scholarly journals Stress relaxation in tunable gels

Soft Matter ◽  
2021 ◽  
Author(s):  
Chiara Raffaelli ◽  
Wouter G Ellenbroek
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Stress Relaxation

Hydrogels are a staple of biomaterials development. Optimizing their use in e.g. drug delivery or tissue engineering requires a solid understanding of how to adjust their mechanical properties. Here, we...

Hydrogels as Antibacterial Biomaterials

2018 ◽  
Vol 24 (8) ◽  
pp. 843-854 ◽  
Author(s):  
Weiguo Xu ◽  
Shujun Dong ◽  
Yuping Han ◽  
Shuqiang Li ◽  
Yang Liu
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Water Content ◽  
Oxygen Permeability ◽  
Structural Diversity ◽  
High Water ◽  
Clinical Applications ◽  
High Water Content ◽  
Biomedical Field

Hydrogels, as a class of materials for tissue engineering and drug delivery, have high water content and solid-like mechanical properties. Currently, hydrogels with an antibacterial function are a research hotspot in biomedical field. Many advanced antibacterial hydrogels have been developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs and structural diversity. In this article, an overview is provided on the preparation and applications of various antibacterial hydrogels. Furthermore, the prospects in biomedical researches and clinical applications are predicted.

scholarly journals Surface Modification of Bacterial Cellulose for Biomedical Applications

2022 ◽  
Vol 23 (2) ◽  
pp. 610
Author(s):  
Teresa Aditya ◽  
Jean Paul Allain ◽  
Camilo Jaramillo ◽  
Andrea Mesa Restrepo
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Surface Modification ◽  
Bacterial Cellulose ◽  
Biomedical Applications ◽  
Human Tissues ◽  
Naturally Occurring ◽  
Microstructure And Mechanical Properties

Bacterial cellulose is a naturally occurring polysaccharide with numerous biomedical applications that range from drug delivery platforms to tissue engineering strategies. BC possesses remarkable biocompatibility, microstructure, and mechanical properties that resemble native human tissues, making it suitable for the replacement of damaged or injured tissues. In this review, we will discuss the structure and mechanical properties of the BC and summarize the techniques used to characterize these properties. We will also discuss the functionalization of BC to yield nanocomposites and the surface modification of BC by plasma and irradiation-based methods to fabricate materials with improved functionalities such as bactericidal capabilities.

scholarly journals Recent advances on polydiacetylene-based smart materials for biomedical applications

2020 ◽  
Vol 4 (4) ◽  
pp. 1089-1104 ◽  
Author(s):  
Fang Fang ◽  
Fanling Meng ◽  
Liang Luo
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Smart Materials ◽  
Biomedical Applications ◽  
Recent Advances ◽  
Smart Biomaterials

This review summarized most recent advances of designing strategies of polydiacetylene-based smart biomaterials with unique colorimetric and mechanical properties, as well as their applications in biosensing, drug delivery, and tissue engineering.

scholarly journals Rheological Characterization of Alginate Based Hydrogels for Tissue Engineering

MRS Advances ◽  
2017 ◽  
Vol 2 (24) ◽  
pp. 1309-1314 ◽  
Author(s):  
Pengfei Duan ◽  
Nehir Kandemir ◽  
Jiajun Wang ◽  
Jinju Chen
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Drug Delivery Systems ◽  
Rheological Characteristics ◽  
Scaffold Material ◽  
Rheological Characterization ◽  
Frequency Sweep ◽  
Strain Sweep

ABSTRACTHydrogels have been widely used in many applications from tissue engineering to drug delivery systems. For both tissue engineering and drug delivery, the mechanical properties are important because they would affect cell-materials interactions and injectability of drugs encapsulated in hydrogel carriers. Therefore, it is important to study the mechanical properties of these hydrogels, particularly at physiological temperature (37°C). This study adopted strain sweep and frequency sweep rotational rheological tests to investigate the rheological characteristics of various tissue engineering relevant hydrogels with different concentrations at 37°C. These hydrogels include alginate, RGD-alginate, and copolymerized collagen/alginate/fibrin. It has revealed that the addition of RGD has negligible effect on the elastic modulus and viscosity of alginate. Alginate gels have demonstrated shear thinning behavior which indicates that they are suitable candidates as carriers for cells or drug delivery. The addition of collagen and fibrin would reinforce the mechanical properties of alginate which makes it a strong scaffold material.

Effect of Microbubble Incorporation on Local Solute Transport in Tissue Engineered Cartilage Constructs

2012 ◽  
Author(s):  
Adam B. Nover ◽  
Krista M. Durney ◽  
Shashank R. Sirsi ◽  
Gerard A. Ateshian ◽  
Mark A. Borden ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Partition Coefficient ◽  
Solute Transport ◽  
Ultrasound Imaging ◽  
Culture Media ◽  
Nutrient Transport ◽  
Medical Applications ◽  
Engineered Cartilage

Previously, microbubbles have been studied for a number of different medical applications including ultrasound imaging contrast and drug delivery [1]. Microbubbles are comprised of a gas enclosed in a lipid shell. Recent research has shown that the inclusion of microbubbles in tissue engineered cartilage constructs has been shown to enhance mechanical and biochemical growth [2,3]. This modification of the tissue engineering scaffold by incorporation of gas-filled microbubbles has been shown to homogenize depth-dependent mechanical properties (Fig. 1) [3], which, in standard constructs, resembles a “U-shaped” strain profile with the stiffest regions on the edges surrounding a soft center [4]. In addition, these microbubble containing constructs are described by a higher partition coefficient than standard constructs, indicating increased solute transport [3]. These results led us to propose the hypothesis that the incorporation of microbubbles: a) increases nutrient transport upon microbubble dissolution, b) creates fluid-filled pores upon gas efflux and subsequent influx of culture media [3]. In this study, the aforementioned hypothesis is interrogated through analysis of local solute diffusivity.

