scholarly journals Selenzyme: Enzyme selection tool for pathway design

2017 ◽  
Author(s):  
Pablo Carbonell ◽  
Jerry Wong ◽  
Neil Swainston ◽  
Eriko Takano ◽  
Nicholas J. Turner ◽  
...  
Keyword(s):  
Synthetic Biology ◽  
Active Regions ◽  
Design Stage ◽  
Phylogenetic Distance ◽  
Selection Tool ◽  
Sequence Selection ◽  
Sustainable Fashion ◽  
Metabolic Pathway Design ◽  
Catalyzed Reactions ◽  
The Right

AbstractSynthetic biology applies the principles of engineering to biology in order to create biological functionalities not seen before in nature. One of the most exciting applications of synthetic biology is the design of new organisms with the ability to produce valuable chemicals including pharmaceuticals and biomaterials in a greener; sustainable fashion. Selecting the right enzymes to catalyze each reaction step in order to produce a desired target compound is, however, not trivial. Here, we present Selenzyme, a free online enzyme selection tool for metabolic pathway design. The user is guided through several decision steps in order to shortlist the best candidates for a given pathway step. The tool graphically presents key information about enzymes based on existing databases and tools such as: similarity of sequences and of catalyzed reactions; phylogenetic distance between source organism and intended host species; multiple alignment highlighting conserved regions, predicted catalytic site, and active regions; and relevant properties such as predicted solubility and transmembrane regions. Selenzyme provides bespoke sequence selection for automated workflows in biofoundries. The tool is integrated as part of the pathway design stage into the design-build-test-learn SYNBIOCHEM pipeline. The Selenzyme web server is available at http://selenzyme.synbiochem.co.uk.

Hamming Distance Model Based Power Analysis for Cryptographic Algorithms

2011 ◽  
Vol 121-126 ◽  
pp. 867-871 ◽  
Author(s):  
Jie Li ◽  
Wei Wei Shan ◽  
Chao Xuan Tian
Keyword(s):  
Integrated Circuit ◽  
Power Analysis ◽  
Hamming Distance ◽  
Data Encryption ◽  
Design Stage ◽  
Early Design Stage ◽  
Model Based ◽  
Cryptographic Algorithms ◽  
Distance Model ◽  
The Right

In order to evaluate the security of Application Specific Integrated Circuit (ASIC) implemented cryptographic algorithms at an early design stage, a Hamming distance model based power analysis is proposed. The Data Encryption Standard (DES) algorithm is taken as an example to illustrate the threats of differential power analysis (DPA) attack against the security of ASIC chip. A DPA attack against the ASIC implementation of a DES algorithm is realized based on hamming distance power model (HD model), and it realized the attack by successfully guessing the right 48-bit subkey. This result indicates that the power analysis attack based on the HD model is simple, rapid and effective for the design and evaluation of security chips.

scholarly journals Design of Multiple Mailboxes

2020 ◽  
Vol 318 ◽  
pp. 01041
Author(s):  
Athena Baronos ◽  
Odysseas Manoliadis ◽  
Aristeidis Pavlidis
Keyword(s):  
3D Visualization ◽  
Building Blocks ◽  
Design Stage ◽  
Extensive Literature ◽  
3D Design ◽  
3D Cad ◽  
Domestic Use ◽  
The Right ◽  
The Cost ◽  
Apartment Complexes

In today’s world the design of multiple mailboxes comes to cover the evolution of logistics in delivering mail where the postman is not required to visit every user. In this research the 3D visualization is used for the design of multiple mailboxes for domestic use. It concerns the design of mailboxes in ergonomic building blocks and apartment complexes in 3D design so that they can be easily manufactured. Between the advantages of this design will be rapid production of ready-made products production of prototypes that enables testing at the design stage and reduces the time and the cost of production. The design when done with 3D CAD can be manufactured with modern machine tooling methods. In this paper after an extensive Literature Review the postal multiple mailboxes is used as a case study in the use of 3D CAD for 3D printing. A methodology is proposed that enables the examination of prototypes at the design stage according to specifications and allows the manufacturing department of a company to prepare the right tools and begin installing production lines. Conclusively this method gives the advantage of designing the product and supporting the production of scaffolds that can be functionally and ergonomically tested before finalizing the production.

scholarly journals Implications of BREEAM Sustainability Assessment on the Design of Hotels

