Incidence of rhegmatogenous retinal detachment in France from 2010 to 2016: seasonal and geographical variations

2021 ◽  
pp. bjophthalmol-2020-318457
Author(s):  
Inès Ben Ghezala ◽  
Anne Sophie Mariet ◽  
Eric Benzenine ◽  
Pierre-Henry Gabrielle ◽  
Florian Baudin ◽  
...  
Keyword(s):  
Incidence Rate ◽  
French Guiana ◽  
Rhegmatogenous Retinal Detachment ◽  
Geographical Location ◽  
Incidence Rates ◽  
Regional Hospital ◽  
Administrative Database ◽  
First Episode ◽  
National Hospital ◽  
Geographical Variations

AimsTo investigate the annual and monthly hospital incidence rate of rhegmatogenous retinal detachments (RRDs) from 2010 to 2016 in France at the national and regional levels.MethodsIn this nationwide database study, we identified hospital and clinic admissions of French residents for a first episode of RRD in France during 2010–2016 from the national administrative database. The annual and monthly hospital incidence rates of RRD per 100 000 population were calculated for the whole country and for each region.ResultsThe average annual national hospital incidence rate of RRD was 21.97±1.04 per 100 000 population. The annual national hospital incidence rate of RRD was the lowest in 2010 (20.91 per 100 000 population) after which it increased until 2015 (23.55 per 100 000 population). The average monthly national RRD hospital incidence rate was the highest in June (2.03±0.12 per 100 000 population) and the lowest in August (1.60±0.09). The average annual age-standardised and sex-standardised regional hospital incidence rate was the highest in Guadeloupe and Pays de la Loire (28.30±2.74 and 26.13±0.84 per 100 000 population, respectively) and the lowest in French Guiana and Martinique (15.51±3.50 and 17.29±2.12 per 100 000 population, respectively).ConclusionsThe average annual national hospital incidence rate of RRD increased from 2010 to 2015. The hospital incidence rate of RRD seemed to vary according to season and geographical location.

scholarly journals Impact of COVID-19 lockdown on surgical procedures for retinal detachment in France: a national database study

2021 ◽  
pp. bjophthalmol-2021-319531
Author(s):  
Florian Baudin ◽  
Eric Benzenine ◽  
Anne-Sophie Mariet ◽  
Inès Ben Ghezala ◽  
Vincent Daien ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Incidence Rate ◽  
Surgical Procedures ◽  
Rhegmatogenous Retinal Detachment ◽  
Incidence Rates ◽  
National Database ◽  
First Episode ◽  
National Hospital ◽  
Database Study ◽  
Increased Activity

Background/aimsThe COVID-19 crisis and the decisions made regarding population lockdown may have changed patient care. We aimed to investigate the incidence rate of rhegmatogenous retinal detachment (RRD) cases during the COVID-19 lockdown period.MethodsIn this nationwide database study, we identified hospital and clinic admissions of French residents for a first episode of RRD in France from 2017 to the lockdown period in 2020. The monthly hospital incidence rates of RRD procedures per 100 000 inhabitants before, during and after lockdown were computed for the whole country. Finally, we assessed the influence of viral incidence on the RRD incidence rate, comparing two regions with highly contrasting viral penetration.ResultsFrom January to July, the average monthly national hospital incidence rate of RRD decreased from a mean of 2.59/100 000 inhabitants during 2017–2019 to 1.57/100 000 inhabitants in 2020. Compared with 2019, during the 8-week lockdown period in 2020, a 41.6% decrease in the number of RRD procedures was observed (p<0.001) with the weekly incidence of RRD decreasing from 0.63/100 000 inhabitants in 2019 to 0.36/100 000 inhabitants. During the 4-month post-lockdown period, no increased activity related to postponed procedures was observed. No difference was found in the rate of RRD surgery when comparing two regions with highly contrasting viral incidence.ConclusionContainment may have been responsible for a decrease in the number of surgical procedures for RRD, without any compensating post-lockdown activity in France. These results might help increase awareness of the management of RRD emergencies.

