scholarly journals Uric Acid or 1-Methyl Uric Acid in the Urinary Bladder Increases Serum Glucose, Insulin, True Triglyceride, and Total Cholesterol Levels in Wistar Rats

2003 ◽  
Vol 3 ◽  
pp. 930-936 ◽  
Author(s):  
T. Balasubramanian
Keyword(s):  
Uric Acid ◽  
Urinary Bladder ◽  
Total Cholesterol ◽  
Serum Levels ◽  
Serum Glucose ◽  
Bladder Mucosa ◽  
Total Body Mass ◽  
Cholesterol Levels ◽  
The Metabolic Syndrome ◽  
Total Body

In animals deprived of food for a long period, a drop in the fat mass below 5% of the total body mass results in an increase in blood glucocorticoids and uric acid levels, followed by foraging activity. Since the glucocorticoids increase the uric acid excretion, an increase in the level of uric acid in the bladder urine could be the signal for this feeding behaviour and subsequent fat storage. Accumulation of fat is associated with hyperglycaemia, hyperinsulinaemia, hyperlipidaemia, and hypercholesterolaemia as seen in the metabolic syndrome or hibernation. It is hypothesized that uric acid or its structurally related compound, 1-methyl uric acid (one of the metabolites of the methyl xanthines namely caffeine, theophylline, and theobromine present in coffee, tea, cocoa, and some drugs), can act on the urinary bladder mucosa and increases the blood glucose, insulin, triglyceride, and cholesterol levels. In rats, perfusion of the urinary bladder with saturated aqueous solution of uric acid or 1-methyl uric acid results in a significant increase in the serum levels of glucose, insulin, true triglyceride, and total cholesterol in comparison with perfusion of the bladder with distilled water at 20, 40, and 80 min. The uric acid or the 1-methyl uric acid acts on the urinary bladder mucosa and increases the serum glucose, insulin, true triglyceride, and total cholesterol levels.

Study Upon the Serum Level of Uric Acid and the Metabolic Syndrome Components

2019 ◽  
Vol 70 (3) ◽  
pp. 1062-1066
Author(s):  
Maria Rada ◽  
Delia Berceanu-Vaduva ◽  
Milan Velimirovici ◽  
Simona Dragan ◽  
Daniel Duda-Seiman ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Level ◽  
Abdominal Obesity ◽  
Cardiometabolic Risk ◽  
Serum Levels ◽  
Mean Value ◽  
The Metabolic Syndrome ◽  
Direct Association ◽  
Metabolic Syndrome Components

The serum level of uric acid (UA) appears to be associated with a variety of cardiometabolic risk factors; however, direct association with the metabolic syndrome (MetS) remains controversial. The aim of this study is to investigate the association between serum levels of UA and the components that define MetS, differentiated by gender. 262 patients were enrolled (132 women and 130 men); mean value of the age: 58.7�16 year. Hyperuricemia was considered when the level of serum UA �7mg/dL in men, and � 6mg/dL in women; MetS was defined according to the IDF criteria. The prevalence of MetS in the studied group was 35.11% and the prevalence of hyperuricemia was 16.79%. Men with hyperuricemia had the highest prevalence of abdominal obesity (87.5% vs. 66.32%, p [0.001) and hypertriglyceridemia (65.62% vs. 45.91%, p [ 0.001) versus men with normal level of serum UA. Women with hyperuricemia also had a significantly higher incidence of abdominal obesity (75% vs. 57.51%, p [0.001), hypertriglyceridemia (58.33% vs. 38.33%, p [0.001), decreased HDL (50% vs. 33.33%, p [0.001) and hyperglycemia (66.66% versus 50%, p [0.001) compared to those with normal levels of serum UA. The majority of men with hyperuricemia have more than 4 of the MetS components. Hyperuricemia had a higher prevalence in patients with MetS, it may be considered as a causal factor of MetS. Elevated levels of serum uric acid were significantly more associated with the increasing number of MetS components. Early detection and treatment of hyperuricemia is essential for preventing the metabolic syndrome and its complications.

scholarly journals Significance of Serological Markers in Neurological Function and Progression Rate of Amyotrophic Lateral Sclerosis

