scholarly journals Potential Role of Epigenetic Mechanisms in the Regulation of Drug Metabolism and Transport

2013 ◽  
Vol 41 (10) ◽  
pp. 1725-1731 ◽  
Author(s):  
Magnus Ingelman-Sundberg ◽  
Xiao-Bo Zhong ◽  
Oliver Hankinson ◽  
Sudheer Beedanagari ◽  
Ai-Ming Yu ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Potential Role ◽  
Epigenetic Mechanisms

EP569 Potential role of PAI-1 in endometrial cancer progression and its regulation by epigenetic mechanisms

2019 ◽  
Author(s):  
J Marí-Alexandre ◽  
C Agababyan ◽  
P Pascual-Utiel ◽  
M Cubertorer-Navarro ◽  
J García-Oms ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Progression ◽  
Potential Role ◽  
Epigenetic Mechanisms ◽  
Pai 1

scholarly journals TCDD Toxicity Mediated by Epigenetic Mechanisms

2018 ◽  
Vol 19 (12) ◽  
pp. 4101 ◽  
Author(s):  
Barbara Patrizi ◽  
Mario Siciliani de Cumis
Keyword(s):  
Cellular Response ◽  
Potential Role ◽  
Endocrine System ◽  
Metabolic Adaptation ◽  
Epigenetic Mechanisms ◽  
Developmental Issues ◽  
Aryl Hydrocarbon ◽  
Expression Of Genes ◽  
Tcdd Toxicity

Dioxins are highly toxic and persistent halogenated organic pollutants belonging to two families i.e., Polychlorinated Dibenzo-p-Dioxins (PCDDs) and Polychlorinated Dibenzo Furans (PCDFs). They can cause cancer, reproductive and developmental issues, damage to the immune system, and can deeply interfere with the endocrine system. Dioxins toxicity is mediated by the Aryl-hydrocarbon Receptor (AhR) which mediates the cellular metabolic adaptation to these planar aromatic xenobiotics through the classical transcriptional regulation pathway, including AhR binding of ligand in the cytosol, translocation of the receptor to the nucleus, dimerization with the AhR nuclear translocator, and the binding of this heterodimeric transcription factor to dioxin-responsive elements which regulate the expression of genes involved in xenobiotic metabolism. 2,3,7,8-TCDD is the most toxic among dioxins showing the highest affinity toward the AhR receptor. Beside this classical and well-studied pathway, a number of papers are dealing with the role of epigenetic mechanisms in the response to environmental xenobiotics. In this review, we report on the potential role of epigenetic mechanisms in dioxins-induced cellular response by inspecting recent literature and focusing our attention on epigenetic mechanisms induced by the most toxic 2,3,7,8-TCDD.

scholarly journals Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placenta

2016 ◽  
Vol 10 (1-2) ◽  
pp. 126-135 ◽  
Author(s):  
Hamid-Reza Kohan-Ghadr ◽  
Leena Kadam ◽  
Chandni Jain ◽  
D. Randall Armant ◽  
Sascha Drewlo
Keyword(s):  
Human Placenta ◽  
Potential Role ◽  
Migration And Invasion ◽  
Epigenetic Mechanisms ◽  
Trophoblast Differentiation

scholarly journals Linking prenatal maternal adversity to developmental outcomes in infants: The role of epigenetic pathways

2012 ◽  
Vol 24 (4) ◽  
pp. 1361-1376 ◽  
Author(s):  
Catherine Monk ◽  
Julie Spicer ◽  
Frances A. Champagne
Keyword(s):  
Infant Development ◽  
Potential Role ◽  
Developmental Trajectories ◽  
Maternal Distress ◽  
Epigenetic Mechanisms ◽  
Placental Function ◽  
In Utero Environment ◽  
And Behavior ◽  
The Impact

AbstractPrenatal exposure to maternal stress, anxiety, and depression can have lasting effects on infant development with risk of psychopathology. Although the impact of prenatal maternal distress has been well documented, the potential mechanisms through which maternal psychosocial variables shape development have yet to be fully elucidated. Advances in molecular biology have highlighted the role of epigenetic mechanisms in regulating gene activity, neurobiology, and behavior and the potential role of environmentally induced epigenetic variation in linking early life exposures to long-term biobehavioral outcomes. In this article, we discuss evidence illustrating the association between maternal prenatal distress and both fetal and infant developmental trajectories and the potential role of epigenetic mechanisms in mediating these effects. Postnatal experiences may have a critical moderating influence on prenatal effects, and we review findings illustrating prenatal–postnatal interplay and the developmental and epigenetic consequences of postnatal mother–infant interactions. The in utero environment is regulated by placental function and there is emerging evidence that the placenta is highly susceptible to maternal distress and a target of epigenetic dysregulation. Integrating studies of prenatal exposures, placental function, and postnatal maternal care with the exploration of epigenetic mechanisms may provide novel insights into the pathophysiology induced by maternal distress.

scholarly journals The Interplay between Oxidative Stress, Exercise, and Pain in Health and Disease: Potential Role of Autonomic Regulation and Epigenetic Mechanisms

Antioxidants ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1166
Author(s):  
Jolien Hendrix ◽  
Jo Nijs ◽  
Kelly Ickmans ◽  
Lode Godderis ◽  
Manosij Ghosh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Pain ◽  
Potential Role ◽  
Mechanisms Of Action ◽  
Autonomic Regulation ◽  
Epigenetic Mechanisms ◽  
Confounding Factors ◽  
Health And Disease ◽  
Underlying Mechanisms

Oxidative stress can be induced by various stimuli and altered in certain conditions, including exercise and pain. Although many studies have investigated oxidative stress in relation to either exercise or pain, the literature presents conflicting results. Therefore, this review critically discusses existing literature about this topic, aiming to provide a clear overview of known interactions between oxidative stress, exercise, and pain in healthy people as well as in people with chronic pain, and to highlight possible confounding factors to keep in mind when reflecting on these interactions. In addition, autonomic regulation and epigenetic mechanisms are proposed as potential mechanisms of action underlying the interplay between oxidative stress, exercise, and pain. This review highlights that the relation between oxidative stress, exercise, and pain is poorly understood and not straightforward, as it is dependent on the characteristics of exercise, but also on which population is investigated. To be able to compare studies on this topic, strict guidelines should be developed to limit the effect of several confounding factors. This way, the true interplay between oxidative stress, exercise, and pain, and the underlying mechanisms of action can be revealed and validated via independent studies.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

The Effect of Path Length and Display Size on Memory for Spatial Information

2012 ◽  
Vol 59 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay
Keyword(s):  
Path Length ◽  
Potential Role ◽  
Spatial Information ◽  
Recall Performance ◽  
Minor Role ◽  
Length Effect ◽  
Serial Memory ◽  
Fixed Reference ◽  
A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

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