INCEFA-PLUS Project: The Impact of Using Fatigue Data Generated From Multiple Specimen Geometries on the Outcome of a Regression Analysis

2020 ◽  
Author(s):  
Alec Mclennan ◽  
Philippe Spätig ◽  
Jean-Christophe Le Roux ◽  
Joshua Waters ◽  
Peter Gill ◽  
...  
Keyword(s):  
Strain Amplitude ◽  
Apparent Difference ◽  
Primary Coolant ◽  
Amplitude Correction ◽  
Solid Specimen ◽  
Fatigue Data ◽  
Data Points ◽  
Potential Risks ◽  
The Impact ◽  
Mean Strain

Abstract The INCEFA-PLUS project (INcreasing Safety in NPPs by Covering gaps in Environmental Fatigue Assessment) aims to generate and analyse Environmentally-Assisted Fatigue (EAF) experimental data studying parameters such as mean strain, hold times and surface finish. To understand the implications of these parameters for environmental fatigue assessments, these tests were carried out at 300 °C in air and light water reactor primary coolant environments (at 230 °C and 300 °C). Over the duration of this project around 230 fatigue data points were generated by different organisations using a common testing methodology, but with differing specimen geometries. Of these 230 data points, 23 were obtained from tests done using hollow specimen designs. Recent work comparing the fatigue lives of hollow to those of solid specimens indicates that on average the use of hollow specimens results in reduced fatigue lives. This has been explained in terms of the additional hoop and radial strains applied to the specimen due to the internal pressure of the hollow specimen. Given the examples published in the literature on the topic, the comparison of data generated using hollow and solid specimen geometries within the INCEFA-PLUS database has been a particular concern. This paper aims to explore the differences between hollow and solid specimen geometries within the INCEFA-PLUS database, highlight the potential risks of including both geometries in a single analysis, and discusses the approach taken by the project to mitigate the identified risks. The work presented in this paper details three approaches for the data obtained from hollow specimens: 1) exclude the data, 2) include the data as is, or 3) include the data with a correction on the strain amplitude. The strain amplitude correction will be based on the theoretical basis presented in Gill et al. [1], and extended to account for the different hollow specimen geometries used across the INCEFA-PLUS programme. This work demonstrates the robustness of the data analysis performed on the INCEFA-PLUS database to the use of differing specimen geometries. It also develops an explanation for the apparent difference in fatigue life between tests conducted on hollow and solid specimens under test conditions that are nominally the same. Furthermore, this paper builds on the mechanistic understanding presented in Gill et al. [1] and generalises across several Laboratories.

scholarly journals Development of a Rapid Risk and Impact Assessment Tool to Enhance Response to Environmental Emergencies in the Early Stages of a Disaster: A Tool Developed by the European Multiple Environmental Threats Emergency NETwork (EMETNET) Project

2021 ◽  
Author(s):  
Emma-Jane Goode ◽  
Eirian Thomas ◽  
Owen Landeg ◽  
Raquel Duarte-Davidson ◽  
Lisbeth Hall ◽  
...  
Keyword(s):  
Public Health ◽  
Impact Assessment ◽  
Assessment Tool ◽  
The European Union ◽  
Protection Mechanism ◽  
Environmental Threats ◽  
Environmental Disasters ◽  
Early Stages ◽  
Potential Risks ◽  
The Impact

AbstractEvery year, numerous environmental disasters and emergencies occur across the globe with far-reaching impacts on human health and the environment. The ability to rapidly assess an environmental emergency to mitigate potential risks and impacts is paramount. However, collating the necessary evidence in the early stages of an emergency to conduct a robust risk assessment is a major challenge. This article presents a methodology developed to help assess the risks and impacts during the early stages of such incidents, primarily to support the European Union Civil Protection Mechanism but also the wider global community in the response to environmental emergencies. An online rapid risk and impact assessment tool has also been developed to promote enhanced collaboration between experts who are working remotely, considering the impact of a disaster on the environment and public health in the short, medium, and long terms. The methodology developed can support the appropriate selection of experts and assets to be deployed to affected regions to ensure that potential public health and environmental risks and impacts are mitigated whenever possible. This methodology will aid defensible decision making, communication, planning, and risk management, and presents a harmonized understanding of the associated impacts of an environmental emergency.

