Association between occupational exposure to irritant agents and a distinct asthma endotype in adults

2021 ◽  
pp. oemed-2020-107065
Author(s):  
Miora Valérie Andrianjafimasy ◽  
Mickaël Febrissy ◽  
Farid Zerimech ◽  
Brigitte Dananché ◽  
Hans Kromhout ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Occupational Exposure ◽  
Immunoglobulin E ◽  
Smoking Status ◽  
Oxidation Products ◽  
Biological Mechanisms ◽  
Childhood Onset ◽  
Cross Sectional ◽  
High Exposure ◽  
Work Related

AimThe biological mechanisms of work-related asthma induced by irritants remain unclear. We investigated the associations between occupational exposure to irritants and respiratory endotypes previously identified among never asthmatics (NA) and current asthmatics (CA) integrating clinical characteristics and biomarkers related to oxidative stress and inflammation.MethodsWe used cross-sectional data from 999 adults (mean 45 years old, 46% men) from the case-control and familial Epidemiological study on the Genetics and Environments of Asthma (EGEA) study. Five respiratory endotypes have been identified using a cluster-based approach: NA1 (n=463) asymptomatic, NA2 (n=169) with respiratory symptoms, CA1 (n=50) with active treated adult-onset asthma, poor lung function, high blood neutrophil counts and high fluorescent oxidation products level, CA2 (n=203) with mild middle-age asthma, rhinitis and low immunoglobulin E level, and CA3 (n=114) with inactive/mild untreated allergic childhood-onset asthma. Occupational exposure to irritants during the current or last held job was assessed by the updated occupational asthma-specific job-exposure matrix (levels of exposure: no/medium/high). Associations between irritants and each respiratory endotype (NA1 asymptomatic as reference) were studied using logistic regressions adjusted for age, sex and smoking status.ResultsPrevalence of high occupational exposure to irritants was 7% in NA1, 6% in NA2, 16% in CA1, 7% in CA2 and 10% in CA3. High exposure to irritants was associated with CA1 (adjusted OR aOR, (95% CI) 2.7 (1.0 to 7.3)). Exposure to irritants was not significantly associated with other endotypes (aOR range: 0.8 to 1.5).ConclusionOccupational exposure to irritants was associated with a distinct respiratory endotype suggesting oxidative stress and neutrophilic inflammation as potential associated biological mechanisms.

scholarly journals Oxidative Stress Biomarkers in Urine of Metal Carpentry Workers Can Be Diagnostic for Occupational Exposure to Low Level of Welding Fumes from Associated Metals

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3167
Author(s):  
Flavia Buonaurio ◽  
Maria Luisa Astolfi ◽  
Daniela Pigini ◽  
Giovanna Tranfo ◽  
Silvia Canepari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Occupational Exposure ◽  
Oxidation Products ◽  
Control Group ◽  
Welding Fumes ◽  
Oxidative Stress Biomarkers ◽  
Limit Values ◽  
Stress Biomarkers ◽  
Specificity And Sensitivity ◽  
The Impact

Urinary concentrations of 16 different exposure biomarkers to metals were determined at the beginning and at the end of a working shift on a group of workers in the metal carpentry industry. Five different oxidative stress biomarkers were also measured, such as the oxidation products of RNA and DNA metabolized and excreted in the urine. The results of workers exposed to metals were compared to those of a control group. The metal concentrations found in these workers were well below the occupational exposure limit values and exceeded the mean concentrations of the same metals in the urine of the control group by a factor of four at maximum. Barium (Ba), mercury (Hg), lead (Pb) and strontium (Sr) were correlated with the RNA oxidative stress biomarker, 8-oxo-7, 8-dihydroguanosine (8-oxoGuo), which was found able to discriminate exposed workers from controls with a high level of specificity and sensitivity. The power of this early diagnostic technique was assessed by means of the ROC curve. Ba, rubidium (Rb), Sr, tellurium (Te), and vanadium (V) were correlated with the level of the protein oxidation biomarker 3-Nitrotyrosine (3-NO2Tyr), and Ba, beryllium (Be), copper (Cu), and Rb with 5-methylcytidine (5-MeCyt), an epigenetic marker of RNA damage. These effect biomarkers can help in identifying those workers that can be defined as “occupationally exposed” even at low exposure levels, and they can provide information about the impact that such doses have on their health.