2020 ◽  
Vol 12 (16) ◽  
pp. 6550 ◽  
Author(s):  
María M. Serrano-Baena ◽  
Paula Triviño-Tarradas ◽  
Carlos Ruiz-Díaz ◽  
Rafael E. Hidalgo Fernández
Keyword(s):  
Sustainability Assessment ◽  
Assessment Method ◽  
Design Stage ◽  
Original Research ◽  
Early Design Stage ◽  
Agenda 2030 ◽  
Original Research Paper ◽  
Tourism And Hospitality Industry ◽  
Tourism And Hospitality ◽  
The Right

This original research paper analyses the actual and important topic of the implications of BREEAM sustainability assessment on the design of hotels and it is a personal response to “The Agenda 2030 for Sustainable Development” and its influence on the Tourism and Hospitality Industry. The paper aims to examine the influence of the sustainable assessment method BREEAM on the design of hotels by using seven case studies and studying the changes that were implemented in order to achieve their targets. Qualitative data were obtained by conducting in-depth interviews and analyzing the supplied documentation. The authors notice that the results revealed that a BREEAM approach might limit the design of the hotels but, including the right measures at the early design stage of the project, the target can be easily achieved.

scholarly journals High-Stiffness, Lock-and-Key Heat-Reversible Locator-Snap Systems for the Design for Disassembly

2009 ◽  
Vol 131 (4) ◽  
Author(s):  
Mohammed Shalaby ◽  
Kazuhiro Saitou
Keyword(s):  
Optimization Problem ◽  
Screw Theory ◽  
Design Stage ◽  
Design For Disassembly ◽  
Element Analysis ◽  
Material Recycling ◽  
High Stiffness ◽  
Multi Objective Genetic Algorithm ◽  
Trade Offs ◽  
The Right

Driven by the moral sense of obligation, legislative and social pressures, manufacturers now consider effective part reuse and material recycling at the end of product life at the design stage. It is a key consideration to use joints that can disengage with minimum labor, part damage, and material contamination. This paper extends our previous work on the design of high-stiffness reversible locator-snap system that can disengage nondestructively with localized heat (Shalaby and Saitou, 2006, “Optimal Heat-Reversible Snap Joints for Frame-Panel Assembly in Aluminum Space Frame Automotive Bodies,” Proceedings of the LCE2006: The 13th CIRP International Conference on Life Cycle Engineering, Leuven, Belgium, May 31–Jun. 2, pp. 411–416; Shalaby and Saitou, 2008, “Design for Disassembly With High-Stiffness, Heat-Reversible Locator-Snap Systems,” ASME J. Mech. Des., 130(12), p. 121701) to include (1) modeling for tolerance stack-up and (2) lock-and-key concept to ensure that snaps only disengage when the right procedure is followed. The design problem is posed as an optimization problem to find the locations, numbers, and orientations of locators and snaps, and the locations and sizes of heating areas, to release the snaps with minimum heat, compliance, and tolerance stack-up. The motion and structural requirements are considered constraints. Screw theory is employed to precalculate the set of feasible types and orientations of locators and snaps that are examined during optimization. Multi-objective genetic algorithm coupled with structural and thermal finite element analysis is used to solve the optimization problem. The method is applied on two case studies. The Pareto-optimal solutions present alternative designs with different trade-offs between the design objectives.

scholarly journals High-Stiffness, Lock-and-Key Heat-Reversible Locator-Snap Systems for the Design for Disassembly

2008 ◽  
Author(s):  
Mohammed Shalaby ◽  
Kazuhiro Saitou
Keyword(s):  
Optimization Problem ◽  
Screw Theory ◽  
Design Stage ◽  
Material Recycling ◽  
High Stiffness ◽  
Multi Objective Genetic Algorithm ◽  
Trade Offs ◽  
Effective Part ◽  
The Right ◽  
Alternative Designs

