scholarly journals Demography, social contact patterns and the COVID-19 burden in different settings of Ethiopia: a modeling study

2020 ◽  
Author(s):  
Filippo Trentini ◽  
Giorgio Guzzetta ◽  
Margherita Galli ◽  
Agnese Zardini ◽  
Fabio Manenti ◽  
...  
Keyword(s):  
Fatal Outcome ◽  
Social Contact ◽  
Demographic Factors ◽  
School Closure ◽  
Sub Saharan Africa ◽  
School Closures ◽  
Mixing Patterns ◽  
Access To Primary Care ◽  
Sub Saharan ◽  
Socio Demographic Factors

AbstractBackgroundCOVID-19 spread may have a dramatic impact in countries with vulnerable economies and limited availability of, and access to, healthcare resources and infrastructures. However, in sub-Saharan Africa a low prevalence and mortality have been observed so far.MethodsWe collected data on individuals’ social contacts in Ethiopia across geographical contexts characterized by heterogeneous population density, work and travel opportunities, and access to primary care. We assessed how socio-demographic factors and observed mixing patterns can influence the COVID-19 disease burden, by simulating SARS-CoV-2 transmission in remote settlements, rural villages, and urban neighborhoods, under the current school closure mandate.ResultsFrom national surveillance data, we estimated a net reproduction number of 1.62 (95%CI 1.55-1.70). We found that, at the end of an epidemic mitigated by school closure alone, 10-15% of the overall population would have been symptomatic and 0.3-0.4% of the population would require mechanical ventilation and/or possibly result in a fatal outcome. Higher infection attack rates are expected in more urbanized areas, but the highest incidence of critical disease is expected in remote subsistence farming settlements.ConclusionsThe relatively low burden of COVID-19 in Ethiopia can be explained by the estimated mixing patterns, underlying demography and the enacted school closures. Socio-demographic factors can also determine marked heterogeneities across different geographical contexts within the same country. Our findings can contribute to understand why sub-Saharan Africa is experiencing a relatively lower attack rate of severe cases compared to high income countries.

scholarly journals Modeling the interplay between demography, social contact patterns, and SARS-CoV-2 transmission in the South West Shewa Zone of Oromia Region, Ethiopia

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Filippo Trentini ◽  
Giorgio Guzzetta ◽  
Margherita Galli ◽  
Agnese Zardini ◽  
Fabio Manenti ◽  
...  
Keyword(s):  
Attack Rate ◽  
Reproduction Number ◽  
Demographic Factors ◽  
School Closure ◽  
Sub Saharan Africa ◽  
The South ◽  
South West ◽  
Mixing Patterns ◽  
Sub Saharan ◽  
Socio Demographic Factors

Abstract Background COVID-19 spread may have a dramatic impact in countries with vulnerable economies and limited availability of, and access to, healthcare resources and infrastructures. However, in sub-Saharan Africa, a low prevalence and mortality have been observed so far. Methods We collected data on individuals’ social contacts in the South West Shewa Zone (SWSZ) of Ethiopia across geographical contexts characterized by heterogeneous population density, work and travel opportunities, and access to primary care. We assessed how socio-demographic factors and observed mixing patterns can influence the COVID-19 disease burden, by simulating SARS-CoV-2 transmission in remote settlements, rural villages, and urban neighborhoods, under school closure mandate. Results From national surveillance data, we estimated a net reproduction number of 1.62 (95% CI 1.55–1.70). We found that, at the end of an epidemic mitigated by school closure alone, 10–15% of the population residing in the SWSZ would have been symptomatic and 0.3–0.4% of the population would require mechanical ventilation and/or possibly result in a fatal outcome. Higher infection attack rates are expected in more urbanized areas, but the highest incidence of critical disease is expected in remote subsistence farming settlements. School closure contributed to reduce the reproduction number by 49% and the attack rate of infections by 28–34%. Conclusions Our results suggest that the relatively low burden of COVID-19 in Ethiopia observed so far may depend on social mixing patterns, underlying demography, and the enacted school closures. Our findings highlight that socio-demographic factors can also determine marked heterogeneities across different geographical contexts within the same region, and they contribute to understand why sub-Saharan Africa is experiencing a relatively lower attack rate of severe cases compared to high-income countries.

scholarly journals The Severity of Malarial-Anemia in Pregnant Women in Biyem-Assi, Yaounde

2021 ◽  
pp. 57-68
Author(s):  
Judith Lum Ndamukong-Nyanga ◽  
Ngo Batandi Helen Virginie ◽  
Tchanga Chanceline Flore ◽  
Fegue Celestine Nadege
Keyword(s):  
Pregnant Women ◽  
Demographic Factors ◽  
Sub Saharan Africa ◽  
Multiparous Women ◽  
Study Population ◽  
Health Institutions ◽  
Sub Saharan ◽  
Socio Demographic Factors ◽  
Primiparous Women ◽  
Prevalence Of Anemia

