(Invited) The New Paradigm in Passive Sweat Wearables: Temporal Profiling of Biomarkers to Elucidate the Relationship between Stress and Inflammation in Passively Expressed Eccrine Sweat

2021 ◽  
Vol MA2021-01 (55) ◽  
pp. 1429-1429
Author(s):  
Shalini Prasad ◽  
Kai-chun Lin ◽  
Badrinath Jagannath ◽  
Madhavi Pali ◽  
Sayali Upasham ◽  
...  
Keyword(s):  
New Paradigm ◽  
The Relationship ◽  
Eccrine Sweat

KEUNTUNGAN DAN RISIKO USAHA MINI PURSE SEINE DI DESA SATHEAN

2017 ◽  
Vol 1 (2) ◽  
pp. 49-57
Author(s):  
Frischilla Pentury ◽  
Eygner Gerald Talakua ◽  
Tati Ngangun
Keyword(s):  
Business Owners ◽  
Purse Seine ◽  
Primary Data ◽  
Business Risk ◽  
New Paradigm ◽  
Risk Calculation ◽  
Business Sustainability ◽  
Profit Analysis ◽  
Business Profit ◽  
The Relationship

The low profits of mini purse seine in Sathean Village will have an impact on the business risks being carried out. The new paradigm states that the relationship between risk and profit levels is quadratic; too much risk can lead to the loss and even destruction of a business. Thus, the fisherman of mini purse seine business owners in Sathean Village needs to manage their business risk well to achieve optimum profit for business sustainability. This study aims to assess business profits and business risks. Primary data was collected on 6 fisherman owners of mini purse seine business owners in Sathean Village as respondents, conducted business profit analysis and business risk calculation based on probability density. The results showed that the business profit was Rp 241,608,203/year or Rp 196,551,994 in the peak season, Rp 41.828.721 in the medium season and Rp 3.2227.488 in the less season.In peak and less seasons, these businesses are at risk or have the opportunity to lose, while in the medium season is not risky.

scholarly journals A New Paradigm in the Relationship between Melatonin and Breast Cancer: Gut Microbiota Identified as a Potential Regulatory Agent

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3141
Author(s):  
Aurora Laborda-Illanes ◽  
Lidia Sánchez-Alcoholado ◽  
Soukaina Boutriq ◽  
Isaac Plaza-Andrades ◽  
Jesús Peralta-Linero ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gut Microbiota ◽  
Bacterial Population ◽  
Kynurenine Pathway ◽  
New Paradigm ◽  
Bacterial Composition ◽  
Glucuronidase Activity ◽  
The One ◽  
The Relationship ◽  
Melatonin Production

In this review we summarize a possible connection between gut microbiota, melatonin production, and breast cancer. An imbalance in gut bacterial population composition (dysbiosis), or changes in the production of melatonin (circadian disruption) alters estrogen levels. On the one hand, this may be due to the bacterial composition of estrobolome, since bacteria with β-glucuronidase activity favour estrogens in a deconjugated state, which may ultimately lead to pathologies, including breast cancer. On the other hand, it has been shown that these changes in intestinal microbiota stimulate the kynurenine pathway, moving tryptophan away from the melatonergic pathway, thereby reducing circulating melatonin levels. Due to the fact that melatonin has antiestrogenic properties, it affects active and inactive estrogen levels. These changes increase the risk of developing breast cancer. Additionally, melatonin stimulates the differentiation of preadipocytes into adipocytes, which have low estrogen levels due to the fact that adipocytes do not express aromatase. Consequently, melatonin also reduces the risk of breast cancer. However, more studies are needed to determine the relationship between microbiota, melatonin, and breast cancer, in addition to clinical trials to confirm the sensitizing effects of melatonin to chemotherapy and radiotherapy, and its ability to ameliorate or prevent the side effects of these therapies.

scholarly journals Ethical Issues in Consent for the Reuse of Data in Health Data Platforms

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Alex McKeown ◽  
Miranda Mourby ◽  
Paul Harrison ◽  
Sophie Walker ◽  
Mark Sheehan ◽  
...  
Keyword(s):  
Social Contract ◽  
Ethical Issues ◽  
Personalised Medicine ◽  
Data Reuse ◽  
Remote Access ◽  
Risk Indicators ◽  
New Paradigm ◽  
The Social ◽  
New Thinking ◽  
The Relationship

