Concentrations of Blood and Milk Ketone Bodies, Blood Isopropanol and Plasma Glucose in Dairy Cows in Relation to the Degree of Hyperketonaemia and Clinical Signs*

2010 ◽  
Vol 31 (1-10) ◽  
pp. 683-693 ◽  
Author(s):  
L. Andersson
Keyword(s):  
Dairy Cows ◽  
Plasma Glucose ◽  
Ketone Bodies ◽  
Clinical Signs

scholarly journals Ketone bodies – causes and effects of their increased presence in cows' body fluids: A review

2021 ◽  
pp. 1492-1503
Author(s):  
Piotr Guliński
Keyword(s):  
Dairy Cows ◽  
High Performance ◽  
Clinical Symptoms ◽  
Ketone Bodies ◽  
Good Condition ◽  
Body Fluids ◽  
Protein Ratio ◽  
Loss Of Appetite ◽  
Point Body ◽  
Main Component

Ketosis is the most common metabolic disease in high-performance dairy cows during the first 6-8 weeks of lactation. Its main symptoms include an excessive amount of so-called ketone bodies in a cow's body fluids. Ketone bodies consist of β-hydroxybutyric acid (βHBA), acetoacetic acid, and acetone. βHBA is the main component with its share of the total volume of ketone bodies in the blood of about 70%. Clinical symptoms of ketosis in cows include loss of appetite, preference for forage to concentrated feed, and acetone odor in their mouth and urine. Those symptoms are accompanied by a production drop, an increase of concurrent illness (mastitis, metritis, and displaced abomasum), and poor reproductive performance. One of the ketosis characteristic effects is an increase in the level of fat in milk (>5%), while protein levels decrease (<2.9%). In the case of subclinical ketosis (SCK), the fat–protein ratio in milk is increased to above 1.4:1. The current consensus for SCK is to consider a cutoff point of βHBA to be at least 1.2 mmol/L in blood plasma. Ketosis prevention is based on keeping perinatal cows in good condition, that is, with around 3.5 points in the five-point body condition scoring, carefully balancing food doses during the first 2 months of lactation with the correct energy–protein ratio. Glucose precursor products should be administered orally, in particular to at-risk herds. Ketosis occurs in 7-14% on average of the total number of cows in a herd. In general, data on the prevalence of SCK vary considerably, depending on their source. Moreover, the problem is mostly observed in poorly-fed animals with high milk production potential. The objectives of this review are to reveal the current situation of ketosis prevalence, the possibility of diagnosis, consequences in dairy cows and to provide some recommendations for ketosis treatment and prevention.

scholarly journals A Study on the Effects of Rumen Acidity on Rumination Time and Yield, Composition, and Technological Properties of Milk from Early Lactating Holstein Cows

Animals ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 66 ◽  
Author(s):  
Sudeb Saha ◽  
Luigi Gallo ◽  
Giovanni Bittante ◽  
Stefano Schiavon ◽  
Matteo Bergamaschi ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Dairy Cows ◽  
Volatile Fatty Acid ◽  
Rumen Fluid ◽  
Clinical Signs ◽  
Nutrient Content ◽  
Holstein Cows ◽  
Time Interval ◽  
Technological Properties ◽  
Daily Time

The use of high grain rations in dairy cows is related to an increase in rumen acidity. This study investigated whether the rumen acidity status affects rumination time (RT), and the production, composition, coagulation properties (MCPs) and cheese yield (CY) of milk. One hundred early-lactating Holstein cows with no clinical signs of disease and fed total mixed rations were used. Rumen fluid was collected once from each cow by rumenocentesis to determine pH and volatile fatty acid (VFA) content. The cows were classified according to the quartile of rumen acidity (QRA), a factor defined by multivariate analysis and associated with VFA and pH. Rumen fluid pH averaged 5.61 in the first quartile and 6.42 in the fourth, and total VFA content increased linearly with increasing rumen acidity. In addition, RT increased as rumen acidity increased, but only in the daily time interval from 08:00 to 12:00. Milk yield linearly decreased as rumen acidity increased, whereas QRA did not affect pH, fat or protein contents of milk. Furthermore, the MCPs, assessed by lactodynamograph, and CY were unaffected by QRA. It is suggested that differences in rumen acidity have little influence on the nutrient content, coagulation properties and CY of milk.

scholarly journals Subacute ruminal acidosis in dairy cows - physiological background, risk factors and diagnostic methods

