Electronic circuit system of high sensitivity mass detection for QCM-biosensor

Structure and principle of the new leakage current particulate matter (PM) sensor are introduced and further study is performed on the PM sensor with the combination of numerical simulation and bench test. High voltage electrode, conductive shell, and heaters are all built-in. Based on the principle of Venturi tube and maze structure design, this sensor can detect transient PM concentrations. Internal flow field of the sensor and distribution condition of PM inside the sensor are analyzed through gas-solid two-phase flow numerical simulation. The experiment was also carried out on the whole sensor system (including mechanical and electronic circuit part) and the output signals were analyzed. The results of simulation and experiment reveal the possibility of PM concentration (mass) detection by the sensor.

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Electromechanical model of a resonating nano-cantilever-based sensor for high-resolution and high-sensitivity mass detection

Nanotechnology ◽

10.1088/0957-4484/12/2/305 ◽

2001 ◽

Vol 12 (2) ◽

pp. 100-104 ◽

Cited By ~ 83

Author(s):

G Abadal ◽

Z J Davis ◽

B Helbo ◽

X Borrisé ◽

R Ruiz ◽

...

Keyword(s):

High Resolution ◽

High Sensitivity ◽

Mass Detection ◽

Electromechanical Model

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Prototype of Frame-Type Cantilever for Biosensor and Femtogram Detection

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.459.134 ◽

2010 ◽

Vol 459 ◽

pp. 134-139 ◽

Cited By ~ 2

Author(s):

Hayato Sone ◽

Shoichi Ichikawa ◽

Yuji Matsubara ◽

Mitsumasa Suzuki ◽

Haruki Okano ◽

...

Keyword(s):

Gold Film ◽

Fem Simulation ◽

High Sensitivity ◽

Film Deposition ◽

Frequency Change ◽

Mass Detection ◽

Atomic Force ◽

Highly Sensitive ◽

Resonance Frequencies ◽

Conventional Type

The possibility of realizing femtogram mass detection using a frame-type microcantilever has been studied in bioscience. To realize highly sensitive mass detection by reducing the viscose resistance in liquids, we designed frame-type cantilevers using finite element modeling (FEM). We fabricated prototypes of mesh-type, hole-type and conventional-type cantilevers using a semiconductor process. The properties of the cantilevers were measured by a conventional atomic force microscope (AFM) system. The measured resonance frequencies of the cantilevers were almost consistent with the calculated results of the FEM simulation in air. The resonance frequency and quality (Q) factor of the mesh-type cantilever were larger than those of the conventional-type cantilever in water. We measured the frequency change due to gold film deposition on the mesh-type cantilever. Then, we estimated the mass sensitivity of the cantilever at about 16.6 fg/Hz. This value is more than 10 times smaller than that of the conventional-type cantilever. These results indicate that the mesh-type cantilever has the advantage of reducing the viscous resistance and achieving high sensitivity in liquids.

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Carbone Monoxide (CO) Detection Device Based on the Nickel Antimonate Oxide and a DC Electronic Circuit

Applied Sciences ◽

10.3390/app9183799 ◽

2019 ◽

Vol 9 (18) ◽

pp. 3799

Author(s):

José Trinidad Guillen Bonilla ◽

Héctor Guillén Bonilla ◽

Verónica María Rodríguez Betancourtt ◽

Antonio Casillas Zamora ◽

Jorge Alberto Ramírez Ortega ◽

...