scholarly journals Evaluation of pulmonary function and respiratory symptoms in pyrochlore mine workers

2016 ◽  
Vol 42 (4) ◽  
pp. 279-285 ◽  
Author(s):  
Ritta de Cássia Canedo Oliveira Borges ◽  
José Cerqueira Barros Júnior ◽  
Fabrício Borges Oliveira ◽  
Marisa Andrade Brunherotti ◽  
Paulo Roberto Veiga Quemelo
Keyword(s):  
Occupational Exposure ◽  
Pulmonary Function ◽  
Respiratory Symptoms ◽  
Smoking Status ◽  
Pulmonary Function Tests ◽  
Cross Sectional ◽  
Mining Company ◽  
Production Sector ◽  
The Mean ◽  
Mine Workers

ABSTRACT Objective: To identify respiratory symptoms and evaluate lung function in mine workers. Methods: This was a cross-sectional observational study involving production sector workers of a pyrochlore mining company. The subjects completed the British Medical Research Council questionnaire, which is designed to evaluate respiratory symptoms, occupational exposure factors, and smoking status. In addition, they underwent pulmonary function tests with a portable spirometer. Results: The study involved 147 workers (all male). The mean age was 41.37 ± 8.71 years, and the mean duration of occupational exposure was 12.26 ± 7.09 years. We found that 33 (22.44%) of the workers had respiratory symptoms and that 26 (17.69%) showed abnormalities in the spirometry results. However, we found that the spirometry results did not correlate significantly with the presence of respiratory symptoms or with the duration of occupational exposure. Conclusions: The frequencies of respiratory symptoms and spirometric changes were low when compared with those reported in other studies involving occupational exposure to dust. No significant associations were observed between respiratory symptoms and spirometry results.

scholarly journals High manganese exposure decreased the risk of high triglycerides in male workers: a cross-sectional study

2019 ◽  
Author(s):  
xiaoyu luo ◽  
zhenfang liu ◽  
xiaoting ge ◽  
sifang huang ◽  
yanting zhou ◽  
...  
Keyword(s):  
Smoking Status ◽  
Weighted Average ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
High Exposure ◽  
Exposed Workers ◽  
Low Exposure ◽  
Elevated Exposure

Abstract Manganese (Mn) is to be involved in lipids metabolism. However, few epidemiological studies have investigated the association between elevated exposure to Mn and the risk of dyslipidemia. Methods: This was a cross-sectional study based on follow-up of the manganese-exposed workers healthy cohort (MEWHC) in 2017. A total of 803 Mn-exposed workers were divided into the low-exposure, and high-exposure group according to Mn-Time Weighted Average (Mn-TWA) ≤0.15mg/m3 or >0.15mg/m3. And we evaluated the associations between Mn-TWA levels and dyslipidemia, and assessed the interaction between Mn-TWA levels and each of the potential interacting factors. Results: After adjustment for potential confounders, we observed mainly significant negative association between high triglycerides (TG) risk and Mn-TWA levels in male (OR = 0.60; 95% CI: 0.39, 0.94; p <0.01). In interaction analyses of male, we did not observe a significant interaction between Mn-TWA levels and pack-years on high TG risk (relative excess risk for the interaction (RERI) = -1.30, 95% CI: -3.29, 0.70, RERI = -1.62, 95% CI: -3.92, 0.67). Similarly, analysis of smoking status, drinking status, high-fat diets frequency, and BMI were nonsignificant interaction with Mn-TWA levels on high TG risk as well. Conclusions: Our study indicated that high Mn exposure was significantly associated with low risk of hyper TG in male workers.Keywords: Manganese; Occupation; Dyslipidemia; Triglycerides

scholarly journals Occupational exposure to organophosphorus and carbamates in farmers in La Cienega, Jalisco, Mexico: oxidative stress and membrane fluidity markers

