Exercise Physiology From 1980 to 2020: Application of the Natural Sciences

2021 ◽  
pp. 1-10
Author(s):  
Jane A. Kent ◽  
Kate L. Hayes
Keyword(s):  
Human Performance ◽  
Exercise Physiology ◽  
Natural Sciences ◽  
The Past ◽  
Interdisciplinary Field ◽  
Advanced Technologies ◽  
Health And Disease ◽  
Fundamental Research ◽  
Research Questions ◽  
Underlying Mechanisms

The field of exercise physiology has enjoyed tremendous growth in the past 40 years. With its foundations in the natural sciences, it is an interdisciplinary field that is highly relevant to human performance and health. The focus of this review is on highlighting new approaches, knowledge, and opportunities that have emerged in exercise physiology over the last four decades. Key among these is the adoption of advanced technologies by exercise physiologists to address fundamental research questions, and the expansion of research topics to range from molecular to organismal, and population scales in order to clarify the underlying mechanisms and impact of physiological responses to exercise in health and disease. Collectively, these advances have ensured the position of the field as a partner in generating new knowledge across many scientific and health disciplines.

scholarly journals Expanding application of the Wiggers diagram to teach cardiovascular physiology

2014 ◽  
Vol 38 (2) ◽  
pp. 170-175 ◽  
Author(s):  
Jamie R. Mitchell ◽  
Jiun-Jr Wang
Keyword(s):  
Exercise Physiology ◽  
Simulated Data ◽  
Premature Ventricular Contractions ◽  
Important Principle ◽  
Temporal Relationships ◽  
Fundamental Understanding ◽  
Health And Disease ◽  
Underlying Mechanisms ◽  
The Many ◽  
The Relationship

Dr. Carl Wiggers' careful observations have provided a meaningful resource for students to learn how the heart works. Throughout the many years from his initial reports, the Wiggers diagram has been used, in various degrees of complexity, as a fundamental tool for cardiovascular instruction. Often, the various electrical and mechanical plots are the novice learner's first exposure to simulated data. As the various temporal relationships throughout a heartbeat could simply be memorized, the challenge for the cardiovascular instructor is to engage the learner so the underlying mechanisms governing the changing electrical and mechanical events are truly understood. Based on experience, we suggest some additions to the Wiggers diagram that are not commonly used to enhance cardiovascular pedagogy. For example, these additions could be, but are not limited to, introducing the concept of energy waves and their role in influencing pressure and flow in health and disease. Also, integrating concepts of exercise physiology, and the differences in cardiac function and hemodynamics between an elite athlete and normal subject, can have a profound impact on student engagement. In describing the relationship between electrical and mechanical events, the instructor may find the introduction of premature ventricular contractions as a useful tool to further understanding of this important principle. It is our hope that these examples can aid cardiovascular instructors to engage their learners and promote fundamental understanding at the expense of simple memorization.

scholarly journals Linking skeletal muscle blood flow and metabolism to the limits of human performance

2017 ◽  
Vol 42 (1) ◽  
pp. 111-115 ◽  
Author(s):  
Robert Boushel
Keyword(s):  
Biological Sciences ◽  
Skeletal Muscle ◽  
Human Performance ◽  
Exercise Physiology ◽  
Muscle Blood Flow ◽  
Muscle Metabolism ◽  
Experimental Methods ◽  
Skeletal Muscle Blood Flow ◽  
Underlying Mechanisms ◽  
Key Questions

Over the last 50 years, Bengt Saltin’s contributions to our understanding of physiology of the circulation, the matching of the circulation to muscle metabolism, and the underlying mechanisms that set the limits for exercise performance were enormous. His research addressed the key questions in the field using sophisticated experimental methods including field expeditions. From the Dallas Bedrest Study to the 1-leg knee model to the physiology of lifelong training, his prodigious body of work was foundational in the field of exercise physiology and his leadership propelled integrative human physiology into the mainstream of biological sciences.

scholarly journals Enlightening the frontiers of neurogastroenterology through optogenetics

2020 ◽  
Vol 319 (3) ◽  
pp. G391-G399
Author(s):  
Anthony C. Johnson ◽  
Tijs Louwies ◽  
Casey O. Ligon ◽  
Beverley Greenwood-Van Meerveld
Keyword(s):  
Delayed Gastric Emptying ◽  
Future Research ◽  
Great Promise ◽  
Gi Tract ◽  
The Past ◽  
Health And Disease ◽  
Fundamental Research ◽  
Irritable Bowel ◽  
New Treatments ◽  
The Brain

Neurogastroenterology refers to the study of the extrinsic and intrinsic nervous system circuits controlling the gastrointestinal (GI) tract. Over the past 5–10 yr there has been an explosion in novel methodologies, technologies and approaches that offer great promise to advance our understanding of the basic mechanisms underlying GI function in health and disease. This review focuses on the use of optogenetics combined with electrophysiology in the field of neurogastroenterology. We discuss how these technologies and tools are currently being used to explore the brain-gut axis and debate the future research potential and limitations of these techniques. Taken together, we consider that the use of these technologies will enable researchers to answer important questions in neurogastroenterology through fundamental research. The answers to those questions will shorten the path from basic discovery to new treatments for patient populations with disorders of the brain-gut axis affecting the GI tract such as irritable bowel syndrome (IBS), functional dyspepsia, achalasia, and delayed gastric emptying.

