Massive-MIMO and Digital mm-Wave Arrays on RF-SoCs using FDM for M-Fold Increase in Antennas per ADC/DAC

AirfugeR (Beckman) direct ultracentrifugation of viral samples on electron microscopy grids offers a rapid way to concentrate viral particles or subunits and facilitate their detection and study. Using the A-100 fixed angle rotor (30°) with a K factor of 19 at maximum speed (95 000 rpm), samples up to 240 μl can be prepared for electron microscopy observation in a few minutes: observation time is decreased and structural details are highlighted. Using latex spheres to calculate the increase in sensitivity compared to the inverted drop procedure, we obtained a 10 to 40 fold increase in sensitivity depending on the size of particles. This technique also permits quantification of viral particles in samples if an aliquot is mixed with latex spheres of known concentration.Direct ultracentrifugation for electron microscopy can be performed on laboratory samples such as gradient or column fractions, infected cell supernatant, or on clinical samples such as urine, tears, cephalo-rachidian liquid, etc..

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Advantages of Complementary Stereo Images as Viewed with the Low-Temperature Field-Emission SEM

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100131206 ◽

1992 ◽

Vol 50 (2) ◽

pp. 1314-1315

Author(s):

William P. Wergin ◽

Eric F. Erbe

Keyword(s):

Fold Increase ◽

Horizontal Displacement ◽

Three Dimensions ◽

Stereo Image ◽

Stereo Pair ◽

Sem Micrograph ◽

Left And Right ◽

The Common ◽

The Brain ◽

Pair Analysis

The eye-brain complex allows those of us with normal vision to perceive and evaluate our surroundings in three-dimensions (3-D). The principle factor that makes this possible is parallax - the horizontal displacement of objects that results from the independent views that the left and right eyes detect and simultaneously transmit to the brain for superimposition. The common SEM micrograph is a 2-D representation of a 3-D specimen. Depriving the brain of the 3-D view can lead to erroneous conclusions about the relative sizes, positions and convergence of structures within a specimen. In addition, Walter has suggested that the stereo image contains information equivalent to a two-fold increase in magnification over that found in a 2-D image. Because of these factors, stereo pair analysis should be routinely employed when studying specimens.Imaging complementary faces of a fractured specimen is a second method by which the topography of a specimen can be more accurately evaluated.

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Prevalence of Self-Reported Depression Symptoms and Perceived Anxiety Among Community-Dwelling U.S. Adults Reporting Tinnitus

Perspectives of the ASHA Special Interest Groups ◽

10.1044/2020_persp-19-00178 ◽

2020 ◽

Vol 5 (4) ◽

pp. 959-970

Author(s):

Kelly M. Reavis ◽

James A. Henry ◽

Lynn M. Marshall ◽

Kathleen F. Carlson

Keyword(s):

Mental Health ◽

Fold Increase ◽

Community Dwelling ◽

Self Report ◽

Depression Symptoms ◽

Community Based Interventions ◽

Data Set ◽

Health Distress ◽

Validated Questionnaire ◽

Mental Health Distress

Purpose The aim of this study was to examine the relationship between tinnitus and self-reported mental health distress, namely, depression symptoms and perceived anxiety, in adults who participated in the National Health and Nutrition Examinations Survey between 2009 and 2012. A secondary aim was to determine if a history of serving in the military modified the associations between tinnitus and mental health distress. Method This was a cross-sectional study design of a national data set that included 5,550 U.S. community-dwelling adults ages 20 years and older, 12.7% of whom were military Veterans. Bivariable and multivariable logistic regression was used to estimate the association between tinnitus and mental health distress. All measures were based on self-report. Tinnitus and perceived anxiety were each assessed using a single question. Depression symptoms were assessed using the Patient Health Questionnaire, a validated questionnaire. Multivariable regression models were adjusted for key demographic and health factors, including self-reported hearing ability. Results Prevalence of tinnitus was 15%. Compared to adults without tinnitus, adults with tinnitus had a 1.8-fold increase in depression symptoms and a 1.5-fold increase in perceived anxiety after adjusting for potential confounders. Military Veteran status did not modify these observed associations. Conclusions Findings revealed an association between tinnitus and both depression symptoms and perceived anxiety, independent of potential confounders, among both Veterans and non-Veterans. These results suggest, on a population level, that individuals with tinnitus have a greater burden of perceived mental health distress and may benefit from interdisciplinary health care, self-help, and community-based interventions. Supplemental Material https://doi.org/10.23641/asha.12568475

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1348: Sildenafil Citrat Causes a 3 Fold Increase in Periurethral Prostatic Blood Flow

The Journal of Urology ◽

10.1016/s0022-5347(18)38573-2 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 355-355 ◽

Cited By ~ 4

Author(s):

Germar M. Pinggera ◽

Antonius Schuster ◽

Ferdinand Frauscher ◽

Georg Bartsch ◽

Hannes Strasser

Keyword(s):

Blood Flow ◽

Fold Increase

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Increased Expression of u-PA and u-PAR on Monocytes by LDL and Lp(a) Lipoproteins – Consequences for Plasmin Generation and Monocyte Adhesion

Thrombosis and Haemostasis ◽

10.1055/s-0037-1614531 ◽

1999 ◽

Vol 81 (04) ◽

pp. 594-560 ◽

Cited By ~ 10

Author(s):

Florence Ganné ◽

Marc Vasse ◽

Jean-Louis Beaudeu ◽

Jacqueline Peynet ◽

Arnaud François ◽

...

