scholarly journals Winter feeding of elk in the Greater Yellowstone Ecosystem and its effects on disease dynamics

2018 ◽  
Vol 373 (1745) ◽  
pp. 20170093 ◽  
Author(s):  
Gavin G. Cotterill ◽  
Paul C. Cross ◽  
Eric K. Cole ◽  
Rebecca K. Fuda ◽  
Jared D. Rogerson ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Population Level ◽  
Research Management ◽  
Natural Food ◽  
Past Century ◽  
Winter Mortality ◽  
Animal Testing ◽  
Resource Subsidies ◽  
The Right ◽  
Host Parasite

Providing food to wildlife during periods when natural food is limited results in aggregations that may facilitate disease transmission. This is exemplified in western Wyoming where institutional feeding over the past century has aimed to mitigate wildlife–livestock conflict and minimize winter mortality of elk ( Cervus canadensis ). Here we review research across 23 winter feedgrounds where the most studied disease is brucellosis, caused by the bacterium Brucella abortus . Traditional veterinary practices (vaccination, test-and-slaughter) have thus far been unable to control this disease in elk, which can spill over to cattle. Current disease-reduction efforts are being guided by ecological research on elk movement and density, reproduction, stress, co-infections and scavengers. Given the right tools, feedgrounds could provide opportunities for adaptive management of brucellosis through regular animal testing and population-level manipulations. Our analyses of several such manipulations highlight the value of a research–management partnership guided by hypothesis testing, despite the constraints of the sociopolitical environment. However, brucellosis is now spreading in unfed elk herds, while other diseases (e.g. chronic wasting disease) are of increasing concern at feedgrounds. Therefore experimental closures of feedgrounds, reduced feeding and lower elk populations merit consideration. This article is part of the theme issue ‘Anthropogenic resource subsidies and host–parasite dynamics in wildlife’.

scholarly journals Food for contagion: synthesis and future directions for studying host–parasite responses to resource shifts in anthropogenic environments

2018 ◽  
Vol 373 (1745) ◽  
pp. 20170102 ◽  
Author(s):  
Sonia Altizer ◽  
Daniel J. Becker ◽  
Jonathan H. Epstein ◽  
Kristian M. Forbes ◽  
Thomas R. Gillespie ◽  
...  
Keyword(s):  
Regional Scale ◽  
Population Level ◽  
Food Resources ◽  
Resource Subsidies ◽  
Conservation Implications ◽  
Contact Rates ◽  
Animal Aggregation ◽  
Infection Processes ◽  
Host Parasite ◽  
Future Work

Human-provided resource subsidies for wildlife are diverse, common and have profound consequences for wildlife–pathogen interactions, as demonstrated by papers in this themed issue spanning empirical, theoretical and management perspectives from a range of study systems. Contributions cut across scales of organization, from the within-host dynamics of immune function, to population-level impacts on parasite transmission, to landscape- and regional-scale patterns of infection. In this concluding paper, we identify common threads and key findings from author contributions, including the consequences of resource subsidies for (i) host immunity; (ii) animal aggregation and contact rates; (iii) host movement and landscape-level infection patterns; and (iv) interspecific contacts and cross-species transmission. Exciting avenues for future work include studies that integrate mechanistic modelling and empirical approaches to better explore cross-scale processes, and experimental manipulations of food resources to quantify host and pathogen responses. Work is also needed to examine evolutionary responses to provisioning, and ask how diet-altered changes to the host microbiome influence infection processes. Given the massive public health and conservation implications of anthropogenic resource shifts, we end by underscoring the need for practical recommendations to manage supplemental feeding practices, limit human–wildlife conflicts over shared food resources and reduce cross-species transmission risks, including to humans. This article is part of the theme issue ‘Anthropogenic resource subsidies and host–parasite dynamics in wildlife’.

scholarly journals Urban Vulnerability Assessment for Pandemic Surveillance—The COVID-19 Case in Bogotá, Colombia

2021 ◽  
Vol 13 (6) ◽  
pp. 3402
Author(s):  
Jeisson Prieto ◽  
Rafael Malagón ◽  
Jonatan Gomez ◽  
Elizabeth León
Keyword(s):  
Vulnerability Assessment ◽  
Disease Transmission ◽  
Urban Areas ◽  
A Priori ◽  
Vulnerability Index ◽  
Past Century ◽  
Vulnerability Factors ◽  
Early Assessment ◽  
Global Citizens ◽  
Urban Vulnerability

