scholarly journals MATHEMATICAL MODELLING OF GLIOBLASTOMA TUMOUR DEVELOPMENT: A REVIEW

2005 ◽  
Vol 15 (11) ◽  
pp. 1779-1794 ◽  
Author(s):  
HARALAMPOS HATZIKIROU ◽  
ANDREAS DEUTSCH ◽  
CARLO SCHALLER ◽  
MATTHIAS SIMON ◽  
KRISTIN SWANSON
Keyword(s):  
Mathematical Modelling ◽  
Tumour Growth ◽  
State Of The Art ◽  
Vascular Tumour ◽  
Open Problems ◽  
Malignant Brain Tumour ◽  
The Past ◽  
Research Perspectives ◽  
Current State ◽  
New Research

During the past several years mathematical models have been applied to various aspects of cancer dynamics, in particular avascular and vascular tumour growth, invasion, angiogenesis, and metastasis. This paper focuses on the most common and malignant brain tumour, glioblastoma, and surveys the growing number of studies dealing with mathematical modelling of this tumour. We attempt to classify these studies by their biomedical relevance and critically analyse their results. The aim of this review is to provide a meaningful reference, to both biomedical and mathematical researchers, of the current state of the art of glioma tumour modelling. The discussion attempts to identify current open problems as well as new research perspectives in the mathematical modelling of glioblastoma growth.

scholarly journals Felid Cardiopulmonary Nematodes: Dilemmas Solved and New Questions Posed

Pathogens ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 30
Author(s):  
Donato Traversa ◽  
Simone Morelli ◽  
Angela Di Cesare ◽  
Anastasia Diakou
Keyword(s):  
Respiratory Infections ◽  
Small Animal ◽  
Biological Information ◽  
Scientific Debate ◽  
The Past ◽  
Research Perspectives ◽  
Unexpected Findings ◽  
New Research ◽  
Alternative Routes ◽  
Applied Knowledge

In the past decade cardiopulmonary nematodes affecting felids have become a core research topic in small animal parasitology. In the late 2000s, an increase in studies was followed by unexpected findings in the early 2010s, which have stimulated research teams to start investigating these intriguing parasites. Prolific scientific debate and exchanges have then fostered field and laboratory studies and epi-zootiological surveys. New data have improved basic and applied knowledge, solved dilemmas and posed new questions. This article discusses the past and present background to felid cardiopulmonary nematodes after the last few years of intense scientific research. New data which have demonstrated the key role of Aelurostrongylus abstrusus and Troglostrongylus brevior in causing respiratory infections in domestic cats, and on the nil to negligible current importance of other species, i.e., Troglostrongylus subcrenatus, Oslerus rostratus and Angiostrongylus chabaudi, are presented. Biological information and hypothesized alternative routes of infection are analysed and discussed. Novel identification and taxonomical data and issues are reported and commented upon. On the whole, recent biological, ecological and epi-zootiological information on felid meta-strongyloids is critically analysed, with the aim to answer outstanding questions, stimulate future studies, and underline new research perspectives.

Analysis of Aluminium Beam-to-Column Joints by the Component Method: Existing Studies and Research Needs

2016 ◽  
Vol 710 ◽  
pp. 409-414 ◽  
Author(s):  
Gianfranco De Matteis ◽  
Giuseppe Brando
Keyword(s):  
Current Knowledge ◽  
Component Method ◽  
The Past ◽  
Research Fields ◽  
Numerical Studies ◽  
Current State ◽  
Moment Resisting ◽  
New Research ◽  
Steel Joints

This paper aims at providing an overview on the current state of the art and on possible future developments concerning the component method implementation for the classification of beam-to-column joints belonging to aluminum moment resisting frames.After a brief discussion on the component method theoretical bases, developed in the past to give a feasible calculation procedure for steel joints, recent experimental and numerical studies, carried out for investigating some aluminum components, are presented and discussed. In particular strengths and weaknesses of the current knowledge are put into evidence, also in light of the peculiarities that make aluminum alloys different from steel. The launch of new research fields, aimed at pursuing an update of the current codes dealing with aluminum structures, is therefore proposed.