Keyword(s):

Fold Increase ◽

Surface Expression ◽

Cell Surface Expression ◽

Atheromatous Plaque ◽

Monocyte Adhesion ◽

Blood Monocytes ◽

Proteolytic Cascade ◽

Ecm Degradation ◽

Dose Dependent Increase ◽

Dose Dependent

SummaryMonocyte-derived foam cells figure prominently in rupture-prone regions of atherosclerotic plaque. As urokinase/urokinase-receptor (u-PA/u-PAR) is the trigger of a proteolytic cascade responsible for ECM degradation, we have examined the effect of atherogenic lipoproteins on monocyte surface expression of u-PAR and u-PA. Peripheral blood monocytes, isolated from 10 healthy volunteers, were incubated with 10 to 200 µg/ml of native or oxidised (ox-) atherogenous lipoproteins for 18 h and cell surface expression of u-PA and u-PAR was analysed by flow cytometry. Both LDL and Lp(a) induced a dose-dependent increase in u-PA (1.6-fold increase with 200 μg/ml of ox-LDL) and u-PAR [1.7-fold increase with 200 μg/ml of ox-Lp(a)]. There is a great variability of the response among the donors, some of them remaining non-responders (absence of increase of u-PA or u-PAR) even at 200 μg/ml of lipoproteins. In positive responders, enhanced u-PA/u-PAR is associated with a significant increase of plasmin generation (1.9-fold increase with 200 μg/ml of ox-LDL), as determined by an amidolytic assay. Furthermore, monocyte adhesion to vitronectin and fibrinogen was significantly enhanced by the lipoproteins [respectively 2-fold and 1.7-fold increase with 200 μg/ml of ox-Lp(a)], due to the increase of u-PAR and ICAM-1, which are receptors for vitronectin and fibrinogen. These data suggest that atherogenous lipoproteins could contribute to the development of atheromatous plaque by increasing monocyte adhesion and trigger plaque weakening by inducing ECM degradation.

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The Effect of Haematoporphyrin Derivative on the Uptake of 67Ga, 59Fe and 65Zn in Tumours

Nuklearmedizin ◽

10.1055/s-0037-1620704 ◽

1978 ◽

Vol 17 (06) ◽

pp. 262-265

Author(s):

A. Phillips Carol ◽

D.M. Taylor

Keyword(s):

Fold Increase ◽

Haematoporphyrin Derivative ◽

Tumour Bearing ◽

Rats And Mice ◽

Prior Administration

The effect of prior administration of haematoporphyrin derivative on the uptake in tumours of 67Ga, 59Fe and 65Zn has been studied in tumour-bearing rats and mice. An approximately two-fold increase in the uptake of 67Ga was observed in the August 15 rat tumour when the nuclide was administered 17 to 24 hr after haematoporphyrin. No increase in the uptake of 67Ga occurred in three mouse tumours. Haematoporphyrin administration did not affect the uptake of 65Zn and 59Fe in any of the tumour systems. It is concluded that the presence of haematoporphyrin does not markedly increase the ability of tumours to accummulate metallic radionuclides.

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Cardiac arrhythmias related to psychiatric medication

Nervenheilkunde ◽

10.1055/s-0038-1627522 ◽

2017 ◽

Vol 36 (09) ◽

pp. 747-750

Author(s):

R. W. Freudenmann ◽

C. Schönfeldt-Lecuona ◽

B. J. Connemann ◽

M. Gahr ◽

M. Elsayed

Keyword(s):

Cardiac Arrhythmias ◽

Torsade De Pointes ◽

General Medicine ◽

Fold Increase ◽

Cardiac Risk ◽

Psychiatric Medication ◽

Cardiac Side Effects ◽

Torsade De Pointes Tachycardia ◽

Multiple Drugs ◽

Available Information

SummaryThis narrative review summarizes current available information about cardiac arrhythmias (QT prolongation, Torsade de pointes Tachycardia [TdP], sudden cardiac death) associated with psychiatric medication. Among the most commonly used antipsychotics, amisulpride and ziprasidone are most frequently associated with TdP. Treatment with some antidepressants (SSRIs, tricyclic antidepressants) is associated with a 5- to 6-fold increase in the incidence of out-of-hospital cardiac arrest. Lithium is associated with bradycardia, T-wave changes and AV-block; anxiolytics of the benzodiazepine group do usually not have cardiac side effects. The combination of multiple drugs (including medications from general medicine) that prolong the QT interval has a particularly high cardiac risk.

