scholarly journals Rapidly increasing SARS-CoV-2 seroprevalence and limited clinical disease in three Malian communities: a prospective cohort study

2021 ◽  
Author(s):  
Issaka Sagara ◽  
John Woodford ◽  
Mamady Kone ◽  
Mahamadoun Hamady Assadou ◽  
Abdoulaye Katile ◽  
...  
Keyword(s):  
Urban Areas ◽  
Herd Immunity ◽  
Mitigation Strategies ◽  
Factors Associated ◽  
Rural Village ◽  
Rural Town ◽  
First Case ◽  
Antigen Elisa ◽  
Minimal Difference ◽  
Ongoing Surveillance

ABSTRACTBackgroundThe extent of SARS-CoV-2 exposure and transmission in Mali and the surrounding region is not well understood, although infection has been confirmed in nearly 14,000 symptomatic individuals and their contacts since the first case in March 2020. We aimed to estimate the cumulative incidence of SARS-CoV-2 in three Malian communities, and understand factors associated with infection.MethodsBetween 27 July 2020 and 29 January 2021, we collected blood samples along with demographic, social, medical and self-reported symptoms information from residents aged 6 months and older in three study communities at two study visits. SARS-CoV-2 antibodies were measured using a highly specific two-antigen ELISA optimized for use in Mali. We calculated cumulative adjusted seroprevalence for each site and evaluated factors associated with serostatus at each visit by univariate and multivariate analysis.FindingsOverall, 94.8% (2533/2672) of participants completed both study visits. A total of 50.3% (1343/2672) of participants were male, and 31.3% (837/2672) were aged <10 years, 27.6% (737/2672) were aged 10-17 years, and 41.1% (1098/2572) were aged ≥18 years. The cumulative SARS-CoV-2 exposure rate was 58.5% (95% CI: 47.5 to 69.4). This varied between sites and was 73.4% (95% CI: 59.2 to 87.5) in the urban community of Sotuba, 53.2% (95% CI: 42.8 to 63.6) in the rural town of Bancoumana, and 37.1% (95% CI: 29.6 to 44.5) in the rural village of Donéguébougou. This equates to an infection rate of approximately 1% of the population every three days in the study communities between visits. Increased age and study site were associated with serostatus at both study visits. There was minimal difference in reported symptoms based on serostatus.InterpretationThe true extent of SARS-CoV-2 exposure in Mali is greater than previously reported and now approaches hypothetical herd immunity in urban areas. The epidemiology of the pandemic in the region may be primarily subclinical and within background illness rates. In this setting, ongoing surveillance and augmentation of diagnostics to characterize locally circulating variants will be critical to implement effective mitigation strategies like vaccines.FundingThis project was funded by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institute of Biomedical Imaging and Bioengineering, and National Cancer Institute.

scholarly journals Rapidly increasing SARS-CoV-2 seroprevalence and limited clinical disease in three Malian communities: a prospective cohort study

2021 ◽  
Author(s):  
Issaka Sagara ◽  
John Woodford ◽  
Mamady Kone ◽  
Mahamadoun Hamady Assadou ◽  
Abdoulaye Katile ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Urban Areas ◽  
Herd Immunity ◽  
Exposure Rate ◽  
Blood Samples ◽  
Factors Associated ◽  
Rural Village ◽  
Rural Town ◽  
Antigen Elisa ◽  
Minimal Difference