scholarly journals Geographical variation and clustering are found in atrial fibrillation beyond socioeconomic differences: a Danish cohort study, 1987–2015

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Kirstine Wodschow ◽  
Kristine Bihrmann ◽  
Mogens Lytken Larsen ◽  
Gunnar Gislason ◽  
Annette Kjær Ersbøll
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Cohort Study ◽  
Incidence Rate ◽  
Socioeconomic Position ◽  
Geographical Variation ◽  
Incidence Rates ◽  
Socioeconomic Differences ◽  
Individual Level ◽  
Geographical Variations

Abstract Background The prevalence and incidence rate of atrial fibrillation (AF) increase worldwide and AF is a risk factor for more adverse cardiovascular diseases including stroke. Approximately 44% of AF cases cannot be explained by common individual risk factors and risk might therefore also be related to the environment. By studying geographical variation and clustering in risk of incident AF adjusted for socioeconomic position at an individual level, potential neighbourhood risk factors could be revealed. Methods Initially, yearly AF incidence rates 1987–2015 were estimated overall and stratified by income in a register-based cohort study. To examine geographical variation and clustering in AF, we used both spatial scan statistics and a hierarchical Bayesian Poisson regression analysis of AF incidence rates with random effect of municipalities (n = 98) in Denmark in 2011–2015. Results The 1987–2015 cohort included 5,453,639 individuals whereof 369,800 were diagnosed with an incident AF. AF incidence rate increased from 174 to 576 per 100,000 person-years from 1987 to 2015. Inequality in AF incidence rate ratio between highest and lowest income groups increased from 23% in 1987 to 38% in 2015. We found clustering and geographical variation in AF incidence rates, with incidence rates at municipality level being up to 34% higher than the country mean after adjusting for socioeconomic position. Conclusions Geographical variations and clustering in AF incidence rates exist. Compared to previous studies from Alberta, Canada and the United States, we show that geographical variations exist in a country with free access to healthcare and even when accounting for socioeconomic differences at an individual level. An increasing social inequality in AF was seen from 1987 to 2015. Therefore, when planning prevention strategies, attention to individuals with low income should be given. Further studies focusing on identification of neighbourhood risk factors for AF are needed.

Neighbourhood characteristics and the incidence of first-episode psychosis and duration of untreated psychosis

2016 ◽  
Vol 46 (7) ◽  
pp. 1367-1378 ◽  
Author(s):  
B. O'Donoghue ◽  
J. P. Lyne ◽  
L. Renwick ◽  
A. Lane ◽  
K. Madigan ◽  
...  
Keyword(s):  
Social Capital ◽  
Incidence Rate ◽  
Psychotic Disorders ◽  
Social Deprivation ◽  
First Episode Psychosis ◽  
Incidence Rates ◽  
First Episode ◽  
Duration Of Untreated Psychosis ◽  
Episode Psychosis ◽  
Neighbourhood Characteristics

BackgroundThe incidence of psychotic disorders varies between geographical areas and it has been hypothesized that neighbourhood-level factors may influence this variation. It is also plausible that the duration of untreated psychosis (DUP) is associated with neighbourhood characteristics. The aims of this study were to determine whether the incidence of first-episode psychosis (FEP) and the DUP are associated with the level of social deprivation, fragmentation, social capital and population density.MethodAll individuals with a FEP from a geographical defined catchment area over a 5-year period were included. Age-standardized incidence rates were calculated for each neighbourhood factor.ResultsA total of 292 cases of FEP were included in the study and 45% had a diagnosis of a schizophrenia-spectrum disorder. The age standardized incidence rate of FEP in the most deprived area was 72.4 [95% confidence interval (CI) 26.4–162.7] per 100 000 person-years compared with 21.5 (95% CI 17.6–26.0) per 100 000 person-years in the most affluent areas. This represents a 3.4-fold increase in FEP incidence in the most deprived areas. The incidence of FEP was also increased in neighbourhoods that were more socially fragmented [incidence rate ratio (IRR) = 2.40, 95% CI 1.05–5.51, p = 0.04] and there was a trend for the incidence to be increased in neighbourhoods with lower social capital (IRR = 1.43, 95% CI 0.99–2.06, p = 0.05). The median DUP was 4 months and was higher in more socially fragmented neighbourhoods.ConclusionsThe incidence of psychotic disorders is related to neighbourhood factors and it may be useful to consider neighbourhood factors when allocating resources for early intervention services.