Recent legislative and social pressures have driven manufacturers to consider effective part reuse and material recycling at the end of product life at the design stage. One of the key considerations is to use joints that can disengage with minimum labor, part damage, and material contamination. This paper extends our previous work on the design of high-stiffness reversible locator-snap system that can disengage non-destructively with localized heat [1, 2], to include 1) modeling for tolerance stack-up and 2) lock-and-key concept to ensure that snaps only disengage when the right procedure is followed. The design problem is posed as an optimization problem to find the locations, numbers, and orientations of locators and snaps, and the number, locations and sizes of heating areas, which realize the release of snaps with minimum heat, compliance, and tolerance stack-up. The motion and structural requirements are considered constraints. Screw Theory is utilized to pre-calculate a set of feasible types and orientations of locators and snaps that are examined during optimization. The optimization problem is solved using Multi Objective Genetic Algorithm (MOGA) coupled with structural and thermal FEA. The method is applied on two case studies. The Pareto-optimal solutions present alternative designs with different trade-offs between the design objectives while meeting all the constraints.

scholarly journals Level of Inclusiveness of People with Disabilities in Ghanaian Health Policies and Reports: A Scoping Review

Disabilities ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 257-277
Author(s):  
Abdul-Aziz Seidu ◽  
Bunmi S. Malau-Aduli ◽  
Kristin McBain-Rigg ◽  
Aduli E. O. Malau-Aduli ◽  
Theophilus I. Emeto
Keyword(s):  
Scoping Review ◽  
Policy Design ◽  
Health Policies ◽  
Design Stage ◽  
Collaborative Partnerships ◽  
Persons With Disabilities ◽  
Scoping Reviews ◽  
Government Websites ◽  
The Right ◽  
Meta Analyses

(1) Background: Globally, persons with disabilities (PWDs) face numerous challenges including access to healthcare. This scoping review sought to assess the level of inclusiveness in Ghanaian health policies and reports for PWDs; (2) Methods: An extensive search and scoping review of health policies/reports in Ghanaian government websites and Google was conducted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for scoping reviews were followed in selecting and reporting the policies/reports. The program evaluation and policy design framework was employed for content analysis; (3) Results: Fifteen policies and reports with political recognition, objectives, and specific resources needed to execute stipulated plans were included. Although these policies and reports had collaborative partnerships with various institutions and organisations in development and implementation plans, the level of inclusiveness of disability issues was very low. Only eight out of the fifteen policies/reports (53%) reviewed considered PWDs, indicating a low level of inclusion. The definition of disability was also limited.; (4) Conclusions: To achieve the sustainable development goal of ‘leaving no one behind’ in line with the provisions of the United Nations Convention on the Right of Persons with Disabilities and the Disability Act 715 of Ghana, it is recommended that subsequent health policies should have an in-depth engagement with PWDs from the conceptual design stage right through to implementation and evaluation.

Prediction of the Dynamic Response of a Ship in Head Waves Using OpenFOAM Toolbox

2020 ◽  
Vol 162 (A1) ◽  
Author(s):  
J Yao
Keyword(s):  
Dynamic Response ◽  
Dynamic Responses ◽  
Navier Stokes ◽  
Design Stage ◽  
Offshore Platforms ◽  
Computational Domain ◽  
Marine Structures ◽  
Time Step ◽  
Head Waves ◽  
The Right

Ships and marine structures, such as oil tanker, offshore platforms, etc., usually face extreme seaway environment in real situation. If under the action of strong waves large amplitude motions will occur, with the result that they may not work as usual or even lose stability. Thus, it is of great importance to access their dynamic responses under such bad conditions at the initial design stage, so as to ensure normal usage and safety. Herein, the original RANS (Reynolds-Averaged Navier-Stokes) solver based on OpenFOAM Toolbox has been extended to predict dynamic responses of ships and marine structures in waves. A new “inlet-velocity boundary condition” was implemented to generate waves. A damping term for wave absorption was added to the right-hand side of RANS equations in order to avoid wave reflection from the boundary where waves leave the computational domain. The related numerical methods are described in this paper. The purpose of this paper is to present a validation of the approach used. The prediction of the dynamic response of a ship in head waves was the focus. Five cases with different wave lengths and heights were considered. The predicted results, i.e. time histories of total resistance, heave and pitch, were compared with available experimental data and analysed. In addition, due to current experience it is very necessary that effort is devoted to determining appropriate grid and time step, so as to ensure the quality of waves generated.

scholarly journals The ethical landscape: identifying the right way to think about the ethical and societal aspects of synthetic biology research and products

2009 ◽  
Vol 6 (suppl_4) ◽  
Author(s):  
Steven Yearley
Keyword(s):  
Synthetic Biology ◽  
Energy Production ◽  
Scientific Practice ◽  
Regulatory Control ◽  
Ethical Review ◽  
Ethical Aspects ◽  
Safety Testing ◽  
Wide Range ◽  
The Right ◽  
Biology Research

