scholarly journals THU0454 SOMATIC SYMPTOMS IN FIBROMYALGIA AND THEIR CORRELATION WITH DRUG TREATMENT

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 464.2-464
Author(s):  
M. Antivalle ◽  
M. Agosti ◽  
A. Batticciotto ◽  
S. Costi ◽  
V. Giorgi ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Drug Users ◽  
Somatic Symptoms ◽  
Dry Mouth ◽  
Appetite Loss ◽  
Blurred Vision ◽  
Chi Square ◽  
Dry Eyes ◽  
Few Data ◽  
Sun Sensitivity

Background:Drug treatment in fibromyalgia (FM) is often disappointingly ineffective, and there are currently very few data to support therapeutic choices towards a personalized medicine approach.Objectives:To evaluate the prevalence of selected somatic symptoms in FM, and to study their relationship with drug treatments.Methods:The study population consisted of 526 patients (471 F 55 M, mean age 47.31±11.33 yrs) affected by FM not associated with other rheumatic diseases. All patients were required to compile a questionnaire reporting the presence of 42 somatic symptoms -as suggested (1) – in the last 7 days. Drug usage was assessed by interview.Results:On average, patients reported the presence of 17.04±6.68 symptoms (range 4-35), with ample variations in the prevalence of different symptoms (Fig. 1), ranging from over 95% (fatigue and muscle pain) to less than 10 %, seizures being reported by only 2 patients (0.4%). 31.1% of patients were not taking any drug for their FM. The most frequently used drugs were analgesics (ANA, 41.7%) followed by benzodiazepines (BD, 29.1%), SSRIs (16%), gabapentinoids (GABA, 14,4%), and NSRI (14.3%) (Fig. 2). Different drugs were associated with a different spectrum of somatic symptoms: as compared to non users, BD users reported a significantly higher (p< 0.05 by chi-square test) prevalence of irritable bowel (65.4% vs 52.3%), fatigue (98.7% vs 94.9%), thinking difficulties (78.4% vs 68.5%), muscle weakness (94.1% vs 81.7%), abdominal pain (55.6% vs 43.9%), insomnia (73.9% vs 56.6%), depression (63.4 % vs 37.2%), constipation (60.1% vs 42.9%), pain in upper abdomen (50.3% vs 40.2%), nausea (53.6% vs 38.3%), nervousness (71.9% vs 61.5%), chest pain (49.0 vs 37.75), blurred vision (65.4% vs 53.6%), dry mouth (72.5% vs 52.3%), itching (56.2% vs 44.5%), vomiting (13.7% vs 7.8%), taste change (22.2% vs 12.7%), dry eyes (55.6% vs 41.0%), breath shortness (56.9% vs 47.7%), appetite loss (33.3% vs 19.7%), painful urination (15.0% vs 8.4%), and bladder spasms (18.3% vs 8.6%). NRSI users reported a significantly higher prevalence of thinking difficulties, constipation, blurred vision, dry mouth, wheezing, dry eyes, easy bruising. Among GABA users, there was a higher prevalence of thinking difficulties, numbness, insomnia, constipation, nausea, dry mouth, dry eyes, appetite loss, sun sensitivity, easy bruising, and bladder spasms. In no cases a higher prevalence of symptoms was recorded in drug non users vs users.Conclusion:The usage of different drugs in FM is associated with different somatic symptoms. The higher prevalence of symptoms in drug users as compared to non users raises serious questions concerning the opportunity or the appropriateness of drug selection in FM.References:[1]Wolfe F., et al. Arthritis Care Res (Hoboken). 2010 May;62(5):600-10Disclosure of Interests: :None declared

FC03-05 - An evaluation of service provision by community drug treatment services for opioid dependent pregnant drug users in England and Wales

2011 ◽  
Vol 26 (S2) ◽  
pp. 1826-1826 ◽  
Author(s):  
R. Perez-Montejano ◽  
E. Finch ◽  
K. Wolff
Keyword(s):  
Drug Treatment ◽  
Service Provision ◽  
Drug Users ◽  
Postal Survey ◽  
Chi Square ◽  
Home Office ◽  
England And Wales ◽  
Methadone Dosage ◽  
Treatment Services ◽  
Opioid Users

