Microvascular alterations in the one-kidney, one-clip renal hypertensive rat

1984 ◽  
Vol 246 (5) ◽  
pp. H728-H732 ◽  
Author(s):  
R. L. Prewitt ◽  
I. I. Chen ◽  
R. F. Dowell
Keyword(s):  
Capillary Density ◽  
Arteriolar Wall ◽  
Microvascular Alterations ◽  
The One ◽  
Renal Hypertensive Rat ◽  
Structural Mechanisms ◽  
Arteriolar Diameter ◽  
Renal Hypertensive Rats ◽  
Made In

The microcirculation was studied in one-kidney, one-clip renal hypertensive rats ( 1KG ) and uninephrectomized controls at 4-6 and 8-10 wk postoperation. Under chloralose-urethan anesthesia the gracilis muscle was transilluminated in situ with a light pipe. Measurements of arteriolar and capillary density and arteriolar diameter were made in three consecutive states: innervated, denervated, and vasodilated with nitroprusside. Arteriolar wall-to-lumen ratio was measured after vasodilation. At 4-6 wk vasoconstriction was significantly greater in 1KG and vasodilated arteriolar diameter was significantly smaller, partially because of an elevated wall-to-lumen ratio. Capillary density in 1KG was reduced in the innervated and denervated states compared with controls. At 8-10 wk in the 1KG , arteriolar vasoconstriction was no longer significantly elevated. However, the vasodilated arteriolar diameter was smaller, wall-to-lumen ratio had increased further, and rarefaction of arterioles and capillaries was present. Thus, with time, structural mechanisms for increasing vascular resistance were seen to displace the active mechanism of vasoconstriction.

scholarly journals Analysis of the Previously Unknown Estampage of the Tonuquq Inscription Found in the Kyakhta Museum of Local Lore of Academician V. A. Obruchev

2021 ◽  
pp. 205-217
Author(s):  
Vladimir V. Tishin ◽  
Keyword(s):  
Field Research ◽  
Careful Analysis ◽  
Academic Community ◽  
Subsequent Work ◽  
Inner Asia ◽  
Russian Academy Of Sciences ◽  
The One ◽  
Academy Of Sciences ◽  
Made In

In July 2019, I received information about the discovery of an estampage of an inscription made in Old Turkic Runic Writing in the fond “Documents. Photo documents” of the Kyakhta Museum of Local Lore of Academician V. A. Obruchev. Judging on several obtained photographs, it has been tentatively identified as To?uquq/Tonyuquq Inscription. It is an epigraphic text on a monument of the period of the so-called Second Eastern Turkic Qaghanate, great nomadic empire that existed in Inner Asia in 682–744 A. D. The monument was discovered in 1897 and has since been repeatedly studied, copied and translated. I could find no information on which of the copies could have been found in Kyakhta. The opportunity to get acquainted with the find in situ came only in December 2019, and it became apparent that this copy has been previously unknown to the academic community. The subsequent work followed two directions. Firstly, it was necessary to establish the origin of the copy, its authorship, dating, and circumstances surrounding its appearance in the collections of the Kyakhta Museum of Local Lore. Secondly, it was necessary to work directly with the discovered copy for the purpose of its comparison with others known copies and, if possible, of identifying differences in copying any of the text fragments. As a result, it has been understood that the copy was made by Chinese scientists and then somehow transferred to St. Petersburg, wherefrom W. Kotwicz sent it to Kyakhta in April 1913 as a supplement to W. Radloff’s “Atlas of Antiquities of Mongolia.” Incidentally, it has been discovered that at least one of the similar copies of the To?uquq/Tonyuquq Inscription, stored today in the fonds of the Institute of Oriental Manuscripts (IOM) of the Russian Academy of Sciences, must be contemporary to the one found in Kyakhta. A careful analysis of the copy itself — eight estampages corresponding to the eight sides of the To?uquq/Tonyuquq Inscription (four sides on two stelae) — has allowed us to conclude that individual fragments differ from the corresponding ones on earliest copies made in 1898 in the course of the Orkhon expedition work, as well as from those made in 1909 in the field research of G. J. Ramstedt. We have also made measurements and description of these estampages.

scholarly journals On wh-movement in Spanish Echo Questions

2017 ◽  
Vol 6 (2) ◽  
pp. 181-205
Author(s):  
Ekaterina Chernova
Keyword(s):  
Syntactic Structure ◽  
The Other ◽  
Echo Features ◽  
The One ◽  
Made In ◽  
Echo Questions

This paper examines Spanish echo questions, an understudied phenomenon even in extensively described languages such as English. In particular, it focuses on a very particular type of echo questions, such as those made in response to a previous yes/no question (e.g. –Did you buy {mumble}?; –Did I buy what?) and makes a detailed description, on the one hand, of inherent echo features, common across most languages, and, on the other, those language-specific. In particular, I argue that wh-in-situ is not the only possible option in Spanish EQs in order to get a proper, echo interpretation. In addition, I offer some evidence from Spanish data in favour of a particular syntactic structure underlying this sort of questions (Sobin 2010).

