scholarly journals PRODUCT AND PROCESS DEVELOPMENT INTENSITY IN PROCESS INDUSTRY: A CONCEPTUAL AND EMPIRICAL ANALYSIS OF THE ALLOCATION OF COMPANY RESOURCES FOR THE DEVELOPMENT OF PROCESS TECHNOLOGY

2002 ◽  
Vol 06 (02) ◽  
pp. 105-130 ◽  
Author(s):  
THOMAS LAGER
Keyword(s):  
Process Development ◽  
Paper Industry ◽  
Explanatory Power ◽  
Theoretical Models ◽  
Process Industry ◽  
Individual Development ◽  
Process Technology ◽  
Beverage Industry ◽  
The Future ◽  
Product And Process

In Process Industry, process development traditionally takes a large part of the company's total development efforts, but has nevertheless not received much attention in academic studies. As a part of a larger research project concerning process development in Process Industry, the allocation of company resources to R&D, and to process development in particular, has been investigated in an exploratory survey to R&D managers in European Process Industry (Mining & Mineral Industry, Food & Beverage Industry, Pulp & Paper Industry, Chemical Industry, Basic Metal Industry, and Other Process Industry). The results show that of the total resources for R&D, 40% was allocated to process development, and over 60% of the companies expected this figure to increase in the future. This figure not only shows the future importance of process development, but also indicates that the importance of product development in this group of companies is at present still rated higher than process development. The results from the study do not fit the most widely used theoretical models, and it is concluded that there is a need for better models with more explanatory power. The new concepts of product and process development intensity are introduced. The product and process development intensities can be looked upon as aggregated measures of individual development efforts by a company, and it is thus argued that they are of overall company strategic importance.

scholarly journals A NEW CONCEPTUAL MODEL FOR THE DEVELOPMENT OF PROCESS TECHNOLOGY IN PROCESS INDUSTRY: A POINT OF DEPARTURE FOR THE TRANSFORMATION OF THE "PROCESS DEVELOPMENT PROCESS" INTO A FORMAL WORK PROCESS?

2000 ◽  
Vol 04 (03) ◽  
pp. 319-346 ◽  
Author(s):  
THOMAS LAGER
Keyword(s):  
Conceptual Model ◽  
Development Process ◽  
Process Development ◽  
Process Industry ◽  
Process Technology ◽  
Work Process ◽  
Starting Point ◽  
Three Phase ◽  
Further Development ◽  
A Company

In an exploratory survey to R&D managers in different sectors of European Process Industry, the importance and present use of a formal work process for process development has been studied. A new conceptual three-phase model for the "process development process", including the identification of production needs, process development and transfer of results to production, was also tested. The results show that only 44% of the companies in the study presently use a formal work process for process development, but the need for such a process is considered to be high. Good support was given for the new conceptual model as a starting point for further development of a company-specific "process development process".

Respect for the Environment is Part of Competitiveness - Best Available Technology Applied to an Old Pulp Mill at Kaskinen

1999 ◽  
Vol 40 (11-12) ◽  
pp. 201-206
Author(s):  
I. Reilama ◽  
N. Ilomäki
Keyword(s):  
Process Development ◽  
Continuous Production ◽  
Production Capacity ◽  
Pulp Mill ◽  
Process Technology ◽  
Line Production ◽  
Nutrient Emissions ◽  
Best Available Technology ◽  
Available Technology ◽  
Process Solutions

Oy Metsä-Botnia Ab's Kaskinen mill produces ECF and TCF bleached softwood and hardwood pulp on a single continuous production line. Production capacity has been raised from 250,000 tonnes to 420,000 tonnes a year after the commission in 1977. The basic process solutions date mainly from the 1970s. However, process technology has been gradually modernised. With systematic and well-timed process development investments the mill has remained competitive and among frontrunners in terms of environmental protection. Today, Kaskinen represent the best available technology (BAT) applicable to old mills. Effluent loading in general and nutrient emissions in particular has diminished during the development projects of the mill. Comparison to other mills shows that as far as effluent emissions are concerned, Kaskinen is one of the best pulp mills in Finland and Scandinavia. In this presentation, Kaskinen is also compared to Metsä-Rauma, the first greenfield TCF mill in the world, which was started up in 1996. Kaskinen's pioneering work on TCF technology was used as a basis for process solutions in the Rauma greenfield project.

