Serum carnitine concentration and the acyl to free carnitine ratio in nondialysis chronic kidney disease and hemodialysis patients

2021 ◽  
Author(s):  
Shoichiro Daimon ◽  
Miyuki Yasuda ◽  
Mitsuhiro Nishitani
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Hemodialysis Patients ◽  
Free Carnitine ◽  
Carnitine Concentration

scholarly journals Reliability and validity of the Persian version of 5-D itching scale among patients with chronic kidney disease

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Amin Kordi Yoosefinejad ◽  
Fatemeh Karjalian ◽  
Marzieh Momennasab ◽  
Shahrokh Ezzatzadegan Jahromi
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Psychometric Properties ◽  
Internal Consistency ◽  
Reliability And Validity ◽  
Hemodialysis Patients ◽  
Life Questionnaire ◽  
Retest Reliability ◽  
Persian Version ◽  
Test Retest Reliability

Abstract Background Hemodialysis is considered a major therapeutic method for patients with chronic kidney disease. Pruritus is a common complaint of hemodialysis patients. The 5-D pruritus scale is amongst the most common tools to evaluate several dimensions of itch. Psychometric properties of the 5-D scale have not been evaluated in Persian speaking population with hemodialysis; hence, the objective of this study was to assess reliability and validity of the Persian version of the scale. Methods Ninety hemodialysis patients (men: 50, women: 40, mean age: 54.4 years) participated in this cross-sectional study. The final Persian version of 5-D scale was given to the participants. Tests Compared: One-third of the participants completed the scale twice within 3–7 days apart to evaluate test- retest reliability. Other psychometric properties including internal consistency, absolute reliability, convergent, discriminative and construct validity, floor/ceiling effects were also evaluated. Results The Persian 5-D scale has strong test-retest reliability (ICC= 0.98) and internal consistency (Cronbach’s alpha= 0.99). Standard error of measurement and minimal detectable change were 0.33 and 0.91, respectively. Regarding convergent validity, the scale had moderate correlation with numeric rating scale (r =0.67) and quality of life questionnaire related to itch (r = 0.59). Exploratory factor analysis revealed two factors within the scale. No floor or ceiling effect was found for the scale. Conclusion The Persian version of 5-D the itching scale is a brief instrument with acceptable reliability and validity. Therefore, the scale could be used by experts, nurses, and other health service providers to evaluate pruritus among Persian speaking hemodialysis patients.

scholarly journals NaPi-IIb inhibition for hyperphosphatemia in chronic kidney disease hemodialysis patients

2020 ◽  
Author(s):  
Sonomi Maruyama ◽  
Thomas C. Marbury ◽  
Jeffrey Connaire ◽  
Daniel Ries ◽  
William Maxwell ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Hemodialysis Patients

Hepatitis C in Chronic Kidney Disease: Predialysis Patients Present More Severe Histological Liver Injury than Hemodialysis Patients?

2007 ◽  
Vol 27 (2) ◽  
pp. 191-196 ◽  
Author(s):  
Lara B. Lemos ◽  
Renata M. Perez ◽  
Marcelo M. Lemos ◽  
Valéria P. Lanzoni ◽  
Sergio A. Draibe ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Hepatitis C ◽  
Kidney Disease ◽  
Liver Injury ◽  
Hemodialysis Patients

scholarly journals Optimization of Thirst Management on CKD Patients Undergoing Hemodialysis by Sipping Ice Cube

2019 ◽  
Vol 2 (1) ◽  
pp. 38
Author(s):  
Yunie Armiyati ◽  
Khoiriyah Khoiriyah ◽  
Ahmad Mustofa
Keyword(s):  
Chronic Kidney Disease ◽  
Experimental Study ◽  
Kidney Disease ◽  
Fluid Intake ◽  
Average Length ◽  
Hemodialysis Patients ◽  
Fluid Restriction ◽  
Compliance Management ◽  
Ice Cube ◽  
Significant Difference

