scholarly journals Prokaryotic Diversity from Extreme Environments of Pakistan and its Potential Applications at Regional Levels

2018 ◽  
Author(s):  
Raees Khan ◽  
Muhammad Israr Khan ◽  
Amir Zeb ◽  
Nazish Roy ◽  
Muhammad Yasir ◽  
...  
Keyword(s):  
Bacterial Diversity ◽  
Functional Diversity ◽  
Wide Spectrum ◽  
Extreme Environments ◽  
Regional Level ◽  
Bioenergy Production ◽  
Prokaryotic Diversity ◽  
Potential Applications ◽  
Biotechnological Processes

AbstractExtremophiles, the microorganisms thriving in extreme environments, provide valuable resources for practicing novel biotechnological processes. Pakistan homes a wide spectrum of extreme environments which harbor various biotechnologically significant microorganisms. This review gauges the structural and functional bacterial diversity of several extreme environments, emphasizing their potentials as a source of extremozymes, and in bioleaching, bioremediation, and bioenergy production at regional level. Further, this review highlights a panoramic account of the local natural conservatories of extremophiles. The inadequacies of current fragmental research are discussed with suggestions to quantitatively define the structural and functional diversity of unexplored extreme localities.

scholarly journals Prokaryotic Diversity from Extreme Environments of Pakistan and its Potential Applications at Regional Levels

2018 ◽  
Author(s):  
RAEES KHAN ◽  
Muhammad Israr Khan ◽  
Amir Zeb ◽  
Nazish Roy ◽  
Muhammad Yasir ◽  
...  
Keyword(s):  
Bacterial Diversity ◽  
Functional Diversity ◽  
Wide Spectrum ◽  
Extreme Environments ◽  
Regional Level ◽  
Bioenergy Production ◽  
Prokaryotic Diversity ◽  
Potential Applications ◽  
Biotechnological Processes

Extremophiles, the microorganisms thriving in extreme environments, provide valuable resources for practicing novel biotechnological processes. Pakistan homes a wide spectrum of extreme environments which harbor various biotechnologically significant microorganisms. This review gauges the structural and functional bacterial diversity of several extreme environments, emphasizing their potentials as a source of extremozymes, and in bioleaching, bioremediation, and bioenergy production at regional level. Further, this review highlights a panoramic account of the local natural conservatories of extremophiles. The inadequacies of current fragmental research are discussed with suggestions to quantitatively define the structural and functional diversity of unexplored extreme localities.

scholarly journals Perspectives on biotechnological applications of archaea

Archaea ◽  
2002 ◽  
Vol 1 (2) ◽  
pp. 75-86 ◽  
Author(s):  
Chiara Schiraldi ◽  
Mariateresa Giuliano ◽  
Mario De Rosa
Keyword(s):  
Current Knowledge ◽  
Extreme Environments ◽  
Industrial Applications ◽  
Biotechnological Applications ◽  
Wild Type ◽  
Extreme Halophiles ◽  
Potential Applications ◽  
Extremophilic Microorganisms ◽  
Biotechnological Processes ◽  
The Subject

Many archaea colonize extreme environments. They include hyperthermophiles, sulfur-metabolizing thermophiles, extreme halophiles and methanogens. Because extremophilic microorganisms have unusual properties, they are a potentially valuable resource in the development of novel biotechnological processes. Despite extensive research, however, there are few existing industrial applications of either archaeal biomass or archaeal enzymes. This review summarizes current knowledge about the biotechnological uses of archaea and archaeal enzymes with special attention to potential applications that are the subject of current experimental evaluation. Topics covered include cultivation methods, recent achievements in genomics, which are of key importance for the development of new biotechnological tools, and the application of wild-type biomasses, engineered microorganisms, enzymes and specific metabolites in particular bioprocesses of industrial interest.

scholarly journals Biodiversity of Secondary Metabolites Compounds Isolated from Phylum Actinobacteria and Its Therapeutic Applications

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4504
Author(s):  
Muhanna Al-shaibani ◽  
Radin Maya Saphira Radin Mohamed ◽  
Nik Sidik ◽  
Hesham Enshasy ◽  
Adel Al-Gheethi ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Extreme Environments ◽  
Software Tool ◽  
Gene Clusters ◽  
Well Being ◽  
Bioactive Substances ◽  
Diverse Range ◽  
Wide Range ◽  
Potential Applications