scholarly journals High-throughput microbioreactor provides a capable tool for early stage bioprocess development

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mathias Fink ◽  
Monika Cserjan-Puschmann ◽  
Daniela Reinisch ◽  
Gerald Striedner
Keyword(s):  
High Throughput ◽  
Process Development ◽  
Early Stage ◽  
Explanatory Power ◽  
Batch Mode ◽  
E Coli ◽  
Speed Up ◽  
Bioreactor System ◽  
Cell Densities ◽  
Microbial Systems

AbstractTremendous advancements in cell and protein engineering methodologies and bioinformatics have led to a vast increase in bacterial production clones and recombinant protein variants to be screened and evaluated. Consequently, an urgent need exists for efficient high-throughput (HTP) screening approaches to improve the efficiency in early process development as a basis to speed-up all subsequent steps in the course of process design and engineering. In this study, we selected the BioLector micro-bioreactor (µ-bioreactor) system as an HTP cultivation platform to screen E. coli expression clones producing representative protein candidates for biopharmaceutical applications. We evaluated the extent to which generated clones and condition screening results were transferable and comparable to results from fully controlled bioreactor systems operated in fed-batch mode at moderate or high cell densities. Direct comparison of 22 different production clones showed great transferability. We observed the same growth and expression characteristics, and identical clone rankings except one host-Fab-leader combination. This outcome demonstrates the explanatory power of HTP µ-bioreactor data and the suitability of this platform as a screening tool in upstream development of microbial systems. Fast, reliable, and transferable screening data significantly reduce experiments in fully controlled bioreactor systems and accelerate process development at lower cost.

scholarly journals Scaling-up production of plant endophytes in bioreactors: concepts, challenges and perspectives

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Seedhabadee Ganeshan ◽  
Seon Hwa Kim ◽  
Vladimir Vujanovic
Keyword(s):  
Crop Production ◽  
Process Development ◽  
Hazard Analysis ◽  
Scale Up ◽  
Process Technology ◽  
Lack Of Information ◽  
Agriculture Industry ◽  
Start Up ◽  
Plant Growth Promoting ◽  
Agriculture And Food

AbstractThe benefit of microorganisms to humans, animals, insects and plants is increasingly recognized, with intensified microbial endophytes research indicative of this realization. In the agriculture industry, the benefits are tremendous to move towards sustainable crop production and minimize or circumvent the use of chemical fertilizers and pesticides. The research leading to the identification of potential plant endophytes is long and arduous and for many researchers the challenge is ultimately in scale-up production. While many of the larger agriculture and food industries have their own scale-up and manufacturing facilities, for many in academia and start-up companies the next steps towards production have been a stumbling block due to lack of information and understanding of the processes involved in scale-up fermentation. This review provides an overview of the fermentation process from shake flask cultures to scale-up and the manufacturing steps involved such as process development optimization (PDO), process hazard analysis (PHA), pre-, in- and post-production (PIP) challenges and finally the preparation of a technology transfer package (TTP) to transition the PDO to manufacturing. The focus is on submerged liquid fermentation (SLF) and plant endophytes production by providing original examples of fungal and bacterial endophytes, plant growth promoting Penicillium sp. and Streptomyces sp. bioinoculants, respectively. We also discuss the concepts, challenges and future perspectives of the scale-up microbial endophyte process technology based on the industrial and biosafety research platform for advancing a massive production of next-generation biologicals in bioreactors.