Incidence of fractures in patients with multiple sclerosis: the Danish National Health Registers

2011 ◽  
Vol 18 (5) ◽  
pp. 622-627 ◽  
Author(s):  
Marloes T Bazelier ◽  
Frank de Vries ◽  
Joan Bentzen ◽  
Peter Vestergaard ◽  
Hubert GM Leufkens ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Incidence Rate ◽  
Femur Fracture ◽  
Incidence Rates ◽  
National Hospital ◽  
Calendar Time ◽  
Risk Of Fracture ◽  
National Hospital Discharge Register ◽  
Rate Ratios ◽  
Health Registers

Background: Patients with multiple sclerosis (MS) are potentially at high risk of fracture due to falls and osteoporosis. Objective: To estimate incidence rates of fractures in MS patients, stratified by fracture type, sex and age, and to compare these rates with controls. Methods: The case population consisted of all patients with an accepted diagnosis of MS in the Danish MS Registry (1949–2007). Data were linked to the National Hospital Discharge Register (1977–2007). Patients with MS ( n = 11,157) were 1:6 matched by year of birth, gender, calendar time and region to persons without MS (controls). Incidence rates of fracture were estimated as the number of fractures per 1000 person-years. Incidence rate ratios (IRRs) were calculated by dividing fracture rates in MS patients by fracture rates in controls. Results: Among patients with MS, the incidence rate of any fracture yielded 22.8 per 1000 person-years. The IRR of any fracture between MS patients and controls was 1.40 (95% CI 1.33–1.46). In particular, IRRs of tibia fracture (3.36 [2.75–4.11]), femur fracture (6.66 [5.06–8.76]) and hip fracture (3.20 [2.83–3.62]) were elevated in MS patients versus controls. Conclusion: Fractures occurred more often in patients with MS, especially fractures of the tibia, hip and femur.

scholarly journals A Systematic Review and Meta-Analysis of the Incidence Rate of Takayasu Arteritis

2020 ◽  
Author(s):  
Megan Rutter ◽  
Jonathan Bowley ◽  
Peter C. Lanyon ◽  
Matthew J. Grainge ◽  
Fiona A. Pearce
Keyword(s):  
Incidence Rate ◽  
Takayasu Arteritis ◽  
Meta Analysis ◽  
Geographical Location ◽  
Incidence Rates ◽  
Future Research ◽  
Autoimmune Rheumatic Disease ◽  
Global Epidemiology ◽  
Newcastle Ottawa Scale ◽  
Different Populations

AbstractObjectivesTakayasu arteritis (TAK), is a rare autoimmune rheumatic disease causing large vessel vasculitis. Onset is typically between the ages of 20-30. It is associated with substantial morbidity and mortality, notably due to its effects on the cardiovascular system. It has a poorly understood global epidemiology. Our objective was to systematically review the available evidence in order to calculate the incidence rate of TAK.MethodsThree databases (Medline, PubMed and Embase) were searched in November 2019 and the results were screened by two reviewers. A random effects meta-analysis was then conducted in R to calculate the overall incidence rate. Heterogeneity was assessed using I2. The quality of the studies was assessed using an adapted Newcastle-Ottawa scale. Further sub-group analyses were performed by quality, sex, research setting and geographical location. Publication bias was assessed using a Begg’s funnel plot.ResultsThe incidence rate for TAK per million person-years with 95% confidence intervals was 1.11 per million person years (95% CI 0.75 – 1.65). The heterogeneity in the data was extremely high in all analyses, which suggests that there was considerable variation in incidence rates across the different populations studied. TAK was found to be more common in women (incidence rate 2.01 per million person-years, 95% CI 1.39-2.90).ConclusionsTAK is an extremely rare disease. It affects women more commonly than men. There is considerable variation in the incidence rate between populations. We suggest that future research should focus on discrete populations in order to better identify genetic and environmental risk factors.

