Effect of Microbubble Incorporation on Local Solute Transport in Tissue Engineered Cartilage Constructs

2012 ◽  
Author(s):  
Adam B. Nover ◽  
Krista M. Durney ◽  
Shashank R. Sirsi ◽  
Gerard A. Ateshian ◽  
Mark A. Borden ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Partition Coefficient ◽  
Solute Transport ◽  
Ultrasound Imaging ◽  
Culture Media ◽  
Nutrient Transport ◽  
Medical Applications ◽  
Engineered Cartilage

Previously, microbubbles have been studied for a number of different medical applications including ultrasound imaging contrast and drug delivery [1]. Microbubbles are comprised of a gas enclosed in a lipid shell. Recent research has shown that the inclusion of microbubbles in tissue engineered cartilage constructs has been shown to enhance mechanical and biochemical growth [2,3]. This modification of the tissue engineering scaffold by incorporation of gas-filled microbubbles has been shown to homogenize depth-dependent mechanical properties (Fig. 1) [3], which, in standard constructs, resembles a “U-shaped” strain profile with the stiffest regions on the edges surrounding a soft center [4]. In addition, these microbubble containing constructs are described by a higher partition coefficient than standard constructs, indicating increased solute transport [3]. These results led us to propose the hypothesis that the incorporation of microbubbles: a) increases nutrient transport upon microbubble dissolution, b) creates fluid-filled pores upon gas efflux and subsequent influx of culture media [3]. In this study, the aforementioned hypothesis is interrogated through analysis of local solute diffusivity.

Hydrogels as Antibacterial Biomaterials

2018 ◽  
Vol 24 (8) ◽  
pp. 843-854 ◽  
Author(s):  
Weiguo Xu ◽  
Shujun Dong ◽  
Yuping Han ◽  
Shuqiang Li ◽  
Yang Liu
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Water Content ◽  
Oxygen Permeability ◽  
Structural Diversity ◽  
High Water ◽  
Clinical Applications ◽  
High Water Content ◽  
Biomedical Field

Hydrogels, as a class of materials for tissue engineering and drug delivery, have high water content and solid-like mechanical properties. Currently, hydrogels with an antibacterial function are a research hotspot in biomedical field. Many advanced antibacterial hydrogels have been developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs and structural diversity. In this article, an overview is provided on the preparation and applications of various antibacterial hydrogels. Furthermore, the prospects in biomedical researches and clinical applications are predicted.

scholarly journals Stress relaxation in tunable gels

Soft Matter ◽  
2021 ◽  
Author(s):  
Chiara Raffaelli ◽  
Wouter G Ellenbroek
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Stress Relaxation

Hydrogels are a staple of biomaterials development. Optimizing their use in e.g. drug delivery or tissue engineering requires a solid understanding of how to adjust their mechanical properties. Here, we...

scholarly journals Surface Modification of Bacterial Cellulose for Biomedical Applications

2022 ◽  
Vol 23 (2) ◽  
pp. 610
Author(s):  
Teresa Aditya ◽  
Jean Paul Allain ◽  
Camilo Jaramillo ◽  
Andrea Mesa Restrepo
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Surface Modification ◽  
Bacterial Cellulose ◽  
Biomedical Applications ◽  
Human Tissues ◽  
Naturally Occurring ◽  
Microstructure And Mechanical Properties

Bacterial cellulose is a naturally occurring polysaccharide with numerous biomedical applications that range from drug delivery platforms to tissue engineering strategies. BC possesses remarkable biocompatibility, microstructure, and mechanical properties that resemble native human tissues, making it suitable for the replacement of damaged or injured tissues. In this review, we will discuss the structure and mechanical properties of the BC and summarize the techniques used to characterize these properties. We will also discuss the functionalization of BC to yield nanocomposites and the surface modification of BC by plasma and irradiation-based methods to fabricate materials with improved functionalities such as bactericidal capabilities.

scholarly journals Recent advances on polydiacetylene-based smart materials for biomedical applications

2020 ◽  
Vol 4 (4) ◽  
pp. 1089-1104 ◽  
Author(s):  
Fang Fang ◽  
Fanling Meng ◽  
Liang Luo
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Smart Materials ◽  
Biomedical Applications ◽  
Recent Advances ◽  
Smart Biomaterials

This review summarized most recent advances of designing strategies of polydiacetylene-based smart biomaterials with unique colorimetric and mechanical properties, as well as their applications in biosensing, drug delivery, and tissue engineering.

scholarly journals Rheological Characterization of Alginate Based Hydrogels for Tissue Engineering

MRS Advances ◽  
2017 ◽  
Vol 2 (24) ◽  
pp. 1309-1314 ◽  
Author(s):  
Pengfei Duan ◽  
Nehir Kandemir ◽  
Jiajun Wang ◽  
Jinju Chen
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Drug Delivery Systems ◽  
Rheological Characteristics ◽  
Scaffold Material ◽  
Rheological Characterization ◽  
Frequency Sweep ◽  
Strain Sweep