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Joel Salazar-Flores ◽  
Fermín P. Pacheco-Moisés ◽  
Genaro G. Ortiz ◽  
Juan H. Torres-Jasso ◽  
Odette Romero-Rentería ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Occupational Exposure ◽  
Membrane Fluidity ◽  
Lipid Peroxides ◽  
Exposed Group ◽  
Occupational Risk ◽  
Cross Sectional ◽  
Toxicological Studies ◽  
Stress Levels ◽  
Markers Of Oxidative Stress

Abstract Background The region of La Cienega in Jalisco Mexico, is an important agricultural reference for the production of corn, sorghum and wheat, among other grains, so the use of pesticides for pest control is high. However, in this rural area there are no toxicological studies that assess the occupational risk of pesticide use. Therefore, this study is the first to determine the oxidative stress levels markers (GSH, GSSG, carbonyl groups, nitric oxide metabolites and lipid peroxides) as well as alteration of the mitochondrial membrane fluidity caused by occupational exposure to organophosphorus and carbamates in farmers of this region. This occupational risk can increase cellular oxidation, which explains the high prevalence of neurodegenerative diseases and cancer in Cienega settlers to be analyzed in future studies. Methods Comparative cross-sectional study was performed using two groups: one not exposed group (n = 93) and another one with occupational exposure (n = 113). The latter group was sub-divided into 4 groups based on duration of use/exposure to pesticides. Oxidative stress levels and membrane fluidity were assessed using spectrophotometric methods. Statistical analyses were performed using SPSS software ver. 19.0 for windows. Results The most commonly used pesticides were organophosphorus, carbamates, herbicide-type glyphosate and paraquat, with an average occupational exposure time of 35.3 years. There were statistically significant differences in markers of oxidative stress between exposed farmers and not exposed group (p = 0.000). However, in most cases, no significant differences were found in markers of oxidative stress among the 4 exposure sub-groups (p > 0.05). Conclusion In the Cienega region, despite the indiscriminate use of organophosphorus and carbamates, there are no previous studies of levels oxidative stress. The results show increased levels of oxidative stress in occupationally exposed farmers, particularly membrane fluidity levels increased three times in contrast to not exposed group.

The influencing factors of the smoking behavior of online ride-hailing drivers in China: A cross-sectional analysis

2021 ◽  
Author(s):  
Xinlin Chen ◽  
Xuefei Gu ◽  
Tingting Li ◽  
Lirong Xu ◽  
Qiaoyan Liu ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Health Literacy ◽  
Tobacco Control ◽  
Influencing Factors ◽  
Smoking Status ◽  
Smoking Behavior ◽  
Cross Sectional ◽  
Current Smoking ◽  
Work Related ◽  
Tobacco Control Policies