The current review aims to summarise the biodiversity and biosynthesis of novel secondary metabolites compounds, of the phylum Actinobacteria and the diverse range of secondary metabolites produced that vary depending on its ecological environments they inhabit. Actinobacteria creates a wide range of bioactive substances that can be of great value to public health and the pharmaceutical industry. The literature analysis process for this review was conducted using the VOSviewer software tool to visualise the bibliometric networks of the most relevant databases from the Scopus database in the period between 2010 and 22 March 2021. Screening and exploring the available literature relating to the extreme environments and ecosystems that Actinobacteria inhabit aims to identify new strains of this major microorganism class, producing unique novel bioactive compounds. The knowledge gained from these studies is intended to encourage scientists in the natural product discovery field to identify and characterise novel strains containing various bioactive gene clusters with potential clinical applications. It is evident that Actinobacteria adapted to survive in extreme environments represent an important source of a wide range of bioactive compounds. Actinobacteria have a large number of secondary metabolite biosynthetic gene clusters. They can synthesise thousands of subordinate metabolites with different biological actions such as anti-bacterial, anti-parasitic, anti-fungal, anti-virus, anti-cancer and growth-promoting compounds. These are highly significant economically due to their potential applications in the food, nutrition and health industries and thus support our communities’ well-being.

Study of Bacterial Diversity from Saline Environments (Salt Mines) of Pakistan and their Applications at Regional Level

2021 ◽  
pp. 65-86
Author(s):  
Inam Ullah Khan ◽  
Muhammad Saqib ◽  
Neeli Habib ◽  
Min Xiao ◽  
Shakeeb Ullah ◽  
...  
Keyword(s):  
Bacterial Diversity ◽  
Regional Level ◽  
Saline Environments ◽  
Salt Mines

scholarly journals Plant Taxonomic Diversity Better Explains Soil Fungal and Bacterial Diversity than Functional Diversity in Restored Forest Ecosystems

Plants ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 479 ◽  
Author(s):  
Hanif ◽  
Guo ◽  
Moniruzzaman ◽  
He ◽  
Yu ◽  
...  
Keyword(s):  
Species Richness ◽  
Microbial Diversity ◽  
Soil Properties ◽  
Bacterial Diversity ◽  
Functional Diversity ◽  
Forest Ecosystems ◽  
Taxonomic Diversity ◽  
Soil Microbial Diversity ◽  
Soil Microbial ◽  
Bacterial Richness

Plant attributes have direct and indirect effects on soil microbes via plant inputs and plant-mediated soil changes. However, whether plant taxonomic and functional diversities can explain the soil microbial diversity of restored forest ecosystems remains elusive. Here, we tested the linkage between plant attributes and soil microbial communities in four restored forests (Acacia species, Eucalyptus species, mixed coniferous species, mixed native species). The trait-based approaches were applied for plant properties and high-throughput Illumina sequencing was applied for fungal and bacterial diversity. The total number of soil microbial operational taxonomic units (OTUs) varied among the four forests. The highest richness of fungal OTUs was found in the Acacia forest. However, bacterial OTUs were highest in the Eucalyptus forest. Species richness was positively and significantly related to fungal and bacterial richness. Plant taxonomic diversity (species richness and species diversity) explained more of the soil microbial diversity than the functional diversity and soil properties. Prediction of fungal richness was better than that of bacterial richness. In addition, root traits explained more variation than the leaf traits. Overall, plant taxonomic diversity played a more important role than plant functional diversity and soil properties in shaping the soil microbial diversity of the four forests.

scholarly journals Phycobiliproteins from extreme environments and their potential applications

2020 ◽  
Vol 71 (13) ◽  
pp. 3827-3842 ◽  
Author(s):  
Anton Puzorjov ◽  
Alistair J McCormick
Keyword(s):  
Hot Springs ◽  
Elevated Temperatures ◽  
Algal Species ◽  
Extreme Environments ◽  
Fundamental Understanding ◽  
Thermophilic Species ◽  
Red Algal ◽  
Potential Applications ◽  
Thermophilic Organisms ◽  
Photosynthetic Adaptation

Abstract The light-harvesting phycobilisome complex is an important component of photosynthesis in cyanobacteria and red algae. Phycobilisomes are composed of phycobiliproteins, including the blue phycobiliprotein phycocyanin, that are considered high-value products with applications in several industries. Remarkably, several cyanobacteria and red algal species retain the capacity to harvest light and photosynthesise under highly selective environments such as hot springs, and flourish in extremes of pH and elevated temperatures. These thermophilic organisms produce thermostable phycobiliproteins, which have superior qualities much needed for wider adoption of these natural pigment–proteins in the food, textile, and other industries. Here we review the available literature on the thermostability of phycobilisome components from thermophilic species and discuss how a better appreciation of phycobiliproteins from extreme environments will benefit our fundamental understanding of photosynthetic adaptation and could provide a sustainable resource for several industrial processes.