Keyword(s):

Electronic Circuit ◽

Chemical Sensor ◽

Electrical Response ◽

High Sensitivity ◽

Optimal Operation ◽

Oxide Powders ◽

Co Detection ◽

Electronic Circuit Implementation ◽

Co Gas

Carbon monoxide (CO) is very toxic to health. CO gas can cause intoxication and even death when the concentration is high or there are long exposure times. To detect atmospheres with CO gas concentration detectors are placed. In this work, a novel CO detection device was proposed and applied for CO detection. For its implementation, four stages were developed: Synthesis of nickel antimonite (NiSb2O6) oxide powders, physical characterization of NiSb2O6 powders, Pellet fabrication and sensitivity test in CO atmospheres and electronic circuit implementation where signal adaptation and signal amplification were considered. Experimentally, a chemical sensor was built and characterized, its signal adaptation circuit was implemented and also it was proved using CO concentrations from 1 to 300 ppm with the operating temperatures of 100, 200, and 300 °C. Its optimal operation was at 300 °C. From the experimental results, the CO detection device had excellent functionality because the chemical sensor based on the nickel antimonite oxide had high sensitivity and good electrical response, whereas the DC electronic circuit had good performance.

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High-Sensitivity Dual Electrochemical QCM for Reliable Three-Electrode Measurements

Sensors ◽

10.3390/s21082592 ◽

2021 ◽

Vol 21 (8) ◽

pp. 2592

Author(s):

Dávid Tóth ◽

Manuel Kasper ◽

Ivan Alic ◽

Mohamed Awadein ◽

Andreas Ebner ◽

...

Keyword(s):

Quartz Crystal ◽

Complex Impedance ◽

High Sensitivity ◽

Electrochemical Quartz Crystal Microbalance ◽

Dissipative Medium ◽

Mass Detection ◽

Multiple Electrodes ◽

Rigid Mass ◽

Energy Storage Applications

An electrochemical quartz crystal microbalance (EC-QCM) is a versatile gravimetric technique that allows for parallel characterization of mass deposition and electrochemical properties. Despite its broad applicability, simultaneous characterization of two electrodes remains challenging due to practical difficulties posed by the dampening from fixture parasitics and the dissipative medium. In this study, we present a dual electrochemical QCM (dual EC-QCM) that is employed in a three-electrode configuration to enable consequent monitoring of mass deposition and viscous loading on two crystals, the working electrode (WE) and the counter electrode (CE). A novel correction approach, along with a three standard complex impedance calibration, is employed to overcome the effect of dampening while keeping high spectral sensitivity. Separation of viscous loading and rigid mass deposition is achieved by robust characterization of the complex impedance at the resonance frequency. Validation of the presented system is done by cyclic voltammetry characterization of Ag underpotential deposition on gold. The results indicate mass deposition of 412.2 ng for the WE and 345.6 ng for the CE, reflecting a difference of the initially-present Ag adhered to the surface. We also performed higher harmonic measurements that further corroborate the sensitivity and reproducibility of the dual EC-QCM. The demonstrated approach is especially intriguing for electrochemical energy storage applications where mass detection with multiple electrodes is desired.

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Pengaruh Medan Listrik Terhadap Komponen Elektronik

Jurnal Ilmiah Poli Rekayasa ◽

10.30630/jipr.14.1.110 ◽

2018 ◽

Vol 14 (1) ◽

pp. 13

Author(s):

Amril -

Keyword(s):

Electromagnetic Induction ◽

Electronic Circuit ◽

High Sensitivity ◽

Test Point ◽

Induction Effect ◽

Test Article ◽

Study Results ◽

Impulse Voltage ◽

Sensitivity Rate ◽

High Sensitivity Rate

This research reviewed the effect of induction voltage resulting of the electromagnetic induction from the thunderbolt attack to the electronic equipment especially if the induction effect to the component has a high sensitivity rate that was IC CMOS component. In this study the experiments done in the laboratory of High Voltage Technique where the impulse voltage as a simulation to the thunderbolt external voltage surge for the Electronic circuit. Experiment I the distance component of the test article to the test point was 5 cm with the impulse voltage of 99.3 kV, induction voltage 158.41 V, Experiment II with the distance of 7.5 cm, the impulse voltage 88.3 kV so the induction voltage 105.62 V IC, in the experiment III the distance of the test article was 10 cm from the test point. The impulse voltage 88.3 kV and the induction voltage was 79.2 V, In the experiment IV the component distance was 15 cm. the impulse voltage 88.3 kV and the induction voltage as big as 52.74 V.From each experiment IC make damage, where distance component from each experiment settled more distant so component no make damage. From the measurement and calculation yields then the induction voltage resulted will damage the IC component conformed to the yield presented by Hasse in the table 2.1 where the component CMOS 70-100V. Where the study results proved that the electromagnetic induction from indirect thunderbolt attach can result an interference and damage to the electronic component tested, as the distance between the component and the ball gap to the impulse tension was very influential in determining of damaged mechanism of IC in self.

