scholarly journals Prevalence, incidence and associated mortality of cardiovascular disease in patients with chronic kidney disease in low- and middle-income countries: a protocol for a systematic review and meta-analysis

BMJ Open ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. e016412 ◽  
Author(s):  
Mazou N Temgoua ◽  
Celestin Danwang ◽  
Valirie Ndip Agbor ◽  
Jean Jacques Noubiap
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Published Data ◽  
Final Report ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low Middle Income Countries ◽  
Incidence And Mortality ◽  
Statistical Heterogeneity

IntroductionChronic kidney disease (CKD) is a global public health problem, with cardiovascular disease (CVD) being the major cause of mortality in these patients. Despite a high burden of CKD among patients in low/middle-income countries (LMICs), evidence on the distribution of CVD among these patients is lacking. This review seeks to determine the prevalence, incidence and mortality risks of CVD in patients with CKD in LMICs.Methods and analysisA systematic search of Medline, Scopus, Embase, Cumulative Index of Nursing and Allied Health and WHO Global Health Library databases for published studies reporting on the prevalence, incidence and associated mortality risk of CVD in CKD patients in LMICs will be conducted from 1 May 1987 to 1 July 2017 with no language restriction. Two authors will independently screen, select studies, extract data and assess the risk of bias in each study. Clinically homogeneous studies will be pooled after assessing for clinical and statistical heterogeneity using the χ2test on Cochrane’s Q statistic which is quantified by I2values; assuming that I2values of 25%, 50% and 75% represent low, medium and high heterogeneity, respectively. Funnel-plot analysis and Egger’s test will be used to detect publication bias. Results will be presented according to WHO Regions (Africa, Americas, Eastern Mediterranean, Europe, South-East Asia and Western Pacific).Ethics and disseminationThis proposed study will not require ethical approval as it will be based on published data. We will publish the final report of this review in a peer-reviewed journal, and the findings will be disseminated to the appropriate health authorities.

scholarly journals The incidence of and risk factors for late presentation of childhood chronic kidney disease: A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0244709
Author(s):  
Lucy Plumb ◽  
Emily J. Boother ◽  
Fergus J. Caskey ◽  
Manish D. Sinha ◽  
Yoav Ben-Shlomo
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Kidney Failure ◽  
Meta Analysis ◽  
Late Presentation ◽  
Cochrane Library ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low Middle Income Countries

Background When detected early, inexpensive measures can slow chronic kidney disease progression to kidney failure which, for children, confers significant morbidity and impacts growth and development. Our objective was to determine the incidence of late presentation of childhood chronic kidney disease and its associated risk factors. Methods We searched MEDLINE, Embase, PubMed, Web of Science, Cochrane Library and CINAHL, grey literature and registry websites for observational data describing children <21 years presenting to nephrology services, with reference to late presentation (or synonyms thereof). Independent second review of eligibility, data extraction, and risk of bias was undertaken. Meta-analysis was used to generate pooled proportions for late presentation by definition and investigate risk factors. Meta-regression was undertaken to explore heterogeneity. Results Forty-five sources containing data from 30 countries were included, comprising 19,339 children. Most studies (37, n = 15,772) described children first presenting in kidney failure as a proportion of the chronic kidney disease population (mean proportion 0.43, 95% CI 0.34–0.54). Using this definition, the median incidence was 2.1 (IQR 0.9–3.9) per million age-related population. Risk associations included non-congenital disease and older age. Studies of hospitalised patients, or from low- or middle-income countries, that had older study populations than high-income countries, had higher proportions of late presentation. Conclusions Late presentation is a global problem among children with chronic kidney disease, with higher proportions seen in studies of hospitalised children or from low/middle-income countries. Children presenting late are older and more likely to have non-congenital kidney disease than timely presenting children. A consensus definition is important to further our understanding and local populations should identify modifiable barriers beyond age and disease to improve access to care.

scholarly journals Tuberculosis in patients with chronic kidney disease: atypical presentation and diagnostic dilemma

2018 ◽  
Vol 8 (3) ◽  
pp. 1-2
Author(s):  
Ravi R. Pradhan
Keyword(s):  
Public Health ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Patient ◽  
Public Health Problem ◽  
Diagnostic Dilemma ◽  
Middle Income ◽  
Extra Pulmonary Tuberculosis ◽  
Middle Income Countries ◽  
Significant Public Health

Tuberculosis (TB) is a serious public health problem, and more common in developing countries like Nepal. Worldwide, it is the second most frequent cause of death from infectious disease. Patient with chronic kidney disease (CKD) under mainte­nance dialysis are more likely to develop TB compared to general population. Given the increasing prevalence of CKD in TB endemic areas, a merging of CKD and TB epidemics could have significant public health implications, especially in low- to middle-income countries like Nepal. Because of increased frequency of extra-pulmonary tuberculosis in patient with CKD, the clinical presentation is atypical and leads to diagnostic dilemma.