Abstract Background The extent of SARS-CoV-2 exposure and transmission in Mali and the surrounding region is not well understood. We aimed to estimate the cumulative incidence of SARS-CoV-2 in three communities, and understand factors associated with infection. Methods Between July 2020 and January 2021, we collected blood samples and demographic, social, medical, and self-reported symptoms information from residents aged 6 months and older over two study visits. SARS-CoV-2 antibodies were measured using a highly specific two-antigen ELISA optimized for use in Mali. We calculated cumulative adjusted seroprevalence for each community and evaluated factors associated with serostatus at each visit by univariate and multivariate analysis. Results Overall, 94.8% (2533/2672) of participants completed both study visits. A total of 31.3% (837/2672) were aged &lt;10 years, 27.6% (737/2672) were aged 10-17 years, and 41.1% (1098/2572) were aged ≥18 years. The cumulative SARS-CoV-2 exposure rate was 58.5% (95% CI: 47.5 to 69.4). This varied between sites and was 73.4% in the urban community of Sotuba, 53.2% in the rural town of Bancoumana, and 37.1% in the rural village of Donéguébougou. Study site and increased age were associated with serostatus at both study visits. There was minimal difference in reported symptoms based on serostatus. Conclusion The true extent of SARS-CoV-2 exposure in Mali is greater than previously reported and may now approach hypothetical ‘herd immunity’ in urban areas. The epidemiology of the pandemic in the region may be primarily subclinical and within background illness rates.

scholarly journals Factors associated with Adherence to Social Distancing Protocols and Hygienic Behavior during the COVID-19 Pandemic

2020 ◽  
Author(s):  
Omid V. Ebrahimi ◽  
Asle Hoffart ◽  
Sverre Urnes Johnson
Keyword(s):  
Urban Areas ◽  
Information Sources ◽  
Mitigation Strategies ◽  
Sensitivity Analyses ◽  
Hygienic Behavior ◽  
Adherence Behavior ◽  
Social Distancing ◽  
Factors Associated ◽  
Increased Risk ◽  
Lower Adherence

Objective: To investigate factors associated with adherence to viral mitigation strategies recommended by the WHO during the COVID-19 pandemic, including adherence to social distancing protocols (SDPs) and adherence to hygienic behavior recommendations (HB). Design: This pre-registered epidemiological study of 4158 adults examines the association between situational, cognitive, affective, behavioral, and personality-based factors with adherence to SDPs and HB during the COVID-19 pandemic. The study further investigates the relationship between central information sources and adherence behavior.Main Outcome Measures: Adherence to social distancing protocols (SDPs) and adherence to hygienic behavior recommendations (HB). Results: Individuals aged between 18-30 reported lowest adherence to SDPs and HB. Greater alcohol consumption was associated with decreased adherence to SDP and HB. Increased risk perception, fear of infection, conscientious personality, and altruistic attitude was associated with greater adherence to SDPs and HB. Males, single individuals, employed individuals, and those without children reported lower adherence to SDPs and HB. Extroverted personality and residents of urban areas were associated with lower adherence to SDPs, but not HB. In contrast to earlier stages of the pandemic, voluntary social distancing was associated with greater adherence to SDPs as opposed to rule-enforced (e.g., mandated) social distancing. Among information sources, increased time spent obtaining information from official (i.e., recognized) newspapers had the strongest favorable association with adherence to both SDPs and HB, followed by information obtainment from recognized television channels. Relying on information from friends and family was associated with decreased adherence to SDPs, but was unrelated to adherence to HB. Sensitivity analyses replicated the findings, supporting the stability and robustness of the proposed models. Conclusion: The present study identifies factors associated with favorable and detrimental adherence behavior along with substantial dissemination routes, presenting strategies which may be utility toward fostering adherence to contemporaneously implemented pandemic mitigation protocols.Key words: COVID-19; Adherence; Compliance; Social Distancing; Physical Distancing; Viral Mitigation; Hygienic Behavior

scholarly journals Prevalence and factors associated with hypertension among school children and adolescents in urban and semi‐urban areas in Cameroon

2021 ◽  
Author(s):  
Chris Nadège Nganou‐Gnindjio ◽  
Doris Bibi Essama ◽  
Jan René Nkeck ◽  
Patrick Yvan Tchebegna ◽  
Kiliane Maeva Tchatchouang ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
School Children ◽  
Urban Areas ◽  
Factors Associated

scholarly journals Country compliance with WHO-recommended antenatal care guidelines: equity analysis of the 2015–2016 Demography and Health Survey in Myanmar