The limits of human performance

2008 ◽  
Vol 44 ◽  
pp. 11-26 ◽  
Author(s):  
Ralph Beneke ◽  
Dieter Böning
Keyword(s):  
Human Performance ◽  
Safety Margin ◽  
Afferent Input ◽  
Metabolic Energy ◽  
Human Organism ◽  
Mechanical Resistance ◽  
As Doping ◽  
Gene And Protein Expression ◽  
Underlying Mechanisms ◽  
Biochemical Research

Human performance, defined by mechanical resistance and distance per time, includes human, task and environmental factors, all interrelated. It requires metabolic energy provided by anaerobic and aerobic metabolic energy sources. These sources have specific limitations in the capacity and rate to provide re-phosphorylation energy, which determines individual ratios of aerobic and anaerobic metabolic power and their sustainability. In healthy athletes, limits to provide and utilize metabolic energy are multifactorial, carefully matched and include a safety margin imposed in order to protect the integrity of the human organism under maximal effort. Perception of afferent input associated with effort leads to conscious or unconscious decisions to modulate or terminate performance; however, the underlying mechanisms of cerebral control are not fully understood. The idea to move borders of performance with the help of biochemicals is two millennia old. Biochemical findings resulted in highly effective substances widely used to increase performance in daily life, during preparation for sport events and during competition, but many of them must be considered as doping and therefore illegal. Supplements and food have ergogenic potential; however, numerous concepts are controversially discussed with respect to legality and particularly evidence in terms of usefulness and risks. The effect of evidence-based nutritional strategies on adaptations in terms of gene and protein expression that occur in skeletal muscle during and after exercise training sessions is widely unknown. Biochemical research is essential for better understanding of the basic mechanisms causing fatigue and the regulation of the dynamic adaptation to physical and mental training.

History of Tour de France from the Geographical Point of View

2013 ◽  
Vol 22 (3-4) ◽  
pp. 255-277 ◽  
Author(s):  
Vladimír Bačík ◽  
Michal Klobučník
Keyword(s):  
Point Of View ◽  
The Past ◽  
Advanced Technologies ◽  
The World ◽  
Spatial Dimensions ◽  
Tour De France ◽  
Wide Circle ◽  
History Of ◽  
Expert Community ◽  
Geographical Point

Abstract The Tour de France, a three week bicycle race has a unique place in the world of sports. The 100th edition of the event took place in 2013. In the past of 110 years of its history, people noticed unique stories and duels in particular periods, celebrities that became legends that the world of sports will never forget. Also many places where the races unfolded made history in the Tour de France. In this article we tried to point out the spatial context of this event using advanced technologies for distribution of historical facts over the Internet. The Introduction briefly displays the attendance of a particular stage based on a regional point of view. The main topic deals with selected historical aspects of difficult ascents which every year decide the winner of Tour de France, and also attract fans from all over the world. In the final stage of the research, the distribution of results on the website available to a wide circle of fans of this sports event played a very significant part (www.tdfrance.eu). Using advanced methods and procedures we have tried to capture the historical and spatial dimensions of Tour de France in its general form and thus offering a new view of this unique sports event not only to the expert community, but for the general public as well.

Hispano-Hebrew strophic poetry

1981 ◽  
Vol 3 (2) ◽  
pp. 36-46
Author(s):  
Ulf Haxen
Keyword(s):  
Cultural Revolution ◽  
Jewish Population ◽  
Natural Sciences ◽  
European History ◽  
The Past ◽  
Belles Lettres ◽  
The Cultural Revolution

The conquest of Spain by the Arabs, allegedly prompted by leaders of the Jewish population after the fall of the Visigothic regime, 711, opened up an era in Medieval European history which stands unmatched as far as cultural enlightenment is concerned. Philosophy, belles lettres and the natural sciences flourished in the academies established by the Arab savants in the main urban centres. In the wake of the cultural revolution, a new branch of scholarship came into being – Hebrew philology. From the midst of this syncretistic, Mozarabic, milieu a remarkable poetic genre emerged. The study of Mozarabic (from Arabic, musta’riba, to become Arabicized) poetry has proved as one of the most fertile and controversial fields of research for Semitist and Romanist scholars during the past decades.