Malaria is a parasitic disease endemic in Sub-Saharan Africa especially in Cameroon. Pregnancy is associated with increased susceptibility to malaria. Closely associated to malaria is anaemia. It is generally accepted that pregnancy ends with childbirth. The outcome of the pregnancy is highly affected by the presence of malaria and anaemia. The aim of ths study was to determine the prevalence and severity of malaria and anemia among pregnant women and the influence of socio-demographic factors on malaria and anaemia prevalences in pregnant women in Biyam- Assi Yaounde. Information on socio-demographic factors was collected from 302 pregnant women attending prenatal clinics in health institutions within the Biyem-Assi Health District of Yaounde VI subdivision using a pretested questionnaire. Peripheral blood was collected and thick smears were prepared for screening Plasmodium parasites. The level of hemoglobin was measured using a haemoglobinometer URIT- 12. Analysis was done using SPSS version 20.0. Out of the 302 women, 146 (51.7%) had Plasmodium falciparum infected red cells. Among the 146 infected women, 36% had mild parasitaemia, 45% had moderate parasitaemia and 19% had severe parasitaemia. The prevalence of anemia in the study population was 53%. There was no significant association between the severity of malaria and the severity of anaemia (p > 0, 05). Parity had a significant influence on the severity of malaria. The level of school education significantly (p < 0, 05) influenced the severity of anaemia. Multiparous women were more affected by malaria than primiparous women. However, in relation to disease severity, primiparous women parasitized by Plasmodium presented a significantly higher risk of severe malaria compared to multiparous women. Malaria and anaemia prevalences in the study population were high (>50%), anaemia severity was directly associated to level of education. We recommend that more sensitization of women should be done to reduce ignorance, prevent malaria and in turn reduce anaemia and improve on the health of mother and baby.

scholarly journals Differential effects of socio-demographic factors on maternal haemoglobin concentration in three sub-Saharan African Countries

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Dickson A. Amugsi ◽  
Zacharie T. Dimbuene ◽  
Catherine Kyobutungi
Keyword(s):  
Haemoglobin Concentration ◽  
Demographic Factors ◽  
Public Health Problem ◽  
Reproductive Age ◽  
Sub Saharan Africa ◽  
Demographic And Health Surveys ◽  
Differential Effects ◽  
Sub Saharan ◽  
Socio Demographic Factors ◽  
Positive Effect

AbstractLow Haemoglobin concentration (Hb) among women of reproductive age is a severe public health problem in sub-Saharan Africa. This study investigated the effects of putative socio-demographic factors on maternal Hb at different points of the conditional distribution of Hb concentration. We utilised quantile regression to analyse the Demographic and Health Surveys data from Ghana, Democratic Republic of the Congo (DRC) and Mozambique. In Ghana, maternal schooling had a positive effect on Hb of mothers in the 5th and 10th quantiles. A one-year increase in education was associated with an increase in Hb across all quantiles in Mozambique. Conversely, a year increase in schooling was associated with a decrease in Hb of mothers in the three upper quantiles in DRC. A unit change in body mass index had a positive effect on Hb of mothers in the 5th, 10th, 50th and 90th, and 5th to 50th quantiles in Ghana and Mozambique, respectively. We observed differential effects of breastfeeding on maternal Hb across all quantiles in the three countries. The effects of socio-demographic factors on maternal Hb vary at the various points of its distribution. Interventions to address maternal anaemia should take these variations into account to identify the most vulnerable groups.

scholarly journals Mobile Learning During School Disruptions in Sub-Saharan Africa

AERA Open ◽  
2021 ◽  
Vol 7 ◽  
pp. 233285842110148
Author(s):  
René F. Kizilcec ◽  
Maximilian Chen ◽  
Kaja K. Jasińska ◽  
Michael Madaio ◽  
Amy Ogan
Keyword(s):  
Early Literacy ◽  
Mobile Learning ◽  
National Curriculum ◽  
Text Message ◽  
Learning Technologies ◽  
Sub Saharan Africa ◽  
Formal Schooling ◽  
School Closures ◽  
Teacher Strikes ◽  
Sub Saharan

School closures due to teacher strikes or political unrest in low-resource contexts can adversely affect children’s educational outcomes and career opportunities. Phone-based educational technologies could help bridge these gaps in formal schooling, but it is unclear whether or how children and their families will use such systems during periods of disruption. We investigate two mobile learning technologies deployed in sub-Saharan Africa: a text-message-based application with lessons and quizzes adhering to the national curriculum in Kenya (N = 1.3 million), and a voice-based platform for supporting early literacy in Côte d’Ivoire (N = 236). We examine the usage and beliefs surrounding unexpected school closures in each context via system log data and interviews with families about their motivations and methods for learning during the disruption. We find that mobile learning is used as a supplement for formal and informal schooling during disruptions with equivalent or higher intensity, as parents feel responsible to ensure continuity in schooling.

