A Computational Method for the Estimation of the Geometrical and Thermophysical Properties of Tumor Using Contact Thermometry

2021 ◽  
Author(s):  
Nimmi Sudarsan ◽  
Arathy K ◽  
Linta Antony ◽  
Sudheesh R S ◽  
Muralidharan M N ◽  
...  
Keyword(s):  
Surface Temperature ◽  
Real Time ◽  
Thermophysical Properties ◽  
Human Subjects ◽  
Research Work ◽  
Estimation Method ◽  
Computational Method ◽  
Heat Transfer Analysis ◽  
Computation Method ◽  
Geometric Center

Abstract Contact thermometry is the measurement of surface temperature using sensors in contact with the medium. These surface temperatures can be potential indicators of any abnormality possibly a tumor. This research work presents a computation method that makes use of contact thermometry to estimate the geometric center, size and thermophysical properties of breast tumor. Wearable thermal sensors captured real time surface temperature readings from discrete point locations. The continuous heat distribution over the domain was formulated using forward heat transfer analysis. The optimization method estimated tumor parameters of the breast and a 3D thermal model was developed from the estimated parameters. Laboratory experiments on breast phantoms were done to validate the estimation method. Furthermore, real time temperature readings of human subjects were recorded and the estimated location and size were then compared with the mammogram results. It was found that, the estimated 2D geometric center and the size in diameter of the tumor closely matches with the mammogram results. Further the thermophysical properties estimated using the proposed method had a higher order in subjects having a tumor making it a tool for breast cancer screening.

scholarly journals Midwave FTIR-Based Remote Surface Temperature Estimation Using a Deep Convolutional Neural Network in a Dynamic Weather Environment

Micromachines ◽  
2018 ◽  
Vol 9 (10) ◽  
pp. 495 ◽  
Author(s):  
Sungho Kim ◽  
Jungho Kim ◽  
Jinyong Lee ◽  
Junmo Ahn
Keyword(s):  
Neural Network ◽  
Surface Temperature ◽  
Convolutional Neural Network ◽  
Real Time ◽  
Real World ◽  
Hyperspectral Image ◽  
Estimation Method ◽  
Deep Convolutional Neural Network ◽  
Temperature Estimation ◽  
Midwave Infrared

Remote measurements of thermal radiation are very important for analyzing the solar effect in various environments. This paper presents a novel real-time remote temperature estimation method by applying a deep learning-based regression method to midwave infrared hyperspectral images. A conventional remote temperature estimation using only one channel or multiple channels cannot provide a reliable temperature in dynamic weather environments because of the unknown atmospheric transmissivities. This paper solves the issue (real-time remote temperature measurement with high accuracy) with the proposed surface temperature-deep convolutional neural network (ST-DCNN) and a hyperspectral thermal camera (TELOPS HYPER-CAM MWE). The 27-layer ST-DCNN regressor can learn and predict the underlying temperatures from 75 spectral channels. Midwave infrared hyperspectral image data of a remote object were acquired three times a day (10:00, 13:00, 15:00) for 7 months to consider the dynamic weather variations. The experimental results validate the feasibility of the novel remote temperature estimation method in real-world dynamic environments. In addition, the thermal stealth properties of two types of paint were demonstrated by the proposed ST-DCNN as a real-world application.

DFT based computational methodology of IC50 prediction

2020 ◽  
Vol 16 ◽  
Author(s):  
Arijit Bag
Keyword(s):  
Present Method ◽  
Dipole Moments ◽  
Research Work ◽  
Organometallic Compounds ◽  
Computational Method ◽  
Unknown Compound ◽  
Drug Designing ◽  
Further Development ◽  
Similar Kind ◽  
Hiv 1

Background: IC50 is one of the most important parameters of a drug. But, it is very difficult to predict this value of a new compound without experiment. There are only a few QSAR based methods available for IC50 prediction which is also highly dependable on huge number of known data. Thus, there is an immense demand for a sophisticated computational method of IC50 prediction, in the field of in-silico drug designing. Objective: Recently developed quantum computation based method of IC50 prediction by Bag and Ghorai requires an affordable known data. In present research work further development of this method is carried out such that the requisite number of known data being minimal. Methods: To retrench the cardinal data span and shrink the effects of variant biological parameters on the computed value of IC50, a relative approach of IC50 computation is pursued in the present method. To predict an approximate value of IC50 of a small molecule, only the IC50 of a similar kind of molecule is required for this method. Results: The present method of IC50 computation is tested for both organic and organometallic compounds as HIV-1 capsid A inhibitor and cancer drugs. Computed results match very well with the experiment. Conclusion: This method is easily applicable to both organic and organometallic com- pounds with acceptable accuracy. Since this method requires only the dipole moments of an unknown compound and the reference compound, IC50 based drug search is possible with this method. An algorithm is proposed here for IC50 based drug search.