ABSTRACTHydrogels have been widely used in many applications from tissue engineering to drug delivery systems. For both tissue engineering and drug delivery, the mechanical properties are important because they would affect cell-materials interactions and injectability of drugs encapsulated in hydrogel carriers. Therefore, it is important to study the mechanical properties of these hydrogels, particularly at physiological temperature (37°C). This study adopted strain sweep and frequency sweep rotational rheological tests to investigate the rheological characteristics of various tissue engineering relevant hydrogels with different concentrations at 37°C. These hydrogels include alginate, RGD-alginate, and copolymerized collagen/alginate/fibrin. It has revealed that the addition of RGD has negligible effect on the elastic modulus and viscosity of alginate. Alginate gels have demonstrated shear thinning behavior which indicates that they are suitable candidates as carriers for cells or drug delivery. The addition of collagen and fibrin would reinforce the mechanical properties of alginate which makes it a strong scaffold material.

scholarly journals Medical applications of membranes: Drug delivery, artificial organs and tissue engineering

2008 ◽  
Vol 308 (1-2) ◽  
pp. 1-34 ◽  
Author(s):  
Dimitrios F. Stamatialis ◽  
Bernke J. Papenburg ◽  
Miriam Gironés ◽  
Saiful Saiful ◽  
Srivatsa N.M. Bettahalli ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Artificial Organs ◽  
Medical Applications

scholarly journals Antibacterial cellulose-based aerogels for wound healing application: A review

2020 ◽  
Vol 7 (10) ◽  
pp. 4032-4040
Author(s):  
Esam Bashir Yahya ◽  
Marwa Mohammed Alzalouk ◽  
Khalifa A. Alfallous ◽  
Abdullah F. Abogmaza
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Medical Applications ◽  
Tissue Engineering Scaffolds

Aerogels have been steadily developed since its first invention to become one of the most promising materials for various medical and non-medical applications. It has been prepared from organic and inorganic materials, in pure forms or composites. Cellulose-based aerogels are considered one of the promising materials in biomedical applications due to their availability, degradability, biocompatibility and non-cytotoxicity compared to conventional silica or metal-based aerogels. The unique properties of such materials permit their utilization in drug delivery, biosensing, tissue engineering scaffolds, and wound dressing. This review presents a summary of aerogel development as well as the properties and applications of aerogels. Herein, we further discuss the recent works pertaining to utilization of cellulose-based aerogels for antibacterial delivery.

Preparation and Characterization of Poly(Vinyl Alcohol)(PVA)/Hydroxyapatite (HA) Nanofibrous Scaffolds

2011 ◽  
Vol 284-286 ◽  
pp. 459-463 ◽  
Author(s):  
Yuan Yuan Qi ◽  
Bin Liu ◽  
Xing Bin Yan
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Tensile Strength ◽  
Drug Delivery Systems ◽  
Poly Vinyl Alcohol ◽  
Elongation At Break ◽  
Nanofibrous Scaffolds ◽  
Potential Applications

Nanofibrous scaffolds of PVA and HA were prepared by electrospinning. SEM showed the scaffolds had porous nanofibrous morphology, and the diameter of the fibers was in the range of 200-1000 nm. FTIR and XRD showed the presence of HA in the scaffolds. The mechanical properties of the scaffolds changed by the adding content of HA. For the nanoscaffolds with 2wt % HA, the ultimate tensile strength and the elongation at break was 7.5 MPa and 17%. The PVA/HA nanoscaffolds prepared by electrospinning indicated good properties, and had a potential applications in bone tissue engineering and drug delivery systems.

scholarly journals Silica Materials for Medical Applications

2008 ◽  
Vol 2 (1) ◽  
pp. 1-9 ◽  
Author(s):  
María Vallet-Regí ◽  
Francisco Balas
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Chemical Composition ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Delivery Systems ◽  
Medical Applications ◽  
Synthesis Techniques ◽  
Silica Materials ◽  
Bone Repairing

The two main applications of silica-based materials in medicine and biotechnology,i.e.for bone-repairing devices and for drug delivery systems, are presented and discussed. The influence of the structure and chemical composition in the final characteristics and properties of every silica-based material is also shown as a function of the both applications presented. The adequate combination of the synthesis techniques, template systems and additives leads to the development of materials that merge the bioactive behavior with the drug carrier ability. These systems could be excellent candidates as materials for the development of devices for tissue engineering.

Engineering of nanometer-sized cross-linked hydrogels for biomedical applications

2010 ◽  
Vol 88 (3) ◽  
pp. 173-184 ◽  
Author(s):  
Jung Kwon Oh
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Water Content ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
High Water ◽  
Delivery Systems ◽  
High Water Content ◽  
Surface Areas

Microgels/nanogels (micro/nanogels) are promising drug-delivery systems (DDS) because of their unique properties, including tunable chemical and physical structures, good mechanical properties, high water content, and biocompatibility. They also feature sizes tunable to tens of nanometers, large surface areas, and interior networks. These properties demonstrate the great potential of micro/nanogels for drug delivery, tissue engineering, and bionanotechnology. This mini-review describes the current approaches for the preparation and engineering of effective micro/nanogels for drug-delivery applications. It emphasizes issues of degradability and bioconjugation, as well as loading/encapsulation and release of therapeutics from customer-designed micro/nanogels.

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