2020 ◽  
Vol 5 (12) ◽  
pp. e002169
Author(s):  
Ngatho Samuel Mugo ◽  
Kyaw Swa Mya ◽  
Camille Raynes-Greenow
Keyword(s):  
Antenatal Care ◽  
Pregnant Women ◽  
Adolescent Mothers ◽  
Health Survey ◽  
Rural Areas ◽  
Urban Areas ◽  
Multinomial Logistic Regression ◽  
Wealth Quintile ◽  
Adjusted Risk ◽  
Factors Associated

IntroductionEarly access to adequate antenatal care (ANC) from skilled providers is crucial for detecting and preventing obstetric complications of pregnancy. We aimed to assess factors associated with the utilisation of the new WHO ANC guidelines including the recommended number, on time initiation and adequate components of ANC contacts in Myanmar.MethodsWe examined data from 2943 mothers aged 15–49 years whose most recent birth occurred in the last 5 years prior to the 2015–2016 Myanmar Demographic and Health Survey. Factors associated with utilisation of the new WHO recommended ANC were explored using multinomial logistic regression and multivariate models. We used marginal standardisation methods to estimate the predicted probabilities of the factors significantly associated with the three measures of ANC.ResultsApproximately 18% of mothers met the new WHO recommended number of eight ANC contacts. About 58% of the mothers received adequate ANC components, and 47% initiated ANC within the first trimester of pregnancy. The predicted model shows that Myanmar could achieve 70% coverage of adequate components of ANC if all women were living in urban areas. Similarly, if ANC was through private health facilities, 63% would achieve adequate components of ANC. Pregnant women from urban areas (adjusted risk ratio (aRR): 4.86, 95% CI 2.44 to 9.68) were more than four times more likely to have adequate ANC components compared with women from rural areas. Pregnant women in the highest wealth quintile were three times more likely to receive eight or more ANC contacts (aRR: 3.20, 95% CI 1.61 to 6.36) relative to mothers from the lowest wealth quintile. On time initiation of the first ANC contact was fourfold for mothers aged 30–39 years relative to adolescent mothers (aRR: 4.07, 95% CI 1.53 to 10.84).ConclusionThe 2016 WHO ANC target is not yet being met by the majority of women in Myanmar. Our results highlight the need to address health access inequity for women who are from lower socioeconomic groups, or are younger, and those living in rural areas.

Factors Associated With Retained Foreign Bodies Following Major Operations

2021 ◽  
pp. 000313482110249
Author(s):  
Arjun Verma ◽  
Zachary Tran ◽  
Joseph Hadaya ◽  
Catherine G. Williamson ◽  
Rhea Rahimtoola ◽  
...  
Keyword(s):  
Pulmonary Infection ◽  
Foreign Bodies ◽  
Laparoscopic Approach ◽  
Mitigation Strategies ◽  
Financial Outcomes ◽  
Factors Associated ◽  
Diagnosis Codes ◽  
Hospitalization Costs ◽  
High Risk Populations ◽  
Nationally Representative

Background Retained surgical foreign bodies (RFB) are associated with inferior clinical and financial outcomes. The present work examined a nationally representative sample of all major operations to identify factors associated with RFB. Study Design The 2005-2017 National Inpatient Sample was used to identify adults undergoing cardiac, neurosurgical, orthopedic, genitourinary, gastrointestinal, vascular, and thoracic operations. International Classifications of Diseases 9th-10th Revisions diagnosis codes were used to identify instances of RFB. Results Of an estimated 71,445,042 hospitalizations, .02% had a diagnosis of RFB, with decreasing incidence from .03 to .02% over the study period (NPtrend < .001). Relative to vascular operations, gastrointestinal (adjusted odds ratio [AOR] 2.12), thoracic (AOR 1.80), and multi-cavity (AOR 2.17) were associated with greater odds of RFB. Laparoscopic approach (AOR .33) and trauma-associated admission (AOR .52, all P < .001) were associated with reduced odds of RFB. Despite similar mortality, RFB was associated with increased odds of pulmonary infection (AOR 1.62), sepsis (AOR 1.26), and wound infection (AOR 5.15), as well as a 2.3-day increment in length of stay and $7700 in hospitalization costs (all P < .001). Conclusion The development of novel mitigation strategies may reduce the incidence of RFB in high-risk populations, such as those undergoing gastrointestinal, thoracic, and multi-cavity operations.

