Analysis of Flow Disturbance in a Stenosed Carotid Artery Bifurcation Using Two-Equation Transitional and Turbulence Models

2008 ◽  
Vol 130 (6) ◽  
Author(s):  
F. P. P. Tan ◽  
G. Soloperto ◽  
S. Bashford ◽  
N. B. Wood ◽  
S. Thom ◽  
...  
Keyword(s):  
Shear Stress ◽  
Carotid Artery ◽  
Laminar Flow ◽  
Wall Shear Stress ◽  
Turbulence Models ◽  
Carotid Bifurcation ◽  
Patient Specific ◽  
Shear Stresses ◽  
Zone Length ◽  
Wall Shear

In this study, newly developed two-equation turbulence models and transitional variants are employed for the prediction of blood flow patterns in a diseased carotid artery where the growth, progression, and structure of the plaque at rupture are closely linked to low and oscillating wall shear stresses. Moreover, the laminar-turbulent transition in the poststenotic zone can alter the separation zone length, wall shear stress, and pressure distribution over the plaque, with potential implications for stresses within the plaque. Following the validation with well established experimental measurements and numerical studies, a magnetic-resonance (MR) image-based model of the carotid bifurcation with 70% stenosis was reconstructed and simulated using realistic patient-specific conditions. Laminar flow, a correlation-based transitional version of Menter’s hybrid k‐ϵ∕k‐ω shear stress transport (SST) model and its “scale adaptive simulation” (SAS) variant were implemented in pulsatile simulations from which analyses of velocity profiles, wall shear stress, and turbulence intensity were conducted. In general, the transitional version of SST and its SAS variant are shown to give a better overall agreement than their standard counterparts with experimental data for pulsatile flow in an axisymmetric stenosed tube. For the patient-specific case reported, the wall shear stress analysis showed discernable differences between the laminar flow and SST transitional models but virtually no difference between the SST transitional model and its SAS variant.

Blood Flow Manipulation in the Aorta With Coarctation and Arch Narrowing for Pediatric Subjects

2020 ◽  
Vol 88 (2) ◽  
Author(s):  
Yuxi Jia ◽  
Kumaradevan Punithakumar ◽  
Michelle Noga ◽  
Arman Hemmati
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Shear Stress ◽  
Wall Shear Stress ◽  
Aortic Arch ◽  
Flow Direction ◽  
Upper Body ◽  
Patient Specific ◽  
Shear Stresses ◽  
Wall Shear

Abstract The characteristics of blood flow in an abnormal pediatric aorta with an aortic coarctation and aortic arch narrowing are examined using direct numerical simulations and patient-specific boundary conditions. The blood flow simulations of a normal pediatric aorta are used for comparison to identify unique flow features resulting from the aorta geometrical anomalies. Despite flow similarities compared to the flow in normal aortic arch, the flow velocity decreases with an increase in pressure, wall shear stress, and vorticity around both anomalies. The presence of wall shear stresses in the trailing indentation region and aorta coarctation opposing the primary flow direction suggests that there exist recirculation zones in the aorta. The discrepancy in relative flowrates through the top and bottom of the aorta outlets, and the pressure drop across the coarctation, implies a high blood pressure in the upper body and a low blood pressure in the lower body. We propose using flow manipulators prior to the aortic arch and coarctation to lower the wall shear stress, while making the recirculation regions both smaller and weaker. The flow manipulators form a guide to divert and correct blood flow in critical regions of the aorta with anomalies.

scholarly journals Multiscale Modeling of Endothelium Derived Wall Shear Stress Regulation in Common Carotid Artery

2019 ◽  
Vol 35 (6) ◽  
pp. 901-914
Author(s):  
Saeed Siri ◽  
Malikeh Nabaei ◽  
Nasser Fatouraee
Keyword(s):  
Mechanical Properties ◽  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Common Carotid Artery ◽  
3D Model ◽  
Stable Condition ◽  
Patient Specific ◽  
Local Flow ◽  
Wall Shear

ABSTRACTShear induced autoregulation is the natural ability of organs to maintain the local hemodynamic stresses in a stable condition in spite of altering perfusion rate. Endothelium cells are shear sensitive mechanoreceptors that are responsible for regulating the arterial wall architecture and mechanical properties in order to maintain homeostasis. This occurs by means of vasoactive mediators, which cause vasodilation or vasoconstriction. In this paper we presented a multiscale model of local flow regulation. First, a lumped parameter model of the whole cardiovascular system was implemented. Then a 3D numerical model of human common carotid artery was constructed considering fluid-structure interaction. The CCA inflow waveform obtained from the extended 0D model was applied to the 3D model as the boundary condition. After applying the Head-Up Tilt test, the local hemodynamics were disturbed. By considering the wall shear stress as the regulation criterion, then altering the arterial mechanical properties and the following vasodilation, shear forces exerted on the inner lining of the vessel were regulated and returned to the normal range. The resulting 0D/3D model can be considered as a plat-form for a more complete model containing local and systemic cardiovascular control mechanisms and patient-specific geometries which can be used for clinical purposes.