scholarly journals Differential kinetics of plasma procalcitonin levels in cerebral malaria in urban Senegalese patients according to disease outcome

2011 ◽  
Vol 2 (1) ◽  
pp. 22 ◽  
Author(s):  
Babacar Mbengue ◽  
Bacary Diatta ◽  
Birahim Niang ◽  
Ngor Diagne ◽  
Mamadou Ndiaye ◽  
...  
Keyword(s):  
Cerebral Malaria ◽  
Severe Malaria ◽  
Fatal Outcome ◽  
Care Facility ◽  
Threshold Level ◽  
Serum Levels ◽  
Sub Saharan Africa ◽  
Serial Killer ◽  
Sub Saharan ◽  
Hôpital Principal

<em>P. falciparum</em> malaria continues as the serial killer of over a million lives yearly, mainly for children in sub-Saharan Africa. For severe malaria, we are still on the quest for a prognostic marker of fatal outcome. We analysed the association between serum levels of Procalcitonin (PCT), a marker of septic inflammation, and clinical outcome in Senegalese patients admitted with confirmed cerebral malaria in the intensive care facility of Hopital Principal. A total of 98 patients living in the hypoendemic urban area of Dakar, Senegal, were enrolled during transmission seasons. Levels of PCT were compared between surviving vs the 26.5 % fatal cases in blood samples of the 3 days following hospitalisation. Mean PCT levels were elevated in patients with active infection, with a large range of values (0.1 to 280 nanog per mL), significantly higher on day 0 in fatal cases than in surviving (53.6 vs 27.3; P=0.01). No exact individual threshold level could indicate occurrence of fatality, however mortality could be most accurately predicted by PCT level above 69 nanog per ML and there was a very clear different profile of evolution of PCT levels on the 3 days of observation decreasing early from day 1 in surviving patients (P&lt;10–3), contrary to fatal cases. These results indicate that PCT kinetic rather than intrinsic level could be of use to predict a reduced risk of fatality in patient with cerebral malaria and could serve as potential predicting marker for severe malaria.

scholarly journals The impact of unplanned school closure on children’s social contact: Rapid evidence review

2020 ◽  
Author(s):  
Samantha Brooks ◽  
Louise Smith ◽  
Rebecca Webster ◽  
Dale Weston ◽  
Lisa Woodland ◽  
...  
Keyword(s):  
Public Health ◽  
Infectious Disease ◽  
Relevant Literature ◽  
Disease Outbreaks ◽  
Social Contact ◽  
School Closure ◽  
School Closures ◽  
Infectious Disease Outbreaks ◽  
Spread Of Infection ◽  
The Impact

Background Emergency school closures are often used as public health interventions during infectious disease outbreaks in an attempt to minimise the spread of infection. However, if children continue to mix with others outside the home during the closures, these measures are unlikely to be effective. ObjectivesThis review aimed to summarise existing literature on children’s activities and contacts made outside the home during unplanned school closures.MethodsWe searched four databases from inception to February 2020 for relevant literature. Main findings were extracted. Results3,343 citations were screened and 19 included in the review. Activities and social contacts appeared to decrease during closures but contact was still common. All studies reported children leaving the house or being looked after by non-household members. There was some evidence that older child age and parental disagreement with closure were predictive of children leaving the house, and mixed evidence regarding the relationship between infection status and leaving the home. Parental agreement with closure was generally high, but some parents disagreed due to perceived low risk of infection and practical issues regarding childcare and financial impact. ConclusionsEvidence suggests that many children continue to leave the house and mix with others during school closures despite public health recommendations to avoid social contact. This review of behaviour during unplanned school closures could be used to improve infectious disease modelling.

scholarly journals The COVID-19 Pandemic and Adolescents’ Experience in Sub-Saharan Africa: A Cross-Country Study Using a Telephone Survey

2021 ◽  
Author(s):  
Dongqing Wang ◽  
Angela Chukwu ◽  
Ourohiré Millogo ◽  
Nega Assefa ◽  
Christabel James ◽  
...  
Keyword(s):  
Mitigation Strategies ◽  
Sub Saharan Africa ◽  
Considerable Proportion ◽  
Computer Assisted ◽  
Food Groups ◽  
School Closures ◽  
Daily Lives ◽  
Inadequate Knowledge ◽  
Adolescent Education ◽  
Sub Saharan