Chronic kidney disease and the aging population

2014 ◽  
Vol 17 (1) ◽  
pp. 6-10
Author(s):  
Marcello Tonelli ◽  
Miguel Riella
Keyword(s):  
Public Policy ◽  
Chronic Kidney Disease ◽  
Economic Development ◽  
Kidney Disease ◽  
General Population ◽  
Population Aging ◽  
Aging Population ◽  
Middle Income ◽  
Middle Income Countries ◽  
Socio Economic Development

The proportion of older people in the general population is steadily increasing worldwide, with the most rapid growth in low- and middle-income countries [1]. This demographic change is to be celebrated, because it is the consequence of socio-economic development and a better life expectancy. However, population aging also has important implications on society – in diverse areas including health systems, labour markets, public policy, social programmes, and family dynamics [2]. A successful response to the aging population will require capitalising on opportunities this transition offers, as well as effectively addressing its challenges.

scholarly journals Challenges for sustainable end-stage kidney disease care in low-middle-income countries: the problem of the workforce

2020 ◽  
Vol 10 (1) ◽  
pp. e49-e54 ◽  
Author(s):  
Charles R. Swanepoel ◽  
Mignon I. McCulloch ◽  
Georgi Abraham ◽  
Jo-Ann Donner ◽  
Mona N. Alrukhaimi ◽  
...  
Keyword(s):  
Kidney Disease ◽  
End Stage Kidney Disease ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low Middle Income Countries ◽  
End Stage

scholarly journals The Effectof Exercise to Glomerular Filtration Barrier System in Diabetic Rat

2019 ◽  
Vol 4 (3) ◽  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Microvascular Complications ◽  
Diabetic Rat ◽  
World Population ◽  
Glomerular Filtration Barrier ◽  
Middle Income ◽  
Middle Income Countries ◽  
Filtration Barrier ◽  
The World

People with diabetes mellitus are spread all over the world. Currently, it is estimated that nearly 425 million (8.8% of the world population), 20 - 79 years old, most (79%) are in low and middle income countries. The estimated number of people with diabetes will increase in 2045 to 625 million [1]. Along with these results the number of macro and microvascular complications is also expected to increase. About 40% of diabetics experience proteinuria in the form of microalbuminuria which is a sign of the progression of chronic kidney disease. Without special intervention 20-40% of patients with microalbuminuria will develop overtnepropathy and around 20% after 20 years theonsetof overt nepropathy will become CKD (Chronic kidney disease) [2].

scholarly journals Missed nursing care in acute care hospital settings in low-middle income countries: a systematic review protocol

2021 ◽  
Vol 6 ◽  
pp. 359
Author(s):  
Abdulazeez Imam ◽  
Sopuruchukwu Obiesie ◽  
Jalemba Aluvaala ◽  
Michuki Maina ◽  
David Gathara ◽  
...  
Keyword(s):  
Systematic Review ◽  
Patient Care ◽  
Nursing Care ◽  
Systematic Reviews ◽  
Published Data ◽  
Care Hospital ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low Middle Income Countries ◽  
Missed Nursing Care

Background:  Missed nursing care (care left undone or task incompletion) is viewed as an important early predictor of adverse patient care outcomes and is a useful indicator to determine the quality of patient care. Available systematic reviews on missed nursing care are based mainly on primary studies from developed countries, and there is limited evidence on missed nursing care from low-middle income countries (LMICs). We propose conducting a systematic review to identify the magnitude of missed nursing care and document factors and reasons associated with this phenomenon in LMIC settings. Methods and analysis:  This protocol was developed using the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols (PRISMA-P). We will conduct literature searching across the Ovid Medline, Embase and EBSCO Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases, from inception to 2021. Two independent reviewers will conduct searches and data abstraction, and discordance will be handled by discussion between both parties. The risk of bias of the individual studies will be determined using the Newcastle-Ottawa Scale (NOS). Ethics and dissemination: Ethical permission is not required for this review as we will make use of already published data. We aim to publish the findings of our review in peer-reviewed journals PROSPERO registration number: CRD42021286897 (27th October 2021)