Excess fluid is a major problem in patients with Chronic Kidney Disease (CKD). CKD patients undergoing hemodialysis must keep limiting fluid intake during the interdialysis period so that excess fluid does not occur. Consequently limiting fluid intake arises thirst and will affect fluid restriction compliance. Management of thirst that can be done in hemodialysis patients, among others, suck ice cubes, gurgling the ripe water and gurgling with mouthwash, each of which has a different action against patients thirst. The purpose of this study was to compare the three interventions "thirst management", namely sipping ice cubes, gargling ripe water and gargling with mouthwash against patient thirst. This study was an experimental study in 27 samples of CKD patients who underwent hemodialysis at Roemani Muhammadiyah Hospital in Semarang divided into 3 groups with each group 9 samples. The results showed that the duration of holding thirst for the group sipping on ice cubes averaged 93 minutes, the gurgling group of ripe water averaged 55 minutes and the average length of time holding the thirst group who gurgling with mouthwash was 69.71 minutes. There was no significant difference in the duration of holding thirst after sucking on ice cubes and gargling ripe water, and gargling with mouthwash (ρ value 0.061). Sipping ice cubes can fight the longest thirst compared to gargling ripe water or gargling with mouthwash. The recommendations of this study are expected to intervene to sipping ice cubes, gargling ripe water and gargling with mouthwash can be used for thirst management in hemodialysis patients.  Hemodialysis patients can choose interventions to reduce the thirst that is most appropriate.

scholarly journals Comparison of muscle strength between hemodialysis patients and non-dialysis patients with chronic kidney disease

2021 ◽  
Vol 33 (10) ◽  
pp. 742-747
Author(s):  
Nobuyuki Shirai ◽  
Suguru Yamamoto ◽  
Yutaka Osawa ◽  
Atsuhiro Tsubaki ◽  
Shinichiro Morishita ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Muscle Strength ◽  
Hemodialysis Patients ◽  
Dialysis Patients

scholarly journals Prevalence and Risk Factors for Chronic Kidney Disease in Family Relatives of a Cameroonian Population of Hemodialysis Patients: A CrossSectional Study

2019 ◽  
Vol 4 (1) ◽  
pp. 12-17
Author(s):  
Mazou Ngou Temgoua ◽  
Gloria Ashuntantang ◽  
Marie José Essi ◽  
Joël Nouktadie Tochie ◽  
Moussa Oumarou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Fasting Blood Glucose ◽  
Hemodialysis Patients ◽  
Biological Data ◽  
Sub Saharan Africa ◽  
Herbal Remedies ◽  
Maintenance Hemodialysis ◽  
Number Of Patients

Background: In sub-Saharan Africa (SSA), the trend in the number of patients admitted for maintenance hemodialysis is on the rise. The identification of risk factors for chronic kidney disease (CKD) ensures adequate primary and secondary preventive measures geared at reducing the burden of CKD in low-resource settings. A family history of CKD is an established risk factor for CKD in high-income countries. However, data on family predisposition to CKD is scarce in the literature on SSA. Objective: The current study aimed to determine the prevalence and risk factors of CKD in family relatives of a Cameroonian population of hemodialysis patients (HDP) followed-up in a major hemodialysis referral center in Cameroon. Methods: The current cross-sectional study was conducted over four months on a consecutive sample of first-degree family relatives of end-stage renal disease patients undergoing maintenance hemodialysis at the hemodialysis unit of the General Hospital of Yaoundé. For each participating family relative, socio-demographic characteristics, clinical data, and biological data including fasting blood glucose, proteinuria, and serum creatinine were collected. Results: A total of 82 first-degree family relatives of HDP were recruited. The prevalence of CKD among the participants was 15.8%. The main identified risk factors for CKD were age (P = 0.0015), female gender (P = 0.0357), hypertension (P = 0.0004), regular intake of herbal remedies (P = 0.0214), and diabetes mellitus (P = 0.0019). Conclusion: Overall, the current findings suggest an urgent need for population education, routine screening of CKD, and the identification of risk factors in first-degree family relatives of HDP in Cameroon.

Assessment of Acute complications and Quality of Life in Hemodialysis patients with Chronic Kidney Disease

2021 ◽  
pp. 2671-2675
Author(s):  
Achsa Thomas ◽  
Julia S. Jacob ◽  
Merin Abraham ◽  
Blessy M. Thomas ◽  
Purnima Ashok
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Hemodialysis Patients ◽  
Health Related Quality ◽  
Muscle Cramps ◽  
Acute Complications ◽  
Related Quality ◽  
Health Related

