scholarly journals The Current Understanding of Precision Medicine and Personalised Medicine in Selected Research Disciplines: Study Protocol of a Systematic Concept Analysis

2022 ◽  
Author(s):  
Nicola Brew-Sam ◽  
Anne Parkinson ◽  
Christian Lueck ◽  
Ellen Brown ◽  
Karen Brown ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Clinical Medicine ◽  
Public Awareness ◽  
Personalised Medicine ◽  
Concept Analysis ◽  
Current Understanding ◽  
Translational Medical Research ◽  
Research Translation ◽  
Analysis Method ◽  
Services Research

Introduction. The terms "precision medicine" and "personalised medicine" have become key terms in health-related research, and in science-related public communication. However, the application of these two concepts and their interpretation in various disciplines are heterogeneous, which also affects research translation and public awareness. This leads to confusion regarding the use and distinction of the two concepts. Methods and analysis. Our study aims at using Rodger's concept analysis method to systematically examine and distinguish the current understanding of the concepts "precision medicine" and "personalised medicine" in clinical medicine, biomedicine (incorporating genomics and bioinformatics), health services research; physics, chemistry, engineering; machine learning, and artificial intelligence, and to identify their respective attributes (clusters of characteristics) and surrogate and related terms. We will analyse similarities and differences in definitions in the respective disciplines and across different (sub)disciplines. The analysis procedure will include (1) a concept identification, (2) a setting, sample, and data source selection, (3) data collection, (4) data analysis and data summary, (5) identification of examples, and (6) identification of implications for further concept development. Ethics and dissemination. Following ethical and research standards, we will comprehensively report the methodology for a systematic analysis following Roger's[1] concept analysis method. Our systematic concept analysis will contribute to the clarification of the two concepts and distinction in their application in given settings and circumstances. Such a broader concept analysis will contribute to non-systematic syntheses of the concepts, or occasional systematic reviews on one of the concepts that have been published in specific disciplines, in order to facilitate interdisciplinary communication, translational medical research, and implementation science.

scholarly journals Perceptions of ‘Precision’ and ‘Personalised’ Medicine in Singapore and Associated Ethical Issues

2021 ◽  
Vol 13 (2) ◽  
pp. 179-194
Author(s):  
Serene Ong ◽  
Jeffrey Ling ◽  
Angela Ballantyne ◽  
Tamra Lysaght ◽  
Vicki Xafis
Keyword(s):  
Precision Medicine ◽  
Ethical Issues ◽  
Personalised Medicine ◽  
Large Population ◽  
Data Sets ◽  
Visual Aids ◽  
Policy Makers ◽  
The Social ◽  
Genomic Analyses ◽  
Common Understanding

AbstractGovernments are investing in precision medicine (PM) with the aim of improving healthcare through the use of genomic analyses and data analytics to develop tailored treatment approaches for individual patients. The success of PM is contingent upon clear public communications that engender trust and secure the social licence to collect and share large population-wide data sets because specific consent for each data re-use is impractical. Variation in the terminology used by different programmes used to describe PM may hinder clear communication and threaten trust. Language is used to create common understanding and expectations regarding precision medicine between researchers, clinicians and the volunteers. There is a need to better understand public interpretations of PM-related terminology. This paper reports on a qualitative study involving 24 focus group participants in the multi-lingual context of Singapore. The study explored how Singaporeans interpret and understand the terms ‘precision medicine’ and ‘personalised medicine’, and which term they felt more aptly communicates the concept and goals of PM. Results suggest that participants were unable to readily link the terms with this area of medicine and initially displayed preferences for the more familiar term of ‘personalised’. The use of visual aids to convey key concepts resonated with participants, some of whom then indicated preferences for the term ‘precision’ as being a more accurate description of PM research. These aids helped to facilitate dialogue around the ethical and social value, as well as the risks, of PM. Implications for programme developers and policy makers are discussed.

scholarly journals PERAN BADAN USAHA MILIK DESA (BUMDES) SEBAGAI UPAYA PENGEMBANGAN EKONOMI MASYARAKAT DESA PEJANGGIK

2021 ◽  
Vol 7 (1) ◽  
pp. 96
Author(s):  
Agus Salihin
Keyword(s):  
Public Awareness ◽  
Economic Empowerment ◽  
Economic Welfare ◽  
Analysis Method ◽  
Data Presentation ◽  
Village Community ◽  
Analysis Technique ◽  
Village Communities ◽  
Economic Improvement