IntroductionOver the last decade a series of guidelines and recommendations have been published in the UK by the Department of Health, the Home Office, Professional and Non-Professional bodies. However, an optimal strategy and consensus in the management and care of opioid dependent pregnant users has yet to be established.ObjectivesDetermination of existing methods for identifying and managing pregnancy in opioid users prescribed methadone by NHS Treatment Services and regional differences.AimTo survey the management, treatment and follow-up of pregnant opioid users prescribed methadone by Drug Treatment Services in England and Wales.MethodsIn 2006 a POSTAL survey was conducted among 223 Community Drug Treatment Services (CDTS).ResultsSixty-six percent of CDTS responded to the survey (n = 154/233). A Chi-square, Mann_Whitney U Test and/or Kruskal-Wallis analysis revealed significant differences in the composition of CDTS and service provision across regions. Half of CDTS (55.3%) provided a methadone dosage regime lower than that recommended for non-pregnant drug users. There were also significant variations on how professionals approached the management of pregnant opioid users. CDTS with an addiction specialist were significantly more likely (p < .01) to advocate high doses of methadone whereas those with a midwife, obstetrician or social worker involved were more likely (p < .05) to suggest low dose methadone and/or detoxification.ConclusionsService provision for pregnant opioid users is comprehensive but there is still variability in some aspects of the treatment received. The way in which methadone is prescribed is not always optimal. Further work is required in this area.

scholarly journals AVALIAÇÃO DA ADESÃO AO TRATAMENTO MEDICAMENTOSO DE PACIENTES COM DISTÚRBIOS PSIQUIÁTRICOS NO SERVIÇO DE EMERGÊNCIA

2018 ◽  
Vol 9 (4) ◽  
Author(s):  
Maria Carolina Barbosa Teixeira Lopes ◽  
Gabriela Parizzi Bianche ◽  
Andréa Fachini Da Costa ◽  
Meiry Fernanda Pinto Okuno ◽  
Ruth Ester Assayag Batista ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Psychiatric Disorders ◽  
Drug Users ◽  
Sao Paulo ◽  
São Paulo ◽  
Chi Square ◽  
Cross Sectional ◽  
Medicinal Treatment ◽  
High Adherence ◽  
Chi Square Test

Objetivo: Identificar o perfil sociodemográfico e clínico e avaliar a adesão ao tratamento medicamentoso domiciliar e, os fatores associados, de pacientes com distúrbios psiquiátricos atendidos no Serviço de Emergência. Metodologia: Estudo transversal e analítico, realizado no Serviço de Emergência do Hospital São Paulo (HSP), de maio a dezembro de 2015. Foram incluídos 98 adultos com transtorno psiquiátrico agudo ou crônico agudizado. A adesão medicamentosa foi avaliada pelo Teste de Morisky-Green. Para verificar os fatores associados à adesão, utilizou-se o teste Qui-Quadrado (p< 0,05). Resultados: Houve predomínio de homens, adultos, que procuraram o serviço para contenção de comportamento por psicose não orgânica não especificada. Os pacientes com abstinência alcoólica e que não eram usuários de drogas apresentaram maior percentual de alta adesão ao tratamento medicamentoso. Conclusões: A adesão foi baixa e associada ao uso de psicotrópicos e drogas ilícitas.Descritores: Adesão à Medicação; Pacientes; Transtornos Mentais; Serviços Médicos de Emergência; Enfermagem.EVALUATION OF ACCESSION TO THE MEDICINAL TREATMENT OF PATIENTS WITH PSYCHIATRIC DISORDERS IN THE EMERGENCY SERVICEObjective: To identify the socio-demographic and clinical profile and to evaluate the adherence to home drug treatment and, the associated factors, of patients with psychiatric disorders attended at the Emergency Department. Methodology: A cross-sectional and analytical study carried out at the Emergency Service of the São Paulo Hospital (HSP), from May to December, 2015. 98 adults with acute or chronic psychiatric disorders were included. Drug adherence was assessed by the Morisky-Green Test. The chi-square test was used to verify the factors associated with adherence (p <0.05). Results: There was a predominance of men, adults, attending the service to contain behavior by unspecified nonorganic psychosis. Patients with alcohol withdrawal and who were not drug users had a higher percentage of high adherence to drug treatment. Conclusions: Adherence was low and associated with the use of psychotropic drugs and illicit drugs.Descriptors: Medication Adherence; Patients; Mental Disorders; Emergency Medical Services; Nursing.EVALUACIÓN DE LA ADHESIÓN AL TRATAMIENTO MEDICAMENTOSO DE PACIENTES CON DISTURBIOS PSIQUIÁTRICOS EN EL SERVICIO DE EMERGENCIAObjetivo: Identificar el perfil sociodemográfico y clínico y evaluar la adhesión al tratamiento medicamentoso domiciliar y, los factores asociados, de pacientes con disturbios psiquiátricos atendidos en el Servicio de Emergencia. Metodología: Estudio transversal y analítico, realizado en el Servicio de Emergencia del Hospital São Paulo (HSP), de mayo a diciembre de 2015. Se incluyeron 98 adultos con trastorno psiquiátrico agudo o crónico agudizado. La adhesión medicamentosa fue evaluada por la prueba de Morisky-Green. Para verificar los factores asociados a la adhesión se utilizó la prueba Qui-Cuadrado (p <0,05). Resultados: Hubo predominio de hombres, adultos, que buscaban el servicio para contención de comportamiento por psicosis no orgánica no especificada. Los pacientes con abstinencia alcohólica y que no eran usuarios de drogas presentaron mayor porcentaje de alta adhesión al tratamiento medicamentoso. Conclusiones: La adhesión fue baja y asociada al uso de psicotrópicos y drogas ilícitas.Descriptores: Cumplimiento de la Medicación; Pacientes, Trastornos Mentales; Servicios Médicos de Urgencia; Enfermería.