Extremophiles in Sustainable Bioenergy Production as Microbial Fuel Cells

2022 ◽  
pp. 286-307
Author(s):  
Mukta Kothari ◽  
Leena Gaurav Kulkarni ◽  
Divita Gupta ◽  
Rebecca Thombre
Keyword(s):  
Fuel Cell ◽  
Microbial Fuel Cells ◽  
Fossil Fuels ◽  
Molecular Mechanisms ◽  
Extreme Environments ◽  
Electrical Energy ◽  
Electrical Systems ◽  
Functional Efficiency ◽  
Potential Applications ◽  
Engineering Constraints

Microbial fuel cell (MFC) technology is considered one of the renewable sources of energy for the production of bioelectricity from waste. Due to the depletion of fossil fuels and environmental considerations, MFC haa garnered increasing importance as it is a sustainable and environmentally-friendly method of generation of bioenergy. In MFC, electroactive bacteria (EAB) and biofilms are harnessed to convert organic substances to electrical energy. Extremophiles survive in extreme environments, and they have demonstrated potential applications in microbial electrical systems (MES) and MFC technology. The key limitations of MFC are the low power output and engineering constraints of the fuel cell. Hence, it is imperative to understand the genetics, key metabolic pathways, and molecular mechanisms of the EAB for enhancing the power generation in MFC. This chapter gives a brief overview of the scope and applications of extremophiles in wastewater treatment, bioelectricity, and biohydrogen production using MFC, eventually enhancing the functional efficiency of MFC.

scholarly journals Translating In Vivo Metabolomic Analysis of Succinate Dehydrogenase–Deficient Tumors Into Clinical Utility

2018 ◽  
pp. 1-12 ◽  
Author(s):  
Ruth T. Casey ◽  
Mary A. McLean ◽  
Basetti Madhu ◽  
Benjamin G. Challis ◽  
Rogier ten Hoopen ◽  
...  
Keyword(s):  
Succinate Dehydrogenase ◽  
Germ Line ◽  
Wide Spectrum ◽  
Motion Artifact ◽  
Resonance Spectroscopy ◽  
Metabolomic Analysis ◽  
Stromal Tumors ◽  
Potential Applications ◽  
Disease Stratification

Purpose Mutations in the mitochondrial enzyme succinate dehydrogenase (SDH) subunit genes are associated with a wide spectrum of tumors, including pheochromocytomas and paragangliomas, GI stromal tumors, renal cell carcinomas, and pituitary adenomas. SDH-related tumorigenesis is believed to be secondary to accumulation of the oncometabolite succinate. Our aim was to investigate the potential clinical applications of proton-1 magnetic resonance spectroscopy (1H-MRS) in a range of suspected SDH-related tumors. Patients and Methods Fifteen patients were recruited to this study. Respiratory-gated single-voxel 1H-MRS was performed at 3T to quantify the content of succinate at 2.4 ppm and choline at 3.22 ppm. Results A succinate peak was seen in six patients, all of whom had germ line SDHx mutations or loss of SDHB by immunohistochemistry. Succinate peaks were also detected in two patients with metastatic wild-type GI stromal tumors and no detectable germ line SDHx mutations but with somatic epimutations in SDHC. Three patients without tumor succinate peaks retained SDHB expression, consistent with SDH functionality. In six patients with borderline or absent peaks, technical difficulties such as motion artifact rendered 1H-MRS difficult to interpret. Sequential imaging in a patient with a metastatic abdominal paraganglioma demonstrated loss of the succinate peak after four cycles of [177Lu]DOTATATE, with a corresponding biochemical response in normetanephrine. Conclusion This study has demonstrated the translation into clinical practice of in vivo metabolomic analysis using 1H-MRS in patients with SDH-deficient tumors. Potential applications include noninvasive diagnosis and disease stratification, as well as monitoring of tumor response to targeted treatments.

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