Catholyte-free electroreduction of CO2 for sustainable production of CO: Concept, process development, techno-economic analysis, and CO2 reduction assessment

2021 ◽  
Author(s):  
Jaeseo Lee ◽  
Wonhee Lee ◽  
Kyung Hwan Ryu ◽  
Joungho Park ◽  
Hyo-Jin Lee ◽  
...  
Keyword(s):  
Economic Analysis ◽  
Process Development ◽  
Co2 Reduction ◽  
Sustainable Production ◽  
Carbon Neutrality ◽  
The Future

Electrochemical CO2 reduction (ECO2R) is considered as one of economically viable means to convert CO2 into useful products, for achieving carbon neutrality in the future. Many studies have been conducted...

The Market Valuation of Environmental Capital Expenditures by Pulp and Paper Companies

2004 ◽  
Vol 79 (2) ◽  
pp. 329-353 ◽  
Author(s):  
Peter M. Clarkson ◽  
Yue Li ◽  
Gordon D. Richardson
Keyword(s):  
Environmental Performance ◽  
Capital Expenditure ◽  
Paper Industry ◽  
Pulp And Paper Industry ◽  
Economic Benefits ◽  
Pulp And Paper ◽  
Market Valuation ◽  
The Future ◽  
Environmental Capital ◽  
Polluting Firms

The objective of this study is to examine the market valuation of environmental capital expenditure investment related to pollution abatement in the pulp and paper industry. The total environmental capital expenditure of $8.7 billion by our sample firms during 1989–2000 supports the focus on this industry. In order to be capitalized, an asset should be associated with future economic benefits. The existing environmental literature suggests that investors condition their evaluation of the future economic benefits arising from environmental capital expenditure on an assessment of the firms' environmental performance. This literature predicts the emergence of two environmental stereotypes: low-polluting firms that overcomply with existing environmental regulations, and high-polluting firms that just meet minimal environmental requirements. Our valuation evidence indicates that there are incremental economic benefits associated with environmental capital expenditure investment by low-polluting firms but not high-polluting firms. We also find that investors use environmental performance information to assess unbooked environmental liabilities, which we interpret to represent the future abatement spending obligations of high-polluting firms in the pulp and paper industry. We estimate average unbooked liabilities of $560 million for high-polluting firms, or 16.6 percent of market capitalization.

Assets and Economic Mobility in a Youth Cohort, 1985–1997

2003 ◽  
Vol 84 (1) ◽  
pp. 51-62 ◽  
Author(s):  
Richard K. Caputo
Keyword(s):  
Low Income ◽  
Economic Status ◽  
Explanatory Power ◽  
Individual Development ◽  
Economic Mobility ◽  
Full Time ◽  
Asset Ownership ◽  
Public And Private ◽  
Positive Economic ◽  
Full Time Employment

This study examined the role of assets in economic mobility within a youth cohort (N = 4,467) between 1985 and 19 97. Increasing percentages of poor and affluent youth resided in families with no change in economic status while increasing percentages of middle-class youth resided in families experiencing downward economic mobility. The rate of economic stasis of youth living in affluent families was about three times that of those in poor families. Length of time of asset ownership influenced economic mobility beyond that of background, sociodemographic, psychological, and other cumulative correlates. In particular, IRAs and tax-deferred annuities were related to positive economic mobility. Robust indicators of positive economic mobility included being a college graduate, number of siblings in family of origin, number of years of full-time employment, number of years living in households where someone received either AFDC/TANF or SSI, and locus of control. Robust indicators of downward economic mobility included age of respondent, number of years married, and being Catholic. Finally, neither sex nor race/ethnicity increased the explanatory power of positive economic mobility beyond that of other correlates regardless of asset ownership. Discussion also includes public and private initiatives to expand IRAs into Individual Development Accounts and to encourage employers to offer (and workers to take advantage of) tax-deferred annuities, particularly for low-income workers.

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