2021 ◽  
Author(s):  
Xiaowen Chen ◽  
Junrong Li ◽  
Yingying Lv ◽  
Wei Zhang ◽  
xiujian Xu ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Creatine Kinase ◽  
Uric Acid ◽  
Total Cholesterol ◽  
Cystatin C ◽  
Control Group ◽  
Progression Rate ◽  
Cholesterol Levels ◽  
Als Patients ◽  
Lateral Sclerosis

Abstract Objective The present study was to investigate the significance of creatinine, uric acid, creatine kinase, total cholesterol, triglyceride, HCY (Homocysteine), and cystatin C in neurological function and progression rate of amyotrophic lateral sclerosis. Methods According to the diagnostic criteria of EI-Escorial (2000), 103 patients with ALS were enrolled. All patients were given corresponding serological tests at the initial diagnosis. The Revised ALS Functional Rating Scale (ALSFRS-R) and Disease Progression Rate (DPR) were evaluated. The detected indexes in blood tests included creatinine, uric acid, creatine kinase, total cholesterol, triglycerides, homocysteine, and cystatin C. All data were input into the computer, and the data analysis was performed by SPSS22.0 statistical software.Results 1. There were significant differences in creatinine, uric acid, creatine kinase,
total cholesterol, HCY and cystatin C between the two groups (P<0.05). The levels of uric acid and creatinine of ALS group were lower than those of the control group, and the levels of creatine kinase, total cholesterol, triglyceride, HCY and cystatin C were higher than that in the control group.
2. The results from correlation analysis demonstrated that there was a significant correlation between ALSFRS-R and creatinine (P<0.01), the correlation coefficient was 0.567 (positive correlation); There was also a significant correlation between DPR and creatinine (P<0.01), and the correlation coefficient was -0.808 (negative correlation). The correlations of DPR with triglyceride and total cholesterol were significantly negative correlated (P<0.05), with -0.201 and -0.210 of correlation coefficients, respectively. The remaining indexes did not show any correlation with ALSFRS-R and DPR.
Conclusions 1. Uric acid and creatinine of ALS patients were lower than that in healthy people. Creatine kinase, triglyceride, total cholesterol, HCY, and cystatin C in ALS patients were higher than those in health controls. There were significant metabolic abnormalities in ALS patients.
2. Creatinine level is an independent risk factor affecting ALSFRS-R. The creatinine and total cholesterol levels are also the independent risk factors affecting DPR. Creatinine and total cholesterol levels could be used as reliable indicators to evaluate the ALSFRS-R and DPR of ALS patients.

Effects of an Alleged Myostatin-Binding Supplement and Heavy Resistance Training on Serum Myostatin, Muscle Strength and Mass, and Body Composition

2004 ◽  
Vol 14 (4) ◽  
pp. 461-472 ◽  
Author(s):  
Darryn S. Willoughby
Keyword(s):  
Body Composition ◽  
Resistance Training ◽  
Muscle Strength ◽  
Serum Levels ◽  
Fat Free Mass ◽  
Double Blind ◽  
Total Body Mass ◽  
Before And After ◽  
Heavy Resistance Training ◽  
Total Body

This study examined 12 wk of resistance training and cystoseim canariensis supplementation on serum levels of myostatin and follistatin-like related gene (FLRG) and muscle strength and body composition. Twenty-two untrained males were randomly assigned to a placebo (PLC) or myostatin binder (MYO) group in a double-blind fashion. Blood was obtained before and after 6 and 12 wk of training. PLC and MYO trained thrice weekly using 3 sets of 6 to 8 repetitions at 85% to 90% 1 repetition maximum. MYO ingested 1200 mg/d of cystoseim canariensis. Data were analyzed with 2-way ANOVA. After training, total body mass, fat-free mass, muscle strength, thigh volume/mass, and serum myostatin and FLRG increased for both groups (P < 0.05); however, there were no differences between groups (P > 0.05). Twelve wk of heavy resistance training and 1200 mg/d of cystoseim canariensis supplementation appears ineffective at inhibiting serum myostatin and increasing muscle strength and mass or decreasing fat mass.

