scholarly journals Clustering NMR: Machine learning assistive rapid (pseudo) two-dimensional relaxometry mapping

Author(s):  
Weng Kung Peng

AbstractLow-field nuclear magnetic resonance (NMR) relaxometry is an attractive approach for point-of-care testing medical diagnosis, industrial food science, and in situ oil-gas exploration. One of the problem however is, the inherently long relaxation time of the (liquid) sample, (and hence low signal-to-noise ratio) causes unnecessarily long repetition time. In this work, we present a new class of methodology for rapid and accurate object classification using NMR relaxometry with the aid of machine learning. We demonstrate that the sensitivity and specificity of the classification is substantially improved with higher order of (pseudo)-dimensionality (e.g., 2D or multidimensional). This new methodology (termed as Clustering NMR) is extremely useful for rapid and accurate object classification (in less than a minute) using the low-field NMR.

Fuel ◽  
2020 ◽  
Vol 260 ◽  
pp. 116328 ◽  
Author(s):  
Strahinja Markovic ◽  
Jonathan L. Bryan ◽  
Aman Turakhanov ◽  
Alexey Cheremisin ◽  
Sudarshan A. Mehta ◽  
...  

2020 ◽  
Author(s):  
Sebastian Kiss ◽  
Neil MacKinnon ◽  
Jan Korvink

Abstract Nuclear magnetic resonance at low field strength is an insensitive spectroscopic technique, precluding portable applications with small sample volumes, such as needed for biomarker detection in body fluids. Here we report a compact double resonant chip stack system that implements in situ dynamic nuclear polarisation of a 130 nL sample volume, achieving a signal enhancement of 54 w.r.t. the thermal equilibrium level at a microwave power level of 0.5W. This work overcomes instrumental barriers to the use of NMR detection for point-of-care applications.


2021 ◽  
Vol 196 ◽  
pp. 107990
Author(s):  
Vladimir Y. Volkov ◽  
Ameen A. Al-Muntaser ◽  
Mikhail A. Varfolomeev ◽  
Nailia M. Khasanova ◽  
Boris V. Sakharov ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sebastian Z. Kiss ◽  
Neil MacKinnon ◽  
Jan G. Korvink

AbstractNuclear magnetic resonance at low field strength is an insensitive spectroscopic technique, precluding portable applications with small sample volumes, such as needed for biomarker detection in body fluids. Here we report a compact double resonant chip stack system that implements in situ dynamic nuclear polarisation of a 130 nL sample volume, achieving signal enhancements of up to − 60 w.r.t. the thermal equilibrium level at a microwave power level of 0.5 W. This work overcomes instrumental barriers to the use of NMR detection for point-of-care applications.


2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Sungmin O. ◽  
Rene Orth

AbstractWhile soil moisture information is essential for a wide range of hydrologic and climate applications, spatially-continuous soil moisture data is only available from satellite observations or model simulations. Here we present a global, long-term dataset of soil moisture derived through machine learning trained with in-situ measurements, SoMo.ml. We train a Long Short-Term Memory (LSTM) model to extrapolate daily soil moisture dynamics in space and in time, based on in-situ data collected from more than 1,000 stations across the globe. SoMo.ml provides multi-layer soil moisture data (0–10 cm, 10–30 cm, and 30–50 cm) at 0.25° spatial and daily temporal resolution over the period 2000–2019. The performance of the resulting dataset is evaluated through cross validation and inter-comparison with existing soil moisture datasets. SoMo.ml performs especially well in terms of temporal dynamics, making it particularly useful for applications requiring time-varying soil moisture, such as anomaly detection and memory analyses. SoMo.ml complements the existing suite of modelled and satellite-based datasets given its distinct derivation, to support large-scale hydrological, meteorological, and ecological analyses.


2021 ◽  
pp. 155335062110186
Author(s):  
Abdel-Moneim Mohamed Ali ◽  
Emran El-Alali ◽  
Adam S. Weltz ◽  
Scott T. Rehrig

Current experience suggests that artificial intelligence (AI) and machine learning (ML) may be useful in the management of hospitalized patients, including those with COVID-19. In light of the challenges faced with diagnostic and prognostic indicators in SARS-CoV-2 infection, our center has developed an international clinical protocol to collect standardized thoracic point of care ultrasound data in these patients for later AI/ML modeling. We surmise that in the future AI/ML may assist in the management of SARS-CoV-2 patients potentially leading to improved outcomes, and to that end, a corpus of curated ultrasound images and linked patient clinical metadata is an invaluable research resource.


2021 ◽  
Vol 13 (7) ◽  
pp. 1250
Author(s):  
Yanxing Hu ◽  
Tao Che ◽  
Liyun Dai ◽  
Lin Xiao

In this study, a machine learning algorithm was introduced to fuse gridded snow depth datasets. The input variables of the machine learning method included geolocation (latitude and longitude), topographic data (elevation), gridded snow depth datasets and in situ observations. A total of 29,565 in situ observations were used to train and optimize the machine learning algorithm. A total of five gridded snow depth datasets—Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSR-E) snow depth, Global Snow Monitoring for Climate Research (GlobSnow) snow depth, Long time series of daily snow depth over the Northern Hemisphere (NHSD) snow depth, ERA-Interim snow depth and Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2) snow depth—were used as input variables. The first three snow depth datasets are retrieved from passive microwave brightness temperature or assimilation with in situ observations, while the last two are snow depth datasets obtained from meteorological reanalysis data with a land surface model and data assimilation system. Then, three machine learning methods, i.e., Artificial Neural Networks (ANN), Support Vector Regression (SVR), and Random Forest Regression (RFR), were used to produce a fused snow depth dataset from 2002 to 2004. The RFR model performed best and was thus used to produce a new snow depth product from the fusion of the five snow depth datasets and auxiliary data over the Northern Hemisphere from 2002 to 2011. The fused snow-depth product was verified at five well-known snow observation sites. The R2 of Sodankylä, Old Aspen, and Reynolds Mountains East were 0.88, 0.69, and 0.63, respectively. At the Swamp Angel Study Plot and Weissfluhjoch observation sites, which have an average snow depth exceeding 200 cm, the fused snow depth did not perform well. The spatial patterns of the average snow depth were analyzed seasonally, and the average snow depths of autumn, winter, and spring were 5.7, 25.8, and 21.5 cm, respectively. In the future, random forest regression will be used to produce a long time series of a fused snow depth dataset over the Northern Hemisphere or other specific regions.


Lab on a Chip ◽  
2021 ◽  
Author(s):  
Zhiqi Zhao ◽  
Qiujin Li ◽  
Linna Chen ◽  
Yu Zhao ◽  
Jixian Gong ◽  
...  

Flexible biosensors for monitoring systems have emerged as a promising portable diagnostics platform due to their potential for in situ point-of-care (POC) analytic devices. Assessment of biological analytes in sweat...


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