Wall Pressure and Shear Stress Variations in a 90-Deg Bifurcation During Pulsatile Laminar Flow

1991 ◽  
Vol 113 (1) ◽  
pp. 111-115 ◽  
Author(s):  
J. M. Khodadadi
Keyword(s):  
Shear Stress ◽  
Laminar Flow ◽  
Wall Shear Stress ◽  
Cross Sections ◽  
Adverse Pressure Gradient ◽  
Wall Pressure ◽  
Navier Stokes ◽  
Shear Stresses ◽  
Navier Stokes Equation ◽  
Wall Shear

Wall pressure distribution and shear stress fields for pulsatile laminar flow in a 90-degree bifurcation with rectangular cross sections are evaluated using the results of the numerical solution of the Navier-Stokes equation. The extent of the adverse pressure gradient on the bottom wall of the main duct and the upstream wall of the branch closely correlate to the behavior of the two dynamic recirculation zones which are formed on these two walls. Multiple zones of high and low shear stresses at various sites in the bifurcation are observed. The extent of the fluctuations of the maximum and minimum shear stress is identified. Next-to-the-wall laser Doppler anemometer velocity measurements are used to estimate the shear stress distribution on the walls. In general, qualitative agreement between the experimental and computed wall shear stress values is observed. The variation of the wall shear stress in the vicinity of the branch is discussed in light of the highly perturbed flow field.

Comparison of Carotid Bifurcation Hemodynamics in Patient-Specific Geometries at Rest and During Exercise

2013 ◽  
Author(s):  
Rodward L. Hewlin ◽  
John P. Kizito
Keyword(s):  
Cardiovascular Disease ◽  
Shear Stress ◽  
Wall Shear Stress ◽  
Normal Stress ◽  
Carotid Bifurcation ◽  
Flow Patterns ◽  
Patient Specific ◽  
Local Risk ◽  
Wall Shear ◽  
Hemodynamic Flow

The ultimate goal of the present study is to determine whether investigations of flow patterns (flow reversal and flow branching) and mechanical factors (wall shear stress and normal stress) have a role in local risk factors and if flow modeling can truly rely on surrogate geometric sites (simplified geometries). Cardiovascular disease is considered to be the leading cause of morbidity and mortality across the world and improved methods of disease management are desperately needed. One of the main forms of cardiovascular disease is atherosclerosis. The presence of atherosclerotic plaques has been shown to be closely related to arterial vessel geometry and hemodynamic flow patterns. Computational fluid dynamic simulations were performed on 3 carotid bifurcation arteries to demonstrate that hemodynamic factors are significant determinants for the development of vascular pathology. Relationships between disturbed flow and various geometric factors from rest-state and exercise were examined. Wall shear stress, normal stress, and vorticity were used to verify the role of age, gender, and geometry on hemodynamic flow patterns.

In-Vitro Blood Flow and Wall Shear Stress Measurements in Idealised and Patient Specific Models of the Carotid Artery Bifurcation

2008 ◽  
Author(s):  
Nicolas A. Buchmann ◽  
Mark C. Jermy
Keyword(s):  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Three Dimensional ◽  
Patient Specific ◽  
Specific Geometry ◽  
Wall Shear ◽  
Magnetic Resonance Imaging Mri ◽  
Vitro Model

This work presents Particle Image Velocimetry (PIV) measurements in idealised and patient specific human carotid artery bifurcations (CAB) under steady and pulsatile flow. The geometry and corresponding boundary conditions were obtained by Magnetic Resonance Imaging (MRI) and replicated in an in-vitro model. A complex three-dimensional flow structure exists inside the CAB and vorticity and wall shear stress data are used to quantify the differences between the idealised and patient specific geometry.

Endothelial Cell Migration in Patient-Specific Models of Intracranial Aneurysm

2010 ◽  
Author(s):  
Liang-Der Jou
Keyword(s):  
Endothelial Cells ◽  
Shear Stress ◽  
Wall Shear Stress ◽  
Morphological Changes ◽  
Critical Role ◽  
Endothelial Cell Migration ◽  
Patient Specific ◽  
Shear Stresses ◽  
Wall Shear

Effects of wall shear stress on atherosclerotic disease are widely studied, but its effects on intracranial aneurysms are less clear. In vitro studies have demonstrated that endothelial cells (EC) go through morphological changes under abnormal wall shear stress, and these studies have also shown that abnormal wall shear stresses lead to a non-uniform EC distributions [1, 2]. Since endothelial cells play a critical role in mechanotransduction, a sub-optimal distribution of EC may affect remodeling of vessel wall.

