A novel biocompatible double network hydrogel consisting of konjac glucomannan with high mechanical strength and ability to be freely shaped

2015 ◽  
Vol 3 (9) ◽  
pp. 1769-1778 ◽  
Author(s):  
Zhiyong Li ◽  
Yunlan Su ◽  
Baoquan Xie ◽  
Xianggui Liu ◽  
Xia Gao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Cell Adhesion ◽  
Mechanical Strength ◽  
Synthetic Polymer ◽  
Natural Polymer ◽  
Tissue Engineering Scaffolds ◽  
Adhesion Properties ◽  
High Mechanical Strength ◽  
Double Network

A novel physically linked double-network (DN) hydrogel was prepared by natural polymer KGM and synthetic polymer PAAm. The DN hydrogels exhibit good mechanical properties, cell adhesion properties, and can be freely shaped, making such hydrogels promising for tissue engineering scaffolds.

scholarly journals Role of Nanoparticle-Polymer Interactions on the Development of Double-Network Hydrogel Nanocomposites with High Mechanical Strength

2020 ◽  
Author(s):  
Andrew Chang ◽  
Nasim Babhadiashar ◽  
Emma Barrett-Catton ◽  
Prashanth Asuri
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
Elastic Moduli ◽  
Theoretical Research ◽  
High Mechanical Strength ◽  
Double Network ◽  
The Past ◽  
Hydrogel Nanocomposites ◽  
Hydrogel Composites

Extensive experimental and theoretical research over the past several decades has culminated in the understanding of the mechanisms behind nanoparticle-mediated enhancements on the mechanical properties of hydrogels. This information is not only crucial to realizing applications that directly benefit from developing hydrogels with high mechanical strength, but also to guide the development of strategies to further enhance hydrogel properties by combining different approaches. In our study, we investigated the effect of combining two approaches – addition of nanoparticles and crosslinking two different polymers (to create double-network hydrogels) – on the mechanical properties of hydrogels. Our studies revealed that these approaches may be combined to synthesize hydrogel composites with enhanced properties; however, both polymers in the double-network hydrogel must strongly interact with the nanoparticles to fully benefit from the addition of nanoparticles. Moreover, the concentration of hydrogel monomers used for the preparation of the double-network hydrogels had a significant effect on the extent of nanoparticle-mediated enhancements; double-network hydrogel nanocomposites prepared using lower monomer concentrations showed higher enhancements in elastic moduli compared to those prepared using high monomer concentrations. Collectively, these results demonstrate that the hypotheses previously developed to understand the role of nanoparticles on the mechanical properties of hydrogel nanocomposites may be extended to double-network hydrogel systems and guide the development of next generation hydrogels with extraordinary mechanical properties through a combination of orthogonal approaches.

scholarly journals Role of Nanoparticle–Polymer Interactions on the Development of Double-Network Hydrogel Nanocomposites with High Mechanical Strength

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 470 ◽  
Author(s):  
Andrew Chang ◽  
Nasim Babhadiashar ◽  
Emma Barrett-Catton ◽  
Prashanth Asuri
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
Elastic Moduli ◽  
Theoretical Research ◽  
High Mechanical Strength ◽  
Double Network ◽  
The Past ◽  
Hydrogel Nanocomposites ◽  
Hydrogel Composites

Extensive experimental and theoretical research over the past several decades has pursued strategies to develop hydrogels with high mechanical strength. Our study investigated the effect of combining two approaches, addition of nanoparticles and crosslinking two different polymers (to create double-network hydrogels), on the mechanical properties of hydrogels. Our experimental analyses revealed that these orthogonal approaches may be combined to synthesize hydrogel composites with enhanced mechanical properties. However, the enhancement in double network hydrogel elastic modulus due to incorporation of nanoparticles is limited by the ability of the nanoparticles to strongly interact with the polymers in the network. Moreover, double-network hydrogel nanocomposites prepared using lower monomer concentrations showed higher enhancements in elastic moduli compared to those prepared using high monomer concentrations, thus indicating that the concentration of hydrogel monomers used for the preparation of the nanocomposites had a significant effect on the extent of nanoparticle-mediated enhancements. Collectively, these results demonstrate that the hypotheses previously developed to understand the role of nanoparticles on the mechanical properties of hydrogel nanocomposites may be extended to double-network hydrogel systems and guide the development of next-generation hydrogels with extraordinary mechanical properties through a combination of different approaches.

