Electrothermal Blinking Vortices for Chaotic Mixing

Author(s):  
Sophie Loire ◽  
Paul Kauffmann ◽  
Paul Gimenez ◽  
Igor Mezić ◽  
Carl Meinhart

Thanks to its favorable reduction scale law, and its easy integration, electrokinetics has emerged over the last fifteen years as one of the major solution to drive flows in fully integrated lab-on-chip. At microscale, an efficient mixing is a keystep which can dramatically accelerate bio-reactions. For thirty years, Dynamical System theory has predicted that chaotic mixing must involve at least 3 dimensions (either time dependent 2D flows or 3D flows). However, in microfluidics, few works have yet presented efficient embedded micromixers. This paper presents experimental and theoretical study of 2D time dependent chaotic mixing using AC electrothermal fluid flows. Experiments and numerical simulations are performed on a top view device and a sideview device. In both devices, a sinusoidal electric signal is applied between 3 interdigitated gold electrodes. A phase signal Vpp = 11V and a ground are switched between the two side electrodes using a step function, whereas the opposite phase signal –Vpp is steadily applied to the center electrode (Figure 1). Flow velocity is measured by micro particle image velocimetry μ PIV. The velocity profile shows a dramatic asymmetry between the two vortices. Therefore, during the switch, vortices overlap, leading to stretching and folding flows required to obtain chaotic mixing (Figure 3 and 4). The experimental measurements validate our electrothermal models based on our previous work [1]. The mixing efficiency of low diffusive particles is studied at multiscale using the mix-variance coefficient (MVC) [2] to evaluate mixing at different scales (Figure 4). To do so, the domain is successively divided in boxes along the x and y direction up to nx and ny boxes, respectively. For each box configuration, average bead concentration is computed. The variance of these concentrations is then evaluated: MVCs=1nxny∑i=1ny∑j=1nxρij-0.52. The result of numerically evaluated MVC in Figure 2 show a dramatic increase of mixing efficiency with blinking vortices compared to steady flow. Theoretical, experimental and simulation results of the mixing process will be presented.

2015 ◽  
Vol 799-800 ◽  
pp. 407-412 ◽  
Author(s):  
Mohamed O. Helmy ◽  
Ahmed M. Fath El-Bab ◽  
Hassan El-Hofy

The accuracy and clogging of microchannels are important for assessing the quality of lab on chip (L-O-C) devices. The clogging affects the fluid mixing efficiency and influences the bonding of substrate. In this paper, inexpensive and quick method for microchannel fabrication in polymethyl methacrylate (PMMA) while reducing the thermal damage is introduced. Accordingly, the substrate was covered with a thin layer of water during CO2laser ablation. The effect of water cooling on the clogging formation, heat affected zone and the microchannel geometry in terms of depth and width is investigated. Clogging formation mechanism in the intersection of Y-channel is studied to improve its quality for microfluidics applications. During the experimental work, the CO2laser power was varied from 2.4 to 6 W at scanning speed from 5 to 12.5 mm/s. The results showed that covering the PMMA substrate with a thin layer of water prevented clogging formation and reduced the heat affected zone.


Author(s):  
Holden Li ◽  
Vipin Vitikkate ◽  
Thomas Kenny

Engineers have long envisioned that a handheld portable blood diagnosis device would be able to give an accurate measurement of chemical content based on a very small sample in the shortest time possible. One of the immediate applications of such device is the Point Of Care (POC) diagnosis system, whereby a single drop of human blood would determine his health status. However, a major technical challenge lies in the ability to separate different particles, which in the case of human blood, is to separate red and white blood cells and plasma in a quick, cheap, reliable device with low power consumption (less than 100mW). In this paper, we present some preliminary results from our tests of ultrasound standing waves as a potential separation mechanism for blood cells. Micro Particle Image Velocimetry (PIV) technique is the studies.


Author(s):  
K Karthikeyan ◽  
L Sujatha

AbstractThis paper deals with design, simulation, fabrication, analysis of mixing efficiency and thin film bonding stability of the micromixer devices with different flow rates used for lab on chip applications. The objective of the present study is to achieve complete mixing with low flow rate and less pressure drop in low cost polymer microfluidic devices. This paper emphasis the design, simulation and fabrication of straight channel micromixer, serpentine channel micromixer with and without quadrant shaped grooves to study the mixing behavior by the effect of structural dimensions of the microfluidic channel at different flow rates. The designed micromixers were tested with varying rates of flow such as 1, 10, 25, 50, 75 and 100 µL/min.