Numerical Analysis of Flow Through a Severely Stenotic Carotid Artery Bifurcation

2001 ◽  
Vol 124 (1) ◽  
pp. 9-20 ◽  
Author(s):  
J. S. Stroud ◽  
S. A. Berger ◽  
D. Saloner
Keyword(s):  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Vortex Shedding ◽  
Plaque Rupture ◽  
Dynamic Pressure ◽  
Stress Gradient ◽  
Turbulence Models ◽  
Wall Shear

The results of computational simulations may supplement MR and other in vivo diagnostic techniques to provide an accurate picture of the hemodynamics in particular vessels, which may help demonstrate the risks of embolism or plaque rupture posed by particular plaque deposits. In this study, a model based on an endarterectomy specimen of the plaque in a carotid bifurcation was examined. The flow conditions include steady flow at Reynolds numbers of 300, 600, and 900 as well as unsteady, pulsatile flow. Both dynamic pressure and wall shear stress are very high, with shear values up to 70 N/m2, proximal to the stenosis throat in the internal carotid artery, and both vary significantly through the flow cycle. The wall shear stress gradient is also strong along the throat. Vortex shedding is observed downstream of the most severe occlusion. Two turbulence models, the Chien and Goldberg varieties of k-ε, are tested and evaluated for their relevance in this geometry. The Chien model better captures phenomena such as vortex shedding. The flow distal to stenosis is likely transitional, so a model that captures both laminar and turbulent behavior is needed.

Basic study on estimation method of wall shear stress in common carotid artery using blood flow imaging

2020 ◽  
Vol 59 (SK) ◽  
pp. SKKE16 ◽  
Author(s):  
Ryo Nagaoka ◽  
Kazuma Ishikawa ◽  
Michiya Mozumi ◽  
Magnus Cinthio ◽  
Hideyuki Hasegawa
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Common Carotid Artery ◽  
Estimation Method ◽  
Flow Imaging ◽  
Basic Study ◽  
Blood Flow Imaging ◽  
Wall Shear

scholarly journals Wall shear stress gradient is independently associated with middle cerebral artery aneurysm development: a case-control CFD patient-specific study based on 77 patients

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mikołaj Zimny ◽  
Edyta Kawlewska ◽  
Anna Hebda ◽  
Wojciech Wolański ◽  
Piotr Ładziński ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Case Control ◽  
Independent Effect ◽  
Patient Specific ◽  
Aneurysm Formation ◽  
Wall Shear ◽  
Mca Aneurysm

Abstract Background Previously published computational fluid dynamics (CFD) studies regarding intracranial aneurysm (IA) formation present conflicting results. Our study analysed the involvement of the combination of high wall shear stress (WSS) and a positive WSS gradient (WSSG) in IA formation. Methods We designed a case-control study with a selection of 38 patients with an unruptured middle cerebral artery (MCA) aneurysm and 39 non-aneurysmal controls to determine the involvement of WSS, oscillatory shear index (OSI), the WSSG and its absolute value (absWSSG) in aneurysm formation based on patient-specific CFD simulations using velocity profiles obtained from transcranial colour-coded sonography. Results Among the analysed parameters, only the WSSG had significantly higher values compared to the controls (11.05 vs − 14.76 [Pa/mm], P = 0.020). The WSS, absWSSG and OSI values were not significantly different between the analysed groups. Logistic regression analysis identified WSS and WSSG as significant co-predictors for MCA aneurysm formation, but only the WSSG turned out to be a significant independent prognosticator (OR: 1.009; 95% CI: 1.001–1.017; P = 0.025). Significantly more patients (23/38) in the case group had haemodynamic regions of high WSS combined with a positive WSSG near the bifurcation apex, while in the control group, high WSS was usually accompanied by a negative WSSG (14/39). From the analysis of the ROC curve for WSSG, the area under the curve (AUC) was 0.654, with the optimal cut-off value −0.37 Pa/mm. The largest AUC was recognised for combined WSS and WSSG (AUC = 0.671). Our data confirmed that aneurysms tend to form near the bifurcation apices in regions of high WSS values accompanied by positive WSSG. Conclusions The development of IAs is determined by an independent effect of haemodynamic factors. High WSS impacts MCA aneurysm formation, while a positive WSSG mainly promotes this process.

scholarly journals Reproducibility of wall shear stress assessment with the paraboloid method in the internal carotid artery with velocity encoded MRI in healthy young individuals

2007 ◽  
Vol 26 (3) ◽  
pp. 598-605 ◽  
Author(s):  
Frieke M.A. Box ◽  
Rob J. van der Geest ◽  
Jeroen van der Grond ◽  
Matthias J.P. van Osch ◽  
Aeilko H. Zwinderman ◽  
...  
Keyword(s):  
Shear Stress ◽  
Carotid Artery ◽  
Wall Shear Stress ◽  
Internal Carotid Artery ◽  
Internal Carotid ◽  
Stress Assessment ◽  
Wall Shear
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