Simulation of the internal temperature in the Passol Laboratory, University of Debrecen

2012 ◽  
Vol 3 (1) ◽  
pp. 63-73 ◽  
Author(s):  
I. Csáky ◽  
F. Kalmár
Keyword(s):  
Temperature Variation ◽  
Air Temperature ◽  
Indoor Air ◽  
Storage Capacity ◽  
Building Structures ◽  
Internal Temperature ◽  
The One ◽  
Heavy Structure ◽  
East West ◽  
Made In

Abstract Nowadays the facades of newly built buildings have significant glazed surfaces. The solar gains in these buildings can produce discomfort caused by direct solar radiation on the one hand and by the higher indoor air temperature on the other hand. The amplitude of the indoor air temperature variation depends on the glazed area, orientation of the facade and heat storage capacity of the building. This paper presents the results of a simulation, which were made in the Passol Laboratory of University of Debrecen in order to define the internal temperature variation. The simulation proved that the highest amplitudes of the internal temperature are obtained for East orientation of the facade. The upper acceptable limit of the internal air temperature is exceeded for each analyzed orientation: North, South, East, West. Comparing different building structures, according to the obtained results, in case of the heavy structure more cooling hours are obtained, but the energy consumption for cooling is lower.

scholarly journals Theoretical Modelling of Ion Exchange Processes in Glass: Advances and Challenges

2021 ◽  
Vol 11 (11) ◽  
pp. 5070
Author(s):  
Xesús Prieto-Blanco ◽  
Carlos Montero-Orille
Keyword(s):  
Ion Exchange ◽  
Diffusion Coefficients ◽  
Molten Salts ◽  
Theoretical Modelling ◽  
Copper Films ◽  
Theoretical Frameworks ◽  
Self Diffusion ◽  
Exchange Processes ◽  
The One ◽  
Made In

In the last few years, some advances have been made in the theoretical modelling of ion exchange processes in glass. On the one hand, the equations that describe the evolution of the cation concentration were rewritten in a more rigorous manner. This was made into two theoretical frameworks. In the first one, the self-diffusion coefficients were assumed to be constant, whereas, in the second one, a more realistic cation behaviour was considered by taking into account the so-called mixed ion effect. Along with these equations, the boundary conditions for the usual ion exchange processes from molten salts, silver and copper films and metallic cathodes were accordingly established. On the other hand, the modelling of some ion exchange processes that have attracted a great deal of attention in recent years, including glass poling, electro-diffusion of multivalent metals and the formation/dissolution of silver nanoparticles, has been addressed. In such processes, the usual approximations that are made in ion exchange modelling are not always valid. An overview of the progress made and the remaining challenges in the modelling of these unique processes is provided at the end of this review.

scholarly journals Modeling and evaluating beat gestures for social robots

2021 ◽  
Author(s):  
Unai Zabala ◽  
Igor Rodriguez ◽  
José María Martínez-Otzeta ◽  
Elena Lazkano
Keyword(s):  
Motion Capture ◽  
Motion Capture System ◽  
Generative Adversarial Network ◽  
Adversarial Network ◽  
Desirable Feature ◽  
Quantitative Results ◽  
Path Lengths ◽  
End Effectors ◽  
The One ◽  
Made In

AbstractNatural gestures are a desirable feature for a humanoid robot, as they are presumed to elicit a more comfortable interaction in people. With this aim in mind, we present in this paper a system to develop a natural talking gesture generation behavior. A Generative Adversarial Network (GAN) produces novel beat gestures from the data captured from recordings of human talking. The data is obtained without the need for any kind of wearable, as a motion capture system properly estimates the position of the limbs/joints involved in human expressive talking behavior. After testing in a Pepper robot, it is shown that the system is able to generate natural gestures during large talking periods without becoming repetitive. This approach is computationally more demanding than previous work, therefore a comparison is made in order to evaluate the improvements. This comparison is made by calculating some common measures about the end effectors’ trajectories (jerk and path lengths) and complemented by the Fréchet Gesture Distance (FGD) that aims to measure the fidelity of the generated gestures with respect to the provided ones. Results show that the described system is able to learn natural gestures just by observation and improves the one developed with a simpler motion capture system. The quantitative results are sustained by questionnaire based human evaluation.