Factors associated with human visceral leishmaniasis cases during urban epidemics in Brazil: a systematic review

Parasitology ◽  
2021 ◽  
pp. 1-9
Author(s):  
Cleya da Silva Santana Cruz ◽  
David Soeiro Barbosa ◽  
Vinícius Cunha Oliveira ◽  
Diogo Tavares Cardoso ◽  
Nathália Sernizon Guimarães ◽  
...  
Keyword(s):  
Systematic Review ◽  
Visceral Leishmaniasis ◽  
Urban Areas ◽  
Grey Literature ◽  
Cochrane Library ◽  
Positive Correlation ◽  
Individual Level ◽  
Factors Associated ◽  
The North ◽  
Unified Health System

Abstract Visceral leishmaniasis (VL) is endemic in 70 countries and has been reported in 12 countries of Latin America, with over 90% of the cases reported in Brazil, where epidemics have occurred since 1980. The objective of this review is to describe the factors associated with the occurrence of VL epidemics in humans in urban areas. A systematic review was conducted according to the PRISMA-P guidelines. The databases PubMed (by Medline), Cochrane Library, Embase, Amed, LILACS and grey literature [Google Scholar and handsearch of the database of the Information System for Notifiable Diseases (SINAN) of Brazil's Unified Health System] were used. The protocol was registered under PROSPERO (CRD42019128998). Climatic, environmental factors and indicators of urban social structure were described as influencing the outbreaks in the North and Northeast regions. Gender and age characteristics were related to a greater chance of developing VL in the Central-West, Northeast and Southeast regions. Vector indicators showed a positive correlation with the incidence of VL in studies in the Northeast region. In the Southeast and Northeast regions, studies revealed the presence of dogs with positive correlation with VL. Knowledge gaps remain regarding the contribution to the increase in the risk factors described in ecological approaches, as no analysis was performed at the individual level, and it is still necessary to discuss the influence of other associated elements in epidemic episodes in the spread of VL.

Healthcare seeking and hospital admissions by people who inject drugs in response to symptoms of injection site infections or injuries in three urban areas of England

2014 ◽  
Vol 143 (1) ◽  
pp. 120-131 ◽  
Author(s):  
V. D. HOPE ◽  
F. NCUBE ◽  
J. V. PARRY ◽  
M. HICKMAN
Keyword(s):  
Hospital Admission ◽  
Injection Site ◽  
Urban Areas ◽  
People Who Inject Drugs ◽  
Hospital Admissions ◽  
Medical Advice ◽  
Respondent Driven Sampling ◽  
Open Wound ◽  
Factors Associated ◽  
Healthcare Burden

SUMMARYPeople who inject drugs (PWID) are vulnerable to infections and injuries at injection sites. The factors associated with reporting symptoms of these, seeking related advice, and hospital admission are examined. PWID were recruited in Birmingham, Bristol and Leeds using respondent-driven sampling (N = 855). During the preceding year, 48% reported having redness, swelling and tenderness (RST), 19% an abscess, and 10% an open wound at an injection site. Overall, 54% reported ⩾1 symptoms, with 45% of these seeking medical advice (main sources emergency departments and General Practitioners). Advice was often sought ⩾5 days after the symptom first appeared (44% of those seeking advice about an abscess, 45% about an open wound, and 35% for RST); the majority received antibiotics. Overall, 9·5% reported hospital admission during the preceding year. Ever being diagnosed with septicaemia and endocarditis were reported by 8·8% and 2·9%, respectively. Interventions are needed to reduce morbidity, healthcare burden and delays in accessing treatment.

