scholarly journals Analysis of solid-state heparin samples by ATR-FTIR spectroscopy

2019 ◽  
Author(s):  
Anthony Devlin ◽  
Courtney J. Mycroft-West ◽  
Marco Guerrini ◽  
Edwin A. Yates ◽  
Mark A. Skidmore
Keyword(s):  
Quality Control ◽  
Multivariate Analysis ◽  
Cost Effective ◽  
World Health Organisation ◽  
Essential Medicines ◽  
World Health ◽  
Sulphated Polysaccharides ◽  
H Nmr ◽  
Alternative Approach ◽  
Alternative Approaches

AbstractThe widely used anticoagulant pharmaceutical, heparin, is a polydisperse, heterogeneous polysaccharide. Heparin is one of the essential medicines defined by the World Health Organisation but, during 2007-2008, was the subject of adulteration. The intrinsic heterogeneity and variability of heparin makes it a challenge to monitor its purity by conventional means. This has led to the adoption of alternative approaches for its analysis and quality control, some of which are based on multivariate analysis of 1H NMR spectra, or exploit correlation techniques. Such NMR spectroscopy-based analyses, however, require costly and technically demanding NMR instrumentation. Here, an alternative approach based on the use of attenuated total reflectance Fourier transform infrared spectroscopy (FTIR-ATR) combined with multivariate analysis is proposed. FTIR-ATR employs more affordable and easy-to-use technology and, when combined with multivariate analysis of the resultant spectra, readily differentiates between glycosaminoglycans of different types, between heparin samples of distinct animal origins and enables the detection of both known heparin contaminants, such as over-sulphated chondroitin sulfate (OSCS), as well as other alien sulphated polysaccharides in heparin samples to a degree of sensitivity comparable to that achievable by NMR. The approach will permit the rapid and cost-effective monitoring of pharmaceutical heparin at any stage of the production process and indeed, in principle, the quality control of any heterogeneous or variable material.

Plain 1 H NMR Analysis Streamlines the Quality Control of Antiviral Favipiravir and Congeneric WHO Essential Medicines

2021 ◽  
Author(s):  
Prabhakar S. Achanta ◽  
Shao‐Nong Chen ◽  
Guido F. Pauli
Keyword(s):  
Quality Control ◽  
Essential Medicines ◽  
Nmr Analysis ◽  
H Nmr

scholarly journals Identification of factors associated with hand hygiene adherence as a support for creating curriculum for nurses training – a multivariate analysis

2020 ◽  
Vol 89 (3) ◽  
pp. e444
Author(s):  
Anna Garus-Pakowska
Keyword(s):  
Multivariate Analysis ◽  
Hand Hygiene ◽  
Infection Prevention ◽  
Participant Observation ◽  
Univariate Analysis ◽  
World Health Organisation ◽  
World Health ◽  
Important Conclusion ◽  
Average Value ◽  
Educational Programmes

Aim. Handwashing is the easiest way to prevent infection but is often neglected. The purpose of the study was to identify the barriers limiting the respect for hygiene procedures by nurses. Material and Methods. The study involved direct quasi-participant observation and a questionnaire of 11 nurses in six wards of three hospitals in Poland. Results. In total,1,195 observations were conducted in which 3,355 activities requiring hygiene procedures were observed over 8 months. The nurses’ knowledge of proper hand hygiene and infection prevention principles were unsatisfactory, with an average value of correct answers in the knowledge test of 8.7 (Max = 15). The univariate analysis indicated the following barriers in hand hygiene: emergencies, allergies, or too few dispensers. In multivariate analysis, the application of hygiene procedures depended on the level of education (higher education – worse compliance with the rules) and subjective conviction that handwashing/glove use was important. Conclusion. Educational programmes on hand hygiene should focus on the World Health Organisation indications that glove use is not a substitute for handwashing.

Quality Control Assessment of Dhatryadi Ghrita with HPTLC Method

2020 ◽  
Vol 8 (2) ◽  
pp. 104-108
Author(s):  
Rashmi Saxena Pal ◽  
Amrita Mishra
Keyword(s):  
Quality Control ◽  
Cost Effective ◽  
Sweet Taste ◽  
World Health ◽  
Research Article ◽  
Herbal Formulation ◽  
Therapeutic Value ◽  
Quality Check ◽  
Health Organization ◽  
Hptlc Method

Background: Standardization of herbal formulation is mandatory for the quality check of drugs for assurance of their therapeutic value. According to the World Health Organization reports, about 80% of the world’s population relies on traditional medicine. Dhatryadi Ghrita, a polyherbal preparation containing eleven ingredients, has a sweet taste, cold potency and sweet post-digestive effects. Objective: In this research article, quality control for ghrita has been assessed for some of the ingredients of Dhatryadi Ghrita. Materials & Methods: Quality control assessment was done with the aid of the HPTLC method. Precoated silica gel GF 254 was used as the stationary phase and the developed method used benzene:ethyl alcohol (9:1v/v). Scanning and quantification of the plates were performed at 254 nm and 366 nm. Result: The study confirms the presence of different constituents of Ghrita. Conclusion: routine analysis of Ghrita was facilitated with simple, accurate and cost-effective HPTLC method. Data has been provided to demonstrate the present and future applicability of the methods of quality control assessment of Dhatryadi Ghrita.

