scholarly journals Ancient protein analysis in archaeology

2021 ◽  
Vol 7 (3) ◽  
pp. eabb9314
Author(s):  
Jessica Hendy
Keyword(s):  
Minimally Invasive ◽  
Protein Analysis ◽  
Important Research ◽  
Research Strategies ◽  
Future Directions ◽  
Disease Evolution ◽  
Nondestructive Techniques ◽  
Recent Developments ◽  
Ancient Proteins ◽  
Health And Disease

The analysis of ancient proteins from paleontological, archeological, and historic materials is revealing insights into past subsistence practices, patterns of health and disease, evolution and phylogeny, and past environments. This review tracks the development of this field, discusses some of the major methodological strategies used, and synthesizes recent developments in archeological applications of ancient protein analysis. Moreover, this review highlights some of the challenges faced by the field and potential future directions, arguing that the development of minimally invasive or nondestructive techniques, strategies for protein authentication, and the integration of ancient protein analysis with other biomolecular techniques are important research strategies as this field grows.

scholarly journals The role of technology in minimally invasive surgery: state of the art, recent developments and future directions

2016 ◽  
Vol 93 (1097) ◽  
pp. 159-167 ◽  
Author(s):  
Michele Tonutti ◽  
Daniel S Elson ◽  
Guang-Zhong Yang ◽  
Ara W Darzi ◽  
Mikael H Sodergren
Keyword(s):  
Minimally Invasive Surgery ◽  
Minimally Invasive ◽  
Invasive Surgery ◽  
State Of The Art ◽  
Future Directions ◽  
Recent Developments

Green Synthesized Nanomaterials as Theranostic Platforms for Cancer Treatment: Principles, Challenges and the Road Ahead

2019 ◽  
Vol 26 (8) ◽  
pp. 1311-1327 ◽  
Author(s):  
Pala Rajasekharreddy ◽  
Chao Huang ◽  
Siddhardha Busi ◽  
Jobina Rajkumari ◽  
Ming-Hong Tai ◽  
...  
Keyword(s):  
Nanoparticle Synthesis ◽  
Research Field ◽  
Synthesis Methods ◽  
Synthetic Approach ◽  
Future Directions ◽  
The Road ◽  
New Methods ◽  
Recent Developments ◽  
Theranostic Applications ◽  
Insight Into

With the emergence of nanotechnology, new methods have been developed for engineering various nanoparticles for biomedical applications. Nanotheranostics is a burgeoning research field with tremendous prospects for the improvement of diagnosis and treatment of various cancers. However, the development of biocompatible and efficient drug/gene delivery theranostic systems still remains a challenge. Green synthetic approach of nanoparticles with low capital and operating expenses, reduced environmental pollution and better biocompatibility and stability is a latest and novel field, which is advantageous over chemical or physical nanoparticle synthesis methods. In this article, we summarize the recent research progresses related to green synthesized nanoparticles for cancer theranostic applications, and we also conclude with a look at the current challenges and insight into the future directions based on recent developments in these areas.

Neurochemistry of L-Glutamate Transport in the CNS: A Review of Thirty Years of Progress

2001 ◽  
Vol 66 (9) ◽  
pp. 1315-1340 ◽  
Author(s):  
Vladimir J. Balcar ◽  
Akiko Takamoto ◽  
Yukio Yoneda
Keyword(s):  
Molecular Biology ◽  
Glutamate Transport ◽  
Mammalian Brain ◽  
Activity Data ◽  
System A ◽  
Recent Developments ◽  
The Central Nervous System ◽  
Health And Disease ◽  
Disease Analysis

