Monocyte-Derived Interleukin-10 Depresses the Bordetella pertussis- Specific Gamma Interferon Response in Vaccinated Infants
2009 ◽
Vol 16
(12)
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pp. 1816-1821
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Keyword(s):
ABSTRACT Antigen-specific gamma interferon (IFN-γ) has been demonstrated to participate in protection against Bordetella pertussis infection. Circulating mononuclear cells from B. pertussis-infected and from pertussis-vaccinated infants secrete high amounts of IFN-γ after in vitro stimulation by B. pertussis antigens, but with a large variation in the secreted IFN-γ levels between individuals. We show here that the inhibition of the specific IFN-γ response can be at least partially attributed to IL-10 secretion by monocytes. This IL-10 secretion was not associated with polymorphisms at positions −1082, −819, and −592 of the IL-10 gene promoter, suggesting that other genetic or environmental factors affect IL-10 expression and secretion.
2001 ◽
Vol 69
(12)
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pp. 7453-7460
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2004 ◽
Vol 72
(4)
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pp. 2425-2428
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2004 ◽
Vol 72
(4)
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pp. 1974-1982
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2000 ◽
Vol 68
(12)
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pp. 7162-7165
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2009 ◽
Vol 16
(7)
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pp. 1003-1011
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