Essential medicines for palliative care

2015 ◽  
Author(s):  
Liliana De Lima ◽  
Lukas Radbruch ◽  
Eduardo Bruera
Keyword(s):  
Health Care ◽  
Palliative Care ◽  
International Association ◽  
Cost Effective ◽  
Access To Medicines ◽  
Essential Medicines ◽  
World Health ◽  
Care Needs ◽  
Health Organization ◽  
Hospice And Palliative Care

The essential medicines concept developed by the World Health Organization (WHO), states that there is a list of minimum medicines for a basic health-care system, including the most efficacious, safe, and cost-effective ones for priority conditions. According to the WHO, essential medicines are those that satisfy the primary health-care needs of the population. Thus, they should always be available, affordable, and cost-effective. However, the vast majority of the global population does not have access to essential medicines. Many organizations have called on governments to adopt policies to improve availability of these essential medicines and developed programmes and projects to increase awareness and knowledge. This chapter describes two such projects developed by the International Association for Hospice and Palliative Care (IAHPC), based on the essential medicines concept to improve access to medicines and appropriate palliative care: the IAHPC List of Essential Medicines in Palliative Care and the Opioid Essential Prescription Package.

Commissioning and evaluation of a radiochromic EBT3 film dosimetry system

2018 ◽  
Vol 18 (1) ◽  
pp. 55-62
Author(s):  
Muhammad Isa Khan ◽  
Muhammad Bilal Tahir ◽  
Muhammad Rafique ◽  
Tahir Iqbal ◽  
Sabiha Zulfiqar ◽  
...  
Keyword(s):  
Linear Accelerator ◽  
Cost Effective ◽  
World Health Organisation ◽  
Radiochromic Film ◽  
World Health ◽  
Film Dosimetry ◽  
Photon Beams ◽  
Output Measurement ◽  
Ionisation Chamber ◽  
Dosimetry System

AbstractPurposeThis work reports our study to commission a radiochromic film dosimetry system using the timely EBT3 film. We carried out dosimetric evaluations on different characteristics of photon beams (e.g., flatness, symmetry and penumbra) in radiation dose delivery.Materials and MethodsA Varian linear accelerator producing 6 and 15 MV photon beams with 120 multi-leaf collimator was used in this study. PTW ionisation chamber was used to measure the beam characteristics such as symmetry, flatness and penumbra and these measurements were used to commission the radiochormic EBT3 film dosimetry system. The results of irradiated films were analysed using the radiochromic film QA Pro software 2016.ResultsThe measured film doses were analysed at two different colour channels (green and red) using two scanning geometries (i.e., upper or lower side of film facing the scanner light source) at two dose levels (10 and 40 Gy). The difference between the ionisation chamber and film results was found insignificant and within the acceptable range as per the World Health Organisation standard.ConclusionResults of the comparison between the ionisation chamber and film measurements show that our radiochormic EBT3 film dosimetry system is reliable and cost-effective in the output measurement of a linear accelerator. Our measurements confirm that our EBT3 film dosimetry agreed well with the ionisation chamber, and can be used as a re-validation tool for linear accelerator quality control.

scholarly journals The contribution of mass drug administration to global health: past, present and future

2014 ◽  
Vol 369 (1645) ◽  
pp. 20130434 ◽  
Author(s):  
Joanne P. Webster ◽  
David H. Molyneux ◽  
Peter J. Hotez ◽  
Alan Fenwick
Keyword(s):  
Global Health ◽  
Drug Administration ◽  
Mass Drug Administration ◽  
Neglected Tropical Diseases ◽  
World Health Organisation ◽  
Essential Medicines ◽  
World Health ◽  
Diagnostic Tools ◽  
Preventive Chemotherapy ◽  
High Coverage

