽  
pp. 556-561
Author(s):  
Smita Lahkar, Prof. Nissar Ahmed Barua
Keyword(s):  
Economic Growth ◽  
Necessary Conditions ◽  
Good Governance ◽  
Legal Rights ◽  
Development Effort ◽  
Administrative Authority ◽  
Contemporary World ◽  
Key Issues ◽  
Higher Rank ◽  
Shed Light

Governance is defined as the exercise of economic, political and administrative authority to manage a country’s affairs at all levels. It comprises mechanisms, processes and institutions, through which citizens and groups articulate their interests, exercise their legal rights meet their obligations and mediate their differences.  Thus, governance can be summed up as a process through which authority in a country is exercised (UNDP, 1997; UNESCO, 2012). Development linked governance has been an issue much debated about in the contemporary world. Since the second half of the 1980’s, growth and development studies have started to shed light on the importance of improving institutions of governance on economic growth. Good institutions, good governance and good leadership are considered by many authors as necessary conditions to support the development effort of a country or region. Good governance is believed to be the single most important factor in eradicating poverty and promoting development, hence, the countries that have a higher rank in the world governance index are often found to be in a higher rank in the other aspects of development. There are several pathways through which governance and its various dimensions can impact a country’s economic growth, therefore, in this paper all the key issues related to governance has been discussed which are indispensable for the development of a nation.

scholarly journals Diverse biological processes coordinate the transcriptional response to nutritional changes in a Drosophila melanogaster multiparent population

2019 ◽  
Author(s):  
E. Ng’oma ◽  
P.A. Williams-Simon ◽  
A. Rahman ◽  
E.G. King
Keyword(s):  
Gene Expression ◽  
Gene Networks ◽  
Sequence Data ◽  
Nutrient Sensing ◽  
Gene Set Enrichment Analysis ◽  
Tissue Type ◽  
Model Organisms ◽  
Laboratory Model ◽  
Fisher Exact Test ◽  
Tissue Samples

AbstractBackgroundEnvironmental variation in the amount of resources available to populations challenge individuals to optimize the allocation of those resources to key fitness functions. This coordination of resource allocation relative to resource availability is commonly attributed to key nutrient sensing gene pathways in laboratory model organisms, chiefly the insulin/TOR signaling pathway. However, the genetic basis of diet-induced variation in gene expression is less clear.ResultsTo describe the natural genetic variation underlying nutrient-dependent differences, we used an outbred panel derived from a multiparental population, the Drosophila Synthetic Population Resource. We analyzed RNA sequence data from multiple female tissue samples dissected from flies reared in three nutritional conditions: high sugar (HS), dietary restriction (DR), and control (C) diets. A large proportion of genes in the experiment (19.6% or 2,471 genes) were significantly differentially expressed for the effect of diet, 7.8% (978 genes) for the effect of the interaction between diet and tissue type (LRT, Padj. < 0.05). Interestingly, we observed similar patterns of gene expression relative to the C diet, in the DR and HS treated flies, a response likely reflecting diet component ratios. Hierarchical clustering identified 21 robust gene modules showing intra-modularly similar patterns of expression across diets, all of which were highly significant for diet or diet-tissue interaction effects (false discovery rate, FDR Padj. < 0.05). Gene set enrichment analysis for different diet-tissue combinations revealed a diverse set of pathways and gene ontology (GO) terms (two-sample t-test, FDR < 0.05). GO analysis on individual co-expressed modules likewise showed a large number of terms encompassing a large number of cellular and nuclear processes (Fisher exact test, Padj. < 0.01). Although a handful of genes in the IIS/TOR pathway including Ilp5, Rheb, and Sirt2 showed significant elevation in expression, known key genes such as InR, chico, insulin peptide genes, and the nutrient-sensing pathways were not observed.ConclusionsOur results suggest that a more diverse network of pathways and gene networks mediate the diet response in our population. These results have important implications for future studies focusing on diet responses in natural populations.

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