scholarly journals Multifaceted origins of sex differences in the brain

2016 ◽  
Vol 371 (1688) ◽  
pp. 20150106 ◽  
Author(s):  
Margaret M. McCarthy
Keyword(s):  
Sex Differences ◽  
State Of The Art ◽  
Human Subjects ◽  
Special Issue ◽  
Molecular Analyses ◽  
The Past ◽  
Current State ◽  
Biological Variable ◽  
Males And Females ◽  
The Brain

Studies of sex differences in the brain range from reductionistic cell and molecular analyses in animal models to functional imaging in awake human subjects, with many other levels in between. Interpretations and conclusions about the importance of particular differences often vary with differing levels of analyses and can lead to discord and dissent. In the past two decades, the range of neurobiological, psychological and psychiatric endpoints found to differ between males and females has expanded beyond reproduction into every aspect of the healthy and diseased brain, and thereby demands our attention. A greater understanding of all aspects of neural functioning will only be achieved by incorporating sex as a biological variable. The goal of this review is to highlight the current state of the art of the discipline of sex differences research with an emphasis on the brain and to contextualize the articles appearing in the accompanying special issue.

scholarly journals Fluorescent Chemosensors for Ion and Molecule Recognition: The Next Chapter

2021 ◽  
Vol 2 ◽  
Author(s):  
Kai-Cheng Yan ◽  
Axel Steinbrueck ◽  
Adam C. Sedgwick ◽  
Tony D. James
Keyword(s):  
State Of The Art ◽  
Fluorescent Chemosensors ◽  
Distant Future ◽  
The Past ◽  
Current Trends ◽  
Current State ◽  
Future Challenges ◽  
Molecule Recognition

Over the past 30 years fluorescent chemosensors have evolved to incorporate many optical-based modalities and strategies. In this perspective we seek to highlight the current state of the art as well as provide our viewpoint on the most significant future challenges remaining in the area. To underscore current trends in the field and to facilitate understanding of the area, we provide the reader with appropriate contemporary examples. We then conclude with our thoughts on the most probable directions that chemosensor development will take in the not-too-distant future.

Iteration Theory: Dynamical Systems and Functional Equations

2003 ◽  
Vol 13 (07) ◽  
pp. 1627-1647 ◽  
Author(s):  
F. Balibrea ◽  
L. Reich ◽  
J. Smítal
Keyword(s):  
Dynamical Systems ◽  
Functional Equations ◽  
Discrete Dynamical Systems ◽  
Iteration Theory ◽  
Open Problems ◽  
Research Directions ◽  
The Past ◽  
New Research

The aim of this paper is to give an account of some problems considered in the past years in the setting of Discrete Dynamical Systems and Iterative Functional Equations, some new research directions and also state some open problems.

scholarly journals Subaqueous mass movements in the context of observations of contemporary slope failure

2020 ◽  
Vol 500 (1) ◽  
pp. 1-12
Author(s):  
Joshu J. Mountjoy ◽  
Aggeliki Georgiopoulou ◽  
Jason Chaytor ◽  
Michael A. Clare ◽  
Davide Gamboa ◽  
...  
Keyword(s):  
Slope Failure ◽  
State Of The Art ◽  
Societal Impact ◽  
Mass Movements ◽  
Spatial And Temporal Scales ◽  
The Past ◽  
Indonesian Archipelago ◽  
Landslide Processes ◽  
New Research

AbstractThe consequences of subaqueous landslides have been at the forefront of societal conscience more than ever in the last few years, with devastating and fatal events in the Indonesian Archipelago making global news. The new research presented in this volume demonstrates the breadth of ongoing investigation into subaqueous landslides, and shows that while events like the recent ones can be devastating, they are smaller in scale than those Earth has experienced in the past. Understanding the spectrum of subaqueous landslide processes, and therefore the potential societal impact, requires research across all spatial and temporal scales. This volume delivers a compilation of state-of-the-art papers covering regional landslide databases, advanced techniques for in situ measurements, numerical modelling of processes and hazards.