Abstract Background：Online ride-hailing is a fast-developing new travel mode, and tobacco control policies on it have not yet been improved. This study aims to reveal the smoking status and influencing factors of ride-hailing drivers, so as to provide a basis for the formulation of tobacco control policies.Methods：The cross-sectional data used in this study were derived from an online survey of full-time ride-hailing drivers in China. Questionnaires were employed to collect variables including sociodemographic and work-related characteristics, health status, health behavior, health literacy, and smoking status. Chi-Square test and multivariate logistic regression were used to analyze the influencing factors of current smoking.Results：A total of 8990 ride-hailing drivers were investigated, in which 5024 were current smokers, accounted to 55.9%. Current smokers (53.7% (2696/5024) v 44.2% (1752/3966); P<0.001) and drivers who smoked on the car (85.8% (1389/1618) v 38.4 (1307/3406); P<0.001) were more likely to allow passengers to smoke. Logistic regression analysis showed that men (OR=0.519, 95%CI (0.416, 0.647)), central regions (OR=1.172, 95%CI (1.049, 1.309)), eastern regions (OR=1.330, 95%CI (1.194, 1.480)), working at both daytime and night (OR=1.287, 95%CI (1.164, 1.424)), and working at non-fixed time (OR=0.847, 95%CI (0.718, 0.999)), 35-54 years old (OR=0.585, 95%CI (0.408, 0.829)), current drinker (OR=1.663, 95%CI (1.526, 1.813)), eating very irregularly (OR=1.370, 95%CI (1.233, 1.523)), the number of days a week of engaging in at least 10 minutes of moderate or vigorous exercise ≥ 3 (OR=0.752, 95%CI (0.646, 0.875)), taking the initiative to acquire health knowledge occasionally (OR=0.882, 95%CI (0.783, 0.992)) or frequently (OR=0.675, 95%CI (0.591, 0.770)) , underweight (OR=1.249, 95%CI (1.001, 1.559)) and overweight (OR=0.846, 95%CI (0.775, 0.924)) were associated with the prevalence of current smoking among online ride-hailing drivers (P<0.05). Conclusions：The smoking rate of ride-hailing drivers was high, and the social demographic and work-related characteristics, and health-related factors all affected their smoking behavior. Tobacco control measures targeted at online-hailing drivers should correct their cultural beliefs about smoking, increase their health literacy, guide them to exercise more and keep a regular schedule, as well as combine with drinking intervention and weight intervention.

scholarly journals Oxidative Stress Markers Are Associated with Persistent Atrial Fibrillation

2007 ◽  
Vol 53 (9) ◽  
pp. 1652-1657 ◽  
Author(s):  
Robert B Neuman ◽  
Heather L Bloom ◽  
Irfan Shukrullah ◽  
Lyndsey A Darrow ◽  
David Kleinbaum ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atrial Fibrillation ◽  
Inflammatory Markers ◽  
Smoking Status ◽  
Serum Markers ◽  
Oxidative Stress Markers ◽  
Cross Sectional ◽  
Stress Markers ◽  
Myocardial Oxidative Stress ◽  
Antioxidant Agents

Abstract Background: Atrial fibrillation (AF) has been associated with myocardial oxidative stress, and antioxidant agents have demonstrated antiarrhythmic benefit in humans. We compared serum markers of oxidation and associated inflammation in individuals with or without AF. Methods: Serum markers of oxidative stress and inflammation were compared in a cross-sectional, case-control design study of 40 male individuals, with or without persistent or permanent AF, who were matched for age, sex, diabetes, and smoking status, known confounding variables for the measurement of oxidative stress. We used derivatives of reactive oxidative metabolites (DROMs) and ratios of oxidized to reduced glutathione (Eh GSH) and cysteine (Eh CySH) to quantify oxidative stress. We also measured inflammatory markers, including high-sensitivity C-reactive protein, interleukins 1β and 6, and tumor necrosis factor α. Results: Univariate, conditional logistical regression analysis showed that oxidative stress but not inflammatory markers were statistically associated with AF (P &lt;0.05). The increase in the odds ratios for AF for Eh GSH, Eh CySH, and DROMs were 6.1 (95% CI, 1.3–28.3; P = 0.02), 13.6 (95% CI, 2.5–74.1; P = 0.01), and 15.9 (95% CI, 1.7–153.9; P = 0.02), respectively. There was a stronger correlation between Eh GSH and Eh CySH (r = 0.66) than between Eh GSH and DROMs (r = 0.41). In multivariate analysis corrected for statins and other AF risk factors differing between the groups, the association of AF and oxidative stress remained significant. Conclusions: These data suggest that oxidative stress markers may have predictive value in AF management.

scholarly journals The Relationship of Individual, Occupational and Psychological Factors With Low Back Pain Among Steel Industry Workers