scholarly journals From COVID-19 adversity comes opportunity: teaching an online integrative medicine course

2021 ◽  
pp. bmjspcare-2020-002713
Author(s):  
Eran Ben-Arye ◽  
Yael Keshet ◽  
Ariel Schiff ◽  
Catherine Zollman ◽  
Emanuela Portalupi ◽  
...  
Keyword(s):  
Integrative Medicine ◽  
Student Attitudes ◽  
Professional Growth ◽  
Academic Community ◽  
Group Discussions ◽  
Item Questionnaire ◽  
Raising Awareness ◽  
Elective Course ◽  
Potential Risks ◽  
The Impact

BackgroundWe examine the impact of a 5-day online elective course in integrative medicine (IM) taking place during the COVID-19 pandemic, attended by 18 medical students from two faculties of medicine in Israel.MethodsThe course curriculum addressed effectiveness and safety of IM practices highlighting supportive and palliative care, demonstrated the work of integrative physicians (IPs) in designing patient-tailored treatments and taught practical skills in communication regarding IM. Group discussions were conducted via Zoom with 32 physicians, healthcare practitioners and IM practitioners working in integrative academic, community and hospital-based settings, in Israel, Italy, UK and Germany. An 18-item questionnaire examined student attitudes and perceived acquisition of skills for implementing what was learned in clinical practice. Student narratives were analysed using ATLAS.Ti software for systematic coding, identifying barriers and advantages of the online learning methodology.ResultsStudents reported a better understanding of the benefits of IM for specific outcomes (p=0.012) and of potential risks associated with these therapies (p=0.048). They also perceived the acquisition of skills related to the IM-focused history (p=0.006), learnt to identify effectiveness and safety of IM treatments (p=0.001), and internalised the referral to IPs for consultation (p=0.001). Student narratives included reflections on the tools provided during the course for assessing effectiveness and safety, enhancing communication with patients, enriching their patient-centred perspective, raising awareness of available therapeutic options, and personal and professional growth.ConclusionsOnline clinical electives in IM are feasible and can significantly increase students’ awareness and modify attitudes towards acquirement of patient-centred perspectives.

scholarly journals A Person-to-Person and Person-to-Place COVID-19 Contact Tracing System Based on OGC IndoorGML

2020 ◽  
Vol 10 (1) ◽  
pp. 2 ◽  
Author(s):  
Soroush Ojagh ◽  
Sara Saeedi ◽  
Steve H. L. Liang
Keyword(s):  
Data Model ◽  
Low Cost ◽  
Large Body ◽  
Contact Tracing ◽  
Trajectory Data ◽  
Sequential Order ◽  
Human Contact ◽  
Wide Availability ◽  
Data Points ◽  
The Impact

With the wide availability of low-cost proximity sensors, a large body of research focuses on digital person-to-person contact tracing applications that use proximity sensors. In most contact tracing applications, the impact of SARS-CoV-2 spread through touching contaminated surfaces in enclosed places is overlooked. This study is focused on tracing human contact within indoor places using the open OGC IndoorGML standard. This paper proposes a graph-based data model that considers the semantics of indoor locations, time, and users’ contexts in a hierarchical structure. The functionality of the proposed data model is evaluated for a COVID-19 contact tracing application with scalable system architecture. Indoor trajectory preprocessing is enabled by spatial topology to detect and remove semantically invalid real-world trajectory points. Results show that 91.18% percent of semantically invalid indoor trajectory data points are filtered out. Moreover, indoor trajectory data analysis is innovatively empowered by semantic user contexts (e.g., disinfecting activities) extracted from user profiles. In an enhanced contact tracing scenario, considering the disinfecting activities and sequential order of visiting common places outperformed contact tracing results by filtering out unnecessary potential contacts by 44.98 percent. However, the average execution time of person-to-place contact tracing is increased by 58.3%.

