Intracellular activity of antibiotics against
Coxiella burnetii
in a model of activated human THP-1 cells
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We evaluated antibiotic activity against the intracellular bacterium Coxiella burnetii using an activated THP-1 cell model of infection. At clinically-relevant concentrations, the intracellular bacterial load was reduced 300-fold by levofloxacin and finafloxacin, 40-fold by doxycycline, 4-fold by ciprofloxacin, and was unaffected by azithromycin. Acidification of the culture media reduced antibiotic activity with the exceptions of doxycycline (no change) and finafloxacin (slight improvement). This model may be used to select antibiotics to be evaluated in-vivo .
2021 ◽
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2013 ◽
Vol 16
(2)
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pp. 210-223
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Astrocyte-Derived CCL2 is Associated with M1 Activation and Recruitment of Cultured Microglial Cells
2016 ◽
Vol 38
(3)
◽
pp. 859-870
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