2021 ◽  
Author(s):  
Fatemeh Ahmadi ◽  
Habibollah Esmaily ◽  
Seyedeh Paria Pakdaman ◽  
Ehsan Rafeemanesh
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Steel Industry ◽  
Smoking Status ◽  
Cross Sectional Study ◽  
P Value ◽  
Low Back ◽  
Job Status ◽  
Cross Sectional ◽  
Work Related

Abstract Objectives: Low back pain (LBP) is one of the most common and most costly work-related musculoskeletal disorders. There are numerous factors that may affect the development of this disease. The aim of this study was to determine the prevalence of low back pain (LBP) and its association with individual, occupational and psychosocial factors among steel industry workers.Methods: For this cross-sectional study, 273 workers in a steel plant were selected by random sampling method. The participants were divided into production (n=168) and administrative (n=105) Workers. Data was collected through in-person interview, physical examination, modified Nordic questionnaire and Osipow questionnaire. Data was analyzed by descriptive statistical methods, chi-square test, t-student،test and logistic regression model using SPSS-20 software. In all statistical analysis P value≤ 0.05 was considered as statistically significant.Results: Despite the young age of participants (39.63±6.32 years) and their short employment duration, the prevalence of LBP was high (38.5%) in this industry. Gender, body mass index, smoking status and total stress score were similar in two groups. No significant relationship was found between LBP and current job status. However, LBP prevalence was significantly associated with age and duration of employment (P<0.05).Conclusion: In our study no association was observed between LBP and the participants' current job status and work- related stress. It appears that life style modifications along with education can decrease the rate of low back pain and its risk factors in employees of this industry.

scholarly journals Comparing Awareness about Occupational Exposure Management among Nursing, Midwifery, and Surgical Technology Students

2018 ◽  
Author(s):  
Nasim NIKBAKHTAN ◽  
Zahra BAGHERSAD ◽  
Saeid SADEGHI DORCHEH ABEDI ◽  
Maryam SHIRAZI ◽  
Jamshid MOHAMMADI CHAMNARI
Keyword(s):  
Occupational Exposure ◽  
Time Management ◽  
Work Experience ◽  
Data Gathering ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Surgical Technology ◽  
Work Related ◽  
Technology Students

Introduction: Occupational exposure with polluted sharp equipment usually occurs during procedures such as transfusion of blood and blood products, blood sampling, disposal of needles, and collection of polluted sharp materials. Considering the fact that students have less work experience and lower practical skills, they are more vulnerable to work-related infections. The present study was conducted to determine and compare the awareness of nursing, midwifery, and surgical technology students about occupational exposure management.Methods: This descriptive-analytical cross-sectional study was conducted on 221 students of nursing, midwifery, and surgical technology selected using the stratified random sampling in 2016. Data gathering tool was a researcher-made questionnaire including the students' demographic characteristics and awareness about occupational exposure management. Data were analyzed by SPSS18 using descriptive and analytical statistical tests.Results: Our findings showed that the mean scores of awareness about occupational exposure management were not significantly different among the nursing, midwifery, and surgical technology students (p value = 0.435). We observed that the students' age and educational level were significantly correlated with their scores of awareness about occupational exposure management (p value < 0.001).Conclusions: Results of the present study indicated poor awareness of the students about in-time management of occupational exposure. Measures such as educational workshops on preventive aspects in occupational exposure, observance of safety principles and comprehensive standards for accurate measurement of viral markers should be taken. Individual health profiles should be designed for each student to improve the occupational exposure management. 

scholarly journals Oxidative stress biomarkers and asthma characteristics in adults of the EGEA study