Shear Modulus and Damping Ratio of Gravel Material

2011 ◽  
Vol 105-107 ◽  
pp. 1426-1432 ◽  
Author(s):  
De Gao Zou ◽  
Tao Gong ◽  
Jing Mao Liu ◽  
Xian Jing Kong
Keyword(s):  
Shear Modulus ◽  
Shear Strain ◽  
Strain Amplitude ◽  
Damping Ratio ◽  
Confining Pressure ◽  
Dynamic Shear Modulus ◽  
Test Results ◽  
Dynamic Shear ◽  
Data Points ◽  
Shear Strain Amplitude

Two of the most important parameters in dynamic analysis involving soils are the dynamic shear modulus and the damping ratio. In this study, a series of tests were performed on gravels. For comparison, some other tests carried out by other researchers were also collected. The test results show that normalized shear modulus and damping ratio vary with the shear strain amplitude, (1) normalized shear modulus decreases with the increase of dynamic shear strain amplitude, and as the confining pressure increases, the test data points move from the low end toward the high end; (2) damping ratio increases with the increase of shear strain amplitude, damping ratio is dependent on confining pressure where an increase in confining pressure decreased damping ratio. According to the test results, a reference formula is proposed to evaluate the maximum dynamic shear modulus, the best-fit curve and standard deviation bounds for the range of data points are also proposed.

Cooperative activation in cardiac muscle: impact of sarcomere length

2002 ◽  
Vol 282 (3) ◽  
pp. H1055-H1062 ◽  
Author(s):  
David P. Dobesh ◽  
John P. Konhilas ◽  
Pieter P. de Tombe
Keyword(s):  
Sarcomere Length ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Significant Function ◽  
Cardiac Myofilament ◽  
Data Points ◽  
On Line ◽  
The Impact ◽  
Cooperative Activation ◽  
Force Relationship

This study was undertaken to determine the impact of sarcomere length (SL) on the level of cooperative activation of the cardiac myofilament at physiological [Mg2+]. Active force development was measured in skinned rat cardiac trabeculae as a function of free [Ca2+] at five SLs (1.85–2.25 μm; 1 mM free [Mg2+]; 15°C). Only muscle preparations with minimal force rundown during the entire protocol were included in the analysis (average 7.2 ± 1.7%). Median SL was measured by on-line computer video micrometry and controlled within 0.01 μm. Care was taken to ensure a sufficient number of data points in the steep portion of the [Ca2+]-force relationship at every SL to allow for accurate fit of the data to a modified Hill equation. Multiple linear regression analysis of the fit parameters revealed that both maximum, Ca2+-saturated force and Ca2+sensitivity were a significant function of SL ( P < 0.001), whereas the level of cooperativity did not depend on SL ( P = 0.2). Further analysis of the [Ca2+]-force relationships revealed a marked asymmetry that, also, was not affected by SL ( P = 0.2–0.6). Finally, we found that the level of cooperativity in isolated skinned myocardium was comparable to that reported for intact, nonskinned myocardium. Our results suggest that an increase in SL induces an increase in the Ca2+ responsiveness of the cardiac sarcomere without affecting the level of cooperativity.

scholarly journals The perception of biopsychosocial impacts of COVID-19 during lockdown restrictions over time in the UK – a mixed methods study

2021 ◽  
Vol 4 (Special2) ◽  
pp. 402-414
Author(s):  
Samuel Grimwood ◽  
Kaz Stuart ◽  
Ruth Browning ◽  
Elaine Bidmead ◽  
Thea Winn-Reed
Keyword(s):  
Social Issues ◽  
Negative Impact ◽  
Mixed Methods Study ◽  
Biological Domain ◽  
Data Points ◽  
Integrated Recovery ◽  
Biopsychosocial Health ◽  
The Uk ◽  
The Impact ◽  
Over Time