Pejanggik Village-Owned Enterprises (BUMDes) is an institution that can assist the community in economic empowerment, especially in village communities to achieve economic welfare and village income. So the purpose of this study is to determine the role of Village-Owned Enterprises as an effort to develop the economy of the Pejanggik Village community. This type of research is descriptive qualitative research. Sember research data consists of BUMDes managers and communities who receive business development assistance. The data collection techniques consist of observation, interview and documentation techniques. While the data analysis technique, the researcher used the analysis method by Milles and Hubarman which included data presentation, data reduction and conclusion drawing. The results of the study can be explained that the role of BUMDes Desa Pejanggik is not going well and has not been able to significantly improve the economy of the Pejanggik Village community. This is due to the lack of available capital, public awareness and inadequate human resources. Keywords: BUMDes, Economic Improvement, Society

The Method of Discover the Attributes' Sequences of Objects in the Formal Context

2013 ◽  
Vol 427-429 ◽  
pp. 2536-2539
Author(s):  
Xue Song Dai ◽  
Yuan Ma ◽  
Wen Xue Hong
Keyword(s):  
Equivalence Relation ◽  
Formal Concept Analysis ◽  
Concept Lattice ◽  
Concept Analysis ◽  
Formal Context ◽  
Formal Concept ◽  
Analysis Method ◽  
Analysis Theory

Formal context is one of the research contents of formal concept analysis theory. In concept lattice, the attributes of the object are equivalent and there is no hierarchy. Facing to this problem, the equivalence relation which is on the attributes' set is defined and the corresponding σ operation is proposed. On this basis, the structure method of attribute hierarchical diagram is presented and attributes' sequences of associated objects are obtained. This conclusion enriches and extends the analysis method of the formal context.

HIV Viral Load: A Concept Analysis and Critique

2014 ◽  
Vol 28 (3) ◽  
pp. 204-227 ◽  
Author(s):  
Marilou Gagnon ◽  
Adrian Guta
Keyword(s):  
Viral Load ◽  
Concept Analysis ◽  
Collection Management ◽  
Practice Research ◽  
Analysis Method ◽  
Critical Approach ◽  
Hiv Viral Load ◽  
Evolutionary View ◽  
Antecedents And Consequences ◽  
Over Time

In this article, we examine the concept of HIV viral load and how it has evolved over time (1995–2013) in the field of HIV/AIDS. Although the termviral loadis used extensively in this field, few efforts have been directed toward the conceptualization of HIV viral load, which is often left unquestioned, undertheorized, and portrayed as a neutral and objective laboratory value that has remained relatively stable over time—with the exception of progressive advancements in technology, techniques, and sensitivity. The purpose of this article is to apply the evolutionary concept analysis method developed by Rodgers (1989, 2000a) to the concept of HIV viral load. To set the stage, we establish the need for a concept analysis of HIV viral load and provide an overview of the evolutionary view. Then, drawing on the steps proposed by Rodgers (2000a), we outline the process of data collection, management, and analysis. We then offer an in-depth discussion of the findings (attributes, antecedents, and consequences) informed by Wuest’s (2000) critical approach to concept analysis. We conclude by highlighting the implications of this analysis for clinical practice, research, and theory.

scholarly journals NARASI HEROISME PEREMPUAN DALAM ISU LINGKUNGAN (Analisis Framing Berita Farwiza Farhan di Media Daring Lokal dan Nasional)

2020 ◽  
Vol 6 (1) ◽  
pp. 51
Author(s):  
Ainal Fitri ◽  
Putri Maulina
Keyword(s):  
News Media ◽  
Public Awareness ◽  
Online News ◽  
Environmental Knowledge ◽  
Local Source ◽  
Environmental Discourse ◽  
Analysis Method ◽  
Framing Analysis ◽  
Media Frames

