scholarly journals Revisiting Mitchell’s chemiosmotic theory in light of new stoichiometric reaction equations of ATPase II

2019 ◽  
Author(s):  
Arindam Kushagra
Keyword(s):  
Transmembrane Potential ◽  
Accurate Estimation ◽  
Chemiosmotic Theory ◽  
To Come ◽  
Reaction Stoichiometry ◽  
New Formulation ◽  
First Time ◽  
Atpase Ii ◽  
The Relationship ◽  
Reaction Equations

AbstractChemiosmotic theory has been reining the field of bioenergetics since its inception. As stoichiometric mechanisms of the underlying chemical reactions have now been elucidated, it calls for a revision in the relationships derived by Mitchell in his seminal review paper. Here in this work, new formulation of the relationship between the pH difference and transmembrane potential, as derived in light of modified ATPase II reaction stoichiometry, has been proposed for the first time. This formulation results in accurate estimation of dependence of transmembrane potential on the pH difference across the two sides of the mitochondrial membrane. Thus, this work is of potential interest and will enable researchers working in the field of bioenergetics involving chemiosmotic theory to come-up with more exact mechanistic explanations.

Estimating discharge in rivers through the combined use of dimensionless isovels and point velocity measurements

2017 ◽  
Vol 48 (3) ◽  
pp. 616-633 ◽  
Author(s):  
G. Farina ◽  
S. Alvisi ◽  
M. Franchini
Keyword(s):  
Cross Section ◽  
Cross Sections ◽  
Accurate Estimation ◽  
Velocity Measurements ◽  
Combined Use ◽  
Point Velocity ◽  
New Formulation ◽  
The Relationship ◽  
River Cross Section

This paper presents a procedure for estimating discharge in a river cross-section based on the combined use of dimensionless isovels and point velocity measurements. Specifically, taking the Biot–Savart law on the magnetic field induced by an electric current in a wire as their basis as already done by other researchers, the authors propose a new formulation of the relationship characterizing the effect of the wetted perimeter on the range of velocities in a cross-section in order to take explicit account of roughness, expressed by means of Manning's coefficient. Once appropriately nondimensionalized, the isoeffect contours can be read as dimensionless isovels. Assuming in situ velocity measurements are available, discharge at a cross-section can be computed using two different methods. The proposed procedure was applied to six case studies characterized by river cross-sections which differed greatly from one another. The results show that the two methods proposed for estimating discharge lead to equivalent outcomes, and in all the cases the procedure as a whole enables a sufficiently accurate estimation of discharge, even when it is based on a limited number of velocity measurements or on the measurement of maximum surface-water velocity alone.

scholarly journals Deep Light-field-driven Saliency Detection from a Single View

2019 ◽  
Author(s):  
Yongri Piao ◽  
Zhengkun Rong ◽  
Miao Zhang ◽  
Xiao Li ◽  
Huchuan Lu
Keyword(s):  
Light Field ◽  
Saliency Detection ◽  
Detection Methods ◽  
Geometric Information ◽  
Single View ◽  
Saliency Maps ◽  
Field Information ◽  
New Formulation ◽  
First Time ◽  
The Relationship

Previous 2D saliency detection methods extract salient cues from a single view and directly predict the expected results. Both traditional and deep-learning-based 2D methods do not consider geometric information of 3D scenes. Therefore the relationship between scene understanding and salient objects cannot be effectively established. This limits the performance of 2D saliency detection in challenging scenes. In this paper, we show for the first time that saliency detection problem can be reformulated as two sub-problems: light field synthesis from a single view and light-field-driven saliency detection. We propose a high-quality light field synthesis network to produce reliable 4D light field information. Then we propose a novel light-field-driven saliency detection network with two purposes, that is, i) richer saliency features can be produced for effective saliency detection; ii) geometric information can be considered for integration of multi-view saliency maps in a view-wise attention fashion. The whole pipeline can be trained in an end-to-end fashion. For training our network, we introduce the largest light field dataset for saliency detection, containing 1580 light fields that cover a wide variety of challenging scenes. With this new formulation, our method is able to achieve state-of-the-art performance.