scholarly journals Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE−/−Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Marcus A. Ulleryd ◽  
Evelina Bernberg ◽  
Li Jin Yang ◽  
Göran M. L. Bergström ◽  
Maria E. Johansson
Keyword(s):  
Total Cholesterol ◽  
Thoracic Aorta ◽  
Atherosclerotic Plaque ◽  
Proinflammatory Cytokines ◽  
Serum Levels ◽  
Adrenoceptor Antagonist ◽  
Plaque Area ◽  
Cholesterol Levels ◽  
Antiatherosclerotic Effect ◽  
Inflammatory Effect

A few studies in animals and humans suggest that metoprolol (β1-selective adrenoceptor antagonist) may have a direct antiatherosclerotic effect. However, the mechanism behind this protective effect has not been established. The aim of the present study was to evaluate the effect of metoprolol on development of atherosclerosis in ApoE−/−mice and investigate its effect on the release of proinflammatory cytokines. Male ApoE−/−mice were treated with metoprolol (2.5 mg/kg/h) or saline for 11 weeks via osmotic minipumps. Atherosclerosis was assessed in thoracic aorta and aortic root. Total cholesterol levels and Th1/Th2 cytokines were analyzed in serum and macrophage content in lesions by immunohistochemistry. Metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta (P<0.05versus Control). Further, metoprolol reduced serum TNFαand the chemokine CXCL1 (P<0.01versus Control for both) as well as decreasing the macrophage content in the plaques (P<0.01versus Control). Total cholesterol levels were not affected. In this study we found that a moderate dose of metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta of ApoE−/−mice. Metoprolol also decreased serum levels of proinflammatory cytokines TNFαand CXCL1 and macrophage content in the plaques, showing that metoprolol has an anti-inflammatory effect.

Cigarette Smoking-Associated Changes in Blood Lipid and Lipoprotein Levels in the 8-to 19-Year-Old Age Group: A Meta-Analysis

PEDIATRICS ◽  
1990 ◽  
Vol 85 (2) ◽  
pp. 155-158
Author(s):  
Wendy Y. Craig ◽  
Glenn E. Palomaki ◽  
A. Myron Johnson ◽  
James E. Haddow
Keyword(s):  
Total Cholesterol ◽  
Old Age ◽  
Ldl Cholesterol ◽  
Meta Analysis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Low Density ◽  
Age Group ◽  
Cholesterol Levels

In this meta-analysis it was demonstrated that, when compared with nonsmokers of similar age, smokers in the 8- to 19-year-old age group have significantly higher serum levels of triglyceride (+11.8%), very-low-density lipoprotein (VLDL)-cholesterol (+12.4%) and low-density lipoprotein (LDL)-cholesterol (+4.1%) and significantly lower serum levels of high-density lipoprotein (HDL)-cholesterol (-8.5%) and total cholesterol (-3.7%). All of these smoking-associated changes are in the same direction as those found in adults, with the exception of total cholesterol levels, which are significantly increased in adult smokers. The extent to which mean triglyceride, LDL-cholesterol, and HDL-choles-terol levels are shifted is significantly greater in the 8-to 19-year-old smokers than in adult smokers. The changes in mean total cholesterol levels among smokers in both age groups represent only the net shifts in the lipoprotein fractions and are therefore likely to be a less sensitive indicator of the possible lipid-related excess coronary artery disease risk in smokers.

scholarly journals The relationship of diet to serum cholesterol levels in young men in Antarctica

1970 ◽  
Vol 24 (1) ◽  
pp. 307-312 ◽  
Author(s):  
D. L. Easty
Keyword(s):  
Total Cholesterol ◽  
Serum Cholesterol ◽  
Serum Levels ◽  
Skinfold Thickness ◽  
Positive Correlation ◽  
Total Intake ◽  
Total Food Intake ◽  
Cholesterol Levels ◽  
Total Food ◽  
Relationship Of

1. Regular estimations of dietary intake, body-weight, skinfold thickness, blood pressure and pulse rate, and serum lipids were made in twenty-four members of an Antarctic expedition over 1 year.2. The mean levels of serum total cholesterol, phospholipids, and triglycerides were 198.5 ±4.85 mg/100 ml, 221.4±5.73 mg/100 ml and 120.9±13.53 mg/100 ml respectively.3. A positive correlation was found between the total intake of fat expressed as calories and the following serum lipid levels: total cholesterol, β-cholesterol, and the cholesterol:phospholipid ratio. Significant positive correlation was also found between the latter serum levels and fat when expressed as a percentage of the total food intake.4. This correlation has not been found in small groups before, and is due to the fact that each estimation was the result of several assessments made over 1 year.5. The survey suggests that the personal serum cholesterol level may be dependent upon the habitual total intake of dietary fat and the percentage of the total calories supplied by fat.