A pandemic devastates the lives of global citizens and causes significant economic, social, and political disruption. Evidence suggests that the likelihood of pandemics has increased over the past century because of increased global travel and integration, urbanization, and changes in land use with a profound affectation of society–nature metabolism. Further, evidence concerning the urban character of the pandemic has underlined the role of cities in disease transmission. An early assessment of the severity of infection and transmissibility can help quantify the pandemic potential and prioritize surveillance to control highly vulnerable urban areas in pandemics. In this paper, an Urban Vulnerability Assessment (UVA) methodology is proposed. UVA investigates various vulnerability factors related to pandemics to assess the vulnerability in urban areas. A vulnerability index is constructed by the aggregation of multiple vulnerability factors computed on each urban area (i.e., urban density, poverty index, informal labor, transmission routes). This methodology is useful in a-priori evaluation and development of policies and programs aimed at reducing disaster risk (DRR) at different scales (i.e., addressing urban vulnerability at national, regional, and provincial scales), under diverse scenarios of resources scarcity (i.e., short and long-term actions), and for different audiences (i.e., the general public, policy-makers, international organizations). The applicability of UVA is shown by the identification of high vulnerable areas based on publicly available data where surveillance should be prioritized in the COVID-19 pandemic in Bogotá, Colombia.

scholarly journals Behavioral Triggers of Skin Conductance Responses and Their Neural Correlates in the Primate Amygdala

2009 ◽  
Vol 101 (4) ◽  
pp. 1749-1754 ◽  
Author(s):  
Christopher M. Laine ◽  
Kevin M. Spitler ◽  
Clayton P. Mosher ◽  
Katalin M. Gothard
Keyword(s):  
Skin Conductance ◽  
Single Unit ◽  
Population Level ◽  
Emotional Reaction ◽  
Neural Population ◽  
Experimental Conditions ◽  
Indirect Measure ◽  
Skin Conductance Responses ◽  
The Right ◽  
Sympathetic Arousal

The amygdala plays a crucial role in evaluating the emotional significance of stimuli and in transforming the results of this evaluation into appropriate autonomic responses. Lesion and stimulation studies suggest involvement of the amygdala in the generation of the skin conductance response (SCR), which is an indirect measure of autonomic activity that has been associated with both emotion and attention. It is unclear if this involvement marks an emotional reaction to an external stimulus or sympathetic arousal regardless of its origin. We recorded skin conductance in parallel with single-unit activity from the right amygdala of two rhesus monkeys during a rewarded image viewing task and while the monkeys sat alone in a dimly lit room, drifting in and out of sleep. In both experimental conditions, we found similar SCR-related modulation of activity at the single-unit and neural population level. This suggests that the amygdala contributes to the production or modulation of SCRs regardless of the source of sympathetic arousal.

NOTE ON THE UNIQUENESS OF AN ENDEMIC EQUILIBRIUM OF AN EPIDEMIC MODEL WITH BOOSTING OF IMMUNITY

2021 ◽  
pp. 1-12
Author(s):  
LIU YANG ◽  
YUKIHIKO NAKATA
Keyword(s):  
Epidemic Model ◽  
Disease Transmission ◽  
Immune Status ◽  
Natural Infection ◽  
Population Level ◽  
Qualitative Property ◽  
Endemic Equilibrium ◽  
Unique Existence ◽  
Nonlinear Version ◽  
Age Dependent

For some diseases, it is recognized that immunity acquired by natural infection and vaccination subsequently wanes. As such, immunity provides temporal protection to recovered individuals from an infection. An immune period is extended owing to boosting of immunity by asymptomatic re-exposure to an infection. An individual’s immune status plays an important role in the spread of infectious diseases at the population level. We study an age-dependent epidemic model formulated as a nonlinear version of the Aron epidemic model, which incorporates boosting of immunity by a system of delay equations and study the existence of an endemic equilibrium to observe whether boosting of immunity changes the qualitative property of the existence of the equilibrium. We establish a sufficient condition related to the strength of disease transmission from subclinical and clinical infective populations, for the unique existence of an endemic equilibrium.

Ecological analysis of secular trends in low birth weight births and adult height in Japan

2017 ◽  
Vol 71 (10) ◽  
pp. 1014-1018 ◽  
Author(s):  
Naho Morisaki ◽  
Kevin Yuji Urayama ◽  
Keisuke Yoshii ◽  
S V Subramanian ◽  
Susumu Yokoya
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Adult Height ◽  
Inverse Correlation ◽  
Population Level ◽  
Vital Statistics ◽  
Secular Trends ◽  
Past Century ◽  
Average Height ◽  
Adult Health