scholarly journals The Man in the Balloon

2020 ◽  
Author(s):  
Valentine Ackland
Keyword(s):  
Romantic Attachment ◽  
Public Domain ◽  
The Public ◽  
Sylvia Townsend Warner ◽  
History Of ◽  
To Come ◽  
First Time ◽  
The Relationship

This article puts into the public domain for the first time a correspondence between Valentine Ackland and Elizabeth Wade White written in January 1951. The affair between the two women which had begun in 1938 ended in 1950, although they continued to correspond and occasionally meet until Ackland’s death in 1969. The letters were written when both women were struggling to come to terms with the end of their physical and romantic attachment and were deeply unhappy. In the letters each correspondent analyses the history of the relationship and the causes of the fracture between them. The letters and their attachments are remarkable representations of love and guilt, heartache and compassion. Their publication adds to our knowledge of an affair which had repercussions for the lives not only of Ackland and Wade White but also for those of their life partners: Sylvia Townsend Warner and Evelyn Holahan.

Affirmative Action and Leadership Attitudes in Brazilian Women Managers

2011 ◽  
Vol 10 (3) ◽  
pp. 139-143 ◽  
Author(s):  
Gazi Islam ◽  
Sarah E. S. Zilenovsky
Keyword(s):  
Affirmative Action ◽  
Latin American ◽  
Women Managers ◽  
Psychological Effects ◽  
Preferential Selection ◽  
Justice Perceptions ◽  
First Time ◽  
The Relationship

This note examines the relationship between affirmative action (AA) program perceptions and women’s self-ascribed capacity and desire to become leaders. We propose that women who believe that their organization implements a program of preferential selection toward women will experience negative psychological effects leading to lowered self-expectations for leadership, but that this effect will be moderated by their justice perceptions of AA programs. We test this proposition empirically for the first time with a Latin American female sample. Among Brazilian women managers, desire but not self-ascribed capacity to lead was reduced when they believed an AA policy was in place. Both desire’s and capacity’s relationships with belief in an AA policy were moderated by justice perceptions.

Cinematic Search for Identity in the Shade of Turkey’s 1960 Coup: The Social Realism Debate and The Hope

2017 ◽  
Vol 6 (1) ◽  
pp. 153-168
Author(s):  
Celal Hayir ◽  
Ayman Kole
Keyword(s):  
Party System ◽  
Social Realism ◽  
New Era ◽  
Cultural Life ◽  
The Social ◽  
Turkish Cinema ◽  
To Come ◽  
First Time ◽  
Democratic Constitution ◽  
Realism Debate

When the Turkish army seized power on May 27th, 1960, a new democratic constitution was carried into effect. The positive atmosphere created by the 1961 constitution quickly showed its effects on political balances in the parliament and it became difficult for one single party to come into power, which strengthened the multi-party-system. The freedom initiative created by 1961’s constitution had a direct effect on the rise of public opposition. Filmmakers, who generally steered clear from the discussion of social problems and conflicts until 1960, started to produce movies questioning conflicts in political, social and cultural life for the first time and discussions about the “Social Realism” movement in the ensuing films arose in cinematic circles in Turkey. At the same time, the “regional managers” emerged, and movies in line with demands of this system started to be produced. The Hope (Umut), produced by Yılmaz Güney in 1970, rang in a new era in Turkish cinema, because it differed from other movies previously made in its cinematic language, expression, and use of actors and settings. The aim of this study is to mention the reality discussions in Turkish cinema and outline the political facts which initiated this expression leading up to the film Umut (The Hope, directed by Yılmaz Güney), which has been accepted as the most distinctive social realist movie in Turkey. 

