Bioavailability of bioactive compounds of guava leaves ( Psidium Guajava ) aqueous extract concentrated by gravitational and microwave‐assisted cryoconcentration

2021 ◽  
Author(s):  
Katia Rezzadori ◽  
Giordana Demaman Arend ◽  
Henrique Jaster ◽  
Elixabet Díaz‐de‐Cerio ◽  
Vito Verardo ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Aqueous Extract ◽  
Psidium Guajava ◽  
Microwave Assisted ◽  
Guava Leaves

Morphological Alterations of the Rat Testicles Following Administration of Graded Doses of Leaves of Guava (Psidium guajava Linn.) Aqueous Extract

2021 ◽  
Author(s):  
Kom-Abasi Daniel Etim ◽  
Ubi Essien Isaac ◽  
Anozeng Oyono Igiri
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Psidium Guajava ◽  
Reproductive Organ ◽  
Seminiferous Tubules ◽  
Morphological Alterations ◽  
Group I ◽  
Guava Leaves ◽  
Guava Leaf ◽  
Dose Response Effect

The current study design to assess the dose-response effect of administering an aqueous extract of guava leaves on the microstructure of the testicles due to the growing use of this plant in complementary and alternative medicine practice. Twenty-four male albino Wistar rats with an average body weight of 160 g apportion to four groups (n=6 each). Group, I served as the control and received distilled water; group II gave a lower dose of 500 mg/kg body weight of guava leaf extract; group III received a medium dose of 750 mg/kg; while group IV administer a higher amount of 1000 mg/kg per day. Treatments were given once daily by gavage and lasted for 14 days, while the stock solution prepares by dissolving 50 g of the extract in 30 ml of water. The cervical dislocation method used to euthanize the rats, dissect the abdominopelvic region to obtain tissue specimens from the testes for histological processing. The outcome exhibited the extract to cause moderate to severe (dose-dependent) morphological alterations with the seminiferous tubules' fibrotic appearance, strict spermatogenic arrest, and necrosis of both the interstitial cells of Leydig and the Sertoli cells. The ingestion of guava leaves at the investigated concentration and doses is harmful to the testicle, the primary reproductive organ in males. It should therefore be consumed with caution when being used primarily in folklore-traditional medicine.

scholarly journals Sustainable Biosynthesis of Antioxidants from Koji Rice Fermented with Aspergillus flavus Using Microwave-Assisted Extraction

2021 ◽  
Vol 11 (1) ◽  
pp. 430
Author(s):  
Hassan Hadi Mehdi Al Rubaiy ◽  
Ammar Altemimi ◽  
Ali Khudair Jaber Al Rikabi ◽  
Naoufal Lakhssassi ◽  
Anubhav Pratap-Singh
Keyword(s):  
Ethyl Acetate ◽  
Aspergillus Flavus ◽  
Bioactive Compounds ◽  
Ethylenediaminetetraacetic Acid ◽  
Ethyl Acetate Extract ◽  
Antioxidant Properties ◽  
Antioxidant Compounds ◽  
Microwave Assisted Extraction ◽  
Microwave Assisted ◽  
Assisted Extraction

The present study proposes microwave-assisted extraction as a sustainable technique for the biosynthesis of bioactive compounds from rice fermented with Aspergillus flavus (koji). First, fermentation conditions (i.e., pH from 3–12, five temperatures from 20–40 °C, and four culture-fermentation media viz. wheat, wheat bran, malt and rice) were optimized for producing microbial bioactive compounds. Microwave extraction was performed at 2450 MHz and 500 W for 20, 30, and 40 s with seven solvents (distilled water, ethyl acetate, hexane, ethanol, chloroform, diethyl ether, and methanol). The obtained results revealed that ethyl acetate is the most appropriate solvent for extraction. Effects of this ethyl acetate extract were compared with a commercial synthetic antioxidant. Antioxidant properties were enhanced by preventing the oxidation of the linoleic acid (C18H32O2) with an inhibition rate (antioxidant efficacy) of 73.13%. Notably, the ferrous ion binding ability was marginally lower when compared to the disodium salt of ethylenediaminetetraacetic acid (EDTA). Additionally, the obtained total content of phenolic compounds in the ethyl acetate extract of fermented rice (koji) by Aspergillus flavus was 232.11 mg based on gallic acid/mL. Antioxidant compounds in the ethyl acetate extract of fermented rice showed stability under neutral conditions, as well as at high temperatures reaching 185 °C during 2 h, but were unstable under acidic and alkaline conditions. The results demonstrate the efficacy of novel microwave-assisted extraction technique for accelerating antioxidant production during rice fermentation.

scholarly journals Anti-nociceptive and anti-inflammatory effects of an aqueous extract of blended leaves of Ocimum gratissimum and Psidium guajava

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Akinyinka O. Alabi ◽  
Abayomi M. Ajayi ◽  
Osarume Omorogbe ◽  
Solomon Umukoro
Keyword(s):  
Acetic Acid ◽  
Aqueous Extract ◽  
Psidium Guajava ◽  
Antinociceptive Activity ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Promising Alternative ◽  
Plate Test ◽  
Ocimum Gratissimum ◽  
Anti Inflammatory