The public health measures instituted by governments to combat the coronavirus disease 2019 (COVID-19) may cause developmental and educational losses to adolescents. The impacts of the COVID-19 pandemic and its mitigation strategies on adolescents in sub-Saharan Africa are unclear. This study aimed to examine adolescents’ knowledge, perceptions, and practices related to COVID-19 and the impacts of the pandemic on the daily lives of adolescents in sub-Saharan Africa. The survey was conducted in Burkina Faso, Ethiopia, and Nigeria using computer-assisted telephone interviews to enable rapid and remote data collection. Two sites were included in each country, with approximately 300 adolescents per site and 1,795 adolescents in total. Variations across the six sites were noted for the proportions of the adolescents who could correctly identify all key COVID-19 symptoms (4–25%), transmission methods (16–59%), and prevention approaches (33–79%). Most (> 72%) of the adolescents were no longer going to school due to school closures. Many adolescents (23–81%) were not receiving any education during the pandemic. A considerable proportion of the adolescents (44–83%) self-assessed as having less ability to learn during the pandemic; many expected it to be very difficult to catch up on education after the pandemic. Decreases in the consumption of major food groups were common across sites. Urgent actions are needed in sub-Saharan Africa to address the inadequate knowledge of COVID-19 among adolescents and the impacts of the pandemic on adolescent education and nutrition.

scholarly journals HIV and Malaria co-infection and the impact of viral load and HAART usage on the development of Plasmodium falciparum Artemisinin and Lumefantrine resistant genes in Nnewi, Anambra State, Nigeria

2021 ◽  
Vol 12 (3) ◽  
pp. 505-516
Author(s):  
Peace Amaka Onwuzurike ◽  
Ifeoma Bessie Enweani ◽  
Ifeoma Mercy Ekejindu
Keyword(s):  
Viral Load ◽  
Sub Saharan Africa ◽  
Hiv Viral Load ◽  
Anambra State ◽  
Viral Loads ◽  
Highly Active ◽  
Resistant Genes ◽  
Sub Saharan ◽  
Socio Demographic Factors ◽  
The Impact

Background: Human Immunodeficiency virus (HIV) and malaria co-infection poses a serious health threat in sub-Saharan Africa and other endemic countries. Highly active anti-retroviral therapy (HAART) is currently used to suppress viral loads. Methods: Blood samples collected from 400 participants comprising 200 HIV sero-positive and 200 sero-negative individuals was added to EDTA sample containers. Malaria parasitemia was evaluated using standard parasitological techniques followed by PCR techniques using the Quick Load One Taq One Step Polymerase Chain Reaction (PCR) for characterization of species of Plasmodium and resistant studies using specific primers. HIV viral load estimation was done using COBAS® TaqMan® Analyzer. Results: Malaria has prevalent rate of 22.75% in the study population, while the prevalence of malaria infection among the HIV sero-positive and sero-negative is 77.0% and 23% respectively. Socio-demographic factors had no significant association with the development of resistant genes. HAART exposed individuals had prevalence of PfK13 (6.9%) and Pfmdr-1 (20.8%). Viral load was significantly related with the development of resistant genes (100%) and (86.1%) for PfK13 and Pfmdr-1 respectively. Conclusion: Unsuppressed viral load in HIV sero-positive individuals heightens the prevalence of malaria parasitaemia and increases the chances of possible emergence and spread of PfK13 and Pfmdr-1 genes.

scholarly journals The impact of unplanned school closure on children’s social contact: Rapid evidence review

2020 ◽  
Author(s):  
Samantha K. Brooks ◽  
Louise E. Smith ◽  
Rebecca K. Webster ◽  
Dale Weston ◽  
Lisa Woodland ◽  
...  
Keyword(s):  
Public Health ◽  
Infectious Disease ◽  
Relevant Literature ◽  
Disease Outbreaks ◽  
Social Contact ◽  
School Closure ◽  
School Closures ◽  
Infectious Disease Outbreaks ◽  
Spread Of Infection ◽  
The Impact

AbstractBackgroundEmergency school closures are often used as public health interventions during infectious disease outbreaks in an attempt to minimise the spread of infection. However, if children continue to mix with others outside the home during the closures, these measures are unlikely to be effective.ObjectivesThis review aimed to summarise existing literature on children’s activities and contacts made outside the home during unplanned school closures.MethodsWe searched four databases from inception to February 2020 for relevant literature. Main findings were extracted.Results3,343 citations were screened and 19 included in the review. Activities and social contacts appeared to decrease during closures but contact was still common. All studies reported children leaving the house or being looked after by non-household members. There was some evidence that older child age and parental disagreement with closure were predictive of children leaving the house, and mixed evidence regarding the relationship between infection status and leaving the home. Parental agreement with closure was generally high, but some parents disagreed due to perceived low risk of infection and practical issues regarding childcare and financial impact.ConclusionsEvidence suggests that many children continue to leave the house and mix with others during school closures despite public health recommendations to avoid social contact. This review of behaviour during unplanned school closures could be used to improve infectious disease modelling.

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