Dothiepin for depression: single nightly dosage

1977 ◽  
Vol 15 (23) ◽  
pp. 92-92
Keyword(s):  
Single Dose ◽  
Depressed Patient ◽  
Large Dose ◽  
Half Life ◽  
Dosage Regimen ◽  
The Body ◽  
Dry Mouth ◽  
Blurred Vision ◽  
Depressed Patients ◽  
Single Large Dose

Depressed patients tend to be forgetful, and for them a simple dosage regimen is particularly appropriate. The use of a single daily dosage depends on the drug having a relatively long (over 36 hours) half-life in the body and being tolerated in a single large dose. Many tricyclic anti-depressives fulfil these requirements provided that the single dose is given before the patient goes to bed. Unwanted effects such as dry mouth and blurred vision, which are troublesome during the day, are not a problem during sleep. The sedative actions of many of these drugs can help the insomniac depressed patient who might otherwise need a separate hypnotic.

scholarly journals Primary Amyloidosis with Dry Eyes and Dry Mouth-A Case Report.

1991 ◽  
Vol 30 (6) ◽  
pp. 597-599 ◽  
Author(s):  
Toshio ITOH ◽  
Shinichiro OHASHI ◽  
Takeshi TSUJINO ◽  
Mutsumi TAKENAKA ◽  
Hitoshi KODAMA ◽  
...  
Keyword(s):  
Case Report ◽  
Dry Mouth ◽  
Primary Amyloidosis ◽  
Dry Eyes

scholarly journals Effect of MS on pregnancy and the effect of pregnancy on MS patients in Isfahan

2020 ◽  
Author(s):  
Freshteh Ashtari ◽  
Fatemeh Mokhtari ◽  
Mohammad Soudavi ◽  
Homa Saadat ◽  
Mahboubeh Valiani
Keyword(s):  
Ectopic Pregnancy ◽  
Protective Role ◽  
Common Symptom ◽  
Demographic Information ◽  
Blurred Vision ◽  
Chi Square ◽  
Pregnancy Status ◽  
History Of ◽  
The Mean ◽  
Spss Software