Environmental discourse is considered as one of the essential narratives since it involves the role of women. In the gender perspective, women in environmental issues are often described as a sidekick. Farwiza Farhan is one of the environmentalists who contributes to the environmental campaign effort. The study aims to focus on the framing of Farwiza Farhan’s figure against her contribution as the keeper of the Leuser Ecosystem (KEL) on online media environmental reports. This study used the Framing Analysis approach, Environmental Journalism, and Heroism concept. The researchers chose and analyzed three news from online news media: serambinews. com as a local source; and republika. co. id and bbc. com as national sources. This research was analyzed by using Zhongdang Pan and Gerald M. Kosicki’s Framing Analysis method. The finding shows that the news media frames Farwiza Farhan as an environmental activist with a heroism narrative. Farwiza is portrayed as a heroic, selfless, courageous, and intelligent personality. She is adaptive and determined to deal with conflict, and she also has initiative and leadership. Heroism is perceived as an environmental perspective-journalism strategy of online news media to deliver environmental knowledge and to raise public awareness towards the environmental issue.

scholarly journals Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults

Biology ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1342
Author(s):  
Esther C. Gallegos-Cabriales ◽  
Ernesto Rodriguez-Ayala ◽  
Hugo A. Laviada-Molina ◽  
Edna J. Nava-Gonzalez ◽  
Rocío A. Salinas-Osornio ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Precision Medicine ◽  
Time Course ◽  
Clinical Medicine ◽  
Whole Body ◽  
Low Grade ◽  
Shotgun Lipidomics ◽  
Medicine Research ◽  
P Gene

We previously reported preliminary characterization of adipose tissue (AT) dysfunction through the adiponectin/leptin ratio (ALR) and fasting/postprandial (F/P) gene expression in subcutaneous (SQ) adipose tissue (AT) biopsies obtained from participants in the GEMM study, a precision medicine research project. Here we present integrative data replication of previous findings from an increased number of GEMM symptom-free (SF) adults (N = 124) to improve characterization of early biomarkers for cardiovascular (CV)/immunometabolic risk in SF adults with AT dysfunction. We achieved this goal by taking advantage of the rich set of GEMM F/P 5 h time course data and three tissue samples collected at the same time and frequency on each adult participant (F/P blood, biopsies of SQAT and skeletal muscle (SKM)). We classified them with the presence/absence of AT dysfunction: low (<1) or high (>1) ALR. We also examined the presence of metabolically healthy (MH)/unhealthy (MUH) individuals through low-grade chronic subclinical inflammation (high sensitivity C-reactive protein (hsCRP)), whole body insulin sensitivity (Matsuda Index) and Metabolic Syndrome criteria in people with/without AT dysfunction. Molecular data directly measured from three tissues in a subset of participants allowed fine-scale multi-OMIC profiling of individual postprandial responses (RNA-seq in SKM and SQAT, miRNA from plasma exosomes and shotgun lipidomics in blood). Dynamic postprandial immunometabolic molecular endophenotypes were obtained to move towards a personalized, patient-defined medicine. This study offers an example of integrative translational research, which applies bench-to-bedside research to clinical medicine. Our F/P study design has the potential to characterize CV/immunometabolic early risk detection in support of precision medicine and discovery in SF individuals.

scholarly journals Analisis Situasi Tutur dalam Perbedaan Berkomunikasi Presiden Jokowi Melalui Cuplikan Video pada Channel Youtube Metrotvnews

2021 ◽  
Vol 17 (2) ◽  
pp. 173
Author(s):  
Asep Purwo Yudi Utumo
Keyword(s):  
Speech Acts ◽  
Speech Act ◽  
Public Awareness ◽  
Descriptive Analysis ◽  
Analysis Method ◽  
Language Variety ◽  
Speech Patterns ◽  
The People ◽  
Communication Differences ◽  
Speech Situation