Introduction: End Stage Renal Disease (ESRD) is the last stage of Chronic Kidney Disease (CKD), where kidneys solely functions at 10 to 15 percent of their normal capacity. Efficacious treatment for ESRD is renal replacement therapies like dialysis and renal transplantation. Health related quality of life (HRQoL) is a neglected aspect of CKD care. Objective: To assess the acute complications and quality of life in hemodialysis patients. Methods: This prospective observational study was conducted for 6 months, 90 patients undergoing hemodialysis were enrolled in the study. Acute complications were assessed during and post dialysis and Health Related Quality of Life were analysed using KDQoL-36TM questionnaire. Result: Among patients assessed; majority of the patients belonged to the age group 30 to 60 years. Acute complications were evaluated and oedema was found in maximum patients followed by muscle cramps, loss of appetite, itching etc. Based on KDQoL-36TM questionnaire, physical functions was mainly affected due to the disease. Oedema and muscle cramps had an impact on the patients physical and mental functioning whereas educational status and addictions showed significance in all domains of KDQOL-36TM. Conclusion: CKD patients undergoing hemodialysis has an intense effect on HRQoL. A better understanding on QOL issues will enable providers to deliver better patient centred care and enhance the overall well-being of the patients.

scholarly journals Oxidative Balance and Inflammation in Hemodialysis Patients: Biomarkers of Cardiovascular Risk?

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Daniele La Russa ◽  
Daniela Pellegrino ◽  
Alberto Montesanto ◽  
Paolo Gigliotti ◽  
Anna Perri ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Cardiovascular Events ◽  
Cardiovascular Complications ◽  
Hemodialysis Patients ◽  
Healthy Population ◽  
Oxidative Balance

During chronic kidney disease, the progressive deterioration of renal function induces several biological/clinical dysfunctions, including enhancement of synthesis of inflammation/oxidative stress mediators. Impaired renal function is an independent cardiovascular risk factor; indeed, cardiovascular complications dominate the landscape of both chronic kidney disease and end-stage renal disease. The aim of this study is to explore the correlation between the global oxidative balance in hemodialysis patients and both inflammatory markers and cardiovascular events. Using photometric tests, this study explored plasmatic oxidative balance in 97 hemodialysis patients compared to a healthy population. In the hemodialysis patients, we showed that oxidative stress values were significantly lower than in controls while effectiveness in the antioxidant barrier was significantly increased in the hemodialysis group. Furthermore, we highlighted a strong correlation between oxidative index and blood levels of C-reactive protein. When patients were divided into two groups based on previous cardiovascular events, we found that subjects with previous cardiovascular events had higher values of both oxidative stress and antioxidant barrier than patients without cardiovascular events. Our results indicated that in hemodialysis patients, the clinical and prognostic significance of oxidative status is very different from general population. As cardiovascular complications represent a strong negative factor for survival of hemodialysis patients, the research of new cardiovascular risk biomarkers in these patients takes on particular importance in order to translate them into clinical practice/primary care.

scholarly journals Proteomic Characterization of High-Density Lipoprotein Particles from Non-Diabetic Hemodialysis Patients

Toxins ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 671 ◽  
Author(s):  
Florens ◽  
Calzada ◽  
Delolme ◽  
Page ◽  
Guebre Egziabher ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cardiovascular Risk ◽  
Kidney Disease ◽  
Hypothesis Test ◽  
Density Lipoprotein ◽  
Biological Properties ◽  
Hemodialysis Patients ◽  
High Density ◽  
High Density Lipoproteins ◽  
Label Free

Chronic kidney disease is associated with an increased cardiovascular risk, and altered biological properties of high-density lipoproteins (HDL) may play a role in these events. This study aimed to describe the HDL proteome from non-diabetic hemodialysis patients and identify potential pathways affected by the dysregulated expression of HDL proteins. HDL were sampled from nine non-diabetic hemodialysis (HD) and eight control patients. Samples were analyzed using a nano-RSLC coupled with a Q-Orbitrap. Data were processed by database searching using SequestHT against a human Swissprot database and quantified with a label-free quantification approach. Proteins that were in at least five of the eight control and six of the nine HD patients were analyzed. Analysis was based on pairwise ratios and the ANOVA hypothesis test. Among 522 potential proteins, 326 proteins were identified to be in the HDL proteome from HD and control patients, among which 10 were significantly upregulated and nine downregulated in HD patients compared to the control patients (p < 0.05). Up and downregulated proteins were involved in lipid metabolism, hemostasis, wound healing, oxidative stress, and apoptosis pathways. This difference in composition could partly explain HDL dysfunction in the chronic kidney disease (CKD) population and participate in the higher cardiovascular risk observed in this population.

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