scholarly journals Insight and psychosis: the next 30 years

2019 ◽  
Vol 217 (3) ◽  
pp. 521-523 ◽  
Author(s):  
Anthony S. David
Keyword(s):  
Conceptual Development ◽  
State Of The Art ◽  
Involuntary Treatment ◽  
The Past ◽  
Current State ◽  
Decision Making Capacity ◽  
Cognitive Neurosciences ◽  
Clinical Associations ◽  
The Relationship ◽  
Made In

Academic interest in the concept of insight in psychosis has increased markedly over the past 30 years, prompting this selective appraisal of the current state of the art. Considerable progress has been made in terms of measurement and confirming a number of clinical associations. More recently, the relationship between insight and involuntary treatment has been scrutinised more closely alongside the link between decision-making capacity and insight. Advances in the clinical and cognitive neurosciences have influenced conceptual development, particularly the field of ‘metacognition’. New therapies, including those that are psychologically and neurophysiologically based, are being tested as ways to enhance insight.

FOREWORD

Geophysics ◽  
1964 ◽  
Vol 29 (2) ◽  
pp. 151-153 ◽  
Author(s):  
Charles C. Bates
Keyword(s):  
Prime Minister ◽  
State Of The Art ◽  
The United States ◽  
The Political ◽  
Bad Faith ◽  
Political Leaders ◽  
The Past ◽  
Current State ◽  
Nuclear Tests ◽  
Test Ban

A decade ago, it would have been the rare geophysicist indeed who would have predicted that his specialty was destined to become a major topic of discussion between such world political leaders as Presidents Eisenhower and Kennedy, Prime Minister Macmillan of Great Britain, and Chairman Khrushchev of the USSR. Yet this has come to pass during the past six years, for in 1958 there started the continuing round of international negotiations directed towards the creation of an effective underground test-ban treaty. During the conduct of these negotiations, it has been repeatedly necessary to assess the current state-of-the-art in seismology and its sister geophysical sciences, for the only detectable signals known to propagate for several hundreds to thousands of miles from underground nuclear tests are seismic in nature. With the United States policy being only to seek an underground-test-ban agreement incorporating strong safeguards against acts of bad faith, it is important that the political safe-guards be backed up by those of a geophysical nature.

scholarly journals Striving for State of the Art with Paradigm Interplay and Meta-Synthesis: Purpose-oriented Network Research Challenges and Good Research Practices as a Way Forward

2019 ◽  
Vol 2 (3) ◽  
pp. 175-186 ◽  
Author(s):  
Robin H Lemaire ◽  
Remco S Mannak ◽  
Sonia M Ospina ◽  
Martijn Groenleer
Keyword(s):  
Public Sector ◽  
State Of The Art ◽  
Research Field ◽  
Research Practices ◽  
The Public ◽  
Research Perspectives ◽  
Current State ◽  
Research Challenges ◽  
Network Research ◽  
Good Research

Abstract With the growing amount and increasing heterogeneity of research on purpose-oriented networks (PONs) in the public sector, it is imperative to find a way to synthesize this research. Drawing on the varied research perspectives on PONs, we advance the idea of paradigm interplay and meta-synthesis as aspirations for the field and argue this is especially key if we want the study of PONs to inform practice. However, we recognize several challenges in the current state of the PON research that prevent the field from making strides in paradigm interplay and meta-synthesis. We discuss six challenges which we consider the most critical: different labels, differences across research foci, variation in measurement, the nestedness of networks, the dynamism of networks, and variation in the network context. We suggest six good research practices that could contribute to overcoming the challenges now so as to make integration of the research field more of a possibility in the future.

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