2020 ◽  
Vol 51 (1) ◽  
pp. 5-17
Author(s):  
Levente Kovács ◽  
Otto Szenci ◽  
Walter Baumgartner ◽  
Mátyás Hejel ◽  
László Rózsa
Keyword(s):  
Risk Factors ◽  
Dairy Cows ◽  
Continuous Measurement ◽  
Clinical Signs ◽  
The United States ◽  
Diagnostic Methods ◽  
Subacute Ruminal Acidosis ◽  
Field Techniques ◽  
Ruminal Ph ◽  
Ruminal Acidosis

According to the latest studies, the prevalence of subacute ruminal acidosis (SARA) is around 20% in early and mid- lactation dairy cows, generating annual losses in the United States of approximately USD 500 million to 1 billion. The diagnosis of SARA is still difficult due to lack of pathognomonic clues and the delayed appearance of certain clinical signs. Therefore, SARA remains neglected or even unrecognized in many dairy herds. SARA is characterized by daily episodes of low ruminal pH, when the pH remains in the range of 5.2 to 6 for a prolonged period due to the accumulation of short-chain fatty acids and insufficient rumen buffering. The causes of SARA are related to high-grain diets, such as feeding excessive amounts of non-structural carbohydrates and highly fermentable forages, and insufficient dietary coarse fibre. SARA is associated with the inflammation of several organs and tissues in dairy cows, and its main long-term health and economic consequences are the fluctuation of feed intake, reduced fibre digestion, depression of milk yield and milk fat content, gastrointestinal damage, diarrhoea, laminitis, liver abscesses, and lameness. The aim of this review is to summarize the information available on the physiological aspects, risk factors, prevalence and possible indicators of SARA in dairy cattle. Basedon the existing literature, rumenocentesis and the use of an oral stomach tube are reliable field techniques to detect SARA. Nowadays, improved field techniques allowing the continuous measurement of reticuloruminal pH are also available for better diagnosis of SARA. Wireless indwelling pH probes may become important tools for the continuous measurement of ruminal pH in the coming years.

scholarly journals Biochemical and Haematological Blood Parameters at Different Stages of Lactation in Cows

2017 ◽  
Vol 74 (1) ◽  
pp. 31 ◽  
Author(s):  
Cristian Ovidiu COROIAN ◽  
Vioara MIRESAN ◽  
Aurelia COROIAN ◽  
Camelia RADUCU ◽  
Luisa ANDRONIE ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Biochemical Parameters ◽  
Post Partum ◽  
Hematological Parameters ◽  
Technological Factor ◽  
Clinical Signs ◽  
Blood Parameters ◽  
Holstein Breed ◽  
Lactating Cows ◽  
Blood Biochemical

The health status of cows is evaluated and depending on haematological and biochemical profile of blood. Nutrition is the main technological factor that can produce profound changes in the metabolic profile in animals (Dhiman et al., 1991; Khaled et al., 1999; Ingvartsen, 2006). Blood parameters analyze can lead to identify if there are errors in nutrition of lactating cows (Payne et al., 1970). The aim of this study was the evaluation of metabolic and biochemical changes that occur during colostrum period and in terms of number of lactations in cows. The biological material was represented by a total of 60 heads of dairy cows from a family farm from Sălaj County, Romania. The cows are all from Holstein breed and presented no clinical signs of any specific pathology. Blood samples were collected from the jugular vein of each cow and analyzed. 10 individuals from each of the six lactations have been randomly selected. Haematological and biochemical parameters showed variations depending on factors analyzed here. In lactation 1 Hb was 7.55±3.05 (g/dl), while in lactation 6 the value was 12.5±2.10 (g/dl). RBC ranged as follows: in lactation 1 - 28.50±2.05 and in lactation 6 - 30.02±2.05. Lymphocytes varied within very wide limits under the influence of lactation: in lactation 1 - 2.8±1.56 and in lactation 6 - 7.55±1.80. The number of lactations and lactation rank have influenced blood biochemical and hematological parameters in dairy cows. Biochemical parameters are influenced by post-partum day, showing the lowest values in the early days of colostral period and the highest in the last few days of the same period.

scholarly journals Venous and arterial ammonia in dairy cows with fatty liver and hepatic failure

2012 ◽  
Vol 49 (No. 6) ◽  
pp. 187-190 ◽  
Author(s):  
P. Mudron ◽  
J. Rehage ◽  
M. Holtershinken ◽  
H. Scholz
Keyword(s):  
Hepatic Encephalopathy ◽  
Liver Failure ◽  
Fatty Liver ◽  
Dairy Cows ◽  
Hepatic Failure ◽  
Clinical Signs ◽  
Plasma Ammonia ◽  
Holstein Friesian ◽  
Triglyceride Content ◽  
Venous Plasma