Background: The COVID-19 pandemic has profoundly impacted the health of individuals physically, mentally, and socially. This study aims to gain a deeper understanding of this impact across the pandemic from a biopsychosocial stance. Methods: A survey created by the research team was employed between November 2020 and February 2021 across social media, relevant organizations, and networks. The survey incorporated 5-time points across the different stages of the pandemic, covering biological, psychological, and social. There were 5 items for each survey (Very Positive affect to Very Negative affect), and analysis was undertaken using SPSS version 16. Descriptive statistics and non-parametric Friedman and Wilcoxon Tests, as well as correlations between the three domains, were implemented. Results: This study included 164 participants (77.0% female and 35.0% male) across 24 out of 38 counties in the UK. The impact of COVID-19 on biological domain was significant across the five data points χ2(4) = 63.99, p < 0.001, psychological χ2(4) = 118.939, p <0.001 and socially χ2(4) = 186.43, p <0.001. Between the 5 data points, 4 out of 5 had a negative impact, however between the first stage of lockdown and the easing of restrictions, findings for biological (Z=-2.35, p <0.05), psychological (Z=-6.61, p < 0.001), and socially (Z = -8.61, p <0.001) were positive. Negative correlations between the three domains across the pandemic are apparent, but in later stages, the biological domain had a positive correlation r = 0.52, p < 0.001. Conclusion: The data shows a negative impact from the self-reported perception of wellbeing from a biopsychosocial stance over time, as well as perceiving the three domains to interact negatively. To address these biopsychosocial issues, the research implies a place-based integrated recovery effort is needed, addressing biological, psychological, and social issues simultaneously. Further research should investigate biopsychosocial health among a more generalizable population.

scholarly journals The impact of COVID-19 “infodemic” on drug-utilization behaviors: implication for Pharmacovigilance

2020 ◽  
Author(s):  
Marco Tuccori ◽  
Irma Convertino ◽  
Sara Ferraro ◽  
Emiliano Cappello ◽  
Giulia Valdiserra ◽  
...  
Keyword(s):  
Social Media ◽  
Emergency Management ◽  
Opinion Leaders ◽  
Angiotensin Ii Receptor ◽  
Angiotensin Ii Receptor Antagonists ◽  
The World ◽  
Potential Risks ◽  
The Impact ◽  
Hazardous Use

The COVID-19 pandemic that hit the world in 2020 triggered a massive dissemination of information (“infodemic”) about the disease channeled through the web and social media. This “infodemic” included also sensational and distorted information about drugs, which likely affected primarily opinion leaders and people particularly active on social media, and subsequently other peoples leading to inadequate choices by individual patients everywhere. In particular, for some drugs approved with other indications, namely chloroquine, hydroxychloroquine, NSAIDs, ACE inhibitors, angiotensin II receptor antagonists, favipiravir and umifenovir, information has spread that has led to a hazardous use. In this article, we analyzed the rationale behind the claim for use of these drugs in COVID-19, the communication about their effect on the disease, the consequences of this communication on people's behavior and the response of some influential regulatory authorities in an attempt to minimize the actual or potential risks arising from this behavior. Finally, we discussed the role of pharmacovigilance stakeholders in emergency management and possible strategies to be put in place to deal with other similar situations in the future.

scholarly journals A survey and analysis of big data management based on computational methodologies