scholarly journals Elevation of serum E-selectin in Thai hyperlipidemia adults

2021 ◽  
Vol 9 (12) ◽  
pp. 3520
Author(s):  
Apinya Michuea ◽  
Somsak Fongsupa ◽  
Thaval Rerksngarm ◽  
Sudawadee Kongkhum
Keyword(s):  
Uric Acid ◽  
Blood Glucose ◽  
Endothelial Dysfunction ◽  
Total Cholesterol ◽  
Blood Lipids ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Specific Marker

Background: Hyperlipidemia is an important risk factor of cardiovascular diseases (CVD), whose pathogenesis involves vascular endothelial dysfunction. Therefore, a specific marker of endothelial dysfunction, serum E-selectin, was assessed in Thai hyperlipidemia adults.Methods: Subjects who had no history of hypertension, diabetes and other serious illness were recruited and classified as normolipidemia (n=100) and hyperlipidemia (n=100), by using the levels of blood lipids (hyperlipidemia: total cholesterol >200 mg/dl, low density lipoprotein cholesterol (LDL-C) >130 mg/dl, and triglyceride >150 mg/dl). Clinical data were collected, and laboratory analysis was done. Serum levels of uric acid, fasting blood glucose (FBS), blood urea nitrogen (BUN), and creatinine were measured by the dry chemistry automate analyzer. Serum E-selectin was measured by using the enzyme-linked immunosorbent assay.Results: The hyperlipidemia subjects had significantly higher serum E-selectin levels than the normolipidemia subjects (18.98±11.58.56 versus 8.85±4.02 ng/ml). E-selectin was significantly correlated with blood lipids; total cholesterol, triglyceride, LDL-C, and HDL-C (r=0.477, 0.441, 0.453, and -0.191, respectively). Moreover, significant correlations of E-selectin with uric acid and fasting blood glucose were also found (r=0.155 and 0.166, respectively).Conclusions: Serum E-selectin levels increased in hyperlipidemia and correlated with uric acid and fasting blood glucose, reflecting the association between hyperlipidemia and pathogenesis of CVD, Therefore, it emphasizes the importance of hyperlipidemia management. 

scholarly journals Relationship between Hyperuricemia and Lipid Profiles in US Adults

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Tao-Chun Peng ◽  
Chung-Ching Wang ◽  
Tung-Wei Kao ◽  
James Yi-Hsin Chan ◽  
Ya-Hui Yang ◽  
...  
Keyword(s):  
Uric Acid ◽  
Total Cholesterol ◽  
Serum Uric Acid ◽  
Apolipoprotein B ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Lipid Profiles ◽  
Nhanes Iii ◽  
Cholesterol Levels ◽  
Reference Serum

Background. Although the link between hyperuricemia and metabolic syndrome had been recognized, the association of the dyslipidemia among individuals with hyperuricemia remains not comprehensively assessed.Methods. Using NHANES III study, we examined the relation between serum lipid profiles and different serum uric acid levels, including serum total cholesterol, LDL cholesterol, triglycerides, HDL cholesterol, apolipoprotein-B, lipoprotein (a), apolipoprotein AI, ratio of triglycerides to HDL cholesterol, and ratio of apolipoprotein-B to AI.Results. After adjusting for potential confounders, average differences (95% confidence interval) comparing the top to the bottom (reference) serum uric acid were 0.29 (0.19, 0.39) mmol/L for total cholesterol, 0.33 (0.26, 0.41) mmol/L for triglycerides, 0.14 (0.01, 0.27) mmol/L for LDL cholesterol, −0.08 (−0.11, −0.05) mmol/L for HDL, and 0.09 (0.05, 0.12) g/L for serum apolipoprotein-B. Notably, ratios of triglycerides to HDL cholesterol and apolipoprotein-B to AI were also linearly associated with uric acid levels (Pfor trend < 0.001).Conclusions. This study suggested that serum LDL cholesterol, triglycerides, total cholesterol, apolipoprotein-B levels, ratio of triglycerides to HDL cholesterol, and ratio of apolipoprotein-B to AI are strongly associated with serum uric acid levels, whereas serum HDL cholesterol levels are significantly inversely associated. In the clinical practice, the more comprehensive strategic management to deal with dyslipidemia and hyperuricemia deserves further investigation.