BackgroundJapan, which currently maintains the highest life expectancy in the world and has experienced an impressive gain in adult height over the past century, has suffered a dramatic twofold increase in low birth weight (LBW) births since the 1970s.MethodsWe observed secular trends in birth characteristics using 64 115 249 live births included the vital statistics (1969–2014), as well as trends in average height among 3 145 521 adults born between 1969 and 1996, included in 79 surveys conducted among a national, subnational or community population in Japan.ResultsLBW rates exhibited a U-shaped pattern showing reductions until 1978–1979 (5.5%), after which it increased. Conversely, average adult height peaked for those born during the same period (men, 171.5 cm; women, 158.5 cm), followed by a reduction over the next 20 years. LBW rate and adult height showed a strong inverse correlation (men, r=−0.98; women, r=−0.88). A prediction model based on birth and economical characteristics estimated the national average of adult height would continue to decline, to 170.0cm (95% CI 169.6 to 170.3) for men and 157.9cm (95% CI 157.5 to 158.3) for women among those born in 2014.ConclusionsAdult height in Japan has started to decline for those born after 1980, a trend that may be attributed to increases in LBW births over time. Considering the known association between shorter adult height and adverse health outcomes, evidence of population-level decline in adult health due to long-term consequences of increasing LBW births in Japan is anticipated.

scholarly journals The site Vavilino 1 on the right bank of the Derkul River in Western Kazakhstan (materials of 2018)

2019 ◽  
Vol 8 (3) ◽  
pp. 166-173
Author(s):  
Talgat Basarbaevich Mamirov
Keyword(s):  
Anthropogenic Activities ◽  
Past Century ◽  
Stone Age ◽  
Cultural Layer ◽  
Stone Artifacts ◽  
The Past ◽  
Western Kazakhstan ◽  
The Right ◽  
Bone Remains ◽  
Excavation Area

The paper is devoted to preliminary data from a study of the Vavilino 1 site in Western Kazakhstan. The monument was first opened by N.M. Malov in 1986, later he picked artifacts from the surface in 1988. In 1991 N.L. Morgunova carried out excavations on the site, which showed the importance of this monument study to understand the Neolithic Volga-Ural interfluve. The monument is located on the right bank of the Derkul River and is currently classified as an emergency. In 2018, employees of the Institute of Archeology named after A.Kh. Margulan in the framework of the Stone Age study in Western Kazakhstan started to work on the monuments of Yeshkitau, Derkul 1 and Vavilino 1. At the Vavilino 1 site a small excavation area - 16 square meters was made, more than a thousand stone artifacts were received; fragments of ceramics and bone remains of animals were poorly diagnosed. Excavations have shown the presence of a 15-20 cm thick cultural layer belonging to the Neolithic time. The upper layer of the monument with a capacity of up to 30 cm was destroyed by anthropogenic activities in the past century. The material from the cultural layer is not numerous; tip scrapers, fragments of plates with retouching, geometrical microliths, prismatic nucleus for plates, etc. are typologically distinguished.

scholarly journals Vaccinating Adolescents and Children Significantly Reduces COVID-19 Morbidity and Mortality across All Ages: A Popula-Tion-Based Modeling Study Using the UK as an Example

Vaccines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1180
Author(s):  
Tinevimbo Shiri ◽  
Marc Evans ◽  
Carla A. Talarico ◽  
Angharad R. Morgan ◽  
Maaz Mussad ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Age Groups ◽  
Population Level ◽  
Vital Role ◽  
Morbidity And Mortality ◽  
Transmission Model ◽  
Base Case ◽  
Global Public Health ◽  
The Uk ◽  
The Impact

Debate persists around the risk–benefit balance of vaccinating adolescents and children against COVID-19. Central to this debate is quantifying the contribution of adolescents and children to the transmission of SARS-CoV-2, and the potential impact of vaccinating these age groups. In this study, we present a novel SEIR mathematical disease transmission model that quantifies the impact of different vaccination strategies on population-level SARS-CoV-2 infections and clinical outcomes. The model employs both age- and time-dependent social mixing patterns to capture the impact of changes in restrictions. The model was used to assess the impact of vaccinating adolescents and children on the natural history of the COVID-19 pandemic across all age groups, using the UK as an example. The base case model demonstrates significant increases in COVID-19 disease burden in the UK following a relaxation of restrictions, if vaccines are limited to those ≥18 years and vulnerable adolescents (≥12 years). Including adolescents and children in the vaccination program could reduce overall COVID-related mortality by 57%, and reduce cases of long COVID by 75%. This study demonstrates that vaccinating adolescents and children has the potential to play a vital role in reducing SARS-CoV-2 infections, and subsequent COVID-19 morbidity and mortality, across all ages. Our results have major global public health implications and provide valuable information to inform a potential pandemic exit strategy.

scholarly journals Assessing the direct and indirect effects of food provisioning and nutrient enrichment on wildlife infectious disease dynamics