AbstractData platforms represent a new paradigm for carrying out health research. In the platform model, datasets are pooled for remote access and analysis, so novel insights for developing better stratified and/or personalised medicine approaches can be derived from their integration. If the integration of diverse datasets enables development of more accurate risk indicators, prognostic factors, or better treatments and interventions, this obviates the need for the sharing and reuse of data; and a platform-based approach is an appropriate model for facilitating this. Platform-based approaches thus require new thinking about consent. Here we defend an approach to meeting this challenge within the data platform model, grounded in: the notion of ‘reasonable expectations’ for the reuse of data; Waldron’s account of ‘integrity’ as a heuristic for managing disagreement about the ethical permissibility of the approach; and the element of the social contract that emphasises the importance of public engagement in embedding new norms of research consistent with changing technological realities. While a social contract approach may sound appealing, however, it is incoherent in the context at hand. We defend a way forward guided by that part of the social contract which requires public approval for the proposal and argue that we have moral reasons to endorse a wider presumption of data reuse. However, we show that the relationship in question is not recognisably contractual and that the social contract approach is therefore misleading in this context. We conclude stating four requirements on which the legitimacy of our proposal rests.

scholarly journals Review Paper: Implications of the “Cancer Stem Cell” Hypothesis on Murine Models of Colon Cancer and Colitis-associated Cancer

2009 ◽  
Vol 46 (5) ◽  
pp. 819-835 ◽  
Author(s):  
M. J. Hynes ◽  
K. M. Huang ◽  
E. H. Huang
Keyword(s):  
Colon Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Murine Models ◽  
New Paradigm ◽  
Cancer Stem Cell Hypothesis ◽  
Molecular Events ◽  
Invaluable Tool ◽  
Relationship Of ◽  
The Relationship

The use of murine models to investigate human diseases has been an invaluable tool. In the areas of inflammation and oncogenesis, such models have provided unique insights into pathogenesis and mechanisms to evaluate potential therapy. As such, one facet of these disease processes links inflammation and cancer. Inflammation is associated with at least 15% of the world's malignancies. One example of this relationship is documented in the association between colitis and colorectal cancer. To date, the precise molecular events linking inflammation and cancer remain unclear. A new paradigm that may bridge these processes includes the cancer stem cell hypothesis. In this review, murine models of colitis, colon cancer, and colitis-associated cancer are discussed in reference to the potential of this paradigm to clarify the relationship of these devastating diseases.

Disambiguating the Role of Paradigms in Mixed Methods Research

2019 ◽  
Vol 14 (1) ◽  
pp. 11-25 ◽  
Author(s):  
Virginia Ghiara
Keyword(s):  
Mixed Methods ◽  
Mixed Methods Research ◽  
New Paradigm ◽  
Clear Cut ◽  
Single Study ◽  
The Relationship ◽  
Ongoing Dialogue

In the mixed methods research (MMR) literature, the term paradigm is used in a number of ways to support very different accounts. This article aims to contribute to the ongoing dialogue about the relationship between MMR and paradigms by analyzing two main claims discussed in the literature: (a) MMR is a new paradigm and (b) MMR mixes different paradigms. Focusing on the notion of paradigms used to support each claim, it clarifies why MMR can be considered a new paradigm and discusses conditions under which it is possible to mix two or more paradigms within a single study. This clarification promotes a more clear-cut use of concepts such as paradigms and worldviews in the literature.

scholarly journals Individuation, Sexuation, Technicity

2020 ◽  
pp. 026327642096740
Author(s):  
Stephen D. Seely
Keyword(s):  
Queer Theory ◽  
Gender And Sexuality ◽  
New Paradigm ◽  
Sexuality Studies ◽  
Gender And Sexuality Studies ◽  
The World ◽  
The Relationship ◽  
Feminist And Queer Theory

Within the context of questions raised by gender and sexuality studies about the relationship between sex and technics, I develop a theory of sexuation derived from Gilbert Simondon’s philosophy of individuation. First, I provide an overview of Simondon’s philosophy of individuation, from the physical to the collective. In the second section, I turn to the question of sexuality, outlining an ontogenetic account in which sexuation is conceived as a process of both individuation and relation that is fundamental to certain living beings. Then, drawing on Simondon’s theorization of technics in its mediating function between humans and the world, I resituate understandings of the relation between sex and technics. While each section – Individuation, Sexuation, Technicity – argues for the significance of these concepts to feminist and queer theory, overall the essay uses Simondon’s work as a new paradigm for gender and sexuality studies and calls for the invention of a sexuate culture.

