Recent trends of copper detection in water samples

Background Water pollution due to the disposal of heavy metals in water bodies is one of the most global concerns that adversely affect the ecosystem and human health because of their non-biodegradability and potential of accumulation. Copper is one of the most present metals in the environment released mainly from disposing of agricultural fertilizers and pesticides, mining operations, chemical, pharmaceutical, and paper manufacturing industries into stream bodies. The elevated exposure to Cu(II) causes severe toxicity, diabetes, anemia, kidney disorders, liver damage, and death. Main body Several researchers developed detection methods and techniques for Cu(II) detection in the different water samples and sources to ensure that Cu(II) concentration falls within the acceptable limit range, including atomic and molecular spectrophotometry, mass spectroscopy, sensors, voltammetry, and chromatography. This review spotlights recent Cu(II) detection trends in water samples, highlighting their detection limits, advantages, and disadvantages. Conclusion Based on the water sample, detection limit, method cost, an appropriate analysis can be used. Recent trends of Cu(II) detection in water samples include atomic and molecular spectrophotometry, mass spectroscopy, sensors, voltammetry, and chromatography. The principle, definitions, experimental work, advantages, and disadvantages of each method are discussed and highlighted.

Systemic biomarkers of exposure associated with ENDS use: a scoping review

ObjectiveThis scoping review provides an overview of the existing literature on biomarkers of exposure from electronic nicotine delivery systems (ENDS) use and identifies gaps in existing knowledge.Data sourcesWe searched two international databases (PubMed and Web of Science) to identify relevant studies published from August 2013 to February 2021.Data selectionStudies were included if they assessed and compared biomarkers of exposure between exclusive ENDS users, non-users, exclusive cigarette smokers, dual users of ENDS and cigarettes or cigarette smokers who switch to ENDS.Data extraction and synthesisOf the 5074 studies identified, 188 studies met criteria and were selected for full-text screening. Of these, 27 studies were selected for inclusion and data extraction.ConclusionsConsistent, although limited, evidence shows that exclusive ENDS users have elevated levels of biomarkers of certain volatile organic compounds (VOCs; eg, acrylamide and acrylonitrile), metals (eg, cadmium and selenium) and propylene glycol compared with non-users; however, evidence for biomarkers of other toxicants (eg, acrolein, benzene and chromium) is mixed. Biomarkers of most VOCs are lower in ENDS users compared with cigarette smokers, and cigarette smokers who switch to ENDS consistently show reductions in VOC biomarkers. Evidence comparing metal exposures from exclusive ENDS use, cigarette smoking and dual use is mixed and depends on the metal. ENDS and e-liquid characteristics as well as use patterns may be associated with elevated exposure to VOCs and metals. Additional rigorous, controlled studies can assess biomarker exposures from ENDS use and inform the overall risk–benefit of ENDS use for different user populations.

Exploring linkages between climate change and sexual health: a scoping review protocol

IntroductionThe effects of climate change and associated extreme weather events (EWEs) present substantial threats to well-being. EWEs hold the potential to harm sexual health through pathways including elevated exposure to HIV and other sexually transmitted infections (STIs), disrupted healthcare access, and increased sexual and gender-based violence (SGBV). The WHO defines four components of sexual health: comprehensive sexuality education; HIV and STI prevention and care; SGBV prevention and care; and psychosexual counselling. Yet, knowledge gaps remain regarding climate change and its associations with these sexual health domains. This scoping review will therefore explore the linkages between climate change and sexual health.Methods and analysisFive electronic databases (MEDLINE, EMBASE, PsycINFO, Web of Science, CINAHL) will be searched using text words and subject headings (eg, Medical Subject Headings (MeSH), Emtree) related to sexual health and climate change from the inception of each database to May 2021. Grey literature and unpublished reports will be searched using a comprehensive search strategy, including from the WHO, World Bank eLibrary, and the Centers for Disease Control and Prevention. The scoping review will consider studies that explore: (a) climate change and EWEs including droughts, heat waves, wildfires, dust storms, hurricanes, flooding rains, coastal flooding and storm surges; alongside (b) sexual health, including: comprehensive sexual health education, sexual health counselling, and HIV/STI acquisition, prevention and/or care, and/or SGBV, including intimate partner violence, sexual assault and rape. Searches will not be limited by language, publication year or geographical location. We will consider quantitative, qualitative, mixed-methods and review articles for inclusion. We will conduct thematic analysis of findings. Data will be presented in narrative and tabular forms.Ethics and disseminationThere are no formal ethics requirements as we are not collecting primary data. Results will be published in a peer-reviewed journal and shared at international conferences.

