Chronic administration of ellagic acid improved the cognition in middle-aged overweight men

2018 ◽  
Vol 43 (3) ◽  
pp. 266-273 ◽  
Author(s):  
Ying Liu ◽  
Shuyi Yu ◽  
Fen Wang ◽  
Haitao Yu ◽  
Xueli Li ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Cognitive Deficits ◽  
Ellagic Acid ◽  
Acid Treatment ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
Middle Aged ◽  
Adult Intelligence Scale ◽  
Saliva Cortisol ◽  
Age Related

This study aimed to investigate if ellagic acid has beneficial effects on cognitive deficits in middle-aged overweight individuals and to propose a possible mechanism. A total of 150 middle-aged male participants, including 76 normal-weight and 74 overweight men, aged between 45 to 55 years, were recruited for this study. Both normal-weight and overweight participants were administered either 50 mg ellagic acid or placebo cellulose daily for 12 weeks. Blood lipids, peripheral brain-derived neurotrophic factor (BDNF), and saliva cortisol were assessed on the last day of the procedure to investigate the effects induced by ellagic acid. The results revealed that ellagic acid treatment improved the levels of blood lipid metabolism with a 4.7% decline in total cholesterol, 7.3% decline in triglycerides, 26.5% increase in high-density lipoprotein, and 6.5% decline in low-density lipoprotein. Additionally, ellagic acid increased plasma BDNF by 21.2% in the overweight group and showed no effects on normal-weight participants. Moreover, the increased saliva cortisol level in overweight individuals was inhibited by 22.7% in a 12-week ellagic acid treatment. Also, compared with placebo, overweight individuals who consumed ellagic acid showed enhanced cognitive function as measured by the Wechsler Adult Intelligence Scale-Revised and the Montreal Cognitive Assessment. To the best of our knowledge, this is the first report showing that ellagic acid prevents cognitive deficits through normalization of lipid metabolism, increase in plasma BDNF level, and reduction of saliva cortisol concentration. These results indicate that ellagic acid has a potential to restore cognitive performance related to mild age-related declines.

scholarly journals The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Qiuying Xu ◽  
Shuwei Li ◽  
Wenjie Tang ◽  
Jiayou Yan ◽  
Xiaolan Wei ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Lipid Metabolism ◽  
Antioxidant Capacity ◽  
Ellagic Acid ◽  
Density Lipoprotein ◽  
Basal Diet ◽  
Lipoprotein Cholesterol ◽  
Heme Oxygenase 1 ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid

Accumulating evidence has demonstrated that the imbalance of lipid metabolism and antioxidant capacity leads to damage to liver. The present study aimed to investigate the effects of ellagic acid (EA), a phenolic compound, on hepatic lipid metabolism and antioxidant activity in mice. In our study, 24 C57BL/6J mice were divided into three groups: (1) control (CON); (2) basal diet+0.1% EA (EA1); and (3) basal diet+0.3% EA (EA2). After the 14-day experiment, the liver was sampled for analysis. The results showed that 0.3% EA administration increased the liver weight. Total cholesterol and low-density lipoprotein cholesterol activities decreased and high-density lipoprotein cholesterol activity increased by EA supplementation. Meanwhile, dietary supplementation with EA dose-dependently decreased the acetyl-CoA carboxylase protein abundance and increased the phospho-hormone-sensitive lipase, carnitine palmitoyltransferase 1B, and peroxisome proliferator-activated receptor alpha protein abundances. Moreover, EA supplementation reduced the malonaldehyde concentration and increased the superoxide dismutase and catalase concentrations. The protein abundances of phospho-nuclear factor-E2-related factor 2, heme oxygenase-1, and NAD(P)H: quinone oxidoreductase 1 increased by EA supplementation in a dose-dependent manner. Taken together, EA supplementation promoted the lipid metabolism and antioxidant capacity to maintain the liver health in mice.

scholarly journals A Meta-Analysis of the Effects of Tai Chi on Glucose and Lipid Metabolism in Middle-Aged and Elderly Diabetic Patients: Evidence from Randomized Controlled Trials