Synthetic biology promises to be highly innovative in its contribution to scientific understanding. But it offers other sorts of innovation too: in the variety of applications that could result and in the wide range of practitioners who could become involved. But directly corresponding to each of these is a kind of regulatory concern. If the entry barriers are low for a form of scientific practice with dramatic implications then the need for regulatory control over access is great since no one wants unlicensed operators releasing experimental organisms. If there are likely to be extensive opportunities for application within the human body and in the open environment (for energy production or novel forms of bioremediation) then the release and safety-testing implications are potentially enormous. Proponents of synthetic biology have been quick to realise that these challenges call for reviews of the societal and ethical aspects of synthetic biology. This paper shows that the template commonly adopted for such reviews draws on bioethics. It goes on to show that this template is far from ideal, both because of limitations in the way that bioethics has been institutionalized and because of key differences between the regulatory demands on synthetic biology and on bioethics. The paper concludes that broader models of societal and ethical review of synthetic biology are urgently required.

scholarly journals Perancangan Identitas Visual dan User Interface Aplikasi JUALOMBOK

2020 ◽  
Vol 2 (1) ◽  
pp. 50-58
Author(s):  
Sukreni Mulya Agustin ◽  
Sandi Justitia Putra
Keyword(s):  
Information Technology ◽  
User Interface ◽  
System Integration ◽  
Interface Design ◽  
Design Stage ◽  
Visual Identity ◽  
Original Application ◽  
The Right ◽  
The City ◽  
Lombok Island

The development of technology and multimedia at this time has been developing rapidly, severalmultimedia applications have also been created and used in various fields. One of its uses is inthe field of e-commerce. Jualombok application is one of the e-commerce that is developing inLombok Island, but it is still tricky in establishing visual identity. In building the right use, acompany needs a visual identity and the correct User Interface for its application. Therefore, inthis study, the author will design a visual identity and User Interface for the JUALOMBOKApplication for the Jualombok marketplace application that has a focus on helping entrepreneurson the island of Lombok develop local MSMEs to promote and sell their products. Thisapplication was designed on November 13, 2017, by one of the companies in the city of Mataram,namely Cv. Sol Interactive. However, the design stage is only limited to the plan because theessential company is information technology, multimedia, and system integration. This researchis a qualitative study by conducting interviews with the company to get the data needed by theauthor relating to the company and the application of Jualombok. The concept used in this studyis the concept of local wisdom in the visual form and color of the logo for the user interfacecharacteristic of the island of Lombok in the log-in display on the user.User Interface Design Juallombok application presents a typical photo of the island of Lombok,namely rice barns and Songket cloth from the Sasak tribe, so that users still recognize thisapplication as an original application made by the company on Lombok Island despite having amodern look. So that both the visual identity and user interface will still remind the audience onthe island of Lombok, following what is desired by the company

scholarly journals Interactive Recommender System for Identifying Learning Partner

2021 ◽  
Vol 11 (6) ◽  
pp. 72-77
Author(s):  
Tanty Oktavia ◽  
◽  
Surya Sujarwo
Keyword(s):  
Higher Education ◽  
Recommender System ◽  
Learning Process ◽  
Selection Process ◽  
Design Science ◽  
Education Institution ◽  
Science Research ◽  
Global Perspective ◽  
Design Stage ◽  
The Right

— Currently, higher education must open their mindset to change the learning process. This process cannot still stay on a conventional process that only involved students and lecturers as learning participants because to capture what the current industry needs and the trend of knowledge, higher education institutions must collaborate with external parties as learning partners to give a global perspective about the industrial needs and trends. The process to identify a learning partner to contribute to the learning process is not easy way. The higher education institution must select which partner has appropriate skills and competency suitable for the subject’s course. Many parameters will be involved in the selection process to identify the right partner. In this proposed system, external parties in this context consist of professionals or educators from the external institution easily can be defined to be selected as learning partners based on their competency and experience, that listed on social media LinkedIn as a professional platform. The method to build this interactive recommender system in this study is based on design science research that identifies step by step design stage to propose the best way solution for the recommender system. The result of this study is an interactive recommender system that can help higher education to find out the best candidate for their learning partner so the collaboration of learning can be implemented effectively

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