1996 ◽  
Vol 06 (12b) ◽  
pp. 2627-2634 ◽  
Author(s):  
A.T. PÉREZ ◽  
R. CHACÓN ◽  
A. CASTELLANOS

This paper studies the effect of continuous and discontinuous time dependent forcings onto dynamical systems. We compare these different forcings in the context of laminar chaotic mixing. It is shown that the response of a Hamiltonian two-dimensional system to a time periodic sinusoidal forcing differs qualitatively and quantitatively from the response to a square wave function of the same frequency. Consequently, the mixing efficiency of both types of forcings are different. Also a periodic function of the same shape as that of the velocity of the unperturbed system is tested as a forcing, its mixing efficiency being intermediate.


2021 ◽  
pp. 2004101
Author(s):  
Marco Giacometti ◽  
Francesca Milesi ◽  
Pietro Lorenzo Coppadoro ◽  
Alberto Rizzo ◽  
Federico Fagiani ◽  
...  
Keyword(s):  

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1113
Author(s):  
Mohammed Asadullah Khan ◽  
Jürgen Kosel

An integrated polymer-based magnetohydrodynamic (MHD) pump that can actuate saline fluids in closed-channel devices is presented. MHD pumps are attractive for lab-on-chip applications, due to their ability to provide high propulsive force without any moving parts. Unlike other MHD devices, a high level of integration is demonstrated by incorporating both laser-induced graphene (LIG) electrodes as well as a NdFeB magnetic-flux source in the NdFeB-polydimethylsiloxane permanent magnetic composite substrate. The effects of transferring the LIG film from polyimide to the magnetic composite substrate were studied. Operation of the integrated magneto hydrodynamic pump without disruptive bubbles was achieved. In the studied case, the pump produces a flow rate of 28.1 µL/min. while consuming ~1 mW power.


Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ali Rostamian ◽  
Ehsan Madadi-Kandjani ◽  
Hamed Dalir ◽  
Volker J. Sorger ◽  
Ray T. Chen

Abstract Thanks to the unique molecular fingerprints in the mid-infrared spectral region, absorption spectroscopy in this regime has attracted widespread attention in recent years. Contrary to commercially available infrared spectrometers, which are limited by being bulky and cost-intensive, laboratory-on-chip infrared spectrometers can offer sensor advancements including raw sensing performance in addition to use such as enhanced portability. Several platforms have been proposed in the past for on-chip ethanol detection. However, selective sensing with high sensitivity at room temperature has remained a challenge. Here, we experimentally demonstrate an on-chip ethyl alcohol sensor based on a holey photonic crystal waveguide on silicon on insulator-based photonics sensing platform offering an enhanced photoabsorption thus improving sensitivity. This is achieved by designing and engineering an optical slow-light mode with a high group-index of n g  = 73 and a strong localization of modal power in analyte, enabled by the photonic crystal waveguide structure. This approach includes a codesign paradigm that uniquely features an increased effective path length traversed by the guided wave through the to-be-sensed gas analyte. This PIC-based lab-on-chip sensor is exemplary, spectrally designed to operate at the center wavelength of 3.4 μm to match the peak absorbance for ethanol. However, the slow-light enhancement concept is universal offering to cover a wide design-window and spectral ranges towards sensing a plurality of gas species. Using the holey photonic crystal waveguide, we demonstrate the capability of achieving parts per billion levels of gas detection precision. High sensitivity combined with tailorable spectral range along with a compact form-factor enables a new class of portable photonic sensor platforms when combined with integrated with quantum cascade laser and detectors.


2021 ◽  
Vol 23 (2) ◽  
Author(s):  
Subhan Shaik ◽  
Aarthi Saminathan ◽  
Deepak Sharma ◽  
Jagdish A Krishnaswamy ◽  
D Roy Mahapatra

Biosensors ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 65
Author(s):  
Puneet Manocha ◽  
Gitanjali Chandwani

Molecular communication is a bioinspired communication that enables macro-scale, micro-scale and nano-scale devices to communicate with each other. The molecular communication system is prone to severe signal attenuation, dispersion and delay, which leads to performance degradation as the distance between two communicating devices increases. To mitigate these challenges, relays are used to establish reliable communication in microfluidic channels. Relay assisted molecular communication systems can also enable interconnection among various entities of the lab-on-chip for sharing information. Various relaying schemes have been proposed for reliable molecular communication systems, most of which lack practical feasibility. Thus, it is essential to design and develop relays that can be practically incorporated into the microfluidic channel. This paper presents a novel design of passive in-line relay for molecular communication system that can be easily embedded in the microfluidic channel and operate without external energy. Results show that geometric modification in the microfluidic channel can act as a relay and restore the degraded signal up-to 28%.


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