Abstract 22: Incidence Rate of Atrial Fibrillation in Cryptogenic Stroke: Results From the Reveal LINQ Real-World Registry

Stroke ◽  
2020 ◽  
Vol 51 (Suppl_1) ◽  
Author(s):  
Scott E Kasner ◽  
Atul Verma ◽  
Suneet Mittal ◽  
Andrea Natale ◽  
Sean C Beinart ◽  
...  
Keyword(s):  
Incidence Rate ◽  
Real World ◽  
Care Pathway ◽  
Cryptogenic Stroke ◽  
Incidence Rates ◽  
First Episode ◽  
Atrial Ablation ◽  
Multi Center Study ◽  
The Impact

Objectives: To determine the incidence rate of AF in real-world patients with prior cryptogenic stroke (CS) or transient ischemic attack (TIA) and to assess the impact of using an insertable cardiac monitor (ICM) on treatments. Methods: The Reveal LINQ registry is an ongoing, observational, multi-center study evaluating the role of the ICM in the patient care pathway. Patients with prior CS or TIA were included. Patients without device data or without any contact after ICM insertion, with a history of AF, prior known atrial ablation, or hemorrhagic stroke were excluded. Device data were adjudicated by at least 2 independent reviewers. Patients were considered to have AF if they had a ≥2 min episode, and to not have AF if no AF was found after 1 year of monitoring. Patients without AF and without 1 year of follow-up were excluded from the general analysis due to limited follow-up time but were included in the AF incidence rates calculation for completeness. Results: In total, 192 patients (61±14 years, 61% male, mean CHA2DS2-VASc score 3.8±1.4) from 29 centers in 8 countries were included. Reasons for monitoring were CS (96%) and TIA (4%). During an average follow-up of 19±6 months, AF was detected in 36 (19%) patients and the incidence of first episode of AF ≥2 min, ≥1 h, ≥6 h, and ≥24 h was 16.7%, 7.9%, 3.7% and 1.7% at 24 months, respectively (figure). Patients with AF were older (68±14 years vs. 60±14, p<0.001). Anticoagulant treatment was initiated in 29 (15%) patients during follow-up , while 14 of 45 initially on anticoagulants discontinued the treatment (13 were free of AF after 1-year follow-up and 1 had a single episode). Other AF-related clinical actions included ablations in 5 patients (2.6%), 1 electrical cardioversion (0.5%) and 3 IPG implants (1.6%). Conclusion: ICM monitoring in cryptogenic stroke/TIA patients is currently being used by clinicians for treatment decisions, but the impact on clinical events and quality of life requires ongoing investigation.

scholarly journals Increasing trend in rhegmatogenous retinal detachment in Korea from 2004 to 2015

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jun Young Park ◽  
Seoung Jun Byun ◽  
Se Joon Woo ◽  
Kyu Hyung Park ◽  
Sang Jun Park
Keyword(s):  
Retinal Detachment ◽  
Incidence Rate ◽  
Rhegmatogenous Retinal Detachment ◽  
Bimodal Distribution ◽  
Incidence Rates ◽  
Health Claims ◽  
Young Generation ◽  
Age Group ◽  
Increasing Trend ◽  
Male Patients