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Increased Protein Synthesis by Human Platelets during Phagocytosis of Latex Particles in Vitro

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647928 ◽

1976 ◽

Vol 35 (02) ◽

pp. 350-357 ◽

Cited By ~ 8

Author(s):

Hana Bessler ◽

Galila Agam ◽

Meir Djaldetti

Keyword(s):

Protein Synthesis ◽

Fold Increase ◽

Human Platelets ◽

Polystyrene Latex ◽

Latex Particles ◽

The Third ◽

Platelet Protein ◽

Dose Dependent ◽

Phagocytotic Activity

SummaryA three-fold increase of protein synthesis by human platelets during in vitro phagocytosis of polystyrene latex particles was detected. During the first two hours of incubation, the percentage of phagocytizing platelets and the number of latex particles per platelet increased; by the end of the third hour, the first parameter remained stable, while the number of latex particles per cell had decreased.Vincristine (20 μg/ml of cell suspension) inhibited platelet protein synthesis. This effect was both time- and dose-dependent. The drug also caused a decrease in the number of phagocytizing cells, as well as in their phagocytotic activity.

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Plasma Components which Interfere with Ristocetin-induced Platelet Aggregation

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647847 ◽

1975 ◽

Vol 33 (03) ◽

pp. 540-546 ◽

Cited By ~ 3

Author(s):

Robert F Baugh ◽

James E Brown ◽

Cecil Hougie

Keyword(s):

Platelet Aggregation ◽

Human Plasma ◽

Plasma Proteins ◽

Binding Protein ◽

Plasma Heating ◽

Protein S ◽

Fold Increase ◽

Normal Human Plasma ◽

Preliminary Examination ◽

Normal Human

SummaryNormal human plasma contains a component or components which interfere with ristocetin-induced platelet aggregation. Preliminary examination suggests a protein (or proteins) which binds ristocetin and competes more effectively for ristocetin than do the proteins involved in ristocetin-induced platelet aggregation. The presence of this protein in normal human plasma also prevents ristocetin-induced precipitation of plasma proteins at levels of ristocetin necessary to produce platelet aggregation (0.5–2.0 mg/ml). Serum contains an apparent two-fold increase of this component when compared with plasma. Heating serum at 56° for one hour results in an additional 2 to 4 fold increase. The presence of a ristocetin-binding protein in normal human plasma requires that this protein be saturated with ristocetin before ristocetin-induced platelet aggregation will occur. Variations in the ristocetin-binding protein(s) will cause apparent discrepancies in ristocetin-induced platelet aggregation in normal human plasmas.

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Pharmacokinetics of Full Length and Two-Domain Tissue Factor Pathway Inhibitor in Combination with Heparin in Rabbits

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649604 ◽

1993 ◽

Vol 70 (03) ◽

pp. 454-457 ◽

Cited By ~ 14

Author(s):

Claus Bregengaard ◽

Ole Nordfang ◽

Per Østergaard ◽

Jens G L Petersen ◽

Giorgio Meyn ◽

...

Keyword(s):

Tissue Factor ◽

Tissue Factor Pathway Inhibitor ◽

Anticoagulant Activity ◽

Fold Increase ◽

Volume Of Distribution ◽

Full Length ◽

Heparin Binding ◽

Extrinsic Pathway ◽

C Terminus ◽

Tissue Factor Pathway

SummaryTissue factor pathway inhibitor (TFPI) is a feed back inhibitor of the initial activation of the extrinsic pathway of coagulation. In humans, injection of heparin results in a 2-6 fold increase in plasma TFPI and recent studies suggest that TFPI may be important for the anticoagulant activity of heparin. Full length (FL) TFPI, but not recombinant two-domain (2D) TFPI, has a poly cationic C-terminus showing very strong heparin binding. Therefore, we have investigated if heparin affects the pharmacokinetics of TFPI with and without this C-terminus.FL-TFPI (608 U/kg) and 2D-TFPI (337 U/kg) were injected intravenously in rabbits with and without simultaneous intravenous injections of low molecular weight heparin (450 anti-XaU/kg).Heparin decreased the volume of distribution and the clearance of FL-TFPI by a factor 10-15, whereas the pharmacokinetics of 2D-TFPI were unaffected by heparin. When heparin was administered 2 h following TFPI the recovery of FL-TFPI was similar to that found in the group receiving the two compounds simultaneously, suggesting that the releasable pool of FL-TFPI is removed very slowly in the absence of circulating heparin.

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