scholarly journals Dynamic Nanohybrid-Polysaccharide Hydrogels for Soft Wearable Strain Sensing

Sensors ◽  
2021 ◽  
Vol 21 (11) ◽  
pp. 3574
Author(s):  
Pejman Heidarian ◽  
Hossein Yousefi ◽  
Akif Kaynak ◽  
Mariana Paulino ◽  
Saleh Gharaie ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Strain Sensors ◽  
Self Healing ◽  
Nano Materials ◽  
Strain Sensing ◽  
Ferric Ions ◽  
Research Activity ◽  
Adhesion Properties ◽  
High Mechanical Strength ◽  
The Moment

Electroconductive hydrogels with stimuli-free self-healing and self-recovery (SELF) properties and high mechanical strength for wearable strain sensors is an area of intensive research activity at the moment. Most electroconductive hydrogels, however, consist of static bonds for mechanical strength and dynamic bonds for SELF performance, presenting a challenge to improve both properties into one single hydrogel. An alternative strategy to successfully incorporate both properties into one system is via the use of stiff or rigid, yet dynamic nano-materials. In this work, a nano-hybrid modifier derived from nano-chitin coated with ferric ions and tannic acid (TA/Fe@ChNFs) is blended into a starch/polyvinyl alcohol/polyacrylic acid (St/PVA/PAA) hydrogel. It is hypothesized that the TA/Fe@ChNFs nanohybrid imparts both mechanical strength and stimuli-free SELF properties to the hydrogel via dynamic catecholato-metal coordination bonds. Additionally, the catechol groups of TA provide mussel-inspired adhesion properties to the hydrogel. Due to its electroconductivity, toughness, stimuli-free SELF properties, and self-adhesiveness, a prototype soft wearable strain sensor is created using this hydrogel and subsequently tested.

scholarly journals High-strength and fibrous capsule–resistant zwitterionic elastomers

2021 ◽  
Vol 7 (1) ◽  
pp. eabc5442
Author(s):  
Dianyu Dong ◽  
Caroline Tsao ◽  
Hsiang-Chieh Hung ◽  
Fanglian Yao ◽  
Chenjue Tang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
High Strength ◽  
Design Principles ◽  
Fibrous Capsule ◽  
High Mechanical Strength ◽  
Capsule Formation ◽  
Locking Mechanism ◽  
Fibrous Capsule Formation

The high mechanical strength and long-term resistance to the fibrous capsule formation are two major challenges for implantable materials. Unfortunately, these two distinct properties do not come together and instead compromise each other. Here, we report a unique class of materials by integrating two weak zwitterionic hydrogels into an elastomer-like high-strength pure zwitterionic hydrogel via a “swelling” and “locking” mechanism. These zwitterionic-elastomeric-networked (ZEN) hydrogels are further shown to efficaciously resist the fibrous capsule formation upon implantation in mice for up to 1 year. Such materials with both high mechanical properties and long-term fibrous capsule resistance have never been achieved before. This work not only demonstrates a class of durable and fibrous capsule–resistant materials but also provides design principles for zwitterionic elastomeric hydrogels.

scholarly journals Porous Cellulose-Collagen Scaffolds For Soft Tissue Regeneration: Influence of Cellulose Derivatives On Mechanical Properties And Compatibility With Adipose-Derived Stem Cells.