Dalam berkomunikasi sehari-hari seorang penutur perlu memperhatikan adanya situasi tutur. Maksud dari sebuah tuturan dapat dipahami dan diidentifikasi oleh mitra tutur karena adanya situasi tutur. Selain itu, situasi tutur juga mempengaruhi penutur untuk menentukan ragam bahasa yang sesuai digunakan ketika tuturan itu terjadi. Penelitian ini mendeskripsikan perbedaan berkomunikasi Presiden Jokowi dalam  situasi  tertentu. Penelitian ini menggunakan metode analisis deskriptif. Metode pengumpulan data pada penelitian ini menggunakan metode simak dan catat. Hasil temuan penelitian ini adalah pola tuturan Presiden Jokowi dalam situasi resmi dengan mitra tutur, yaitu pemimpin negara, wartawan, dan atau masyarakat melalui media massa menggunakan tindak tutur lokusi, ilokusi, dan performatif. Produk tindak verbal dari tuturan tersebut adalah penggunaan ragam bahasa formal. Pola tuturan Presiden Jokowi dalam situasi tidak resmi dengan mitra tutur, yaitu rakyat secara langsung menggunakan tindak tutur perlokusi. Produk tindak verbal dari tuturan tersebut adalah penggunaan ragam bahasa santai. Manfaat penelitian ini adalah untuk meningkatkan kesadaran masyarakat agar semakin memperhatikan tuturan yang digunakan agar tidak terjadi kesalahpahaman. Selain itu, masyarakat juga perlu memperhatikan penggunaan ragam bahasa dalam situasi tutur tertentu.Kata kunci: Tindak tutur, situasi tutur, ragam bahasa, ragam formal, ragam santai In daily communication, a speaker needs to pay attention to the existence of a speech situation. The meaning of a speech can be understood and identified by the speech partner because of the speech situation. In addition, the speech situation also influences the speaker to determine the appropriate variety of language used when the speech occurs. This study describes President Jokowi's communication differences in certain situations. This research uses descriptive analysis method. The method of collecting data in this study used the observation and note method. The findings of this study are the speech patterns of President Jokowi in official situations with speech partners, namely state leaders, journalists, and / or the community through the mass media using locusive, illocutionary and performative speech acts. The product of the verbal act of the speech is the use  of various formal languages. President Jokowi's speech patterns in informal situations with speech partners, namely the people directly use perlocution speech acts. The product of the verbal act of the speech is the use of a variety of casual language. The benefit  of  this research is to increase public awareness in order to pay more attention to the utterances  used in order to avoid misunderstandings. Apart from that, people also need to pay attention to the use of various languages in certain speech situations.Key words; Speech act, speech situation, language variety, formal variety, casual variety

Is mRNA indeed Useful in Clinical Management of Cervical Pathology?

2021 ◽  
pp. 121-128
Author(s):  
Panagiotis Cherouveim ◽  
Antonios Athanasiou ◽  
Evangelos Paraskevaidis
Keyword(s):  
Clinical Practice ◽  
Precision Medicine ◽  
Clinical Management ◽  
Screening Test ◽  
Personalised Medicine ◽  
Added Value ◽  
High Grade ◽  
Hpv Testing ◽  
Advantages And Disadvantages ◽  
Comparative Advantages

Personalised medicine and precision medicine are being applied in more medical fields in the last years. The need for personalisation is especially pronounced in cervical pathology, since in the majority of cases an abnormal screening test does not necessarily imply high-grade lesion, regardless of whether the screening test is cytology or HPV testing. The chapter aims to summarize the exact added value that mRNA presents for management in clinical practice as well as highlight comparative advantages and disadvantages with other triage strategies.

scholarly journals COPD biomarkers and phenotypes: opportunities for better outcomes with precision imaging

2018 ◽  
Vol 52 (5) ◽  
pp. 1801570 ◽  
Author(s):  
George R. Washko ◽  
Grace Parraga
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Precision Medicine ◽  
Personalised Medicine ◽  
Chronic Obstructive ◽  
Resonance Imaging ◽  
Early Disease ◽  
Obstructive Pulmonary Disease ◽  
Thoracic Imaging ◽  
Quantitative Understanding

A number of chronic diseases have benefited from both imaging and personalised medicine, but unfortunately, for patients with chronic obstructive pulmonary disease (COPD), there has been little clinical uptake or recognition of the key advances in thoracic imaging that might help detect disease early, or, perhaps more importantly, might help develop and phenotype patients for novel or personalised therapies that may halt disease progression. We outline our vision for how computed tomography and magnetic resonance imaging may be used to better inform COPD patient care, and, perhaps more importantly, how these may be used to help develop new therapies directed at early disease. We think that imaging and precision medicine should be considered and used together as “precision imaging” at specific stages of COPD when the major pathologies may be more responsive to therapy. While “precision medicine” is the tailoring of medical treatment to individual patients, we define “precision imaging” as the tailoring of specific therapies and interventions to individual patients with a detailed quantitative understanding of their specific imaging phenotypes and measurements. Finally, we stress the importance of “seeing” the pathology, because without this understanding, you can neither treat nor cure patients with COPD.

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