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Ya-nv Liu ◽  
Lin Wang ◽  
Xin Fan ◽  
Shijie Liu ◽  
Qi Wu ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Randomized Controlled Trials ◽  
Tai Chi ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Controlled Trials ◽  
Middle Aged ◽  
Randomized Controlled ◽  
Glucose And Lipid Metabolism

This research review aimed to evaluate the effect of practicing Tai Chi on glucose and lipid metabolism in middle-aged and elderly diabetic patients. Furthermore, it aimed to provide a theoretical basis for the practice of Tai Chi as a way to improve glucose and lipid metabolism in middle-aged and elderly diabetic patients. Therefore, we searched for randomized controlled trials on the practice of Tai Chi in middle-aged and elderly diabetic patients in Chinese- and English-language electronic databases, such as Web of Science, PubMed, the Cochrane Library, EMBASE, Google Scholar, CNKI, Wanfang Database, and Weipu. We collected articles published no later than August 1, 2020. The methodological quality of the included studies was evaluated according to the standards of the Cochrane Collaboration System Evaluation Manual (version 5.1.0). Finally, 14 articles were included, showing an average Physiotherapy Evidence Database scale score of 6.57. The articles were meta-analyzed using Stata 14.0 software, showing that practicing Tai Chi improved middle-aged and elderly diabetic patients’ fasting blood glucose (WMD = −0.60, 95% CI [−1.08, −0.12], p = 0.015 ), glycosylated hemoglobin (WMD = −0.87, 95% CI [−1.60, −0.14], p = 0.019 ), total cholesterol (WMD = −0.48, 95% CI [−0.83, −0.14], p = 0.006 ), triglycerides (WMD = −0.21, 95% CI [−0.37, −0.04], p = 0.014 ), and low-density lipoprotein cholesterol level significantly (WMD = −0.32, 95% CI [−0.63,−0.00], p = 0.050 ). Conversely, patients’ high-density lipoprotein cholesterol levels (WMD = 0.09, 95% CI [−0.01, 0.17], p = 0.136 ) showed no obvious improvement. In conclusion, practicing Tai Chi in sessions lasting longer than 50 minutes (at least three times per week, for at least 12 weeks) can effectively improve glucose and lipid metabolism in middle-aged and elderly diabetic patients. However, several other factors affect glucose and lipid metabolism; therefore, further high-quality research is needed. Protocol registration number: INPLASY2020120107.

scholarly journals Oxidised low-density lipoprotein concentration – early marker of an altered lipid metabolism in young women with PCOS

2006 ◽  
Vol 155 (1) ◽  
pp. 131-136 ◽  
Author(s):  
Djuro Macut ◽  
Svetozar Damjanović ◽  
Dimitrios Panidis ◽  
Nikolaos Spanos ◽  
Biljana Glišić ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Density Lipoprotein ◽  
Young Women ◽  
High Density Lipoprotein Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Normal Weight ◽  
Low Density ◽  
Apo B ◽  
Oxidised Low Density Lipoprotein

Objective: Women with polycystic ovary syndrome (PCOS) are assumed to be at increased risk for cardiovascular diseases. This study examined the variations in oxidised low-density lipoprotein (OxLDL) concentration in relation to insulin levels in young women with PCOS. Design: Cross-sectional clinical study in tertiary cares research hospitals. A total of 179 women with PCOS (79 overweight) and 56 age- and body mass index-matched controls were examined. Methods: Blood samples were collected in follicular phase of the cycle for the basal glucose, total-, high-density lipoprotein-cholesterol (HDL-C) and LDL-cholesterol, OxLDL, triglycerides, apolipoprotein–A1 (Apo-A1) and B (Apo-B), lipoprotein (a), insulin, testosterone and sex hormone-binding globulin (SHBG). Homeostatic model index (HOMA) and free androgen index (FAI) were determined. Results: Overweight and normal weight women with PCOS had higher concentrations of OxLDL than their control counterparts (P=0.007 and 0.003 respectively). Both the basal insulin (P=0.003) and HOMA values (P<0.001) were significantly higher in overweight than normal weight patients. Testosterone and FAI were higher in patients than in the respective controls (P<0.001). The only independent predictor of increased OxLDL concentration in normal weight patients was Apo-B-to-Apo-A1 ratio (P<0.001, odds ratio (OR) 6.1; 95% confidence interval (CI) 2.3–16.4), while in obese PCOS, it was total cholesterol-to-high-density lipoprotein cholesterol ratio (P<0.001, OR 2.8; 95% CI 1.6–4.9). Conclusion: Young normal weight and overweight PCOS women have similarly increased OxLDL levels. Our results may indicate the presence of primary alteration in lipid metabolism in patients with PCOS. To answer the question whether the alteration in LDL particle size can by itself pose a higher cardiovascular risk, a careful follow-up of these women is needed.