2020 ◽  
Vol 6 (20) ◽  
pp. 48-53
Author(s):  
Shweta Kumari
Keyword(s):  
Big Data ◽  
Data Management ◽  
Data Analytics ◽  
Big Data Analytics ◽  
Business Enterprise ◽  
Enormous Amount ◽  
Current Scenario ◽  
Data Points ◽  
The Impact ◽  
Day By Day

n a business enterprise there is an enormous amount of data generated or processed daily through different data points. It is increasing day by day. It is tough to handle it through traditional applications like excel or any other tools. So, big data analytics and environment may be helpful in the current scenario and the situation discussed above. This paper discussed the big data management ways with the impact of computational methodologies. It also covers the applicability domains and areas. It explores the computational methods applicability scenario and their conceptual design based on the previous literature. Machine learning, artificial intelligence and data mining techniques have been discussed for the same environment based on the related study.

scholarly journals RESPONSIBLE MARKETING AND ADVERTISING IN GAMBLING: A CRITICAL REVIEW

2015 ◽  
Vol 8 (3) ◽  
pp. 21-35 ◽  
Author(s):  
Adrian Parke ◽  
Andrew Harris ◽  
Jonathan Parke ◽  
Jane Rigbye ◽  
Alex Blaszczynski
Keyword(s):  
Online Community ◽  
Social Activity ◽  
Informed Choice ◽  
Responsible Gambling ◽  
Gambling Behaviour ◽  
Harm Minimisation ◽  
Positive Attitudes ◽  
Media Platform ◽  
Potential Risks ◽  
The Impact

Marketing and advertising play a significant role in the adoption of attitudes and societal norms, which have been shown to have a direct impact on behavioural intentions, ultimately leading to behavioural execution. Concurrent with other attempts to inform policy strategy with respect to harm minimisation in gambling there is a paucity of evidence pertaining to the impact that gambling advertising has on gambling behaviour, gambling-related harm, and the efficacy of advertising regulations to minimise harm. There appears to be an overwhelming portrayal of gambling as a normative, legitimate social activity, at the expense of highlighting the potential risks involved. Furthermore, new marketing techniques utilising the social media platform are able to instil emotive and positive attitudes towards gambling brands and products, as well as enabling consumers to widely share and recommend gambling products across their online community, sometimes exposing under-age and vulnerable populations to gambling. The following paper critically reviews existing research investigating the impact of current gambling advertising and marketing campaigns on both vulnerable (i.e. adolescents and problem gamblers) and normal adult populations, looking specifically at the impact of exposure, the positive framing of gambling, and the transparency of marketing techniques. It is concluded that marketing and advertising in gambling needs to facilitate more informed choice for consumers, and a more balanced approach in the framing of gambling. It is suggested that risk information is presented asynchronously to gambling promotions, as opposed to being delivered as peripheral information, and moreover future strategies need to be based on robust empirical evidence demonstrating the impact of responsible gambling advertising and marketing on behaviour.

scholarly journals The concept of implementation of specifications on cosmetic products in Ukraine

2021 ◽  
Vol 7 (3) ◽  
pp. 41-52
Author(s):  
I. S. Kazakova ◽  
S. M. Kovalenko ◽  
V. O. Lebedynets ◽  
V. S. Kazakova ◽  
O. V. Tkachenko
Keyword(s):  
Content Analysis ◽  
Research Methods ◽  
Impact Factors ◽  
Cosmetic Products ◽  
Technical Regulation ◽  
Consumer Market ◽  
Implementation Plan ◽  
Potential Risks ◽  
The Impact ◽  
Logical Research

Aim. To develop the сoncept of implementation of specifications on cosmetic products in Ukraine.Materials and methods. As research materials the processes of technical regulation of cosmetic products were studied, logical, research methods, as well as the method of content analysis were used.Results. The analysis of the practice of regulating the turnover of cosmetic products was performed; it allowed identifying potential risks in the process of implementing specifications on cosmetic products in Ukraine. Based on the results of the systematization of the impact factors on implementation of the normative legal act the model of its implementation plan was developed, and the main procedures for applying the general provisions of the document were described.Conclusions. Taking into account the problems of implementation of specifications on cosmetic products the concept of implementation regulating the rules of the turnover of cosmetic products at the Ukrainian consumer market has been proposed.

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