scholarly journals OP0110 A COHORT STUDY ON THE BIDIRECTIONAL RELATIONSHIP BETWEEN PERIODONTITIS AND OSTEOARTHRITIS OVER A 15-YEAR FOLLOW-UP

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 61.2-61
Author(s):  
K. S. K. MA ◽  
E. Thota ◽  
T. Van Dyke

Background:Recently, osteoarthritis has been proposed to be driven by complement-mediated inflammatory cascades. That is, in addition to the conventional degenerative model, our knowledge of osteoarthritis pathogenesis has been expanded with an inflammation-dependent theory.Objectives:To identify the relationship between osteoarthritis and periodontitis.Methods:144,788 periodontitis patients and 144,788 propensity score-matched controls without history of periodontitis were enrolled in this cohort study. A Cox proportional hazard model was used to estimate the risk of osteoarthritis. Survival analysis was utilized to assess the time-dependent effect of periodontitis on osteoarthritis. Age and gender were stratified to identify susceptible subgroups. A symmetrical case-control analysis was designed to determine the relationship between periodontitis and history of osteoarthritis.Results:Patients with periodontitis had higher risk of osteoarthritis (HR =1.15, 95% CI =1.12–1.17, P < 0.001) and severe osteoarthritis that led to total knee/hip replacement (HR =1.12, 95% CI =1.03–1.21, P < 0.01) than controls, which was time-dependent (log-rank test P < 0.01). The effect of periodontitis on osteoarthritis was significant in both genders and age subgroups over 30 years old (all P < 0.001). Among them, females (HR=1.27, 95% CI = 1.13–1.42, P < 0.001) and patients aged over 51 (HR= 1.21, 95% CI =1.10-1.33, P < 0.001) with periodontitis were predisposed to severe osteoarthritis that led to total knee/hip replacement. In addition, periodontitis patients were more likely to have a history of osteoarthritis (OR = 1.11, 95% CI = 1.06 - 1.17, P < 0.001).Conclusion:These findings suggest a bidirectional relationship between osteoarthritis and periodontitis. Patients with periodontitis presented with a higher risk of osteoarthritis, including severe osteoarthritis that led to total knee/hip replacement. Likewise, periodontitis was more likely to develop following osteoarthritis.References:[1]Wang Q, Rozelle AL, Lepus CM, et al. Identification of a central role for complement in osteoarthritis. Nat Med 2011;17:1674-9. Temoin S, Chakaki A, Askari A, et al.[2]Identification of oral bacterial DNA in synovial fluid of patients with arthritis with native and failed prosthetic joints. J Clin Rheumatol 2012;18:117-21.Disclosure of Interests:None declared

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 48.2-48
Author(s):  
K. S. K. MA ◽  
T. Van Dyke

Background:Fibromyalgia has been proposed to be driven by chronic inflammation and infections that are associated with early rheumatoid arthritis and inflammatory arthritis. Other than the central sensitization model, our knowledge of fibromyalgia pathogenesis has been expanded with an inflammation-dependent theory, which is stimulated by prolonged spinal cord hyperexcitability.Objectives:To determine the relationship between periodontitis and fibromyalgia.Methods:In this cohort study, 196,428 periodontitis patients and 196,428 propensity score-matched non-periodontitis controls were enrolled. A Cox proportional hazard model was utilized to estimate the risk of fibromyalgia and survival analysis was adopted to assess the time-dependent effect of periodontitis on fibromyalgia. Subgroup analyses stratified by age, gender, and follow-up years were conducted to identify susceptible populations. A symmetrical cohort was designed to ascertain the relationship between fibromyalgia and the risk of periodontitis.Results:Patients with history of periodontitis were more likely to develop fibromyalgia than non-periodontitis controls (HR =1.42, 95% CI =1.39–1.44, P < 0.001), which persisted in the survival analysis (log-rank test P < 0.0001). This effect was significant in both genders and all age subgroups, and was particularly evident in males (HR=1.52, 95% CI = 1.48–1.56, P < 0.001) and younger periodontitis patients (HR= 1.55, 95% CI =1.50-1.60, P < 0.001). Fibromyalgia patients who never had periodontitis presented with higher risk for periodontitis over time (HR = 1.43, 95% CI = 1.40 - 1.45, P < 0.001).Conclusion:This is the first longitudinal study that addresses the bidirectional relationship between fibromyalgia and periodontitis, in which periodontitis may serve as a risk factor or early sign of fibromyalgia. Based on the observed relationship between fibromyalgia and periodontitis, regular follow-ups and patient education are recommended for patients with either disease.Disclosure of Interests:None declared


2011 ◽  
Vol 52 (3) ◽  
pp. 365-384 ◽  
Author(s):  
EMILY CALLACI

ABSTRACTThis article explores the relationship between understandings of youth sexuality and mobility, and racial nationalism in late colonial Tanganyika through a history of dansi: a dance mode first popularized by Tanganyikan youth in the 1930s. Dansi's heterosocial choreography and cosmopolitan connotations provoked widespread anxieties among rural elders and urban elites over the mobility, economic autonomy, and sexual agency of youth. In urban commercial dancehalls in the 1950s, dansi staged emerging cultural solidarities among migrant youth, while also making visible social divisions based on class and gender. At the same time, nationalist intellectuals attempted to reform dansi according to an emerging political rhetoric of racial respectability.