scholarly journals Age-Related Changes in Serum Lipid Levels, Hepatic Morphology, Antioxidant Status, Lipid Metabolism Related Gene Expression and Enzyme Activities of Domestic Pigeon Squabs (Columba livia)

Animals ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1121
Author(s):  
Qianqian Xu ◽  
Huaiyu Li ◽  
Wenting Zhou ◽  
Xiaoting Zou ◽  
Xinyang Dong
Keyword(s):  
Lipid Metabolism ◽  
Cholesterol Level ◽  
Antioxidant Status ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Columba Livia ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Age Related

The objective of this study was to evaluate the age-related changes in antioxidant status and the lipid metabolism of pigeon squabs (Columba livia), by determining the BW, antioxidant indices, serum lipid levels, lipid metabolism-related enzyme activities, lipid metabolism-related gene expression, and liver morphology in squabs. Ten squabs were randomly selected and sampled on the day of hatching (DOH), days 7 (D7), 14 (D14) and 21 (D21) post-hatch, respectively. The results showed that BW of squabs increased linearly from DOH to D21. The minimum fold of BW gain was observed in the phase from D14 to D21. Serum triglyceride and free fatty acid levels displayed linear and quadratic trends as age increased, with these maximum responses in D14. Serum low-density lipoprotein cholesterol level responded to age linearly and quadratically with the minimum in D14. Serum high-density lipoprotein cholesterol level and the ratio of high-density lipoprotein cholesterol to low-density lipoprotein cholesterol increased linearly with age, whereas the very low-density lipoprotein cholesterol level decreased linearly. The activities of glutathione peroxidase, catalase, and superoxide dismutase in liver displayed linear and quadratic trends as age increased, with these minimum responses in D14. Hepatic malondialdehyde concentration responded to age linearly and quadratically, with the maximum in D14. Activities of lipoprotein lipase, hepatic lipase, and 3-hydroxy-3-methyl glutaryl coenzyme A reductase in liver responded to age linearly and quadratically, with these minimum responses in D14. Hepatic hormone-sensitive lipase activity displayed linear and quadratic trends as age increased with the maximum in D14. Hepatic acetyl CoA carboxylase activity on D14 was significantly lower than squabs on DOH and D7. Hepatic carnitine palmitoyltransferase 1 mRNA expression responded to age linearly and quadratically, with minimum response in D14. Hepatic mRNA expression of acetyl CoA carboxylase and fatty acid synthetase increased linearly with age. Hepatic Oil-Red-O staining area displayed a quadratic trend as age increased, with the maximum response in D14. In conclusion, the phase from DOH to D14 was a crucial development stage for growth, antioxidant status and lipid metabolism in pigeon squabs. The results suggest it is better to take nutritional manipulation in squabs before D14.

