scholarly journals Rho-associated protein kinase inhibitor induced morphological changes in type VI collagen in the human trabecular meshwork

2019 ◽  
Vol 104 (3) ◽  
pp. 392-397
Author(s):  
Mizu Okamoto ◽  
Miyuki Nagahara ◽  
Takuma Tajiri ◽  
Naoya Nakamura ◽  
Nahoko Fukunishi ◽  
...  
Keyword(s):  
Trabecular Meshwork ◽  
Kinase Inhibitor ◽  
Morphological Changes ◽  
Open Angle Glaucoma ◽  
Rho Kinase ◽  
Cross Sectional Study ◽  
Total Width ◽  
Type Vi Collagen ◽  
Cross Sectional ◽  
Age Range

AimsTo investigate morphological changes in type VI collagen in the human trabecular meshwork associated with the rho kinase inhibitor ripasudil.MethodsThis cross-sectional study evaluated the effects of ripasudil eye drop administration (RA) or no ripasudil eye drop administration (NRA) in patients with primary open-angle glaucoma (POAG; age range 60–80 years) who underwent conventional outflow reconstruction between December 2015 and September 2016 at Tokai University Hachioji Hospital. The juxtacanalicular tissue was removed and imaged using transmission electron microscopy. Type VI collagen comprises cross-banded aggregates with transverse bands 30 nm apart repeating every 105 nm. The transverse bands are called the outer rod-like region (ORR) and the intervals are called the inner rod-like region (IRR). The waveform intensity in the type VI collagen was analysed in electron micrographs using Fourier transformation to detect the IRR and ORR borders.ResultsTen eyes of 10 patients were included (n=5/group). The baseline characteristics did not differ significantly between groups. ORR width was significantly smaller in the RA group (37.85±3.43 nm) than in the NRA group (50.62±5.23 nm, p<0.05), whereas IRR width was significantly greater in the RA group (70.68±10.84 nm) than in the NRA group (58.19±5.34 nm, p<0.05). Morphological changes in the type VI collagen total width tended to correlate with the duration of ripasudil administration (r=0.9, p=0.08).ConclusionsRipasudil administration in patients with POAG induced morphological changes in type VI collagen. Patients with POAG administered RA had a significantly smaller ORR width and a significantly greater IRR width than patients with POAG not administered RA.

Rho kinase inhibitor for primary open-angle glaucoma and ocular hypertension

2020 ◽  
Author(s):  
Josefine Clement Freiberg ◽  
Alexander von Spreckelsen ◽  
Naira Khachatryan ◽  
Miriam Kolko ◽  
Augusto Azuara-Blanco ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Primary Open Angle Glaucoma ◽  
Kinase Inhibitor ◽  
Open Angle Glaucoma ◽  
Rho Kinase ◽  
Open Angle ◽  
Rho Kinase Inhibitor

scholarly journals Determining Orthodontic Knowledge and Awareness in Young Adults

2021 ◽  
pp. 030157422110221
Author(s):  
Jyoti Mishra ◽  
Sudhir Kapoor ◽  
Jitendra Bhagchandani ◽  
Sonahita Agarwal ◽  
Vaibhav Vashishta ◽  
...  
Keyword(s):  
Orthodontic Treatment ◽  
Adult Population ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Group I ◽  
Insignificant Difference ◽  
Age Range ◽  
Ethical Clearance ◽  
Structured Questionnaire

Aim and Objective: To assess the level of awareness among local adult population (orthodontically untreated) regarding orthodontic treatment and procedures. Materials and Methods: A cross-sectional study was planned by accessing 100 subjects comprising of 2 groups (50 male and 50 female). After due ethical clearance, a self-structured questionnaire consisting of 17 questions was given to a group of randomly selected 100 individuals with an age range of 20 to 30 years. Results: The overall awareness of orthodontics as a speciality among both the groups was only 52% to 56%. Statistically insignificant difference was found in the knowledge and awareness of orthodontic treatment among both male and female subjects, that is, Group I and II. Also, those who knew about the orthodontic treatment did not opt for it because of high cost and longer duration involved. Conclusion: More than half of the population is unaware of the scope of orthodontic treatment, and thus, they do not seek any assistance. Hence, more efforts are needed to create awareness about orthodontics and the associated benefits.

scholarly journals Relación entre conducta prosocial, resolución de problemas y consumo de drogas en adolescentes

2016 ◽  
Vol 32 (2) ◽  
pp. 609 ◽  
Author(s):  
Olga Hernández-Serrano ◽  
José P. Espada ◽  
Alejandro Guillén-Riquelme
Keyword(s):  
Problem Solving ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Prosocial Behaviour ◽  
Cross Sectional ◽  
Problem Solving Skills ◽  
Problem Solving Strategies ◽  
And Gender ◽  
Prosocial Behaviours ◽  
Age Range