2017 ◽  
Vol 50 (6) ◽  
pp. 1701193 ◽  
Author(s):  
Miora Andrianjafimasy ◽  
Farid Zerimech ◽  
Zeina Akiki ◽  
Helene Huyvaert ◽  
Nicole Le Moual ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Function ◽  
Asthma Control ◽  
Exhaled Breath Condensate ◽  
Oxidation Products ◽  
Antioxidant Enzyme Activities ◽  
Exhaled Breath ◽  
Oxidative Stress Biomarkers ◽  
Cross Sectional ◽  
Asthma Outcomes

Asthma is an oxidative stress related disease, but associations with asthma outcomes are poorly studied in adults. We aimed to study the associations between several biomarkers related to oxidative stress and various asthma outcomes.Cross-sectional analyses were conducted in 1388 adults (mean age 43 years, 44% with asthma) from the Epidemiological Study of the Genetics and Environment of Asthma (EGEA2). Three blood antioxidant enzyme activities (biomarkers of response to oxidative stress) and exhaled breath condensate 8-isoprostanes and plasma fluorescent oxidation products (FlOPs) levels (two biomarkers of damage) were measured. Associations between biomarkers and 1) ever asthma and 2) asthma attacks, asthma control and lung function in participants with asthma were evaluated using regression models adjusted for age, sex and smoking.Biomarkers of response were unrelated to asthma outcomes. Higher 8-isoprostane levels were significantly associated with ever asthma (odds ratio for one interquartile range increase 1.28 (95% CI 1.06–1.67). Among participants with asthma, 8-isoprostane levels were negatively associated with adult-onset asthma (0.63, 0.41–0.97) and FlOPs levels were positively associated with asthma attacks (1.33, 1.07–1.65), poor asthma control (1.30, 1.02–1.66) and poor lung function (1.34, 1.04–1.74).Our results suggest that 8-isoprostanes are involved in childhood-onset asthma and FlOPs are linked to asthma expression.

scholarly journals Evaluation of Work-Related Symptoms by Job Exposure Matrix in Chronic Pulmonary Diseases - A Cross-sectional Study

2021 ◽  
Vol 24 (9) ◽  
pp. 696-700
Author(s):  
Lahya Afshari Saleh ◽  
Atefeh Matoori ◽  
Reza Basiri ◽  
Habibollah Esmaily ◽  
Farzaneh Rahimpour ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Occupational Exposure ◽  
Health And Safety ◽  
Cross Sectional Study ◽  
Chronic Obstructive ◽  
Job Exposure Matrix ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Work Related ◽  
Chronic Pulmonary Diseases

Background: Despite the high prevalence of occupational airway disorders, they are usually underestimated by physicians. This study designed to study the prevalence of work-related symptoms (WRS) and their association with occupational exposure in outpatient pulmonary clinics. Methods: Adults with more than one year of lower respiratory symptoms were included. Retired patients, housewives and those unable to perform spirometry were excluded. Demographic, anthropometric and medical data were documented. The Persian version of National institute for health and safety respiratory questionnaire was used to classify job titles. WRS were defined as 2 (or more) positive questions with improvement of symptoms on days off work. Job exposure matrix (JEM) was used for classifying the type of occupational exposure into one of three categories: high molecular weight (HKW), low molecular weight (LMW) and mixed. Results: A total of 250 patients (69% male) with mean (±SD) age of 40 (±11.6) years, 178 cases of asthma and 59 chronic obstructive pulmonary disease (COPD) cases entered. Occupational exposure was seen in 51.2% of patients (26, 51 and 51 cases with HMW, LMW and mixed, respectively). WRS were lower in those who exercised regularly (24.6% vs. 39.4%) and higher in those with eczema (62.5% vs. 33.6%). Eczema had an odds ratio (OR) of 4.13 (95% CI 1.3 to 12.9, P = 0.01). Exposure to LMW almost tripled the risk of WRS (OR: 2.9, 95% CI: 1.4 to 5.9, P = 0.003) in our patients. Conclusion: Pulmonologists are firmly advised to take their patients’ occupational and vocational exposures into consideration for treatment plans, especially in those with positive history of eczema and exposure to LMW.

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