JOINT ESTIMATION OF THE TRANSMISSIBILITY AND SEVERITY OF EBOLA VIRUS DISEASE IN REAL TIME

2017 ◽  
Vol 25 (04) ◽  
pp. 587-603 ◽  
Author(s):  
YUSUKE ASAI ◽  
HIROSHI NISHIURA
Keyword(s):  
Real Time ◽  
Ebola Virus ◽  
Virus Disease ◽  
Critical Role ◽  
Estimation Method ◽  
Case Fatality ◽  
Ascertainment Bias ◽  
Joint Estimation ◽  
Ebola Virus Disease ◽  
Strong Impact

The effective reproduction number [Formula: see text], the average number of secondary cases that are generated by a single primary case at calendar time [Formula: see text], plays a critical role in interpreting the temporal transmission dynamics of an infectious disease epidemic, while the case fatality risk (CFR) is an indispensable measure of the severity of disease. In many instances, [Formula: see text] is estimated using the reported number of cases (i.e., the incidence data), but such report often does not arrive on time, and moreover, the rate of diagnosis could change as a function of time, especially if we handle diseases that involve substantial number of asymptomatic and mild infections and large outbreaks that go beyond the local capacity of reporting. In addition, CFR is well known to be prone to ascertainment bias, often erroneously overestimated. In this paper, we propose a joint estimation method of [Formula: see text] and CFR of Ebola virus disease (EVD), analyzing the early epidemic data of EVD from March to October 2014 and addressing the ascertainment bias in real time. To assess the reliability of the proposed method, coverage probabilities were computed. When ascertainment effort plays a role in interpreting the epidemiological dynamics, it is useful to analyze not only reported (confirmed or suspected) cases, but also the temporal distribution of deceased individuals to avoid any strong impact of time dependent changes in diagnosis and reporting.

scholarly journals Real-time Array Shape Estimation Method of Horizontal Suspended Linear Array Based on Non-acoustic Auxiliary Sensors

IEEE Access ◽  
2021 ◽  
pp. 1-1
Author(s):  
Zonglun Che ◽  
Jun Wang ◽  
Jing Zhu ◽  
Bingbing Zhang ◽  
Yang Zhang ◽  
...  
Keyword(s):  
Real Time ◽  
Linear Array ◽  
Estimation Method ◽  
Shape Estimation ◽  
Array Shape Estimation

scholarly journals Improvement of Reliability Determination Performance of Real Time Kinematic Solutions Using Height Trajectory

Sensors ◽  
2021 ◽  
Vol 21 (2) ◽  
pp. 657
Author(s):  
Aoki Takanose ◽  
Yoshiki Atsumi ◽  
Kanamu Takikawa ◽  
Junichi Meguro
Keyword(s):  
Real Time ◽  
Urban Areas ◽  
Estimation Method ◽  
Tall Buildings ◽  
Autonomous Driving ◽  
Reliability Estimation ◽  
Height Variation ◽  
Position Information ◽  
Real Time Kinematic ◽  
Evaluation Test

Autonomous driving support systems and self-driving cars require the determination of reliable vehicle positions with high accuracy. The real time kinematic (RTK) algorithm with global navigation satellite system (GNSS) is generally employed to obtain highly accurate position information. Because RTK can estimate the fix solution, which is a centimeter-level positioning solution, it is also used as an indicator of the position reliability. However, in urban areas, the degradation of the GNSS signal environment poses a challenge. Multipath noise caused by surrounding tall buildings degrades the positioning accuracy. This leads to large errors in the fix solution, which is used as a measure of reliability. We propose a novel position reliability estimation method by considering two factors; one is that GNSS errors are more likely to occur in the height than in the plane direction; the other is that the height variation of the actual vehicle travel path is small compared to the amount of movement in the horizontal directions. Based on these considerations, we proposed a method to detect a reliable fix solution by estimating the height variation during driving. To verify the effectiveness of the proposed method, an evaluation test was conducted in an urban area of Tokyo. According to the evaluation test, a reliability judgment rate of 99% was achieved in an urban environment, and a plane accuracy of less than 0.3 m in RMS was achieved. The results indicate that the accuracy of the proposed method is higher than that of the conventional fix solution, demonstratingits effectiveness.