Abstract Background Multiple sclerosis is a chronic disease of the central nervous System.Most women with MS are diagnosed during their reproductive ages.This study evaluated the effect of pregnancy on MS and the effect of MS disease on fertility and pregnancy health. Material & methods: A retrospective descriptive-analytic study was conducted on 110 women suffering from MS with a history of pregnancy(between 2007 and 2017years) in Isfahan, Iran.Samples were selected in a census model.Women completed a researcher-constructed questionnaire by telephone.The questionnaire consisted of three parts: demographic information,MS and its symptoms and its treatment, and the third part was related to the reproductive system and the history of pregnancy associated with MS. Data were analyzed by SPSS software version 16 using Chi-square, ANOVA and t-test.Results The mean age of women with MS was 32.4 years.The most common primary symptom was blurred vision(42.7%).In this population,the average number of pregnancies was 1.61,the number of deliveries was 1.35,the number of abortions was 0.24,the history of ectopic pregnancy was 0.01,the number of alive children was 1.36 and the number of dead children was 0.01.The average time of the last MS attack before the pregnancy was 21.36 months. Fatigue(24.5%) was the most common symptom exacerbated during pregnancy. MS symptoms improved in55.0% of subjects in the second trimester.Discussion MS had no effect on the pregnancy status, such as the number of abortions,ectopic pregnancy, alive and dead children and the duration of pregnancy.The symptoms of the disease are improved during pregnancy.Therefore, pregnancy has a protective role against MS.

scholarly journals Risk Factors of HIV among Voluntary Counseling and Testing Centers Clients, Elgenina Town, West Darfur, Sudan.

2019 ◽  
Vol 3 (3) ◽  
pp. 60-70
Author(s):  
Ahmed, M. Hussein ◽  
Ahmed Mokhtar Osman Mohammed ◽  
Dawria, Adam
Keyword(s):  
Drug Users ◽  
Hiv Positive ◽  
P Value ◽  
Unsafe Sex ◽  
Chi Square ◽  
Voluntary Counseling And Testing ◽  
Counseling And Testing ◽  
Chi Square Test ◽  
Nonprobability Sample ◽  
Structured Questionnaire

This study was conducted in two (VCTs) at Elgenina town, the capital of West Darfur State in Sudan in period from November 2010 to February 2011, the study included all people attending VCTs in Elgeniena town for voluntary checking one hundred and fifty clients who visited the (VCT) centers and volunteered were included in this study, nonprobability sample, 150 volunteers was taken and covered all ages, One ml of blood was taken from each of the study sample and tested by rapid Immune Chromatographic (ICT) for HIV, a structured questionnaire was designed and the interviewed after a written consent to participate in the study was signed, data was analyzed using the SPSS statistical programmer and for possible association between study variables, the Chi square test was used, the study showed that 35 volunteers (23.33%) were positives, of whom 54.3% 19 were males. People having more than one sex partner were high 63.6% with statistically significant factor of getting infection (P.value = 0.00). Also, practicing unsafe sex were 5.2% another major risky (P.value = 0.00). Among the HIV positive cases 34.3% were drug users, compared to 20.9% from the HIV negatives (p. value = 0.10). There is no relation between education level and infection with HIV (p .value = 0.154). Forty two percent of the participants were single, 30% married, 10% divorced, 7.3% widows and 10.7% were separate

Drug Treatment Needs of Hispanic Drug Users in Long Beach, California

2004 ◽  
Vol 34 (4) ◽  
pp. 879-894 ◽  
Author(s):  
Dennis G. Fisher ◽  
Grace L. Reynolds ◽  
Catherine M. Moreno-Branson ◽  
Adi Jaffe ◽  
Michele M. Wood ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Drug Users ◽  
Long Beach ◽  
Treatment Needs

Predictors of uptake of aspirin (ASA) chemoprevention in Lynch syndrome (LS).