CLINICAL AND THERAPEUTIC VALUE OF ADIPOKINES IN PATIENTS WITH CHRONIC KIDNEY DISEASE

2020 ◽  
pp. 5-9
Author(s):  
Ya. M Fylenko
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Adipose Tissue ◽  
Kidney Disease ◽  
Therapeutic Potential ◽  
Interdisciplinary Approach ◽  
Blood Lipid ◽  
The Body ◽  
Incidence And Mortality

This review is devoted to the analysis of the role of adipokines in formation of pathological changes in renal function and structure. The patients with chronic kidney disease have a high risk of cardiovascular disease. Currently, the role of systemic hormonal and metabolic factors in the pathogenesis of the kidneys is growing. A promising area of pathogenetic prevention and treatment of kidney disease is an interdisciplinary approach, whereat the adipokine imbalance is of particular interest. Adipose tissue and its messengers, adipokines, are known to be highly associated with kidney disease. Adipocytes are metabolically active cells, producing the signaling lipids, metabolites and protein factors, i.e. adipokines. The interaction of adipose tissue with the kidney is called the adipose kidney axis, being important for the normal functioning of the body, as well as its response to an injury. It has a strong therapeutic potential in respect of the growing rates of chronic kidney disease. Adipocyte hypertrophy is often accompanied by the development of tissue fibrosis, hypoxia, and secretion of pro−inflammatory cytokines (such as tumor necrosis factor or interleukin, which triggers the cell inflammation). Dysfunction of adipose tissue contributes to the development of cardiovascular disease at the local and systemic levels. Thus, for the early diagnosis of chronic kidney disease into the diagnostic program, in addition to the generally accepted indices, the determination of adipokines: for example, serum leptin, adiponectin, omentin, visfatin, microalbuminuria, blood lipid spectrum, intrarenal and functional status of the kidneys with the assessment of functional renal reserve is recommended to be included. Early detection of the disease, new approaches to its diagnosis and treatment can help in reducing the risk of a high incidence and mortality from renal disease. Key words: chronic kidney disease, nephropathy, adipokines, leptin, resistin, adiponectin, visfatin, omentin.

scholarly journals Chronic kidney disease in low-income to middle-income countries: the case for increased screening

2017 ◽  
Vol 2 (2) ◽  
pp. e000256 ◽  
Author(s):  
Cindy George ◽  
Amelie Mogueo ◽  
Ikechi Okpechi ◽  
Justin B Echouffo-Tcheugui ◽  
Andre Pascal Kengne
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Low Income ◽  
Middle Income ◽  
Middle Income Countries

scholarly journals Prevalence and factors associated with suicide among medical professionals in low/middle-income countries: a systematic review protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e028884
Author(s):  
Godfrey Zari Rukundo ◽  
Helen Byakwaga ◽  
Alison Kinengyere ◽  
Achille Mwira Bapolisi ◽  
Miriela Betancourt ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Medical Professionals ◽  
Data Set ◽  
Middle Income ◽  
Factors Associated ◽  
Middle Income Countries ◽  
Low Middle Income Countries ◽  
Statistical Heterogeneity

IntroductionA number of studies in low/middle-income countries (LMICs) have reported varying prevalence of suicide among medical professionals with low rates. This may be because of the methods used in suicide assessment and the stigma associated with it. For this study, the prevalence of suicidal ideation, attempt and completed suicide, as well as the factors associated with suicidality and methods used during suicidal acts, will be documented.Methods and analysisStudies published in peer-reviewed journals in which the prevalence and factors associated with suicidal ideation, attempt and completion among medical professionals in LMICs will be included. The Cochrane Library (CENTRAL), PsychINFO, PubMed and Embase will be systematically searched. We will search for all the papers available in the databases up to March 31 2019. Methodological quality of the articles will be assessed using the quality in prognostic studies tool. The risk of bias of the articles will be assessed using Cochrane risk of bias assessment tool for non-randomised studies. In the event of no statistical heterogeneity, a meta-analysis of the findings will be conducted.Ethics and disseminationEthical permission will not be required since this work does not involve the use of participant data that can be used to identify individuals. Findings from this study will be available for clinicians and other medical professionals, scientists and policy makers. On request, a data set of the study can be provided.Trial registration numberCRD42018095990.

Sign in / Sign up

Export Citation Format

Share Document