High-precision roll attitude estimation of decoupled canards relative to the projectile body using bipolar hall-effect sensors

2021 ◽  
pp. 1-9
Author(s):  
Tingting Yin ◽  
Zhong Yang ◽  
Youlong Wu ◽  
Fangxiu Jia
Keyword(s):  
Hall Effect ◽  
Real Time ◽  
High Precision ◽  
Solution Method ◽  
Estimation Method ◽  
Estimation Algorithm ◽  
Attitude Estimation ◽  
Fuzzy Algorithms ◽  
Positioning Method ◽  
Hall Effect Sensors

The high-precision roll attitude estimation of the decoupled canards relative to the projectile body based on the bipolar hall-effect sensors is proposed. Firstly, the basis engineering positioning method based on the edge detection is introduced. Secondly, the simplified dynamic relative roll model is established where the feature parameters are identified by fuzzy algorithms, while the high-precision real-time relative roll attitude estimation algorithm is proposed. Finally, the trajectory simulations and grounded experiments have been conducted to evaluate the advantages of the proposed method. The positioning error is compared with the engineering solution method, and it is proved that the proposed estimation method has the advantages of the high accuracy and good real-time performance.

scholarly journals High-Accuracy Real-Time Kinematic Positioning with Multiple Rover Receivers Sharing Common Clock

2021 ◽  
Vol 13 (4) ◽  
pp. 823
Author(s):  
Lin Zhao ◽  
Jiachang Jiang ◽  
Liang Li ◽  
Chun Jia ◽  
Jianhua Cheng
Keyword(s):  
Real Time ◽  
Ambiguity Resolution ◽  
Temporal Stability ◽  
Estimation Method ◽  
Satellite System ◽  
Integer Ambiguity ◽  
Dual Frequency ◽  
Kinematic Positioning ◽  
Real Time Kinematic ◽  
Satellite Visibility

Since the traditional real-time kinematic positioning method is limited by the reduced satellite visibility from the deprived navigational environments, we, therefore, propose an improved RTK method with multiple rover receivers sharing a common clock. The proposed method can enhance observational redundancy by blending the observations from each rover receiver together so that the model strength will be improved. Integer ambiguity resolution of the proposed method is challenged in the presence of several inter-receiver biases (IRB). The IRB including inter-receiver code bias (IRCB) and inter-receiver phase bias (IRPB) is calibrated by the pre-estimation method because of their temporal stability. Multiple BeiDou Navigation Satellite System (BDS) dual-frequency datasets are collected to test the proposed method. The experimental results have shown that the IRCB and IRPB under the common clock mode are sufficiently stable for the ambiguity resolution. Compared with the traditional method, the ambiguity resolution success rate and positioning accuracy of the proposed method can be improved by 19.5% and 46.4% in the restricted satellite visibility environments.

Research on the Distributed Characteristics of the Delay for Network Coding Based Real-Time Multicast in MANETs

2014 ◽  
Vol 530-531 ◽  
pp. 768-772
Author(s):  
Guo Ping Tan ◽  
Lin Feng Tan ◽  
Lei Cao ◽  
Mei Yan Ju
Keyword(s):  
Maximum Likelihood ◽  
Probability Distribution ◽  
Network Coding ◽  
Real Time ◽  
Lognormal Distribution ◽  
Ad Hoc ◽  
Estimation Method ◽  
Likelihood Estimation ◽  
Actual Distribution ◽  
Delay Distribution

For the study of the applications of partial network coding based real-time multicast protocol (PNCRM) in Mobile Ad hoc networks, the researches should be developed in the probability distribution of delay. In this paper, NS2 is used to obtain the delay of data packets through simulations. Because the delay does not obey the strict normal distribution, the maximum likelihood estimate method based on the lognormal distribution is used to process the data. Using MATLAB to obtain the actual distribution of the natural logarithm of delay, then drawing the delay distribution with the maximum likelihood estimation method based on the lognormal distribution, the conclusion that the distributions obtained by the above mentioned methods are basically consistent can be obtained. So the delay distribution of PNCRM meets the lognormal distribution and the characteristic of delay probability distribution can be estimated.

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