2018 ◽  
Vol 373 (1745) ◽  
pp. 20170101 ◽  
Author(s):  
David J. Civitello ◽  
Brent E. Allman ◽  
Connor Morozumi ◽  
Jason R. Rohr
Keyword(s):  
Nutrient Enrichment ◽  
Management Strategies ◽  
Wildlife Disease ◽  
Host Population ◽  
Food Provisioning ◽  
Resource Subsidies ◽  
Predator Species ◽  
Interacting Species ◽  
Integrative View ◽  
Host Parasite

Anthropogenic resource supplementation can shape wildlife disease directly by altering the traits and densities of hosts and parasites or indirectly by stimulating prey, competitor or predator species. We first assess the direct epidemiological consequences of supplementation, highlighting the similarities and differences between food provisioning and two widespread forms of nutrient input: agricultural fertilization and aquatic nutrient enrichment. We then review an aquatic disease system and a general model to assess whether predator and competitor species can enhance or overturn the direct effects of enrichment. All forms of supplementation can directly affect epidemics by increasing host population size or altering parasite production within hosts, but food provisioning is most likely to aggregate hosts and increase parasite transmission. However, if predators or competitors increase in response to supplementation, they could alter resource-fuelled outbreaks in focal hosts. We recommend identifying the traits of hosts, parasites or interacting species that best predict epidemiological responses to supplementation and evaluating the relative importance of these direct and indirect mechanisms. Theory and experiments should examine the timing of behavioural, physiological and demographic changes for realistic, variable scenarios of supplementation. A more integrative view of resource supplementation and wildlife disease could yield broadly applicable disease management strategies. This article is part of the theme issue ‘Anthropogenic resource subsidies and host–parasite dynamics in wildlife’.

Introduction

2011 ◽  
pp. 7-10
Author(s):  
Anne Billson
Keyword(s):  
North America ◽  
South Korea ◽  
Past Century ◽  
Film Festival ◽  
The Past ◽  
The Right ◽  
World Premiere

This chapter introduces the Swedish vampire film, Låt den rätte komma (Let the Right One In), which not only stands out from contemporary vampire films, but ranks among the very best vampire movies of the past century. The chapter mentions director Tomas Alfredson and screenwriter John Ajvide Lindqvist, who adapted Låt den rätte komma from his own novel of the same name. It also mentions a song by the lugubrious British rock singer-songwriter Morrissey as Lindqvist's inspiration for the title of his novel 'Let the Right One Slip In'. It recounts Let the Right One In's world premiere on 26 January 2008 at the Göteborg International Film Festival in Sweden and screening at other festivals in Europe, North America, Australia and South Korea. The chapter explains why Let the Right One In stands head and shoulders above other recent horror movies like Twilight from 2008.

Unique Ethical Issues in Chemistry

2018 ◽  
Author(s):  
Jeffrey Kovac
Keyword(s):  
Ethical Issues ◽  
Human Life ◽  
Environmental Pollutants ◽  
Building Blocks ◽  
Natural Sciences ◽  
The Other ◽  
Past Century ◽  
Chemical Systems ◽  
Fundamental Knowledge ◽  
The Right

What makes chemistry unique? And how does this uniqueness reflect on chemistry’s unique concerns with ethics? As Roald Hoffmann (1995) argues, it is because chemistry is in the “tense middle,” occupying a space between several pairs of extremes. Perhaps most important, chemistry has always inhabited a frontier between science and technology, the pure and the applied, the theoretical and the practical (Bensaude-Vincent and Simon 2008). Unlike the other natural sciences, chemistry traces its origins both to philosophy and the craft tradition. Chemists are discoverers of knowledge and creators of new substances. The objects of study in chemistry, molecules and the macroscopic systems made up of molecules, are intermediate between the very small, the elementary particles, and the very large, the cosmos. Chemical systems are the right size to affect humans directly, for better or worse. They are the building blocks of biological organisms, they are the substances we eat and drink, they are the drugs that have improved human health dramatically over the past century, they comprise the materials we use to construct the products we use daily, but they are also the environmental pollutants that can plague our world. Chemicals can also be used as weapons. Being in the middle means that chemists face a unique set of ethical issues that I try to explicate in this chapter. These issues derive, in part, from the nature of chemistry as a science, a science that does not fit the neat picture drawn in the first chapter of textbooks. They also derive from the fact that ethics is an inquiry into right human conduct: What is a good life? Chemistry has perhaps contributed more to the betterment of human life than any other science, but at the same time has also contributed significantly to the deterioration of the environment. As explained in Chapter 3, much of chemistry is conducted in Pasteur’s quadrant, where both the search for fundamental knowledge and considerations of use are important. Chemical synthesis is perhaps the central activity of chemistry.

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