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Atomic-Scale Finite Element Method for Analyzing the Sensitivity of Graphyne-Based Resonators

Journal of Nanomaterials ◽

10.1155/2018/2580171 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6

Author(s):

Haw-Long Lee ◽

Yu-Ching Yang ◽

Win-Jin Chang

Keyword(s):

Finite Element Method ◽

Finite Element ◽

Boundary Conditions ◽

High Sensitivity ◽

Atomic Scale ◽

Mass Detection ◽

Attached Mass ◽

Different Boundary Conditions ◽

Future Design ◽

Element Method

An atomic-scale finite element method was applied to analyze the sensitivities of α-, β-, γ-, and 6,6,12-graphyne-based resonators in mass detection under different boundary conditions. These sensitivities are then compared with that of a graphene-based resonator obtained in a previous study. According to the analysis results, among the graphyne-based resonators, the α type shows the highest sensitivity, while the γ type shows the lowest. In addition, the sensitivity decreases as the resonator size increases. We also find that the location of the attached mass has a significant effect on the sensitivity of the γ-graphyne-based resonators with different attached masses. The α-graphyne-based resonator with a small attached mass is also sensitive to change in location. However, the situation is different for a large attached mass. This study is significant for the future design and application of a graphyne-based resonator with high sensitivity.

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Development of determination methods of quetiapine fumarate for forensic-pharmaceutical purposes

ScienceRise Pharmaceutical Science ◽

10.15587/2519-4852.2021.228132 ◽

2021 ◽

pp. 4-12

Author(s):

Olena Bevz ◽

Igor Sych ◽

Angelina Shaposhnyk ◽

Irina Sych ◽

Olga Kryvanych ◽

...

Keyword(s):

Uv Light ◽

Generic Drugs ◽

High Sensitivity ◽

Ammonia Solution ◽

Mass Detection ◽

Quetiapine Fumarate ◽

Forensic Examination ◽

Mass Spectrometric Detector ◽

Thermo Fisher Scientific ◽

Dragendorff Reagent

Quetiapine fumarate (an antipsychotic) is part of numerous generic drugs that are in fairly wide demand among the population, therefore, more and more data appear on the counterfeiting and smuggling of funds, as well as non-medical use, which are life-threatening for the population and explain the high prevalence of the active ingredient as object of forensic examination. The aim. To develop an algorithm for conducting a forensic pharmaceutical examination and propose a method for determining quetiapine fumarate for forensic pharmaceutical purposes. Materials and methods. All studies were performed using reagents that meet the EP, USP and USPU requirements, Class A glassware and qualified devices. Identification by IR spectroscopy was performed in the range from 500 to 4000 cm-1 on the device “Nicolet 380 FT-IR Spectrometer by Thermo Fisher Scientific” using a prefix “Smart Perfomer” with a ZnSe crystal. The UV absorption spectra of the solutions were recorded using a Specord 205 spectrophotometer from Analytik Jena AG (Germany). TLC was performed on Merck chromatographic plates (silica gel 60G F254, Germany). The following systems were used as mobile phases: hexane – acetone – 25 % ammonia solution (60: 40: 2); methanol – 25 % ammonia solution (100: 1.5), hexane – acetone – 25 % ammonia solution (50: 45: 5). Detection was performed under UV light (254 nm), followed by spraying with Dragendorff reagent. Analysis by gas chromatography with mass detection was performed using a GC gas chromatograph with a mass spectrometric detector GCMS-QP2020. Data were analyzed using the program: GCMSsolution, LabSolutions Insight (Shimadzu Corporation, Tokyo, Japan). Results. An algorithm for conducting a forensic pharmaceutical examination in accordance with the current legislation of Ukraine has been developed, methods for determining quetiapine for forensic pharmaceutical purposes have been proposed. Conclusions. The developed methods for determining quetiapine meet the requirements of the current legislation of Ukraine and the Ministry of Justice of Ukraine. The obtained data prove the high sensitivity and reproducibility of the methods and prove the possibility of their introduction into the practice of forensic examination