scholarly journals NIR responsive tumor vaccine in situ for photothermal ablation and chemotherapy to trigger robust antitumor immune responses

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Lirong Zhang ◽  
Jingjing Zhang ◽  
Lixia Xu ◽  
Zijian Zhuang ◽  
Jingjin Liu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Tumor Vaccine ◽  
Oxidative Polymerization ◽  
Delivery Mode ◽  
Tumor Treatment ◽  
One Pot ◽  
Photothermal Ablation ◽  
Prolonged Retention ◽  
The One

Abstract Background Therapeutic tumor vaccine (TTV) that induces tumor-specific immunity has enormous potentials in tumor treatment, but high heterogeneity and poor immunogenicity of tumor seriously impair its clinical efficacy. Herein, a novel NIR responsive tumor vaccine in situ (HA-PDA@IQ/DOX HG) was prepared by integrating hyaluronic acid functionalized polydopamine nanoparticles (HA-PDA NPs) with immune adjuvants (Imiquimod, IQ) and doxorubicin (DOX) into thermal-sensitive hydrogel. Results HA-PDA@IQ NPs with high photothermal conversion efficiency (41.2%) and T1-relaxation efficiency were using HA as stabilizer by the one-pot oxidative polymerization. Then, HA-PDA@IQ loaded DOX via π-π stacking and mixed with thermal-sensitive hydrogel to form the HA-PDA@IQ/DOX HG. The hydrogel-confined delivery mode endowed HA-PDA@IQ/DOX NPs with multiple photothermal ablation performance once injection upon NIR irradiation due to the prolonged retention in tumor site. More importantly, this mode enabled HA-PDA@IQ/DOX NPs to promote the DC maturation, memory T cells in lymphatic node as well as cytotoxic T lymphocytes in spleen. Conclusion Taken together, the HA-PDA@IQ/DOX HG could be served as a theranostic tumor vaccine for complete photothermal ablation to trigger robust antitumor immune responses.

scholarly journals When to Substitute a Missing Upper Lateral With a Canine: A Simplified Approach

2021 ◽  
pp. 030157422098054
Author(s):  
Renu Datta
Keyword(s):  
Anterior Segment ◽  
Specific Treatment ◽  
Simplified Approach ◽  
Special Cases ◽  
Randomized Control ◽  
The One ◽  
Individual Presentation ◽  
Available Information ◽  
Missing Tooth ◽  
Made In

Introduction: The upper lateral incisor is the most commonly missing tooth in the anterior segment. It leads to esthetic and functional imbalance for the patients. The ideal solution is the one that is most conservative and which fulfills the functional and esthetic needs of the concerned individual. Canine substitution is evolving to be the treatment of choice in most of the cases, because of its various advantages. These are special cases that need more time and effort from the clinicians due to space discrepancy in the upper and lower arches, along with the presentation of individual malocclusion. Aims and Objectives: Malocclusion occurring due to missing laterals is more complex, needing more time and effort from the clinicians because of space discrepancy, esthetic compromise, and individual presentation of the malocclusion. An attempt has been made in this article to review, evaluate, and tabulate the important factors for the convenience of clinicians. Method: All articles related to canine substitution were searched in the electronic database PubMed, and the important factors influencing the decision were reviewed. After careful evaluation, the checklist was evolved. Result: The malocclusions in which canine substitution is the treatment of choice are indicated in the tabular form for the convenience of clinicians. Specific treatment-planning considerations and biomechanics that can lead to an efficient and long-lasting result are also discussed. Conclusion: The need of the hour is an evidence-based approach, along with a well-designed prospective randomized control trial to understand the importance of each factor influencing these cases. Until that time, giving the available information in a simplified way can be a quality approach to these cases.