ЗУБРЫ НА СЕВЕРЕ РОССИИ — НАСТОЯЩЕЕ И БУДУЩЕЕ

2019 ◽  
pp. 42-44
Author(s):  
I.V. GUSAROV ◽  
V.A. OSTAPENKO ◽  
T.V. NOVIKOVА
Keyword(s):  
Biological Diversity ◽  
Climatic Conditions ◽  
Economic Consequences ◽  
European Bison ◽  
Rare And Endangered Species ◽  
The North ◽  
Rare And Endangered ◽  
Relationship Of ◽  
First Time ◽  
The Relationship

Впервые в мире создана популяция зубров на территории 60 градусов северной широты. В новых климатических условиях разведения и сохранения зубров определены и проанализированы факторы существования вида на севере Европейской части РФ. Выявлены признаки, динамика численности, которые являются составной частью системы, предназначенной для управления биоразнообразием. Интродукция, являясь процессом введения в экосистему нехарактерных для нее видов, может усиливать изменения биоценозов как положительно, так и отрицательно. Насколько быстро и успешно проходит процесс адаптации заселенного вида, и усматривается его влияние на окружающую среду зависит дальнейшее существование зубров и в целом биоразнообразия. В статье обсуждаются вопросы взаимоотношения зубров с другими видами копытных и хозяйственной деятельностью человека, а также дальнейшим использованием зубров в сельскохозяйственном производстве. Пластичность зубров, выявление изменений и их анализ при вселении видов в новые условия обитания необходимы не только для определения развития или деградации биоценозов и в целом экосистемы, но и прогноза социально-экономических последствий интродукции как одного из методов сохранения редких и исчезающих видов фауны.For the first time in the world, a bison population has been created in an area of 60 degrees north latitude. In the new climatic conditions of breeding and preservation of bison, the factors of the species existence in the north of the European part of the Russian Federation are identified and analyzed. The signs, dynamics of abundance, which are an integral part of the system designed to manage biodiversity are identified, since the preservation of biological diversity on the planet is one of the main problems of our time. Introduction, being the process of introducing non-typical species into an ecosystem, can enhance changes in biocenoses, both positively and negatively. The question posing sounds especially when it comes to such a large hoofed animal as the European bison. How quickly and successfully the process of adaptation of the universe takes place and its environmental impact is seen depends on the continued existence of bison and biodiversity in general. The article discusses the relationship of bison with other types of ungulates and human activities, as well as the further use of bison in agricultural production. How these issues will be resolved positively depends on the future of these animals. Thus, the plasticity of bison, the identification of changes and their analysis, with the introduction of species into new habitat conditions is necessary not only to determine the development or degradation of biocenoses and the ecosystem as a whole, but also to predict the socio-economic consequences due to the introduction as one of the methods of preserving rare and endangered species of fauna.

A University Education

2017 ◽  
Author(s):  
David Willetts
Keyword(s):  
Higher Education ◽  
Modern Society ◽  
University Education ◽  
Modern World ◽  
Controversial Issues ◽  
The Us ◽  
The Individual ◽  
The University ◽  
First Time ◽  
The Relationship

Universities have a crucial role in the modern world. In England, entrance to universities is by nation-wide competition which means English universities have an exceptional influence on schools--a striking theme of the book. This important book first investigates the university as an institution and then tracks the individual on their journey to and through university. In A University Education, David Willetts presents a compelling case for the ongoing importance of the university, both as one of the great institutions of modern society and as a transformational experience for the individual. The book also makes illuminating comparisons with higher education in other countries, especially the US and Germany. Drawing on his experience as UK Minister for Universities and Science from 2010 to 2014, the author offers a powerful account of the value of higher education and the case for more expansion. He covers controversial issues in which he was involved from access for disadvantaged students to the introduction of L9,000 fees. The final section addresses some of the big questions for the future, such as the the relationship between universities and business, especially in promoting innovation.. He argues that the two great contemporary trends of globalisation and technological innovation will both change the university significantly. This is an authoritative account of English universities setting them for the first time in their new legal and regulatory framework.