2017 ◽  
Author(s):  
Babette Hellemans

This pioneering textbook explores the theoretical background of cultural variety, both in past and present. How is it possible to study 'culture' when the topic covers the arts, literature, movies, history, sociology, anthropology and gender studies? Understanding Culture examines the evolution of a concept with varying meanings depending on changing norms. Offering a long-duration analysis of the relationship between culture and nature, this book looks at the origins of studying culture from an international perspective. Using examples from the several scholarly traditions in the practice of studying culture, Understanding Culture is a key introduction to the area. It identifies the history of interpreting culture as a meeting point between the long-standing historical investigation of 'humanism' and 'postmodernism' and is a comprehensive resource for those who wish to further their engagement with culture as both a historical and contemporary phenomenon.


2021 ◽  
Vol 17 ◽  
Author(s):  
Mansoureh Refaei ◽  
Soodabeh Aghababaei ◽  
Mansoureh Yazdkhasti ◽  
Farideh Kazemi ◽  
Fatemeh Farahmandpour

Background: Several risk factors have been identified for postpartum hemorrhage, one of which being the duration of the third stage of labour. This stage refers to the interval between the expulsion of the fetus to the expulsion of the placenta. Some bleeding occurs in this stage due to the separation of the placenta Objective: This study aimed to identify the factors associated with the length of the third stage of labour. Methods: In this cross-sectional study, 300 women hospitalized for vaginal birth were selected via convenience sampling. The study data were collected using a researcher-made questionnaire. Then, the data were analyzed using univariate and multivariate linear regression analyses. Results: The mean (SD) age of the participants was 26.41 (6.26) years. Investigation of the relationship between the study variables and the time of placental separation indicated that a minute increase in the length of membranes rupture caused a 0.003minute decrease in the time of placental separation. However, this time increased by 2.75, 6.68, and 2.86 minutes in the individuals without the history of abortion, those with the history of stillbirth, and those who had not received hyoscine, respectively. The results of multivariate analysis indicated that suffering from preeclampsia or hypertension, history of stillbirth, not receiving hyoscine, and not receiving misoprostol increased the length of the third stage by 4.40, 8.55, 2.38, and 6.04 minutes, respectively. Conclusion: Suffering from preeclampsia and having the history of stillbirth increased and using hyoscine and misoprostol decreased the length of the third stage of labour. However, no significant relationship was found between the length of the third stage of labour and mother’s age, gestational age, parity, mother’s body mass index, mother’s chronic disorders, history of manual placenta removal, length of the first and second stages, membranes rupture, induction, amount of oxytocin after delivery, and infant’s weight and gender.


2018 ◽  
Vol 31 (04) ◽  
pp. 571-577 ◽  
Author(s):  
Margaret Miller ◽  
Dennis Orwat ◽  
Gelareh Rahimi ◽  
Jacobo Mintzer

ABSTRACTIntroduction:The relationship between Alzheimer’s Disease (AD) and alcohol addiction is poorly characterized. Arrests for driving under the influence (DUI) can serve as a proxy for alcohol addiction. Therefore, the potential association between DUI and AD could be helpful in understanding the relationship between alcohol abuse and AD.Materials and methods:A retrospective, population-based cohort study using state health and law enforcement data was performed. The study cross-referenced 141,281 South Carolina Alzheimer’s Disease Registry cases with state law enforcement data.Results:Of the 2,882 registry cases (1.4%) found to have a history of at least one DUI arrest, cases were predominantly White (58.7%) and male (77.4%). Results showed a correlation coefficient of 0.7 (p &lt; 0.0001) between the age of first DUI arrest and the age of AD diagnosis. A dose-response relationship between the number of DUIs and age of AD onset was found to exist, where those with a history of DUI arrest were diagnosed an average of 9.1 years earlier, with a further 1.8 years earlier age at diagnosis in those with two or more arrests for DUI. A history of DUI arrest was also found to be negatively associated with survival after diagnosis, with a 10% decreased life expectancy in those with a DUI arrest history.Conclusions:Driving under the influence, a potential indicator of alcohol addiction, is associated with an earlier onset of AD registry diagnosis and shortened survival after diagnosis. This study contributes to the growing body of evidence suggesting that some cases of AD are alcohol related and, possibly, postponable or preventable.