The Exposure of Pharmacists and Pharmacy Assistants to COVID-19: A Cross-sectional Study in Libya

Introduction: As per the WHO reports dated July 7, 2021, 184,324,026 confirmed cases of COVID-19 were found in the world and 196,894 cases were found in Libya. Healthcare workers (HCWs), pharmacists, in particular, have been affected a lot because of COVID-19. Community pharmacies are considered workplaces with elevated exposure risk to COVID-19. Method: This study aims to roughly estimate the risk of COVID-19 exposure among pharmacists and pharmacy assistants working in pharmacies in Libya. An anonymous cross-sectional online survey was conducted among pharmacists and pharmacy assistants working in hospital pharmacies and community pharmacies. Between November 11th, 2020 and January 7th, 2021, a Google Form questionnaire was delivered through social media and instant messaging platforms, to certified community pharmacists and pharmacy assistants residing in Libya. Results: Out of 207 respondents, the majority (72.4%) reported having at least one or more flu-like symptoms. In addition, 52.17% of them reported that one of their relatives had at least one or more flu-like symptoms. The most common symptoms reported by respondents were headache (46.9%), tiredness (42.5%), fever (31.9%), and loss of smell and taste sensation (29.0%). The period with the highest number of all the symptomatic respondents as well as those with symptoms suggestive of COVID-19 was between August to October 2020. Correspondingly, 108 (52.17%) symptomatic respondents had a relative with symptoms. Conclusion: The majority of respondents reported having flu-like symptoms in the period from August to October. Moreover, the highest cumulative number of people with suggestive COVID-19 symptoms reported their symptoms in the same period.

Development and Comparison of Dengue Vulnerability Indices Using GIS-Based Multi-Criteria Decision Analysis in Lao PDR and Thailand

Dengue is a continuous health burden in Laos and Thailand. We assessed and mapped dengue vulnerability in selected provinces of Laos and Thailand using multi-criteria decision approaches. An ecohealth framework was used to develop dengue vulnerability indices (DVIs) that explain links between population, social and physical environments, and health to identify exposure, susceptibility, and adaptive capacity indicators. Three DVIs were constructed using two objective approaches, Shannon’s Entropy (SE) and the Water-Associated Disease Index (WADI), and one subjective approach, the Best-Worst Method (BWM). Each DVI was validated by correlating the index score with dengue incidence for each spatial unit (district and subdistrict) over time. A Pearson’s correlation coefficient (r) larger than 0.5 and a p-value less than 0.05 implied a good spatial and temporal performance. Spatially, DVIWADI was significantly correlated on average in 19% (4–40%) of districts in Laos (mean r = 0.5) and 27% (15–53%) of subdistricts in Thailand (mean r = 0.85). The DVISE was validated in 22% (12–40%) of districts in Laos and in 13% (3–38%) of subdistricts in Thailand. The DVIBWM was only developed for Laos because of lack of data in Thailand and was significantly associated with dengue incidence on average in 14% (0–28%) of Lao districts. The DVIWADI indicated high vulnerability in urban centers and in areas with plantations and forests. In 2019, high DVIWADI values were observed in sparsely populated areas due to elevated exposure, possibly from changes in climate and land cover, including urbanization, plantations, and dam construction. Of the three indices, DVIWADI was the most suitable vulnerability index for the study area. The DVIWADI can also be applied to other water-associated diseases, such as Zika and chikungunya, to highlight priority areas for further investigation and as a tool for prevention and interventions.

Acute, Low-Dose Neutron Exposures Adversely Impact Central Nervous System Function

A recognized risk of long-duration space travel arises from the elevated exposure astronauts face from galactic cosmic radiation (GCR), which is composed of a diverse array of energetic particles. There is now abundant evidence that exposures to many different charged particle GCR components within acute time frames are sufficient to induce central nervous system deficits that span from the molecular to the whole animal behavioral scale. Enhanced spacecraft shielding can lessen exposures to charged particle GCR components, but may conversely elevate neutron radiation levels. We previously observed that space-relevant neutron radiation doses, chronically delivered at dose-rates expected during planned human exploratory missions, can disrupt hippocampal neuronal excitability, perturb network long-term potentiation and negatively impact cognitive behavior. We have now determined that acute exposures to similar low doses (18 cGy) of neutron radiation can also lead to suppressed hippocampal synaptic signaling, as well as decreased learning and memory performance in male mice. Our results demonstrate that similar nervous system hazards arise from neutron irradiation regardless of the exposure time course. While not always in an identical manner, neutron irradiation disrupts many of the same central nervous system elements as acute charged particle GCR exposures. The risks arising from neutron irradiation are therefore important to consider when determining the overall hazards astronauts will face from the space radiation environment.

SARS-COV-2 SEROPREVALENCE AMONG EMERGENCY PROVIDERS AND THE IMPORTANCE OF PERSONAL PROTECTIVE EQUIPMENT.