Intellectual Difficulty and Moral Responsibility

2017 ◽  
Keyword(s):  
Moral Responsibility ◽  
To Come ◽  
The Relationship

This chapter considers the relationship between intellectual difficulty and moral responsibility. It focuses on this question: if it is difficult for us to come to believe the truth about some matter, and we do not in fact come to believe it, so that we are ignorant of that matter, does that affect our responsibility if we then act from our ignorance? Answering this question requires getting clearer on both intellectual difficulty and moral responsibility for actions done from ignorance. This chapter takes up both tasks, distinguishing three different kinds of intellectual difficulty—skill-related difficulty in performing, effort-related difficulty in performing, and difficulty in trying—and two different families of views regarding moral responsibility: agential control views and agential revelation views. The chapter then considers the interaction between these different kinds of intellectual difficulty and these different views of moral responsibility, focusing particularly on the familiar case of the Ancient Slaveholder.

scholarly journals Variation in VKORC1 Is Associated with Vascular Dementia

2021 ◽  
Vol 80 (3) ◽  
pp. 1329-1337
Author(s):  
Jure Mur ◽  
Daniel L. McCartney ◽  
Daniel I. Chasman ◽  
Peter M. Visscher ◽  
Graciela Muniz-Terrera ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Vascular Dementia ◽  
Genetic Variant ◽  
Warfarin Dose ◽  
Uk Biobank ◽  
Parental History ◽  
Genome Wide ◽  
History Of ◽  
First Time ◽  
The Relationship

Background: The genetic variant rs9923231 (VKORC1) is associated with differences in the coagulation of blood and consequentially with sensitivity to the drug warfarin. Variation in VKORC1 has been linked in a gene-based test to dementia/Alzheimer’s disease in the parents of participants, with suggestive evidence for an association for rs9923231 (p = 1.8×10–7), which was included in the genome-wide significant KAT8 locus. Objective: Our study aimed to investigate whether the relationship between rs9923231 and dementia persists only for certain dementia sub-types, and if those taking warfarin are at greater risk. Methods: We used logistic regression and data from 238,195 participants from UK Biobank to examine the relationship between VKORC1, risk of dementia, and the interplay with warfarin use. Results: Parental history of dementia, APOE variant, atrial fibrillation, diabetes, hypertension, and hypercholesterolemia all had strong associations with vascular dementia (p < 4.6×10–6). The T-allele in rs9923231 was linked to a lower warfarin dose (βperT - allele = –0.29, p < 2×10–16) and risk of vascular dementia (OR = 1.17, p = 0.010), but not other dementia sub-types. However, the risk of vascular dementia was not affected by warfarin use in carriers of the T-allele. Conclusion: Our study reports for the first time an association between rs9923231 and vascular dementia, but further research is warranted to explore potential mechanisms and specify the relationship between rs9923231 and features of vascular dementia.

scholarly journals ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis

2021 ◽  
Vol 22 (9) ◽  
pp. 4691
Author(s):  
Anastasia V. Poznyak ◽  
Evgeny E. Bezsonov ◽  
Ali H. Eid ◽  
Tatyana V. Popkova ◽  
Ludmila V. Nedosugova ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Renin Angiotensin System ◽  
Myocardial Damage ◽  
Angiotensin Converting Enzyme 2 ◽  
Adjacent Element ◽  
Chinese Province ◽  
Coronavirus Infection ◽  
First Time ◽  
The Relationship ◽  
Interspecies Barrier

COVID-19 is a highly contagious new infection caused by the single-stranded RNA Sars-CoV-2 virus. For the first time, this infection was recorded in December 2019 in the Chinese province of Wuhan. The virus presumably crossed the interspecies barrier and passed to humans from a bat. Initially, the disease was considered exclusively in the context of damage to the respiratory system, but it quickly became clear that the disease also entails serious consequences from various systems, including the cardiovascular system. Among these consequences are myocarditis, myocardial damage, subsequent heart failure, myocardial infarction, and Takotsubo syndrome. On the other hand, clinical data indicate that the presence of chronic diseases in a patient aggravates the course and outcome of coronavirus infection. In this context, the relationship between COVID-19 and atherosclerosis, a condition preceding cardiovascular disease and other disorders of the heart and blood vessels, is particularly interesting. The renin-angiotensin system is essential for the pathogenesis of both coronavirus disease and atherosclerosis. In particular, it has been shown that ACE2, an angiotensin-converting enzyme 2, plays a key role in Sars-CoV-2 infection due to its receptor activity. It is noteworthy that this enzyme is important for the normal functioning of the cardiovascular system. Disruptions in its production and functioning can lead to various disorders, including atherosclerosis.

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