Antidiabetic effects of dendropanoxide from leaves of Dendropanax morbifera Leveille in normal and streptozotocin-induced diabetic rats

2010 ◽  
Vol 30 (8) ◽  
pp. 870-875 ◽  
Author(s):  
Hyung-In Moon
Keyword(s):  
Uric Acid ◽  
Total Cholesterol ◽  
Serum Insulin ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Antidiabetic Drug ◽  
Antidiabetic Effect ◽  
Dendropanax Morbifera ◽  
Aspartate Amino Transferase ◽  
Antidiabetic Effects

The present study evaluated the antidiabetic effect of Dendropanoxide (DP) from Dendropanax morbifera Leveille in normal and streptozotocin-induced diabetic rats. DP in the streptozotocin-induced diabetic rats showed significant hypoglycemic activity for 14 days significantly decreased the serum glucose, total cholesterol, triglycerides, urea, uric acid, creatinine, aspartate amino transferase (AST) and alanine amino transferase (ALT) while it increased the serum insulin in diabetic rats but not in normal rats (p < 0.05; at doses of 30, 60 and 100 mg/kg for 14 days). A comparison was made between the action of DP and glibenclamide (600 μg/kg), a known antidiabetic drug. The antidiabetic effect of the DP was more effective than that observed with glibenclamide.

scholarly journals Maternal Cardiovascular Risk Assessment 3-to-11 Years Postpartum in Relation to Previous Occurrence of Pregnancy-Related Complications

2019 ◽  
Vol 8 (4) ◽  
pp. 544 ◽  
Author(s):  
Ilona Hromadnikova ◽  
Katerina Kotlabova ◽  
Lenka Dvorakova ◽  
Ladislav Krofta
Keyword(s):  
Uric Acid ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Lipoprotein A ◽  
Cholesterol Levels ◽  
Delivery Date ◽  
History Of ◽  
Severity Of The Disease ◽  
Previous Occurrence

The aim of the present study was to assess the long-term outcomes of women 3-to-11 years postpartum in relation to the previous occurrence of pregnancy-related complications such as gestational hypertension (GH), preeclampsia (PE) and fetal growth restriction (FGR). Body mass index (BMI), waist circumference values, the average values of systolic (SBP) and diastolic (DBP) blood pressures and heart rate, total serum cholesterol levels, serum HDL (high-density lipoprotein) cholesterol levels, serum LDL (low-density lipoprotein) cholesterol levels, serum triglycerides levels, serum lipoprotein A levels, serum CRP (C-reactive protein) levels, plasma homocysteine levels, serum uric acid levels, individual and relative risks of having a heart attack or stroke over the next ten years were compared between groups (50 GH, 102 PE, 34 FGR and 90 normal pregnancies) and correlated with the severity of the disease with regard to clinical signs (25 PE without severe features, 77 PE with severe features), and delivery date (36 early PE, 66 late PE). The adjustment for potential covariates was made, where appropriate. At 3–11 years follow-up women with a history of GH, PE regardless of the severity of the disease and the delivery date, PE without severe features, PE with severe features, early PE, and late PE had higher BMI, waist circumferences, SBP, DBP, and predicted 10-year cardiovascular event risk when compared with women with a history of normotensive term pregnancy. In addition, increased serum levels of uric acid were found in patients previously affected with GH, PE regardless of the severity of the disease and the delivery date, PE with severe features, early PE, and late PE. Higher serum levels of lipoprotein A were found in patients previously affected with early PE. The receiver operating characteristic (ROC) curve analyses were able to identify a substantial proportion of women previously affected with GH or PE with a predisposition to later onset of cardiovascular diseases. Women with a history of GH and PE represent a risky group of patients that may benefit from implementation of early primary prevention strategies.

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