Abstract Background To investigate the antinociceptive and anti-inflammatory activities of aqueous extract of a blended mixture of dried leaves of Ocimum gratissimum and Psidium guajava, a traditional analgesic drug polyherbal (TADP) used as a remedy for pain-related conditions. Methods Antinociceptive activity of TADP (100, 200 and 400 mg/kg) was evaluated in the hot plate test and acetic acid-induced nociception in mice while the anti-inflammatory was evaluated in carrageenan-induced paw oedema in rats. Levels of nitrite, myeloperoxidase, glutathione and malondialdehyde were assayed in carrageenan-induced paw tissue. Results TADP (200 and 400 mg/kg) significantly prolong the latency time in the hot-plate test. TADP (100–400 mg/kg) produced a dose-dependent significant inhibition of the acetic-acid induced abdominal constriction. The antinociceptive activity of TADP in the presence of naloxone and atropine was not reversed whereas yohimbine and glibenclamide significantly reversed it. TADP (100, 200 and 400 mg/kg) significantly reduced the swelling in the carrageenan-induced oedema model and also produced a reduction in the nitrite and myeloperoxidase level. TADP (400 mg/kg) significantly reduced malondialdehyde concentration and increase glutathione level in the carrageenan-induced rat paw. TADP significantly decrease the number of cellular infiltrates in the histopathological assessment. Conclusion These results indicate that polyherbal product containing blended leaves of Ocimum gratissimum and Psidium guajava possess antinociceptive and anti-inflammatory properties, hence represents a promising alternative remedy in inflammation-induced pain.

Optimisation of microwave‐assisted extraction and functional elucidation of bioactive compounds from Cola nitida pod

2021 ◽  
Author(s):  
Olusegun Abayomi Olalere ◽  
Chee‐Yuen Gan ◽  
Olumide Esan Akintomiwa ◽  
Oladayo Adeyi ◽  
Abiola Adeyi
Keyword(s):  
Bioactive Compounds ◽  
Microwave Assisted Extraction ◽  
Microwave Assisted ◽  
Assisted Extraction ◽  
Cola Nitida

scholarly journals Microwave-Assisted Extraction and Ultrasound-Assisted Extraction of Bioactive Compounds from Grape Pomace

2020 ◽  
Vol 16 (1-2) ◽  
Author(s):  
Cassiano Brown da Rocha ◽  
Caciano Pelayo Zapata Noreña
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Bioactive Compounds ◽  
Grape Pomace ◽  
Total Phenolic ◽  
Microwave Assisted Extraction ◽  
Ultrasound Assisted Extraction ◽  
Microwave Assisted ◽  
Assisted Extraction ◽  
Ultrasound Assisted

AbstractThe grape pomace is a by-product from the industrial processing of grape juice, which can be used as a source of bioactive compounds. The aim of this study was to separate the phenolic compounds from grape pomace using an acidic aqueous solution with 2 % citric acid as a solvent, using both ultrasound-assisted extraction, with powers of 250, 350 and 450 W and times of 5, 10 and 15 min, and microwave-assisted extraction using powers of 600, 800 and 1,000 W and times of 5, 7 and 10 min. The results showed that for both methods of extraction, the contents of total phenolic compounds and antioxidant activity by ABTS and DPPH increased with time, and microwave at 1,000 W for 10 min corresponded to the best extraction condition. However, the contents of phenolic compounds and antioxidant activity were lower than exhaustive extraction using acidified methanol solution.

Optimisation of microwave-assisted extraction from Phyllanthus amarus for phenolic compounds-enriched extracts and antioxidant capacity

2016 ◽  
Vol 70 (6) ◽  
Author(s):  
Van T. Nguyen ◽  
Michael C. Bowyer ◽  
Ian A. van Altena ◽  
Christopher J. Scarlett
Keyword(s):  
Phenolic Compounds ◽  
Antioxidant Capacity ◽  
Bioactive Compounds ◽  
Pharmacological Activity ◽  
Extraction Efficiency ◽  
Phyllanthus Amarus ◽  
Microwave Assisted Extraction ◽  
Microwave Assisted ◽  
Assisted Extraction ◽  
Extraction Parameters

Abstractis known as a healing herb which has traditionally been used in the treatment of various diseases such as hepatitis, diabetes and cancer. The extraction parameters have great effects on the extraction efficiency of bioactive compounds and pharmacological activity of the extracts. This study sought to optimise the microwave-assisted extraction parameters for phenolic compounds-enriched extracts and antioxidant capacity from

Optimization of microwave-assisted extraction recovery of bioactive compounds from Origanum glandulosum and Thymus fontanesii

2019 ◽  
Vol 129 ◽  
pp. 395-404 ◽  
Author(s):  
Nacim Nabet ◽  
Bienvenida Gilbert-López ◽  
Khodir Madani ◽  
Miguel Herrero ◽  
Elena Ibáñez ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Microwave Assisted Extraction ◽  
Extraction Recovery ◽  
Microwave Assisted ◽  
Assisted Extraction

scholarly journals Study to find the best extraction solvent for use with guava leaves ( Psidium guajava L.) for high antioxidant efficacy

2014 ◽  
Vol 2 (2) ◽  
pp. 174-180 ◽  
Author(s):  
Jongkwon Seo ◽  
Soojung Lee ◽  
Marcus L. Elam ◽  
Sarah A. Johnson ◽  
Jonghoon Kang ◽  
...  
Keyword(s):  
Psidium Guajava ◽  
Extraction Solvent ◽  
Guava Leaves
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