COVID-19, infection prevention and control within acute inpatient mental health facilities: a new challenge requiring a new approach

2020 ◽  
Vol 16 (2) ◽  
pp. 69-74
Author(s):  
Lisa McLean ◽  
Louise Forrester
Keyword(s):  
Mental Health ◽  
Prevention And Control ◽  
Infection Prevention ◽  
Mental Health Problems ◽  
Social Contact ◽  
Infection Prevention And Control ◽  
New Paradigm ◽  
Mental Health Settings ◽  
And Control ◽  
The Relationship

Mental Health inpatient units have a primary purpose of treating mental health problems, managing disturbance and promoting social contact and support networks. These factors can conflict with optimal infection prevention and control (IPC) measures.<br/> This commentary describes an IPC perspective of the challenges in managing the effects of the COVID-19 pandemic that are specific to acute mental health settings. It points out the main areas for IPC and mental health practice development.<br/> The need for a new paradigm in the relationship between IPC and mental health specialists is identified. Recent collaboration between mental health and IPC specialists in evaluating personal protective equipment (PPE) for use in restraint is outlined.

scholarly journals Is theory the best practise: A review of research in work psychology in Serbia (1995-2019)

2021 ◽  
Vol 24 (1) ◽  
pp. 101-127
Author(s):  
Mirosava Đurišić-Bojanović ◽  
Slavica Maksić
Keyword(s):  
Social Development ◽  
Human Resource Development ◽  
Practical Knowledge ◽  
Social Changes ◽  
Applied Psychology ◽  
New Paradigm ◽  
Social Relevance ◽  
Research Activities ◽  
Work Psychology ◽  
The Relationship

The paper deals with the relationship between academic, applied and practical knowledge in the field of applied psychology, which has the potential to contribute to economic and social development. The aim of the analysis is to make an initial insight into the dominant topics and social relevance of research activities in the field of work psychology in Serbia in the period of significant social changes (1995-2019). The material for the analysis consisted of abstracts of papers in the field of work psychology, which were presented at two leading national conferences - Empirical Research in Psychology and the Meeting of Psychologists of Serbia (N = 657). The thematic analytical procedure was used for the construction of the code system used for defining the criteria for collecting relevant data. Exploratory sequential design and comparative longitudinal analysis were used for data processing. The general conclusion based on qualitative data analysis suggests the existence of social relevance of research activities in the field of work psychology in this period. The results of the analysis were also considered from the perspective of some recent models of strategic planning and social development. The obtained results indicate the emergence of new topics and areas, as well as the existence of a link between significant social changes and research activities in the field of work psychology in this period. Some elements of the new paradigm of the positive human resource development practice are highlighted. The paper concludes with discussing the broader theoretical-methodological and practical implications of the obtained findings for work psychology.

scholarly journals ANALISIS TERHADAP UNDANG-UNDANG NOMOR 23 TAHUN 2011 TENTANG PENGELOLAAN ZAKAT (PERSPEKTIF HUKUM ISLAM)

2016 ◽  
Vol 15 (2) ◽  
Author(s):  
Budi Rahmat Hakim
Keyword(s):  
Islamic Law ◽  
Legal Framework ◽  
The State ◽  
New Paradigm ◽  
New Era ◽  
Key Issues ◽  
The Individual ◽  
Relationship Of ◽  
The Relationship ◽  
Tax Deduction

The Birth of Law No. 23/2011 marks a new era of transformation of the national charity which has given rise to a new paradigm of charity management in our country. Some rules are the result of constitutive ijtihadin the ?eld of charity gets a reaction from some quarters, especially related to the management of charity by the state authority. Regardless of the debate which led to the material and formal lawsuit, there are several key issues to be further analyzed in relation to the reconstruction of ?qh paradigm evaluated from the perspective of contemporary Islamic law. First, the authorities and the involvement of the state as charities through the agency or institution that is of?cially established or recognized by the state, so that the management of charity can be done effectively, guaranteed. And have legal certainty. Secondly, the absence of sanctions for muzaki who shirk the obligation of charity in Law No.23 / 2011 shows that the payment of charity is voluntary, therefore charity regulations in Indonesia are still considered weak in the legal framework that can bind to the individual or business entity that is exposed to the taxpayer , Third, the reform paradigm of subject, object and charity tas{arruf ?eld have already accommodated in Law No.23 / 2011 in accordance with the principle of mas}lah}atand justice. Fourth, the relationship of charity and tax reaf?rmed in the amendment of new Law charity as?scal incentives for charity payers to make charity as a reduction of PKP (tax deduction), although this provision has not been able to realize the position of charitywhich is more signi?cant as a tax deduction(tax credit).

Sign in / Sign up

Export Citation Format

Share Document