Comparison of Associations between One-Carbon Metabolism, Lipid Metabolism, and Fatty Liver Markers in Normal-Weight and Overweight People Aged 20–40 Years

2021 ◽  
pp. 1-10
Author(s):  
Monika A. Młodzik-Czyżewska ◽  
Artur Szwengiel ◽  
Anna M. Malinowska ◽  
Agata Chmurzynska
Keyword(s):  
Body Weight ◽  
Lipid Metabolism ◽  
Fatty Liver ◽  
Carbon Metabolism ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Normal Weight ◽  
Serum Folate ◽  
Obese People ◽  
One Carbon Metabolism

The aim of the present study was to compare biomarkers of one-carbon metabolism (OCM), lipid metabolism, and fatty liver in people with normal and increased body weight. The study was performed on 421 participants, aged 20–40 years, enrolled in Poznan, Poland, in 2016–2018. Choline and betaine intakes were assessed. DNA samples were genotyped for polymorphisms of phosphatidylethanolamine N-methyltransferase (<i>PEMT</i>; rs7946 and rs12325817), methylene tetrahydrofolate reductase (<i>MTHFR</i>; rs180113), methylenetetrahydrofolate dehydrogenase (<i>MTHFD1</i>; rs2236225), and dihydrofolate reductase (<i>DHFR</i>; rs70991108). To assess the associations between blood metabolites (choline, betaine, folate, L-carnitine, o-acetyl-L-carnitine, and trimethylamine N-oxide]), circulating lipids, and fatty liver indices, multiple logistic regression analyses were performed. Overweight/obese participants had 5.8% higher choline (<i>p</i> &#x3c; 0.05) and 10% higher L-carnitine (<i>p</i> &#x3c; 0.001) levels than normal-weight subjects. Serum folate and betaine levels were associated with lower total cholesterol (<i>p</i> &#x3c; 0.001 and <i>p</i> &#x3c; 0.05), low-density lipoprotein (LDL) cholesterol (<i>p</i> &#x3c; 0.001 and <i>p</i> &#x3c; 0.05, respectively), triacylglycerols (<i>p</i> &#x3c; 0.01 and <i>p</i> &#x3c; 0.001), and triglyceride glucose index (<i>p</i> &#x3c; 0.001 and <i>p</i> &#x3c; 0.01, respectively), though only in overweight/obese people. The <i>PEMT</i> rs12325817 CC genotype was associated with higher levels of high-density lipoprotein (HDL) cholesterol (<i>p</i> &#x3c; 0.01) in overweight/obese people. The associations between OCM markers, fatty liver indices, and blood lipids differ in subjects with normal and excessive body weight.

scholarly journals Age-Related Changes in Cognitive and Sensory Processing: Focus on Middle-Aged Adults

2015 ◽  
Vol 24 (2) ◽  
pp. 94-97 ◽  
Author(s):  
Larry E. Humes
Keyword(s):  
Older Adults ◽  
Cognitive Processing ◽  
Sensory Processing ◽  
Middle Aged ◽  
Cognitive Measures ◽  
Adult Intelligence Scale ◽  
Wechsler Adult Intelligence Scale ◽  
Age Related ◽  
Wechsler Adult Intelligence ◽  
Middle Aged Adults

Purpose The purpose of this article was to examine the effects of age on (a) various psychophysical measures of threshold sensitivity and temporal processing in hearing, vision, and touch and (b) measures of cognitive processing as assessed by the Wechsler Adult Intelligence Scale–Third Edition (Wechsler, 1997). Method Age group differences and correlations with age were examined, as were associations among age, sensory processing, and cognition. Results The group analyses showed significant differences on most sensory and cognitive measures such that middle-aged adults performed significantly worse than young adults and significantly better than older adults. Correlations of performance with age were also significant when analyses were restricted to just the young and middle-aged adults. Last, sensory processing, but not age, was significantly correlated with cognitive processing when analyses were restricted to just the young and middle-aged adults. Conclusion Middle-aged adults experienced declines in both sensory and cognitive processing. The declines in both the cognitive and sensory domains were such that, for most measures in each domain, the performance of middle-aged adults fell somewhere between that of young and older adults.

scholarly journals Inflamm-Aging Is Associated with Lower Plasma PTX3 Concentrations and an Impaired Capacity of PBMCs to Express hTERT following LPS Stimulation