The review highlights the landmark studies leading from the discovery and initial characterization of the Na+-dependent "high affinity" uptake in the mammalian brain to the cloning of individual transporters and the subsequent expansion of the field into the realm of molecular biology. When the data and hypotheses from 1970's are confronted with the recent developments in the field, we can conclude that the suggestions made nearly thirty years ago were essentially correct: the uptake, mediated by an active transport into neurons and glial cells, serves to control the extracellular concentrations of L-glutamate and prevents the neurotoxicity. The modern techniques of molecular biology may have provided additional data on the nature and location of the transporters but the classical neurochemical approach, using structural analogues of glutamate designed as specific inhibitors or substrates for glutamate transport, has been crucial for the investigations of particular roles that glutamate transport might play in health and disease. Analysis of recent structure/activity data presented in this review has yielded a novel insight into the pharmacological characteristics of L-glutamate transport, suggesting existence of additional heterogeneity in the system, beyond that so far discovered by molecular genetics. More compounds that specifically interact with individual glutamate transporters are urgently needed for more detailed investigations of neurochemical characteristics of glutamatergic transport and its integration into the glutamatergic synapses in the central nervous system. A review with 162 references.

Duality beyondPersons and Groups

2020 ◽  
pp. 391-413
Author(s):  
Sophie Mützel ◽  
Ronald Breiger
Keyword(s):  
Social Network ◽  
Social Network Analysis ◽  
Network Analysis ◽  
Network Data ◽  
Future Directions ◽  
Affiliation Networks ◽  
The Social ◽  
Recent Developments ◽  
Principle Of Duality ◽  
Seminal Article

This chapter focuses on the general principle of duality, which was originally introduced by Simmel as the intersection of social circles. In a seminal article, Breiger formalized Simmel’s idea, showing how two-mode types of network data can be transformed into one-mode networks. This formal translation proved to be fundamental for social network analysis, which no longer needed data on who interacted with whom but could work with other types of data. In turn, it also proved fundamental for the analysis of how the social is structured in general, as many relations are dual (e.g. persons and groups, authors and articles, organizations and practices), and are thus susceptible to an analysis according to duality principles. The chapter locates the concept of duality within past and present sociology. It also discusses the use of duality in the analysis of culture as well as in affiliation networks. It closes with recent developments and future directions.

scholarly journals Performance-Issues-Mitigation-Techniques for On-Chip-Antennas – Recent Developments in RF, MM-Wave, and Thz Bands With Future Directions

IEEE Access ◽  
2020 ◽  
Vol 8 ◽  
pp. 219577-219610
Author(s):  
Rashid Karim ◽  
Adnan Iftikhar ◽  
Rashad Ramzan
Keyword(s):  
Future Directions ◽  
Recent Developments ◽  
Mitigation Techniques ◽  
Performance Issues ◽  
On Chip

scholarly journals Glycosaminoglycans: Carriers and Targets for Tailored Anti-Cancer Therapy

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 395
Author(s):  
Aikaterini Berdiaki ◽  
Monica Neagu ◽  
Eirini-Maria Giatagana ◽  
Andrey Kuskov ◽  
Aristidis M. Tsatsakis ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Academic Research ◽  
Cancer Therapeutics ◽  
Disease Evolution ◽  
Structure Changes ◽  
Recent Developments ◽  
Distribution Composition ◽  
Membrane Components ◽  
Cancer Tissues

The tumor microenvironment (TME) is composed of cancerous, non-cancerous, stromal, and immune cells that are surrounded by the components of the extracellular matrix (ECM). Glycosaminoglycans (GAGs), natural biomacromolecules, essential ECM, and cell membrane components are extensively altered in cancer tissues. During disease progression, the GAG fine structure changes in a manner associated with disease evolution. Thus, changes in the GAG sulfation pattern are immediately correlated to malignant transformation. Their molecular weight, distribution, composition, and fine modifications, including sulfation, exhibit distinct alterations during cancer development. GAGs and GAG-based molecules, due to their unique properties, are suggested as promising effectors for anticancer therapy. Considering their participation in tumorigenesis, their utilization in drug development has been the focus of both industry and academic research efforts. These efforts have been developing in two main directions; (i) utilizing GAGs as targets of therapeutic strategies and (ii) employing GAGs specificity and excellent physicochemical properties for targeted delivery of cancer therapeutics. This review will comprehensively discuss recent developments and the broad potential of GAG utilization for cancer therapy.

scholarly journals The Past, Present and Future of Cannabis sativa Tissue Culture

