Alcohol Consumption and Smoking Habits in Male Patients with Pulmonary Tuberculosis

Tubercular infection is still a pervasive public health problem in Nepal despite the massive efforts of National Health Service stakeholders. High bacterial infectivity, transmissibility, increasing drug resistance and non compliance to the therapy have been adding up challenges to prevention and control of tuberculosis. This study was conducted to observe the treatment compliance pattern among new pulmonary sputum smear positive cases of tuberculosis. A cross sectional study was carried out in the year 2009. The 114 new smear positive pulmonary tuberculosis patients registered in the six selected DOTS centres of the Banke Disrtict were randomly selected. Participants were selected from each DOTS centre by probability proportionate sampling methods. Data were analyzed by SPSS (11.0 Version) and P< 0.05 was considered as significant. Overall compliance to DOTS was 86.80 percent; of these, 57.00 percent showed excellent and regular compliance followed by nearly 30 percent good compliance. And 13.20 percent participants were non complaint to DOTS therapy. Positive Family behaviors were positively associated with compliance while alcohol consumption was found to be negatively associated with compliance however; age, sex and income were found to be non significant factors for compliance. Feeling of getting cure even before the course of DOTS therapy (feeling better after 2-3 months regular treatment) and drinking habits were found to be the major causes of non compliance. Supportive family behaviors and avoidance of alcohol consumption may promote the compliance. Excellent treatment compliance in the face of many odds is highly encouraging and the pattern can be useful in treatment despite little non compliances; furthermore compliance can be enhanced by acting on these causes of non compliances. Key words: Pulmonary, Tuberculosis, DOTS, Banke, Nepal

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Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand

Belitung Nursing Journal ◽

10.33546/bnj.1337 ◽

2021 ◽

Author(s):

Apichaya Thontham ◽

Rapin Polsook

Keyword(s):

Adverse Drug Reaction ◽

Drug Reaction ◽

Pulmonary Tuberculosis ◽

Adverse Drug Reactions ◽

Newly Diagnosed ◽

Symptom Experience ◽

Drug Reactions ◽

Male And Female ◽

Distressing Symptom ◽

Male Patients

Background: Patients with newly diagnosed pulmonary tuberculosis often suffer from adverse drug reaction symptoms, which leads to the automatic discontinuation of anti-tuberculosis drugs. Thus, understanding symptom experience of adverse drug reactions is necessary.Objective: This study aimed to examine differences in symptoms experienced in four dimensions: presence, frequency, severity, and distress of adverse drug reactions, between male and female patients.Methods: This was a quantitative survey with a cross-sectional design, with data collected between January and April 2020. A total of 394 patients with newly diagnosed pulmonary tuberculosis was selected through a purposive sampling technique. The symptom experiences of adverse drug reactions were measured using a validated instrument. Data were analyzed using mean, standard deviation, and independent t-test.Results: The most commonly reported symptom was itchiness (24.1% in males and 34.9% in females). Vomiting occurred as the most frequent symptom among males (x̅ ± SD = 2.73 ± .88), and fatigue was found to be the most severe and distressing symptom across male patients (x̅ ± SD = 2.50 ± 1.61 and 2.06 ± 1.30, respectively). In contrast, yellowing of the eyes and skin was most frequent and severe among females (x̅ ± SD = 3.17 ± .75 and 3.83 ± 1.47, respectively). In addition, flu-like symptoms were evaluated as the most distressing symptom for female patients (x̅ ± SD = 2.80 ± 1.09). The symptom burdens of the females ranged significantly and reached higher than those of the male patients at a p-value of .05 (t = 3.33).Conclusion: Females taking anti-tuberculosis drugs should be carefully monitored to deal with adverse drug reaction symptoms. This finding would help to decrease the severity of disease and improve their quality of life.Funding: This study received funding from the Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University, Bangkok, Thailand (GCUGR1125633058M).

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LIFE QUALITY OF PATIENTS WITH NEWLY DIAGNOSED PULMONARY TUBERCULOSIS WHEN USING ALCOHOL

International Medical Journal ◽

10.37436/2308-5274-2020-1-19 ◽

2020 ◽

pp. 88-92

Author(s):

I. I. Hrek ◽

Anton Viktorovych Rohozhyn ◽

V. B. Kushnir ◽

Yu. O. Zaikina ◽

Maryna Mykolayivna Kochuieva

Keyword(s):

Quality Of Life ◽

Alcohol Consumption ◽

Pulmonary Tuberculosis ◽

Life Quality ◽

Newly Diagnosed ◽

Integral Index ◽

Key Words Tuberculosis ◽

Sf 36 ◽

Unique Approach

Interest to the studies of life quality by scientists and practitioners is constantly growing, as this unique approach allows to fundamentally change the traditional view of the problem of the disease and the patient. By investigating the quality of life as an integral index of the patient's condition, it is possible to assess the complex impact of the disease on the patient's life, to compare the effectiveness of various interventions, to predict the disease course. However, the problem of assessing the quality of life in patients with tuberculosis under conditions of alcohol consumption remains poorly understood. To establish the level of quality of life in patients, 102 men with newly diagnosed tuberculosis, with preserved sensitivity to anti−tuberculosis drugs were examined. The AUDIT test was used to assess their alcohol consumption, and the MOS SF−36 questionnaire was used to analyze the quality of life parameters. The study also assessed quality of life parameters and alcohol consumption in groups with varying prevalence of tuberculosis and the presence of mycobacteria or no bacterial excretion. According to the findings, the following conclusions can be drawn: pulmonary tuberculosis leads to a decrease in quality of life with the greatest depression in the group of patients who abuse alcohol; quality of life indices are significantly lower in patients with advanced tuberculosis and bacterial excretion, while the level of alcohol consumption in these groups is significantly higher than in patients with localized forms and lack of bacterial excretion. Interestingly, when interviewing patients, none of them rated their health as "excellent", answering the first question of the SF−36 questionnaire, and 100 % of respondents to question 11 answered "definitely not" to the statement "I expect my health to deteriorate". The obtained research data on the parameters of quality of life in patients with tuberculosis can be used to achieve the highest effectiveness of therapy and targeted psychosocial rehabilitation. Key words: tuberculosis, alcohol, quality of life, bacterial excretion.

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