Preparation and Characterization of Poly(Vinyl Alcohol)(PVA)/Hydroxyapatite (HA) Nanofibrous Scaffolds

2011 ◽  
Vol 284-286 ◽  
pp. 459-463 ◽  
Author(s):  
Yuan Yuan Qi ◽  
Bin Liu ◽  
Xing Bin Yan
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Tensile Strength ◽  
Drug Delivery Systems ◽  
Poly Vinyl Alcohol ◽  
Elongation At Break ◽  
Nanofibrous Scaffolds ◽  
Potential Applications

Nanofibrous scaffolds of PVA and HA were prepared by electrospinning. SEM showed the scaffolds had porous nanofibrous morphology, and the diameter of the fibers was in the range of 200-1000 nm. FTIR and XRD showed the presence of HA in the scaffolds. The mechanical properties of the scaffolds changed by the adding content of HA. For the nanoscaffolds with 2wt % HA, the ultimate tensile strength and the elongation at break was 7.5 MPa and 17%. The PVA/HA nanoscaffolds prepared by electrospinning indicated good properties, and had a potential applications in bone tissue engineering and drug delivery systems.

Engineering of nanometer-sized cross-linked hydrogels for biomedical applications

2010 ◽  
Vol 88 (3) ◽  
pp. 173-184 ◽  
Author(s):  
Jung Kwon Oh
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Water Content ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
High Water ◽  
Delivery Systems ◽  
High Water Content ◽  
Surface Areas

Microgels/nanogels (micro/nanogels) are promising drug-delivery systems (DDS) because of their unique properties, including tunable chemical and physical structures, good mechanical properties, high water content, and biocompatibility. They also feature sizes tunable to tens of nanometers, large surface areas, and interior networks. These properties demonstrate the great potential of micro/nanogels for drug delivery, tissue engineering, and bionanotechnology. This mini-review describes the current approaches for the preparation and engineering of effective micro/nanogels for drug-delivery applications. It emphasizes issues of degradability and bioconjugation, as well as loading/encapsulation and release of therapeutics from customer-designed micro/nanogels.

scholarly journals Smart Hydrogels Meet Carbon Nanomaterials for New Frontiers in Medicine

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 570
Author(s):  
Simone Adorinni ◽  
Petr Rozhin ◽  
Silvia Marchesan
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Carbon Nanomaterials ◽  
Wearable Electronics ◽  
Smart Systems ◽  
Innovative Potential

Carbon nanomaterials include diverse structures and morphologies, such as fullerenes, nano-onions, nanodots, nanodiamonds, nanohorns, nanotubes, and graphene-based materials. They have attracted great interest in medicine for their high innovative potential, owing to their unique electronic and mechanical properties. In this review, we describe the most recent advancements in their inclusion in hydrogels to yield smart systems that can respond to a variety of stimuli. In particular, we focus on graphene and carbon nanotubes, for applications that span from sensing and wearable electronics to drug delivery and tissue engineering.

Isomeric control of the mechanical properties of supramolecular filament hydrogels

2018 ◽  
Vol 6 (1) ◽  
pp. 216-224 ◽  
Author(s):  
Yi-An Lin ◽  
Myungshim Kang ◽  
Wei-Chiang Chen ◽  
Yu-Chuan Ou ◽  
Andrew G. Cheetham ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Fine Tuning ◽  
Great Promise ◽  
Network Structures ◽  
Peptide Design

Supramolecular filament hydrogels are an emerging class of biomaterials that hold great promise for regenerative medicine, tissue engineering, and drug delivery. The use of isomeric hydrocarbons in the peptide design enables fine-tuning of the mechanical properties of their supramolecular filament hydrogels without altering their network structures.

Silk Proteins in Drug Delivery: An Overview

2018 ◽  
Vol 4 (4) ◽  
pp. 514-518 ◽  
Author(s):  
Dishari Dutta ◽  
Chowdhury Mobaswar Hossain ◽  
Avijit Biswas
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Bombyx Mori ◽  
Self Assembly ◽  
Biomedical Application ◽  
Silk Proteins ◽  
Molecular Weights ◽  
Structure And Morphology ◽  
Biodegradable Properties

Primarily Silk is classified as Mulberry silk (collected from Bombyx mori) and Non-Mulberry silk (collected from sources other than Bombyx mori). Whilst Mulberry silk has gained its importance in biomedical application due to superior biocompatibility and biodegradable properties when compared to synthetic protologues; such edge cutting popularity is quite new among Non-Mulberry variant. Silk proteins namely Sericin and Fibroin, are reported to have been employed in tissue engineering and drug delivery owing to its biocompatibility, slow biodegradability, self-assembly, excellent mechanical properties and controllable structure and morphology. Silk is less inflammatory than other common biodegradable polymers. Fibroin is the fibre used in textile and biomedical devices whereas Sericin is glue like material which binds the fibres together. The fibroin is further divided into two, based on the molecular weights of chains of amino acid. Sericin, being the glue-like material and constitute the part of silk which was generally washed away during extraction of fibroin used as textile material. Researchers have reported that Sericin do not produce immunogenic responses unless associated with fibroin. The review focuses on silk proteins and its utility in drug delivery.

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