2021 ◽  
pp. 146-164
Author(s):  
E.O. Zyatkova ◽  
◽  
I.Y. Stoyanova ◽  
K.G. Yazykov ◽  
◽  
...  

In the article the manifestation of gelotophobia (fear of being laughed at) in the 1st, 2nd and 3rd-year students aged 17–22 years is described. The aim of the present study was to in-vestigate the manifestation of the fear of being laughed at and its influence on the components of students’ psychological health as a factor of predisposition to mental health disorders. According to this aim, three tasks were set. The first task was to identify the differences in gelotophobia depending on the duration of education and gender. The second task was to establish a link between personality traits and the level of gelotophobia. The third task was to observe the relationship between components of psychological health (resilience, stress management) and the level of gelotophobia. To identify the level of fear of being laughed at in a sample of students, we set the scales of the "GELOPH-15" questionnaire and specified them as low, moderate and high gelotophobia scores. Then, using the frequency analysis of students’ answers to this questionnaire, we found out that most responses indicated a moderate level of gelotophobia (71%), only 16% of answers indicate a low level, and 10% of answers present a high level of fear of being laughed at. Also 3% of students did not answer this ques-tionnaire. The results of this study demonstrated that gelotophobia is more typical for female than for male students. The data also showed that the manifestation of gelotophobia didn’t correlate to the duration of education. A comparative analysis using the Student's t-test in the female and male subgroups identified that young women in socially significant cases could hardly tolerate negative situations. Young men, on the other hand, were able to cope with stressful situations if they had internal balance. Using the Spearman rank test, a correlation analysis was performed between the scales of the characterological questionnaire and the level of gelotophobia. A relationship with the total score of gelotophobia, as well as with the average and low score of gelotophobia was found. No correlation with a high score of gelotophobia was found. The analysis of the results obtained showed that resilience and its components (involvement, control and risk acceptance) helps to reduce stress and the influ-ence of negative factors that cause fear in socially significant situations. The results corre-spond to the above stated aims and tasks. Further work in this direction will make it possible to develop a program of psychological support for students.


2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Vanessa DeClercq ◽  
Yunsong Cui ◽  
Cynthia Forbes ◽  
Scott A. Grandy ◽  
Melanie Keats ◽  
...  

The objective of this study was to examine the relationship between adipokines and adiposity in individuals with rheumatoid and osteoarthritis in the Atlantic PATH cohort. Using a nested case-control analysis, participants in the Atlantic PATH cohort with rheumatoid or osteoarthritis were matched for measures of adiposity with participants without a history of arthritis. Both measured and self-reported data were used to examine disease status, adiposity, and lifestyle factors. Immunoassays were used to measure plasma markers. BMI was positively correlated with percentage body fat, fat mass index (FMI), and a change in BMI from 18 years of age in all 3 groups. There were no statistical differences between levels of plasma adipokines; adiponectin levels were 6.6, 7.9, and 8.2 μg/ml, leptin levels were 10.3, 13.7, and 11.5 ng/ml, and resistin levels were 10.0, 12.1, and 10.8 ng/ml in participants without arthritis, with rheumatoid arthritis, and with osteoarthritis, respectively. Those with higher levels of adiponectin were more likely to have osteoarthritis (but not rheumatoid arthritis). No association was found between arthritis types and leptin or resistin. This study demonstrates differences in measures of adiposity and adipokines in specific types of arthritis and highlights the need for more research targeting specific adipokines during arthritic disease progression.


2014 ◽  
Vol 43 (4) ◽  
pp. 429-436 ◽  
Author(s):  
Sultana Monira Hussain ◽  
Yuanyuan Wang ◽  
Flavia M. Cicuttini ◽  
Julie A. Simpson ◽  
Graham G. Giles ◽  
...  

2020 ◽  
Vol 5 (2) ◽  
pp. 144-149
Author(s):  
Budi Asty Andini ◽  
Khobibah Khobibah ◽  
Mimi Ruspita

Background: Sexual intercourse during pregnancy is a physiological need for pregnant women that is influenced by factors of perception from within oneself and previous experience and gender role factors in the family with the aim of knowing the relationship between gender roles and sexual relations in pregnant women. Methods: Non-experimental research with a population of all pregnant women in the village of Curugsewu in the District of Patean. The total sample of pregnant women receiving antenatal care was 30 with the Kendal statistical test. Results: significance T = 0.022 <0.005 there is a relationship between gender roles and sexual relations of sufficient strength in the negative direction -391*.Conclusion: there is a relationship between gender roles and sexual relations, the husband's role is very dominant but the frequency of sex in early pregnancy is largely not done because it is influenced by cultural factors and a history of previous abortion sex.


Sign in / Sign up

Export Citation Format

Share Document