Abstract Background To determine the 12-year incidence of and trends in rhegmatogenous retinal detachment (RRD) requiring surgery in Korea. Methods This was a nationwide, population-based, retrospective study. We identified 53,179 patients with incident RRD requiring surgery using the Korean National Health Claims Database from 2004 to 2015. We estimated the crude incidence rates and age- and sex-standardized incidence rates per 100,000 person-years in each year during the study period. A joinpoint regression analysis was performed to determine the trend. Results The average annual incidence rate was 9.78 (95% CI: 9.70–9.86). Male patients showed an incidence rate (10.68 [95% CI: 10.57–10.80]) 1.20 times that of female patients (8.87 [95% CI: 8.76–8.98]). The incidence showed a bimodal distribution; the highest peak was in the 60–64 year age group (23.77 [95% CI: 23.18–24.35]) and the second peak was in the 20–24 year age group (7.68 [95% CI: 7.41–7.95]). An increasing trend of RRD incidence was observed in the total population throughout the study period using joinpoint analysis (annual percentage change [APC], 2.05; 95% CI: 0.7–3.4). The increasing trend was more prominent among individuals aged under 50 years (APC, 3.44; 95% CI: 2.3–4.6), while among those aged 50 years or above, the increasing incidence was observed only in male patients. Conclusions In Korea, the incidence of RRD has increased recently. People in the < 50 year age group accounted for the major part of this significant increase, which is related to the increasing incidence of myopia in the young generation in Asia.

scholarly journals A Systematic Review and Meta-Analysis of the Incidence Rate of Takayasu Arteritis

Rheumatology ◽  
2021 ◽  
Author(s):  
Megan Rutter ◽  
Jonathan Bowley ◽  
Peter C Lanyon ◽  
Matthew J Grainge ◽  
Fiona A Pearce
Keyword(s):  
Incidence Rate ◽  
Takayasu Arteritis ◽  
Meta Analysis ◽  
Geographical Location ◽  
Incidence Rates ◽  
Future Research ◽  
Autoimmune Rheumatic Disease ◽  
Global Epidemiology ◽  
Newcastle Ottawa Scale ◽  
Different Populations

Abstract Objectives Takayasu arteritis (TAK), is a rare autoimmune rheumatic disease causing large vessel vasculitis. Onset is typically between the ages of 20-30. It is associated with substantial morbidity and mortality, notably due to its effects on the cardiovascular system. It has a poorly understood global epidemiology. Our objective was to systematically review the available evidence in order to calculate the incidence rate of TAK. Methods Three databases (Medline, PubMed and Embase) were searched in November 2019 and the results were screened by two reviewers. A random effects meta-analysis was then conducted in R to calculate the overall incidence rate. Heterogeneity was assessed using I2. The quality of the studies was assessed using an adapted Newcastle-Ottawa scale. Further sub-group analyses were performed by quality, sex, research setting and geographical location. Publication bias was assessed using a Begg’s funnel plot. Results The incidence rate for TAK per million person-years with 95% confidence intervals was 1.11 per million person years (95% CI 0.70 – 1.76). The heterogeneity in the data was extremely high in all analyses, which suggests that there was considerable variation in incidence rates across the different populations studied. TAK was found to be more common in women (incidence rate 2.01 per million person-years, 95% CI 1.39-2.90). Conclusions TAK is an extremely rare disease. It affects women more commonly than men. There is considerable variation in the incidence rate between populations. We suggest that future research should focus on discrete populations in order to better identify genetic and environmental risk factors.