2022 ◽  
Author(s):  
Katarína Kacvinská ◽  
Martina Trávničková ◽  
Lucy Vojtová ◽  
Petr Poláček ◽  
Jana Dorazilová ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Stem Cells ◽  
Cell Adhesion ◽  
Soft Tissue ◽  
Vascular Tissue ◽  
Biological Properties ◽  
Cellulose Derivatives ◽  
Adipose Derived Stem Cells ◽  
Soft Tissue Regeneration

Abstract This study deals with cellulose derivatives in relation to the collagen fibrils in composite collagen-cellulose scaffolds for soft tissue engineering. Two types of cellulose, i.e., oxidized cellulose (OC) and carboxymethyl cellulose (CMC), were blended with collagen (Col) to enhance its elasticity, stability and sorptive biological properties, e.g. hemostatic and antibacterial features. The addition of OC supported the resistivity of the Col fibrils in a dry environment, while in a moist environment OC caused a radical drop. The addition of CMC reduced the mechanical strength of the Col fibrils in both environments. The elongation of the Col fibrils was increased by both types of cellulose derivatives in both environments, which is closely related to tissue like behaviour. In these various mechanical environments, the ability of human adipose-derived stem cells (hADSCs) to adhere and proliferate was significantly greater in the Col and Col/OC scaffolds than in the Col/CMC scaffold. This is explained by deficient mechanical support and loss of stiffness due to the high swelling capacity of CMC. Although Col/OC and Col/CMC acted differently in terms of mechanical properties, both materials were observed to be cytocompatible, with varying degrees of further support for cell adhesion and proliferation. While Col/OC can serve as a scaffolding material for vascular tissue engineering and for skin tissue engineering, Col/CMC seems to be more suitable for moist wound healing, e.g. as a mucoadhesive gel for exudate removal, since there was almost no cell adhesion.

Morphology of Polyamideliquid Crystalline Polymer Blend

1990 ◽  
Vol 215 ◽  
Author(s):  
K. Nishii ◽  
M. Usui ◽  
T. Muraya ◽  
K. Kimura
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
Polymer Blend ◽  
Liquid Crystalline Polymer ◽  
Liquid Crystalline ◽  
Crystalline Polymer ◽  
Polymer Structure ◽  
High Mechanical Strength ◽  
Blend Morphology ◽  
The Relationship

Polymer blend technology is attractive from the standpoint of both science and industry, and many combinations have been studied. Recently, the polymer blends, including liquid crystalline polymer, have been especially worthy of notice, [1,2,3]. In order to obtain materials with a high mechanical strength and moldability for use in thin molded items, we chose polyamide (PA)-liquid crystalline polymer (LCP) blends. In this study, we first measured the mechanical properties, then studied the features of the polymer structure. We also examined the relationship between morphology and mechanical properties. As a result, we found that the mechanical properties of the blends depended largely on blend morphology, and that mechanical strength increased as blend compatibility increased. On the other hand, we also found that the blends showed compatible and microheterogeneous dispersion at less than 25 wt% LCP, while at more than 30 wt% LCP, blends tended to show twophase separation.

Computational Design and Optimization of Nerve Guidance Conduits for Improved Mechanical Properties and Permeability

2019 ◽  
Vol 141 (5) ◽  
Author(s):  
Shuo Zhang ◽  
Sanjairaj Vijayavenkataraman ◽  
Geng Liang Chong ◽  
Jerry Ying Hsi Fuh ◽  
Wen Feng Lu
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Mechanical Strength ◽  
Tensile Modulus ◽  
Computational Design ◽  
Structural Features ◽  
Nerve Tissue ◽  
High Porosity ◽  
Engineering Research ◽  
Design And Optimization

Nerve guidance conduits (NGCs) are tubular tissue engineering scaffolds used for nerve regeneration. The poor mechanical properties and porosity have always compromised their performances for guiding and supporting axonal growth. Therefore, in order to improve the properties of NGCs, the computational design approach was adopted to investigate the effects of different NGC structural features on their various properties, and finally, design an ideal NGC with mechanical properties matching human nerves and high porosity and permeability. Three common NGC designs, namely hollow luminal, multichannel, and microgrooved, were chosen in this study. Simulations were conducted to study the mechanical properties and permeability. The results show that pore size is the most influential structural feature for NGC tensile modulus. Multichannel NGCs have higher mechanical strength but lower permeability compared to other designs. Square pores lead to higher permeability but lower mechanical strength than circular pores. The study finally selected an optimized hollow luminal NGC with a porosity of 71% and a tensile modulus of 8 MPa to achieve multiple design requirements. The use of computational design and optimization was shown to be promising in future NGC design and nerve tissue engineering research.