Background: Healthcare workers (HCWs) have elevated exposure risks to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there is limited published information regarding the transmission rate and the seroconversion among HCWs. The goals of this study are to determine the seroprevalence among emergency providers and the correlation between working hours and utilization of personal protective equipment with the likelihood of seroconversion. Methods: This prospective study evaluated Emergency Department physicians and advanced practice providers, who had been tested for SARSCoV-2 IgG serology, at 10 different hospitals in the location area. An anonymous survey was sent to the Emergency Department providers via email inquiring about the following: results of serology and/or nasopharyngeal testing, the testing site used, the presence or absence of COVID-19 symptoms, utilization of personal protective equipment (PPEs), exposure to potential COVID-19 patients, and average clinical hours since March. Results: 43 participants responded to the survey. 3 had positive SARS-CoV-2 antibody or viral tests indicating exposures to COVID-19 despite utilization of various types of PPE. There was a surprisingly high number of HCWs treating known/suspected COVID-19 patients without proper PPE (18.6%). 21 (48.8%) HCWs routinely wore an N-95 mask, 11 (25.6%) used a powered air-purifying respirator (PAPR), 6 (14%) wore surgical masks, and 5 (11.6%) used elastomeric face respirators. None of the COVID-19 positive HCWs used a PAPR while treating known or suspected COVID-19 patients. Conclusion: Our knowledge regarding the complications related to SARS-CoV-2 infection post-acute phase remains limited. Our data suggest PAPR use may be protective compared to other PPE modalities. There can be unanticipated long-term morbidities that result from an infection with SARS-CoV-2. Therefore, frontline HCWs, who have an inherently elevated exposure to this virus, must use PPE and maintain vigilance while treating patients, regardless of the presence of COVID-19 symptoms.

The Effect of Route Choice in Children’s Exposure to Ultrafine Particles Whilst Walking to School

Children walking to school are at a high risk of exposure to air pollution compared with other modes because of the time they spend in close proximity to traffic during their commute. The aim of this study is to investigate the effect of a walker’s route choice on their exposure to ultrafine particles (UFP) on the walk to school. During morning commutes over a period of three weeks, exposure to UFP was measured along three routes: two routes were alongside both sides of a busy arterial road with significantly higher levels of traffic on one side compared to the other, and the third route passed through quiet streets (the background route). The results indicate that the mean exposure for the pedestrian walking along the background route was half the exposure experienced on the other two routes. Walkers on the trafficked side were exposed to elevated concentrations (>100,000 pt/cc) 2.5 times longer than the low-trafficked side. However, the duration of the elevated exposure for the background route was close to zero. Public health officials and urban planners may use the results of this study to promote healthier walking routes to schools, especially those planned as part of organized commutes.

Presentation of a participatory approach to develop preventive measures to reduce COVID-19 transmission in child care

Background It can be suspected that work in child care facilities is associated with an elevated exposure risk towards SARS-CoV-2 infections. It is still unclear under which conditions employees in those facilities can safely pursue their work. Preventive workplace-related measures to reduce transmission dynamics in this work environment need to be developed. These measures need to build on a solid scientific foundation and be ready for practical use at the same time. Therefore, the aim of the study is to present a participatory approach to identify, minimize, and eliminate workplace-specific COVID-19 transmission within child care. The approach presented combines quantitative as well as qualitative elements and includes a screening of critical workplace conditions and the development of preventive measures to foster a safe workplace design. Methods First, 428 employees of different child care facilities in a large German city reported their subjective risk of infection, fear of infection, and support received by the employer. Second, the participants commented in detail about high risk conditions during work. Third, employees provided suggestions for preventive measures. We conducted a qualitative analysis of free text answers to evaluate which aspects are perceived as critical from an employee perspective. Results Participants provided valuable and practicable ideas on how to design and improve preventive measures to reduce COVID-19 transmission in child care dealing with structural conditions, the interaction with the parents, the implementation of preventive measures and recommendations for policy makers. Conclusions These new insights help to organize pandemic risk management in order to align theoretical based measures with the practical realization. We encourage researchers to adapt the approach presented to other work areas in order to foster participation of employees in work design to reduce COVID-19 transmission.

Systematic Review of Pharmacogenetic Factors That Influence High-Dose Methotrexate Pharmacokinetics in Pediatric Malignancies

Methotrexate (MTX) is a mainstay therapeutic agent administered at high doses for the treatment of pediatric and adult malignancies, such as acute lymphoblastic leukemia, osteosarcoma, and lymphoma. Despite the vast evidence for clinical efficacy, high-dose MTX displays significant inter-individual pharmacokinetic variability. Delayed MTX clearance can lead to prolonged, elevated exposure, causing increased risks for nephrotoxicity, mucositis, seizures, and neutropenia. Numerous pharmacogenetic studies have investigated the effects of several genes and polymorphisms on MTX clearance in an attempt to better understand the pharmacokinetic variability and improve patient outcomes. To date, several genes and polymorphisms that affect MTX clearance have been identified. However, evidence for select genes have conflicting results or lack the necessary replication and validation needed to confirm their effects on MTX clearance. Therefore, we performed a systematic review to identify and then summarize the pharmacogenetic factors that influence high-dose MTX pharmacokinetics in pediatric malignancies. Using the PRISMA guidelines, we analyzed 58 articles and 24 different genes that were associated with transporter pharmacology or the folate transport pathway. We conclude that there is only one gene that reliably demonstrates an effect on MTX pharmacokinetics: SLCO1B1.