<p>The objectives of the present study are the following ones: 1) to study the use of drugs, the prosocial behaviour and the problem-solving skills with respect to age and gender, and 2) to analyze the association of both the prosocial behaviour and the problem-solving skills with the use of drugs. An exploratory cross-sectional study was performed, amongst a sample of 567 students in Spanish Compulsory Secondary Education (48.14% males) with an age range from 14 to 17 years (<em>M </em>= 14.92; <em>SD </em>= 0.90). Statistically significant differences were found concerning alcohol use and the prosocial behaviour with respect to gender, as well as concerning alcohol and cannabis use with respect to age. Logistic regression analyses revealed statistical significance of the prosocial behaviour with respect to the use of alcohol and cannabis. The ability in problem-solving was the most important protective predictor with respect to the abuse of cannabis. The results from this study enhance the importance of tailored interventions based on the promotion of prosocial behaviours and/or problem-solving strategies as fundamental protective factors for substance use amongst adolescents.</p>

scholarly journals Proton magnetic spectroscopy agreed better with magnetic resonance image to lateralization of epileptogenic zone than with surface electroencephalography

2013 ◽  
Vol 71 (9A) ◽  
pp. 584-590
Author(s):  
Ricardo Andre Amorim Leite ◽  
Maria Concepcion Garcia Otaduy ◽  
Gilson Edmar Goncalves e Silva ◽  
Maria Lucia Brito Ferreira ◽  
Maria de Fatima Vasco Aragao
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Image ◽  
Cross Sectional Study ◽  
Epileptogenic Zone ◽  
Agreement Rate ◽  
Cross Sectional ◽  
Surface Eeg ◽  
Study Type ◽  
Age Range ◽  
Coefficient Of Asymmetry

Objective To analyze the agreement rate of proton magnetic spectroscopy with magnetic resonance image (MRI) and surface electroence-phalography (EEG) in extratemporal neocortical epilepsies. Methods A cross-sectional study, type series of cases included 33 patients, age range 13–59 years old, of both gender, presenting structural alteration identified by MRI (75.8%) or by neurophysiologic techniques (72.7%). The variables were alterations of N-acetyl-aspartate/choline, N-acetyl-aspartate/creatine, choline/creatine, and N-acetyl-aspartate/cho-line+creatine coefficient of asymmetry. Results Agreement rates of lateralization by coefficient of asymmetry of NAA/Cho, NAA/Cr, Co/Cr, and NAA/Cho+Cr with MRI, independent of alteration of surface EEG, were equal to 93.3, 57.9, 15.4, and 93.3%, respectively, modifying to 100, 33.3, 0, and 100%, in 16 patients, with lateralization agreement of MRI and surface EEG. Conclusion Proton magnetic spectroscopy agreed better with MRI to lateralization of epileptogenic zone than with surface EEG.

scholarly journals Factors of tooth extraction among adult patients attending in exodontia department of Dhaka Dental College and Hospital

2013 ◽  
Vol 2 (1) ◽  
pp. 7-10
Author(s):  
T Nasreen ◽  
ME Haq
Keyword(s):  
Tooth Extraction ◽  
Food Habit ◽  
Cross Sectional Study ◽  
Vital Role ◽  
Treatment Schedule ◽  
Cross Sectional ◽  
Dental Patient ◽  
Treatment Centre ◽  
Age Range ◽  
Tooth Extractions

In the management of the adult dental patient efforts are geared towards the preservation of permanent dentition as it is important for maintaining normal occlusal relationship, play role in aesthesis, speech, influence food habit and nutrition. This hospital based descriptive type of cross sectional study was done at Exodontia Department of Dhaka Dental College and Hospital to identify the factors that contribute in tooth extraction among the respondents. The study was carried out during the month of January to June 2009 and 110 respondents selected purposively. The study showed the majority of the respondents (57.3%) were in the age group of 20-39 years. Their mean age was 36.85.years, SD of age was ±13.85 and age range was 15-85 years. Among the respondents 46.4% were male and 53.6% were female. Dental caries was the leading cause of tooth extractions in 68% cases. It was also observed that post filling complication contributed in 33% cases of extraction. Patient requests due to economic cause in 16% cases, negligence in 11% cases and even distance of the treatment centre from residence reported in 15% cases. The treatment philosophy of the centre played a vital role. Heavy rush of the patient and inconvenient conservative treatment schedule caused many unnecessary extractions DOI: http://dx.doi.org/10.3329/bjodfo.v2i1.15996 Ban J Orthod & Dentofac Orthop, October 2011; Vol-2, No.1, 7-10

scholarly journals Awareness and Attitudes toward Corneal Donations among Applicants and Staff of a Driver, Vehicle and Licensing Authority (DVLA) in Ghana