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Development of a Highly Sensitive Humidity Sensor Based on a Piezoelectric Micromachined Ultrasonic Transducer Array Functionalized with Graphene Oxide Thin Film

Sensors ◽

10.3390/s18124352 ◽

2018 ◽

Vol 18 (12) ◽

pp. 4352 ◽

Cited By ~ 9

Author(s):

Changhe Sun ◽

Qiongfeng Shi ◽

Mahmut Yazici ◽

Chengkuo Lee ◽

Yufei Liu

Keyword(s):

Graphene Oxide ◽

Humidity Sensor ◽

Ultrasonic Transducer ◽

Simultaneous Detection ◽

High Sensitivity ◽

Relative Sensitivity ◽

Fast Response ◽

Structure Design ◽

Oxide Thin Film ◽

Mass Detection

A novel relative humidity sensor that is based on a linear piezoelectric micromachined ultrasonic transducer (pMUT) array was proposed and microfabricated for high sensitivity, fast response, and good stability. The humidity-sensitive graphene oxide (GO) film was deposited on the pMUT array with a facile drop-casting method and characterized by scanning electron microscope (SEM), atomic force microscope (AFM), and Fourier transform infrared spectrum (FTIR). With the humidity level ranging from 10% to 90% RH, the sensor exhibited a high sensitivity of 719 Hz/% RH and an extremely high relative sensitivity of 271.1 ppm/% RH. The humidity-sensing results also showed good short-term repeatability and long-term stability, fast response and recovery, and low hysteresis. Moreover, the temperature coefficient of frequency (TCF) of the present humidity sensor was investigated and it could be easily compensated owing to the pMUT array structure design. This work confirmed that the GO functionalized pMUT is an excellent candidate in humidity detection and it may enable many potential applications, such as ultrasensitive mass detection and simultaneous detection of multiple parameters.

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Use of Molecular Methods for the Rapid Mass Detection ofSchistosoma mansoni(Platyhelminthes: Trematoda) inBiomphalariaspp. (Gastropoda: Planorbidae)

Journal of Tropical Medicine ◽

10.1155/2017/8628971 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 13

Author(s):

Roberta Lima Caldeira ◽

Liana Konovaloffi Jannotti-Passos ◽

Omar Dos Santos Carvalho

Keyword(s):

Low Cost ◽

High Sensitivity ◽

Cost Effective ◽

Trematode Species ◽

Intermediate Hosts ◽

Mass Detection ◽

Molecular Approaches ◽

Polymerase Chain ◽

Low Prevalence ◽

Pooled Samples

The low stringency-polymerase chain reaction (LS-PCR) and loop-mediated isothermal amplification (LAMP) assays were used to detect the presence ofS. mansoniDNA in (1) Brazilian intermediate hosts (Biomphalaria glabrata,B. straminea,andB. tenagophila) with patentS. mansoniinfections, (2)B. glabratasnails with prepatentS. mansoniinfections, (3) various mixtures of infected and noninfected snails; and (4) snails infected with other trematode species. The assays showed high sensitivity and specificity and could detectS. mansoniDNA when one positive snail was included in a pool of 1,000 negative specimens ofBiomphalaria. These molecular approaches can provide a low-cost, effective, and rapid method for detecting the presence ofS. mansoniin pooled samples of field-collectedBiomphalaria. These assays should aid mapping of transmission sites in endemic areas, especially in low prevalence regions and improve schistosomiasis surveillance. It will be a useful tool to monitor low infection rates of snails in areas where control interventions are leading towards the elimination of schistosomiasis.

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