Microcellular Injection Molding of Thermoplastic Polyurethane (TPU) Scaffolds Using Carbon Dioxide and Water as Co-Blowing Agents

2013 ◽  
Author(s):  
Hao-Yang Mi ◽  
Xin Jing ◽  
Lih-Sheng Turng ◽  
Xiang-Fang Peng
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Thermoplastic Polyurethane ◽  
Dynamic Mechanical Properties ◽  
Skin Layer ◽  
Tissue Engineering Scaffolds ◽  
Blowing Agents ◽  
Microcellular Injection Molding ◽  
Noticeable Reduction ◽  
Free Transport

In this study, a novel microcellular injection foaming method employing supercritical CO2 (scCO2) and water as co-blowing agents was developed to produce thermoplastic polyurethane (TPU) tissue engineering scaffolds with a uniform porous structure and no solid skin layer. Various characterization techniques were applied to investigate the cell morphology, crystallization behavior, and static and dynamic mechanical properties of solid molded samples, foamed samples using CO2 or water as a single blowing agent, and foamed samples using both CO2 and water as co-blowing agents. Compared with CO2 foamed scaffolds, scaffolds produced by the co-blowing method exhibit much more uniform cell morphologies without a noticeable reduction in mechanical properties. Moreover, these TPU scaffolds have almost no skin layer, which permits free transport of nutrients and waste throughout the samples, which is highly desirable in tissue engineering. The effect of these blowing agents on the shear viscosity of various samples is also reported.

Fabricating high mechanical strength γ-Fe2O3 nanoparticles filled poly(vinyl alcohol) nanofiber using electrospinning process potentially for tissue engineering scaffold

2016 ◽  
Vol 32 (4) ◽  
pp. 411-428 ◽  
Author(s):  
Nor Hasrul Akhmal Ngadiman ◽  
Noordin Mohd Yusof ◽  
Ani Idris ◽  
Denni Kurniawan ◽  
Ehsan Fallahiarezoudar
Keyword(s):  
Tissue Engineering ◽  
Mechanical Strength ◽  
Young’S Modulus ◽  
Flow Rate ◽  
Vinyl Alcohol ◽  
Young's Modulus ◽  
Electrospinning Process ◽  
Poly Vinyl Alcohol ◽  
Tissue Engineering Scaffolds ◽  
Rotating Speed

The use of electrospinning has gained substantial interest in the development of tissue engineering scaffolds due to its ability to produce nanoscale fibers which can mimic the geometry of extracellular tissues. Besides geometry, mechanical property is one of the main elements to be considered when developing tissue engineering scaffolds. In this study, the electrospinning process parameter settings were varied in order to find the optimum setting which can produce electrospun nanofibrous mats with good mechanical properties. Maghemite (γ-Fe2O3) was mixed with poly(vinyl alcohol) and then electrospun to form nanofibers. The five input variable factors involved were nanoparticles content, voltage, flow rate, spinning distance, and rotating speed, while the response variable considered was Young’s modulus. The performance of electrospinning process was systematically screened and optimized using response surface methodology. This work truly demonstrated the sequential nature of designed experimentation. Additionally, the application of various designs of experiment techniques and concepts was also demonstrated. Results revealed that electrospun nanofibrous mats with maximum Young’s modulus (273.51 MPa) was obtained at optimum input settings: 9 v/v% nanoparticle content, 35 kV voltage, 2 mL/h volume flow rate, 8 cm spinning distance, and 3539 r/min of rotating speed. The model was verified successfully by performing confirmation experiments. The nanofibers characterization demonstrated that the nanoparticles were well dispersed inside the nanofibers, and it also showed that the presence of defects on the nanofibers can decrease their mechanical strength. The biocompatibility performance was also evaluated and it was proven that the presence of γ-Fe2O3 enhanced the cell viability and cell growth rate. The developed poly(vinyl alcohol)/γ-Fe2O3 electrospun nanofiber mat has a good potential for tissue engineering scaffolds.

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