Nationwide trends in the incidence of orbital lymphoma from 1999 to 2016 in South Korea

2020 ◽  
pp. bjophthalmol-2020-316796
Author(s):  
Su Kyung Jung ◽  
Jiwon Lim ◽  
Suk Woo Yang ◽  
Young-Joo Won
Keyword(s):  
South Korea ◽  
B Cell ◽  
Incidence Rate ◽  
Cell Lymphoma ◽  
Survival Rates ◽  
B Cell Lymphoma ◽  
Population Based ◽  
Incidence Rates ◽  
Annual Percent Change ◽  
Orbital Lymphoma

Background/AimsLymphomas are the most frequent neoplasm of the orbit. However, the epidemiology of orbital lymphomas is not well reported. This study aimed to provide a population-based report on the epidemiology of orbital lymphomas and measure the trends in the incidence of orbital lymphoma cancer in South Korea.MethodsNationwide cancer incidence data from 1999 to 2016 were obtained from the Korea Central Cancer Registry. Age-standardised incidence rates and annual percent changes were calculated according to sex and histological types. The analysis according to the Surveillance, Epidemiology, and End Results summary stage classifications was performed from 2006 to 2016. Survival rates were estimated for cases diagnosed from 1999 to 2016.ResultsA total of 630 patients (median age: 54 years) with orbital lymphoma in the orbital soft tissue were included in this study. The age-standardised incidence rates increased from 0.03 to 0.08 per 100 000 individuals between 1999 and 2016, with an annual percent change of 6.61%. The most common histopathological type of orbital lymphoma was extra marginal zone B cell lymphoma, accounting for 82.2% of all orbital lymphomas during 1999–2016, followed by diffuse large B cell lymphoma (9.2%). Five-year, 10-year and 15-year overall survival (OS) of orbital lymphoma was 90.8%, 83.8% and 75.8%, respectively. OS showed a significant decrease as age increased and no significant differences between men and women.ConclusionThe incidence rate of orbital lymphoma is very low in South Korea. However, the incidence rate has increased over the past years. Orbital lymphomas have a worse prognosis as age increases.

scholarly journals COVID-19 among the inhabitants of the slums in the city of Buenos Aires: a population-based study

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e044592
Author(s):  
Alejandro Macchia ◽  
Daniel Ferrante ◽  
Gabriel Battistella ◽  
Javier Mariani ◽  
Fernán González Bernaldo de Quirós
Keyword(s):  
Incidence Rate ◽  
Buenos Aires ◽  
Reporting System ◽  
Incidence Rates ◽  
Health Reporting ◽  
Rt Pcr ◽  
Slum Dwellers ◽  
Integrated Health ◽  
The Impact ◽  
The City

ObjectiveTo summarise the unfolding of the COVID-19 epidemic among slum dwellers and different social strata in the city of Buenos Aires during the first 20 weeks after the first reported case.DesignObservational study using a time-series analysis. Natural experiment in a big city.SettingPopulation of the city of Buenos Aires and the integrated health reporting system records of positive RT-PCR for COVID-19 tests.ParticipantsRecords from the Argentine Integrated Health Reporting System for all persons with suspected and RT-PCR-confirmed diagnosis of COVID-19 between 31 January and 14 July 2020.OutcomesTo estimate the effects of living in a slum on the standardised incidence rate of COVID-19, corrected Poisson regression models were used. Additionally, the impact of socioeconomic status was performed using an ecological analysis at the community level.ResultsA total of 114 052 people were tested for symptoms related with COVID-19. Of these, 39 039 (34.2%) were RT-PCR positive. The incidence rates for COVID-19 towards the end of the 20th week were 160 (155 to 165) per 100 000 people among the inhabitants who did not reside in the slums (n=2 841 997) and 708 (674 to 642) among slums dwellers (n=233 749). Compared with the better-off socioeconomic quintile (1.00), there was a linear gradient on incidence rates: 1.36 (1.25 to 1.46), 1.61 (1.49 to 1.74), 1.86 (1.72 to 2.01), 2.94 (2.74 to 3.16) from Q2 to Q5, respectively. Slum dwellers were associated with an incidence rate of 14.3 (13.4 to 15.4).ConclusionsThe distribution of the epidemic is socially conditioned. Slum dwellers are at a much higher risk than the rest of the community. Slum dwellers should not be considered just another risk category but an entirely different reality that requires policies tailored to their needs.

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