2019 ◽  
Author(s):  
Seth Lartey ◽  
ELLEN KONADU ANTWI-ADJEI ◽  
Solomon Agyapong ◽  
Abdul-Kabir Mohammed ◽  
Derrick N.O. Mensah ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Corneal Transplant ◽  
Cross Sectional ◽  
Willingness To Donate ◽  
Drivers License ◽  
Study Population ◽  
Good Potential ◽  
Potential Mode ◽  
Corneal Donation ◽  
Age Range

Abstract Background: Corneal transplantations are surgeries performed for irreparable corneal diseases and damage. However, there is a gap between the number of potential recipients and the number of donor corneas available. The main aim of the study was to determine the awareness and attitudes toward corneal donation among applicants and staff of DVLA, Kumasi-Ghana. Methods: A descriptive cross-sectional study was conducted. 100 participants were selected using convenient sampling method. A structured questionnaire was used to elicit responses from participants concerning awareness and attitudes toward corneal transplant. Results: The mean ± SD age of the participants was 32.05 ± 11.48years and age range, 18-67years. Males were 66% whilst females constituted 34%. 32.7% of the participants were aware of corneal donation. Majority of the participants were Christians (83.1%) and Singles (63%). Television was the source of information with the highest preponderance (49.4%). 67.3% were willing to donate their corneas after death. 63.9% were willing to indicate their donor statuses on drivers’ license form which had a significant association with willingness to donate cornea after death (p<0.05, ᵪ 2 = 12.187). Conclusion: There is a poor level of awareness (32.7%) of transplant and donation amongst the study population but a good level of willingness to donate organs (67%). Consent via driving license would seem to be a good potential mode of obtaining consent to supplement the harvesting of adequate tissues for transplant if adequate awareness is created.

scholarly journals Profile of Osteomyelitis Patients Visiting the Orthopedic Clinic of Dr. Hasan Sadikin General Hospital, Indonesia, in 2017–2018

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Aditya Nugraha ◽  
Hermawan Nagar Rasyid ◽  
Hadyana Sukandar
Keyword(s):  
Staphylococcus Aureus ◽  
General Hospital ◽  
Sampling Method ◽  
Operative Procedure ◽  
Bone Destruction ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Male Patients ◽  
The Common ◽  
Age Range

Background: Osteomyelitis is an inflammatory process caused by microorganism infection that leads to bone destruction. Osteomyelitis may affect all bones, particularly long bones, and infects all ages. This disease is hard to diagnose and the treatment is complex due to the disease’s heterogenicity, pathophysiology, clinical presentation, and management. This study aimed to determine the profile of osteomyelitis inpatients and outpatients presented to the Orthopedic Clinic of Dr. Hasan Sadikin General Hospital Bandung, IndonesiaMethods: This was a descriptive cross-sectional study conducted from July to October 2019 using the total sampling method. Data were collected from the medical records of osteomyelitis inpatients and outpatients presented to the Orthopedic Clinic of Dr. Hasan Sadikin General Hospital Bandung, Indonesia from 2017–2018. Data were then analyzed descriptively and the results were presented in frequencies.Result: In total, 90 data were retrieved. Most of data presented male patients (n= 69, 76.7%) with the age range of 20–29 years old (24.4%). The majority of these patients experienced chronic onset of disease (94.4%) located on the tibia (51.1%), which was caused by a post-operative procedure (61.1%). The most common treatment was operative procedure without antibiotic beads (51.1%). Staphylococcus aureus was the common pathogens identified in these patients (22.2%).Conclusion: The majority of osteomyelitis patients are males in productive age with chronic onset of disease located on the tibia caused by a post-operative procedure. Staphylococcus aureus is the common pathogen involved and the most common treatment is an operative procedure without antibiotic beads.

scholarly journals Evaluation of the Involvement of Facial and Cervical Spaces in Odontogenic Infections in Patients Referred to Shahid Rahnemoon Hospital from 2014 to 2018

2020 ◽  
Vol 9 (40) ◽  
pp. 2960-2964
Author(s):  
Mohsen Barzegar ◽  
Amir Vaghefi ◽  
Adele Pouyafard ◽  
Seyed Mojtaba Alavikia
Keyword(s):  
Statistical Tests ◽  
Systemic Disease ◽  
Cross Sectional Study ◽  
Mean Body Temperature ◽  
Cross Sectional ◽  
Odontogenic Infections ◽  
Source Of Infection ◽  
The Mean ◽  
Buccal Space ◽  
Age Range