In the present study we aimed to compare the arterial and venous plasma ammonia in dairy cows with fatty liver and hepatic failure. 75 Holstein-Friesian dairy cows were used in the investigation. Clinical examinations revealed liver failure in 14 cows (group LF). Diagnosis of hepatic failure was based on the clinical signs of hepatic encephalopathy, including anorexia, depressed consciousness, ataxia, somnolence, and coma, and on venous plasma ammonia &gt;35 &micro;mol/l. The other cows were divided according to their liver triglyceride content (wet tissue) into the following groups: low triglycerides (LT) &lt; 30 mg/g (n = 24), medium triglycerides (MT) 30&ndash;100 mg/g (n =&nbsp;31), and high triglycerides (HT) &gt;100 mg/g (n = 6). Both arterial and venous plasma ammonia levels were highest in cows with hepatic failure (93.0 &plusmn; 44.9 and 70.4 &plusmn; 34.1 &micro;mol/l, respectively). We observed that arterial ammonia was significantly higher than venous ammonia (p &lt; 0.01) only in the dairy cows suffering from liver failure, implying a higher informative value of arterial ammonia in detection of liver function damage in cattle demonstrating signs of hepatic encephalopathy.

Histological examination of non-lactating bovine udders inoculated with Lactobacillus perolens CRL 1724

2012 ◽  
Vol 80 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Ignacio D Frola ◽  
Matías S Pellegrino ◽  
Gabriel Magnano ◽  
José A Giraudo ◽  
María C Espeche ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Histological Examination ◽  
Inflammatory Reaction ◽  
Bovine Mastitis ◽  
Clinical Signs ◽  
Structural Aspect ◽  
Post Inoculation ◽  
Lactating Dairy Cows ◽  
Preliminary Study ◽  
Cell Alterations

The effect of intramammary inoculation of Lactobacillus perolens CRL 1724 on bovine udders at drying off was evaluated through histological examination of the canal and cistern tissues. The persistence of the strain in the udder 7 d post inoculation was also determined. Lb. perolens CRL 1724 was recovered from all mammary quarters and no clinical signs or teat damage were observed after inoculation of 106 cfu/ml. The udders showed a normal structural aspect and there were no modifications of the milk appearance. Lb. perolens CRL 1724 cells were evidenced on the surface of the epithelial cells of the cistern without causing any morphological modifications or cell alterations. Lb. perolens CRL 1724 produces a mild inflammatory reaction, characterized by recruitment of neutrophils to the epithelial zone and a slight hyperaemia into blood vessels. This preliminary study provides important information for further studies directed towards the inclusion of Lb. perolens CRL 1724 in the design of probiotic products for preventing bovine mastitis in non-lactating dairy cows.

scholarly journals Effects of starvation on intermediary metabolism in the lactating cow. A comparison with metabolic changes occurring during bovine ketosis

1972 ◽  
Vol 128 (5) ◽  
pp. 1311-1318 ◽  
Author(s):  
G. D. Baird ◽  
R. J. Heitzman ◽  
K. G. Hibbitt
Keyword(s):  
Fatty Acids ◽  
Plasma Concentration ◽  
Dairy Cows ◽  
Blood Concentration ◽  
Ketone Bodies ◽  
Fat Metabolism ◽  
Metabolic Changes ◽  
Initial Increase ◽  
Blood Concentrations ◽  
Lactating Dairy Cows

1. The purpose of this study was to determine the nature of the metabolic changes associated with carbohydrate and fat metabolism that occurred in the blood and liver of lactating dairy cows during starvation for 6 days. 2. During starvation, the blood concentrations of the free fatty acids and ketone bodies increased, whereas that of citrate decreased. After an initial increase, the blood concentration of glucose subsequently declined as starvation progressed. Starvation caused a significant decrease in the plasma concentration of serine and a significant increase in that of leucine. 3. After 6 days of starvation the hepatic concentrations of oxaloacetate, citrate, phosphoenolpyruvate, 2-phosphoglycerate, 3-phosphoglycerate, glucose, glycogen, ATP and NAD+ had all decreased, as had the hepatic activities of phosphopyruvate carboxylase (EC 4.1.1.32) and pyruvate kinase (EC 2.7.1.40). 4. The above metabolic changes are similar to those previously found to occur in cows suffering from spontaneous ketosis (Baird et al., 1968; Baird & Heitzman, 1971). 5. Milk yield decreased progressively during starvation. 6. There were marked differences in the ability of individual animals to resist the onset of severe starvation ketosis.

Sign in / Sign up

Export Citation Format

Share Document