Mass drug administration (MDA) is a means of delivering safe and inexpensive essential medicines based on the principles of preventive chemotherapy, where populations or sub-populations are offered treatment without individual diagnosis. High-coverage MDA in endemic areas aims to prevent and alleviate symptoms and morbidity on the one hand and can reduce transmission on the other, together improving global health. MDA is the recommended strategy of the World Health Organisation to control or eliminate several neglected tropical diseases (NTDs). More than 700 million people now receive these essential NTD medicines annually. The combined cost of integrated NTD MDA has been calculated to be in the order of $0.50 per person per year. Activities have recently been expanded due, in part, to the proposed attempt to eliminate certain NTDs in the coming two decades. More than 1.9 billion people need to receive MDA annually across several years if these targets are to be met. Such extensive coverage will require additional avenues of financial support, expanded monitoring and evaluation focusing on impact and drug efficacy, as well as new diagnostic tools and social science strategies to encourage adherence. MDA is a means to help reduce the burden of disease, and hence poverty, among the poorest sector of populations. It has already made significant improvements to global health and productivity and has the potential for further successes, particularly where incorporated into sanitation and education programmes. However logistical, financial and biological challenges remain.

PS-039 Essential medicines by the world health organisation and their convenience in elderly patients

2017 ◽  
Author(s):  
R Fernández ◽  
D Sevilla Sanchez ◽  
H Del Rio Torres ◽  
C Codina Jané
Keyword(s):  
Elderly Patients ◽  
World Health Organisation ◽  
Essential Medicines ◽  
World Health ◽  
The World

scholarly journals The Relevance of Defined Daily Dose concept in Drug Utilisation Research: A Review

2021 ◽  
Vol 11 (4-S) ◽  
pp. 162-165
Author(s):  
Agnus Baiju ◽  
Rosmin Jacob ◽  
K. Krishnakumar
Keyword(s):  
Drug Utilisation ◽  
Anatomical Therapeutic Chemical ◽  
Cost Effective ◽  
World Health Organisation ◽  
Economic Consequences ◽  
World Health ◽  
Special Focus ◽  
Defined Daily Dose ◽  
Rational Drug ◽  
Daily Dose

According to World Health Organisation (WHO), drug utilisation is defined as the marketing, distribution, prescription and the use of drugs in society with special focus on resulting medical, social and economic consequences and it has turned into a powerful scientific tool for ensuring the rational and cost-effective use of drugs. A standard method is required to identify and aggregate drug data. This manuscript provides an overview of the WHO Anatomical Therapeutic Chemical (ATC) classification and the associated measure, Defined Daily Dose (DDD), as a methodology for evaluating drug utilisation. Keywords: Drug utilisation research, Anatomical Therapeutic Chemical classification system, Defined Daily Dose, Rational drug use.

scholarly journals Identification of Schistosoma mansoni eggs and other soil transmitted intestinal parasites in stool using Odongo-Aginya method

2019 ◽  
Author(s):  
John Paul Byagamy ◽  
Geoffrey Maxwell Malinga ◽  
Harriet Angwech ◽  
Richard Echodu ◽  
Emmanuel Igwaro Odongo-Aginya
Keyword(s):  
Cell Walls ◽  
Intestinal Parasites ◽  
Field Research ◽  
Cost Effective ◽  
World Health Organisation ◽  
World Health ◽  
Morphological Appearance ◽  
Immunodeficiency Virus ◽  
Long Time ◽  
Eggs And Larvae

Abstract Objective World Health Organisation recommends Kato-Katz technique for quantitative diagnosis of Schistosoma (S) mansoni and other soil transmitted intestinal parasites in field research. However, the prepared slides in Kato-Katz technique cannot be examined immediately and after 1 to 2 hours, the eggs of parasites with thin cell walls over clear in glycerine and morphology of the eggs are not preserved. These disadvantages are overcome using Odongo-Aginya method as illustrate by S. mansoni eggs and other soil transmitted intestinal parasites in stool in the results. Result The Odongo-Aginya method composed of compound stains of 7.5% nigrosin in 10% formalin and 0.5% eosin yellowin10% formalin mixed 1:1 ratio can be examined immediately. This method illustrated very clearly morphological appearance of S. mansoni and other soil transmitted intestinal parasites. This method showed a clear appearance of intestinal parasites eggs and larvae immediately after preparation and also after six weeks. The prepared slide also maintains the morphological appearance of the eggs even of the hookworm for a long time when the slides are kept in cool dry place. This method is reliable, reproducible, cost effective, easy to learn, quick and safe especially when handling specimens from Human Immunodeficiency virus infected patients.

scholarly journals Identifying the most effective essential medicines policies for quality use of medicines: A replicability study using three World Health Organisation data-sets

PLoS ONE ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. e0228201
Author(s):  
Kathleen Anne Holloway ◽  
Verica Ivanovska ◽  
Solaiappan Manikandan ◽  
Mathaiyan Jayanthi ◽  
Anbarasan Mohan ◽  
...  
Keyword(s):  
World Health Organisation ◽  
Essential Medicines ◽  
World Health ◽  
Data Sets ◽  
Quality Use Of Medicines
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