BACKGROUND Odontogenic infections are recognized as one of the most common diseases in the world. Organisms that cause dental infection and are a part of the oral normal flora include dental plaque bacteria, mucosal surface bacteria, and gingival bacteria. This study aimed to investigate the prevalence of odontogenic infections by involving the facial and cervical spaces in patients referred to Shahid Rahnemoon Hospital from 2014 to 2018. METHODS This was a descriptive cross-sectional study. The sampling method was census and 308 patients with all types of odontogenic infections associated with the involvement of the facial and cervical spaces referred to Shahid Rahnemoon Hospital from 2014 to 2018 were included in the study. Questionnaire was used for data collection. The data was entered into SPSS version 23 software and analysed using statistical tests. RESULTS The mean age of participants was 31.10 ± 14.48; the mean number of hospitalization days was 4.83 ± 2.52 days; the mean body temperature was 37.45 ± 0.54. Of the 308 patients studied, 221 (71.8 %) had no history of systemic disease. Also, 294 (5 %) had no airway involvement. The most commonly prescribed antibiotic was penicillin + metronidazole with a frequency of 54.9 %, The most common tooth that was the source of infection was mandibular tooth no. 6 with a frequency of 22.7 %, the most common type of treatment was incision + drainage + antibiotic therapy with a frequency of 44.2 %; the most common involved area was the submandibular + buccal space with a frequency of 20.1 % and the most common age range of involvement was 20 - 29 years. CONCLUSIONS In odontogenic infections, penicillin + metronidazole is the most commonly used antibiotic and buccal + submandibular space is the most common area involved. KEY WORDS Odontogenic Infection, Facial Spaces, Cervical Spaces

scholarly journals New Images for Old Symbols: Meanings That Children Give to a Traditional Game

2021 ◽  
Vol 12 ◽  
Author(s):  
Alfonso García-Monge ◽  
Henar Rodríguez-Navarro ◽  
Daniel Bores-García
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Cultural Meanings ◽  
Cross Sectional ◽  
The Individual ◽  
Age Range ◽  
Traditional Game

Traditional games are considered agents of enculturation. This article explores the procedure to access the cultural meanings transmitted in a traditional game. The goal is to understand what children aged 6–11 make of the game called ‘the chained bear’ and to compare the meanings retrieved with those of different traditional versions of the game. For such a purpose, through an exploratory cross-sectional study, cartoons depicting people playing the game were exhibited and viewers (n = 359; age range: 6–11; Mean age = 8.79; SD = 1.81) were asked to interpret them as a drama play, as well as contributing a title, a plot and saying how they would name the characters. The results show that, beyond the individual images that each child created in their mind, most of them coincided in stories about harassment and defense and theft and protection. These plots match those of the ludic tradition, showing that the actions evoke different pictures to each individual, but share common cultural meanings in turn. The study shows a procedure to access the meanings that traditional games transmit and confirms that games contain pieces of culture, which makes them agents of enculturation.

scholarly journals Morphological changes in the trabecular meshwork and Schlemm’s canal after treatment with topical intraocular pressure-lowering agents

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ji-Hye Park ◽  
Hyun Woo Chung ◽  
Eun Gyu Yoon ◽  
Min Jung Ji ◽  
Chungkwon Yoo ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Trabecular Meshwork ◽  
Morphological Changes ◽  
Open Angle Glaucoma ◽  
Anterior Segment ◽  
Schlemm’S Canal ◽  
Schlemm's Canal ◽  
Before And After ◽  
Treatment Naïve ◽  
Aqueous Outflow

AbstractGlaucoma treatment is usually initiated with topical medication that lowers the intraocular pressure (IOP) by reducing the aqueous production, enhancing the aqueous outflow, or both. However, the effect of topical IOP-lowering medications on the microstructures of the aqueous outflow pathway are relatively unknown. In this retrospective, observational study, 56 treatment-naïve patients with primary open-angle glaucoma were enrolled. Images of the nasal and temporal corneoscleral limbus were obtained using anterior segment optical coherence tomography (AS-OCT). The conjunctival vessels and iris anatomy were used as landmarks to select the same limbal area scan, and the trabecular meshwork (TM) width, TM thickness, and Schlemm’s canal (SC) area were measured before and after using the IOP-lowering agents for 3 months. Among the 56 patients enrolled, 33 patients used prostaglandin (PG) analogues, and 23 patients used dorzolamide/timolol fixed combination (DTFC). After 3 months of DTFC usage, the TM width, TM thickness, and SC area did not show significant changes in either the nasal or temporal sectors. Conversely, after prostaglandin analog usage, the TM thickness significantly increased, and the SC area significantly decreased (all P < 0.01). These findings warrant a deeper investigation into their relationship to aqueous outflow through the conventional and unconventional outflow pathways after treatment with PG analogues.

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