2021 ◽  
Vol 39 (3_suppl) ◽  
pp. 49-49
Author(s):  
Michael J. Hall ◽  
Margie Clapper ◽  
Wen-Chi J Chang ◽  
Yana Chertock ◽  
Minhhuyen J Nguyen
Keyword(s):  
Older Age ◽  
Prevention Measures ◽  
Chi Square ◽  
Endoscopic Screening ◽  
Written Information ◽  
And Gender ◽  
Few Data ◽  
Medical Recommendations ◽  
Ethnicity And Gender

49 Background: Substantial data support efficacy of ASA in colorectal adenoma and cancer (CRC) chemoprevention. In 2011, the CaPP2 Phase 3 trial showed benefit of 600 mg ASA daily for prevention of LS-associated CRC (HR 0.41,p=0.02) in persons w/ASA adherence >2 yrs. Anecdotally, uptake of ASA by LS pts has been low, but few data exist. We examined uptake and predictors of ASA chemoprevention among LS pts receiving follow-up at our center since 2011. Methods: Pts evaluated by Fox Chase’s Risk Assessment Program receive in-person medical recommendations and written information about cancer (CA) prevention measures including ASA. Medical records of 127 LS pts were retrospectively reviewed. Demographics, gene affected, personal Hx of CA, ASA use, and ASA dose were collected. Majority (94.5%) of cohort had documentation of ongoing LS endoscopic screening at our center—only 3.2% had no recent follow-up (past 3 yrs) and 2.4% had recently died (past 3 yrs). Chi-square tests and multivariable logistic regression were used in analyses. Results: Overall 24.4% (31/127) of pts reported ASA use for chemoprevention (see Table). Nearly half (48.4%) of ASA users took 81 mg ASA daily, and only 22.6% reported taking >600 mg ASA daily. ASA use was associated with older age, MLH1/ MSH2+ vs MSH6/ PMS2+, and personal Hx of CRC. In the multivariable logistic model, older age (OR 2.80, p=0.04) and MLH1/ MSH2+ (OR 2.64,p=0.07) were significant and borderline significant, respectively. Adding race/ethnicity and gender strengthened the effect of age>60 (OR 3.11, p=0.03), and improved fit (pseudoR2=16.8%). Conclusions: Uptake of ASA chemoprevention by LS pts is overall modest, but older age is associated with ASA uptake for chemoprevention. Among ASA users, fewer than 1 in 4 take the 600 mg daily dose shown effective in CaPP2. Confirmatory trials as well as efforts to elucidate barriers to ASA chemoprevention in LS are needed. [Table: see text]

Drug Use by Pregnant Women

2017 ◽  
Author(s):  
Linda C. Fentiman
Keyword(s):  
Health Care ◽  
Substance Use ◽  
Drug Use ◽  
Prenatal Care ◽  
Drug Treatment ◽  
Pregnant Women ◽  
Health Care Professionals ◽  
Drug Users ◽  
Substance Use And Abuse ◽  
Weak Evidence

This chapter examines the use of drugs—both legal and illegal–by pregnant women, noting increased medical and legal supervision of pregnancy and women’s substance use and abuse. Many states require health care professionals to report pregnant women who admit to, or are suspected of, using alcohol or other drugs. The result can be involuntary detention commitment for “treatment.” Women have been prosecuted for homicide after they suffer a stillbirth despite weak evidence that the stillbirth was caused by drug use. Prosecution of these women is counterproductive, because it drives pregnant drug users underground, away from both prenatal care and drug treatment.

Narcan as biomedical panic: The war on overdose and the harms of harm reduction

2020 ◽  
pp. 136248062096477
Author(s):  
Philip R Kavanaugh
Keyword(s):  
Public Health ◽  
Drug Treatment ◽  
Harm Reduction ◽  
Drug Users ◽  
Opioid Addiction ◽  
The State ◽  
Opioid Overdose ◽  
State Response ◽  
Drug Companies ◽  
The Us

As the opioid overdose crisis in the US persists, governments have coordinated with drug companies to propagate the overdose reversal drug naloxone (Narcan) as a ‘kinder/gentler’ state response, deriving from a supposedly progressive harm reduction ethos. Drawing on Derrida’s deconstruction of pharmakon, I show how Narcan is rendered paradoxical and terminal, diverting attention from the structural antecedents of opioid addiction and resources for drug treatment while reproducing corporeal suffering in those revived. I further highlight how Narcan is positioned in a wider array of regressive governing practices that legitimate the state’s punitive drug war and demonization of drug users. Narcan thus provides a useful opening between the state and contemporary biomedicine to theorize how harm reduction and public health unfurl in insidious and corrosive ways.

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