Современный образ войны и проблема ее трасформации

2018 ◽  
Vol 13 (3) ◽  
pp. 29
Author(s):  
D. A. Abgadzhava ◽  
A. S. Vlaskina
Keyword(s):  
Armed Conflict ◽  
Armed Conflicts ◽  
Social Progress ◽  
The Political ◽  
Military Conflict ◽  
The Past ◽  
Advanced Technologies ◽  
The Social ◽  
Political Boundaries ◽  
Modern War

War is an essential part of the social reality inherent in all stages of human development: from the primitive communal system to the present, where advanced technologies and social progress prevail. However, these characteristics do not make our society more peaceful, on the contrary, according to recent research and reality, now the number of wars and armed conflicts have increased, and most of the conflicts have a pronounced local intra-state character. Thus, wars in the classical sense of them go back to the past, giving way to military and armed conflicts. Now the number of soldiers and the big army doesn’t show the opponents strength. What is more important is the fact that people can use technology, the ideological and informational base to win the war. According to the history, «weak» opponent can be more successful in conflict if he has greater cohesion and ideological unity. Modern wars have already transcended the political boundaries of states, under the pressure of certain trends, they are transformed into transnational wars, that based on privatization, commercialization and obtaining revenue. Thus, the present paper will show a difference in understanding of terms such as «war», «military conflict» and «armed conflict». And also the auteurs will tell about the image of modern war and forecasts for its future transformation.

Novel Findings of Anti-cancer Property of Propofol

2018 ◽  
Vol 18 (2) ◽  
pp. 156-165 ◽  
Author(s):  
Jiaqiang Wang ◽  
Chien-shan Cheng ◽  
Yan Lu ◽  
Xiaowei Ding ◽  
Minmin Zhu ◽  
...  
Keyword(s):  
General Anesthesia ◽  
Cancer Progression ◽  
Molecular Mechanisms ◽  
Intravenous Anesthetic ◽  
The Past ◽  
Anti Cancer ◽  
Underlying Mechanisms ◽  
Recent Attention

Background: Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia. Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear. Conclusion: This review focused on the findings within the past ten years and aimed to provide a general overview of propofol's malignance-modulating properties and the potential molecular mechanisms.

Introduction to biometric measures for Games User Research

2018 ◽  
Author(s):  
Lennart E. Nacke
Keyword(s):  
Physiological Data ◽  
Biometric Data ◽  
User Research ◽  
Academic Practice ◽  
The Past ◽  
Informed Decisions ◽  
Trade Offs ◽  
Research Questions ◽  
Industry Professionals

This chapter presents the physiological metrics used in Games User Research (GUR). Aimed at GUR professionals in the games industry, it explains what methods are available to researchers to measure biometric data while subjects are engaged in play. It sets out when it is appropriate to use biometric measures in GUR projects, the kind of data generated, and the differing ways it can be analysed. The chapter also discusses the trade-offs required when interpreting physiological data, and will help games researchers to make informed decisions about which research questions can benefit from biometric methodologies. As the equipment needed to collect biometric data becomes more sophisticated as well as cheaper, physiological testing of players during a game’s development will become more common. At the same time, Games User Researchers will become more discriminating in its use. Where in the past professionals in the games industry have used biometric testing to generate quick, actionable feedback about player responses to elements of a game, and have been less concerned with the scientific robustness of their methodology, as GUR develops a new breed of games industry professionals are attempting to deploy good academic practice in their researches.

scholarly journals DNA Methylation Profiles of Tph1A and BDNF in Gut and Brain of L. Rhamnosus-Treated Zebrafish

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 142
Author(s):  
Mariella Cuomo ◽  
Luca Borrelli ◽  
Rosa Della Monica ◽  
Lorena Coretti ◽  
Giulia De Riso ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Molecular Mechanisms ◽  
The Past ◽  
Targeted Analysis ◽  
Lack Of Information ◽  
High Resolution Power ◽  
Resolution Level ◽  
Health And Disease ◽  
High Doses ◽  
The Brain

The bidirectional microbiota–gut–brain axis has raised increasing interest over the past years in the context of health and disease, but there is a lack of information on molecular mechanisms underlying this connection. We hypothesized that change in microbiota composition may affect brain epigenetics leading to long-lasting effects on specific brain gene regulation. To test this hypothesis, we used Zebrafish (Danio Rerio) as a model system. As previously shown, treatment with high doses of probiotics can modulate behavior in Zebrafish, causing significant changes in the expression of some brain-relevant genes, such as BDNF and Tph1A. Using an ultra-deep targeted analysis, we investigated the methylation state of the BDNF and Tph1A promoter region in the brain and gut of probiotic-treated and untreated Zebrafishes. Thanks to the high resolution power of our analysis, we evaluated cell-to-cell methylation differences. At this resolution level, we found slight DNA methylation changes in probiotic-treated samples, likely related to a subgroup of brain and gut cells, and that specific DNA methylation signatures significantly correlated with specific behavioral scores.

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