scholarly journals Prevalence and factors associated with intimate partner violence among the adolescent girls and young women in South Africa: findings the 2017 population based cross-sectional survey

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jacqueline Mthembu ◽  
Musawenkosi Mabaso ◽  
Sarah Reis ◽  
Khangelani Zuma ◽  
Nompumelelo Zungu
Keyword(s):  
South African ◽  
Adolescent Girls ◽  
Young Women ◽  
Partner Violence ◽  
Urban Areas ◽  
Population Based ◽  
Intimate Partner ◽  
Low Ses ◽  
Cross Sectional ◽  
Factors Associated

Abstract Background Evidence indicate that intimate partner violence (IPV) is disturbingly high among South African adolescent girls and young women (AGYW). Understanding prevalence and risk factors for IPV among these emerging adults is critical for developing appropriate interventions to prevent adverse health outcomes later in life. This study investigates the prevalence and factors associated with lifetime physical IPV experience among AGYW, aged 15–24 years, using the South African national HIV prevalence, incidence, behaviour and communication survey conducted in 2017. Methods The data used in this secondary analysis was obtained from a cross-sectional, population-based household survey data, conducted using a multi-stage stratified random cluster sampling approach. Multivariate stepwise backward logistic regression modelling was used to determine factors associated with IPV. Results Of 716 AGYW that responded to the two commonly answered questions on IPV, 13.1% (95% CI: 9.6–17.6) indicated that they experienced IPV. The odds of reporting experiences of IPV were significantly lower among AGYW residing in high SES households [AOR = 0.09 (95% CI: 0.02–0.47), p = 0.004] than low SES households, and those residing in rural informal/tribal areas [AOR = 0.01 (95% CI: 0.00–0.22), p = 0.004] than urban areas. AGYW experiencing IPV had higher odds of reporting psychological distress compared to their counterparts [AOR = 4.37 (95% CI, 0.97–19.72), p = 0.054]. Conclusion The findings highlight the need for targeted structural and psychosocial interventions in low SES households and especially in urban areas.

scholarly journals Factors Associated with Happiness among Malaysian Elderly

2021 ◽  
Vol 18 (7) ◽  
pp. 3831
Author(s):  
Shamsul Azhar Shah ◽  
Nazarudin Safian ◽  
Saharuddin Ahmad ◽  
Wan Abdul Hannan Wan Ibadullah ◽  
Zulkefley bin Mohammad ◽  
...  
Keyword(s):  
Emotional Support ◽  
Rural Areas ◽  
Social Engagement ◽  
Urban Areas ◽  
Elderly Population ◽  
Handgrip Strength ◽  
The Elderly ◽  
Evaluation Study ◽  
Factors Associated ◽  
Urban And Rural Areas

Happiness is an essential component to experience healthy ageing. Hence, understanding the factors that contribute to happiness is important. This study aimed to determine the factors associated with happiness among the elderly population in Malaysia. In this study, 1204 respondents were recruited from urban and rural areas in Selangor. A face-to-face interview was conducted using the Bahasa Malaysia version of the Japan Gerontological Evaluation Study questionnaire. The inclusion criteria include Malaysians who are 60-years old and above and can converse in the Malaysian language. Those who encounter less than seven scores for the Abbreviated Mental Test were excluded from the study. Among the 1204 respondents, 953 (79.2%) were happy. Sociodemographic characteristics showed that being a men, age of 60 to 74 years, and living in urban areas were significantly associated with happiness. A logistic regression model showed that locality (aOR 1.61), income category (Bottom 40% aOR 0.49; Middle-class group 40% aOR 1.40), social engagement (active aOR 1.77; less active aOR 1.25), receiving emotional support (aOR 2.11) and handgrip strength (aOR 1.02) were significantly associated with happiness. Thus, ensuring the elderly population in receiving emotional support and active social engagement among them can enhance their happiness level.

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