Plants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 185
Author(s):  
Adrian S. Monthony ◽  
Serena R. Page ◽  
Mohsen Hesami ◽  
Andrew Maxwell P. Jones
Keyword(s):  
Tissue Culture ◽  
Disease Virus ◽  
Cannabis Sativa ◽  
Clonal Plants ◽  
Future Directions ◽  
The Past ◽  
Recent Developments ◽  
History Of ◽  
Drug Type

The recent legalization of Cannabis sativa L. in many regions has revealed a need for effective propagation and biotechnologies for the species. Micropropagation affords researchers and producers methods to rapidly propagate insect-/disease-/virus-free clonal plants and store germplasm and forms the basis for other biotechnologies. Despite this need, research in the area is limited due to the long history of prohibitions and restrictions. Existing literature has multiple limitations: many publications use hemp as a proxy for drug-type Cannabis when it is well established that there is significant genotype specificity; studies using drug-type cultivars are predominantly optimized using a single cultivar; most protocols have not been replicated by independent groups, and some attempts demonstrate a lack of reproducibility across genotypes. Due to culture decline and other problems, the multiplication phase of micropropagation (Stage 2) has not been fully developed in many reports. This review will provide a brief background on the history and botany of Cannabis as well as a comprehensive and critical summary of Cannabis tissue culture. Special attention will be paid to current challenges faced by researchers, the limitations of existing Cannabis micropropagation studies, and recent developments and future directions of Cannabis tissue culture technologies.

scholarly journals Machine Learning for Design Optimization of Electromagnetic Devices: Recent Developments and Future Directions

2021 ◽  
Vol 11 (4) ◽  
pp. 1627
Author(s):  
Yanbin Li ◽  
Gang Lei ◽  
Gerd Bramerdorfer ◽  
Sheng Peng ◽  
Xiaodong Sun ◽  
...  
Keyword(s):  
Machine Learning ◽  
Design Optimization ◽  
Optimization Methods ◽  
Machine Learning Algorithms ◽  
Cloud Services ◽  
Robust Design Optimization ◽  
Support Vector ◽  
Future Directions ◽  
Electromagnetic Devices ◽  
Recent Developments

This paper reviews the recent developments of design optimization methods for electromagnetic devices, with a focus on machine learning methods. First, the recent advances in multi-objective, multidisciplinary, multilevel, topology, fuzzy, and robust design optimization of electromagnetic devices are overviewed. Second, a review is presented to the performance prediction and design optimization of electromagnetic devices based on the machine learning algorithms, including artificial neural network, support vector machine, extreme learning machine, random forest, and deep learning. Last, to meet modern requirements of high manufacturing/production quality and lifetime reliability, several promising topics, including the application of cloud services and digital twin, are discussed as future directions for design optimization of electromagnetic devices.

AlGaN/GaN HEMTs: RECENT DEVELOPMENTS AND FUTURE DIRECTIONS

2008 ◽  
Vol 18 (04) ◽  
pp. 913-922 ◽  
Author(s):  
SIDDHARTH RAJAN ◽  
UMESH K. MISHRA ◽  
TOMÁS PALACIOS
Keyword(s):  
Field Effect ◽  
High Speed ◽  
Digital Circuits ◽  
Field Effect Transistors ◽  
Rf Power ◽  
Power Performance ◽  
Future Directions ◽  
Recent Developments ◽  
Gan Hemts ◽  
State Of Art

This paper provides an overview of recent work and future directions in Gallium Nitride transistor research. We discuss the present status of Ga -polar AlGaN / GaN HEMTs and the innovations that have led to record RF power performance. We describe the development of N -polar AlGaN / GaN HEMTs with microwave power performance comparable with state-of-art Ga -polar AlGaN / GaN HEMTs. Finally we will discuss how GaN -based field effect transistors could be promising for a less obvious application: low-power high-speed digital circuits.

scholarly journals Proteoglycans in health and disease: emerging concepts and future directions

FEBS Journal ◽  
2010 ◽  
Vol 277 (19) ◽  
pp. 3863-3863 ◽  
Author(s):  
Renato V. Iozzo ◽  
Nikos Karamanos
Keyword(s):  
Future Directions ◽  
Health And Disease
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