Engaging with the science and politics of biodiversity futures: a literature review

2021 ◽  
pp. 1-8
Author(s):  
Carina Wyborn ◽  
Elena Louder ◽  
Mike Harfoot ◽  
Samantha Hill
Keyword(s):  
Human Life ◽  
Global Environmental Change ◽  
Life Forms ◽  
Trade Offs ◽  
Global Environmental ◽  
Science And Politics ◽  
Science Community ◽  
Impact On Biodiversity ◽  
Made In

Summary Future global environmental change will have a significant impact on biodiversity through the intersecting forces of climate change, urbanization, human population growth, overexploitation, and pollution. This presents a fundamental challenge to conservation approaches, which seek to conserve past or current assemblages of species or ecosystems in situ. This review canvases diverse approaches to biodiversity futures, including social science scholarship on the Anthropocene and futures thinking alongside models and scenarios from the biophysical science community. It argues that charting biodiversity futures requires processes that must include broad sections of academia and the conservation community to ask what desirable futures look like, and for whom. These efforts confront political and philosophical questions about levels of acceptable loss, and how trade-offs can be made in ways that address the injustices in the distribution of costs and benefits across and within human and non-human life forms. As such, this review proposes that charting biodiversity futures is inherently normative and political. Drawing on diverse scholarship united under a banner of ‘futures thinking’ this review presents an array of methods, approaches and concepts that provide a foundation from which to consider research and decision-making that enables action in the context of contested and uncertain biodiversity futures.

scholarly journals Two Separate Cases: Complex Chromosomal Abnormality Involving Three Chromosomes and Small Supernumerary Marker Chromosome in Patients with Impaired Reproductive Function

Genes ◽  
2020 ◽  
Vol 11 (12) ◽  
pp. 1511
Author(s):  
Tatyana V. Karamysheva ◽  
Tatyana A. Gayner ◽  
Vladimir V. Muzyka ◽  
Konstantin E. Orishchenko ◽  
Nikolay B. Rubtsov
Keyword(s):  
Genetic Counseling ◽  
Chromosome Rearrangement ◽  
Marker Chromosome ◽  
Reproductive Function ◽  
Small Supernumerary Marker Chromosome ◽  
Comprehensive Chromosome Screening ◽  
The Family ◽  
Multicolor Banding ◽  
The One

For medical genetic counseling, estimating the chance of a child being born with chromosome abnormality is crucially important. Cytogenetic diagnostics of parents with a balanced karyotype are a special case. Such chromosome rearrangements cannot be detected with comprehensive chromosome screening. In the current paper, we consider chromosome diagnostics in two cases of chromosome rearrangement in patients with balanced karyotype and provide the results of a detailed analysis of complex chromosomal rearrangement (CCR) involving three chromosomes and a small supernumerary marker chromosome (sSMC) in a patient with impaired reproductive function. The application of fluorescent in situ hybridization, microdissection, and multicolor banding allows for describing analyzed karyotypes in detail. In the case of a CCR, such as the one described here, the probability of gamete formation with a karyotype, showing a balance of chromosome regions, is extremely low. Recommendation for the family in genetic counseling should take into account the obtained result. In the case of an sSMC, it is critically important to identify the original chromosome from which the sSMC has been derived, even if the euchromatin material is absent. Finally, we present our view on the optimal strategy of identifying and describing sSMCs, namely the production of a microdissectional DNA probe from the sSMC combined with a consequent reverse painting.

Recent progress in the freeze-etching technique

1971 ◽  
Vol 261 (837) ◽  
pp. 121-131 ◽  
Keyword(s):  
High Vacuum ◽  
Molecular Size ◽  
Etching Technique ◽  
Structural Distortions ◽  
Shadow Casting ◽  
Structural Details ◽  
Freeze Etching ◽  
The One ◽  
Insight Into ◽  
Made In

The freeze-etching technique must be improved if structures at the molecular size level are to be seen. The limitations of the technique are discussed here together with the progress made in alleviating them. The vitrification of living specimens is limited by the fact that very high freezing rates are needed. The critical freezing rate can be lowered on the one hand by the introduction of antifreeze agents, on the other hand by the application of high hydrostatic pressure. The fracture process may cause structural distortions in the fracture face of the frozen specimen. The ‘double-replica’ method allows one to evaluate such artefacts and provides an insight into the way that membranes split. During etching there exists the danger of contaminating the fracture faces with condensable gases. Because of specimen temperatures below —110 °C, special care has to be taken in eliminating water vapour from the high vacuum. An improvement in coating freeze-etched specimens has resulted from the application of electron guns for evaporation of the highest melting-point metals. If heat transfer from gun to specimen is reduced to a minimum, Pt, Ir, Ta, W and C can be used for shadow casting. Best results are obtained with Pt-C and Ta-W . With the help of decoration effects Pt-C shadow castings give the most information about the fine structural details of the specimen.

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