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Aaron L. Slusher ◽  
Tiffany M. Zúñiga ◽  
Edmund O. Acevedo
Keyword(s):  
Gene Expression ◽  
Young Adults ◽  
Telomere Length ◽  
Immune Cell ◽  
Ex Vivo ◽  
Middle Aged ◽  
Human Telomerase Reverse Transcriptase ◽  
Negatively Associated ◽  
Htert Gene ◽  
Age Related

Age-related elevations in proinflammatory cytokines, known as inflamm-aging, are associated with shorter immune cell telomere lengths. Purpose. This study examined the relationship of plasma PTX3 concentrations, a biomarker of appropriate immune function, with telomere length in 15 middle-aged (40-64 years) and 15 young adults (20-31 years). In addition, PBMCs were isolated from middle-aged and young adults to examine their capacity to express a key mechanistic component of telomere length maintenance, human telomerase reverse transcriptase (hTERT), following ex vivo cellular stimulation. Methods. Plasma PTX3 and inflammatory cytokines (i.e., IL-6, IL-10, TGF-β, and TNF-α), PBMC telomere lengths, and PBMC hTERT gene expression and inflammatory protein secretion following exposure to LPS, PTX3, and PTX3+LPS were measured. Results. Aging was accompanied by the accumulation of centrally located visceral adipose tissue, without changes in body weight and BMI, and alterations in the systemic inflammatory milieu (decreased plasma PTX3 and TGF-β; increased TNF-α (p≤0.050)). In addition, shorter telomere lengths in middle-aged compared to young adults (p=0.011) were negatively associated with age, body fat percentages, and plasma TNF-α (r=−0.404, p=0.027; r=−0.427, p=0.019; and r=−0.323, p=0.041, respectively). Finally, the capacity of PBMCs to increase hTERT gene expression following ex vivo stimulation was impaired in middle-aged compared to young adults (p=0.033) and negatively associated with telomere lengths (r=0.353, p=0.028). Conclusions. Proinflammation and the impaired hTERT gene expression capacity of PBMCs may contribute to age-related telomere attrition and disease.

scholarly journals Differences in the Effects of Anthocyanin Supplementation on Glucose and Lipid Metabolism According to the Structure of the Main Anthocyanin: A Meta-Analysis of Randomized Controlled Trials

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2003
Author(s):  
Risa Araki ◽  
Akira Yada ◽  
Hirotsugu Ueda ◽  
Kenichi Tominaga ◽  
Hiroko Isoda
Keyword(s):  
Lipid Metabolism ◽  
Meta Analysis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Resistance Index ◽  
Lipoprotein Cholesterol ◽  
Controlled Trials ◽  
Oh Groups ◽  
Chemical Structures ◽  
Glucose And Lipid Metabolism

The effectiveness of anthocyanins may differ according to their chemical structures; however, randomized clinical controlled trials (RCTs) or meta-analyses that examine the consequences of these structural differences have not been reported yet. In this meta-analysis, anthocyanins in test foods of 18 selected RCTs were categorized into three types: cyanidin-, delphinidin-, and malvidin-based. Delphinidin-based anthocyanins demonstrated significant effects on triglycerides (mean difference (MD): −0.24, p < 0.01), low-density lipoprotein cholesterol (LDL-C) (MD: −0.28, p < 0.001), and high-density lipoprotein cholesterol (HDL-C) (MD: 0.11, p < 0.01), whereas no significant effects were observed for cyanidin- and malvidin-based anthocyanins. Although non-significant, favorable effects on total cholesterol (TC) and HDL-C were observed for cyanidin- and malvidin-based anthocyanins, respectively (both p < 0.1). The ascending order of effectiveness on TC and LDL-C was delphinidin-, cyanidin-, and malvidin-based anthocyanins, and the differences among the three groups were significant (both p < 0.05). We could not confirm the significant effects of each main anthocyanin on glucose metabolism; however, insulin resistance index changed positively and negatively with cyanidin- and delphinidin-based anthocyanins, respectively. Therefore, foods containing mainly unmethylated anthocyanins, especially with large numbers of OH groups, may improve glucose and lipid metabolism more effectively than those containing methylated anthocyanins.

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